메뉴 건너뛰기




Volumn 300, Issue 19, 2008, Pages 2253-2262

Ginkgo biloba for prevention of dementia: A randomized controlled trial

(18)  DeKosky, Steven T a,h,i   Williamson, Jeff D b   Fitzpatrick, Annette L c   Kronmal, Richard A c   Ives, Diane G a   Saxton, Judith A a   Lopez, Oscar L a   Burke, Gregory b   Carlson, Michelle C d   Fried, Linda P d   Kuller, Lewis H a   Robbins, John A e   Tracy, Russell P f   Woolard, Nancy F b   Dunn, Leslie a   Snitz, Beth E a   Nahin, Richard L g   Furberg, Curt D b  


Author keywords

[No Author keywords available]

Indexed keywords

GINKGO BILOBA EXTRACT; PLACEBO;

EID: 56649112752     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2008.683     Document Type: Article
Times cited : (601)

References (49)
  • 1
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health. 1998;88(9):1337-1342.
    • (1998) Am J Public Health , vol.88 , Issue.9 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 2
    • 0031695094 scopus 로고    scopus 로고
    • Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study
    • Aguero-Torres H, Fratiglioni L, Guo Z, Viitanen M, von Strauss E, Winblad B. Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study. Am J Public Health. 1998;88(10):1452-1456.
    • (1998) Am J Public Health , vol.88 , Issue.10 , pp. 1452-1456
    • Aguero-Torres, H.1    Fratiglioni, L.2    Guo, Z.3    Viitanen, M.4    von Strauss, E.5    Winblad, B.6
  • 4
    • 15044349673 scopus 로고    scopus 로고
    • Underrecognition of cognitive impairment in assisted living facilities
    • Magsi H, Malloy T. Underrecognition of cognitive impairment in assisted living facilities. J Am Geriatr Soc. 2005;53(2):295-298.
    • (2005) J Am Geriatr Soc , vol.53 , Issue.2 , pp. 295-298
    • Magsi, H.1    Malloy, T.2
  • 6
    • 0031080693 scopus 로고    scopus 로고
    • Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761)
    • Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J Mol Cell Cardiol. 1997;29(2):733-742.
    • (1997) J Mol Cell Cardiol , vol.29 , Issue.2 , pp. 733-742
    • Pietri, S.1    Maurelli, E.2    Drieu, K.3    Culcasi, M.4
  • 7
    • 0037126035 scopus 로고    scopus 로고
    • Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
    • Luo Y, Smith JV, Paramasivam V, et al. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci U S A. 2002;99(19):12197-12202.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12197-12202
    • Luo, Y.1    Smith, J.V.2    Paramasivam, V.3
  • 8
    • 0031788259 scopus 로고    scopus 로고
    • The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease
    • Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Arch Neurol. 1998;55(11):1409-1415.
    • (1998) Arch Neurol , vol.55 , Issue.11 , pp. 1409-1415
    • Oken, B.S.1    Storzbach, D.M.2    Kaye, J.A.3
  • 10
    • 0030759072 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group
    • Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia: North American EGb Study Group. JAMA. 1997;278(16):1327-1332.
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1327-1332
    • Le Bars, P.L.1    Katz, M.M.2    Berman, N.3    Itil, T.M.4    Freedman, A.M.5    Schatzberg, A.F.6
  • 11
    • 28244446721 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type
    • Schneider LS, DeKosky ST, Farlow MR, Tariot PN, Hörr R, Kieser M. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr Alzheimer Res. 2005;2(5):541-551.
    • (2005) Curr Alzheimer Res , vol.2 , Issue.5 , pp. 541-551
    • Schneider, L.S.1    DeKosky, S.T.2    Farlow, M.R.3    Tariot, P.N.4    Hörr, R.5    Kieser, M.6
  • 12
    • 49449087355 scopus 로고    scopus 로고
    • McCarney R, Fisher P, Iliffe S, et al. Ginkgo biloba for mild to moderate dementia in a community setting: a pragmatic, randomised, parallel-group, double-blind, placebo-controlled trial [published online June 9, 2008]. Int J Geriatr Psychiatry. doi: 10.1002/gps.2055.
    • McCarney R, Fisher P, Iliffe S, et al. Ginkgo biloba for mild to moderate dementia in a community setting: a pragmatic, randomised, parallel-group, double-blind, placebo-controlled trial [published online June 9, 2008]. Int J Geriatr Psychiatry. doi: 10.1002/gps.2055.
  • 13
    • 0029871249 scopus 로고    scopus 로고
    • Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
    • Kanowski S, Herrmann WM, Stephan K, Wierich W, Hörr R. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry. 1996;29(2):47-56.
    • (1996) Pharmacopsychiatry , vol.29 , Issue.2 , pp. 47-56
    • Kanowski, S.1    Herrmann, W.M.2    Stephan, K.3    Wierich, W.4    Hörr, R.5
  • 14
    • 42149166010 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline
    • Dodge HH, Zitzelberger T, Oken BS, Howieson D, Kaye J. A randomized placebo-controlled trial of Ginkgo biloba for the prevention of cognitive decline. Neurology. 2008;70(19 pt 2):1809-1817.
    • (2008) Neurology , vol.70 , Issue.19 PART 2 , pp. 1809-1817
    • Dodge, H.H.1    Zitzelberger, T.2    Oken, B.S.3    Howieson, D.4    Kaye, J.5
  • 15
    • 33750576826 scopus 로고    scopus 로고
    • The GuidAge study: Methodological issues: a 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint
    • Vellas B, Andrieu S, Ousset PJ, Ouzid M, Mathiex-Fortunet H. The GuidAge study: methodological issues: a 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint. Neurology. 2006;67(9)(suppl 3):S6-S11.
    • (2006) Neurology , vol.67 , Issue.9 SUPPL. 3
    • Vellas, B.1    Andrieu, S.2    Ousset, P.J.3    Ouzid, M.4    Mathiex-Fortunet, H.5
  • 16
    • 33646205347 scopus 로고    scopus 로고
    • The Ginkgo Evaluation of Memory (GEM) study: Design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    • DeKosky ST, Fitzpatrick A, Ives DG, et al. The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia. Contemp Clin Trials. 2006;27(3):238-253.
    • (2006) Contemp Clin Trials , vol.27 , Issue.3 , pp. 238-253
    • DeKosky, S.T.1    Fitzpatrick, A.2    Ives, D.G.3
  • 17
    • 33750302960 scopus 로고    scopus 로고
    • Recruitment of the elderly into a pharmacologic prevention trial: The Ginkgo Evaluation of Memory Study experience
    • Fitzpatrick AL, Fried LP, Williamson J, et al. Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory Study experience. Contemp Clin Trials. 2006;27(6):541-553.
    • (2006) Contemp Clin Trials , vol.27 , Issue.6 , pp. 541-553
    • Fitzpatrick, A.L.1    Fried, L.P.2    Williamson, J.3
  • 18
    • 0004235298 scopus 로고
    • American Psychiatric Association, 4th ed. Washington, DC: American Psychiatric Association;
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 19
    • 0027425211 scopus 로고
    • The Clinical Dementia Rating (CDR): Current version and scoring rules
    • Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412-2414.
    • (1993) Neurology , vol.43 , Issue.11 , pp. 2412-2414
    • Morris, J.C.1
  • 20
    • 67949086828 scopus 로고    scopus 로고
    • Snitz BE, Saxon J, Lopez OL, et al. Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) Study. Aging Ment Health. 2009;13(2). In press.
    • Snitz BE, Saxon J, Lopez OL, et al. Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) Study. Aging Ment Health. 2009;13(2). In press.
  • 21
    • 4544350756 scopus 로고    scopus 로고
    • Mild cognitive impairment: Beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    • Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment: beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256(3):240-246.
    • (2004) J Intern Med , vol.256 , Issue.3 , pp. 240-246
    • Winblad, B.1    Palmer, K.2    Kivipelto, M.3
  • 22
    • 0030775196 scopus 로고    scopus 로고
    • Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
    • Maurer K, Ihl R, Dierks T, Frolich L. Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. J Psychiatr Res. 1997;31(6):645-655.
    • (1997) J Psychiatr Res , vol.31 , Issue.6 , pp. 645-655
    • Maurer, K.1    Ihl, R.2    Dierks, T.3    Frolich, L.4
  • 24
    • 0023194048 scopus 로고
    • The Modified Mini-Mental State (3MS) examination
    • Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987;48(8):314-318.
    • (1987) J Clin Psychiatry , vol.48 , Issue.8 , pp. 314-318
    • Teng, E.L.1    Chui, H.C.2
  • 25
    • 0030470196 scopus 로고    scopus 로고
    • The Alzheimer's Disease Assessment Scale
    • Mohs RC. The Alzheimer's Disease Assessment Scale. Int Psychogeriatr. 1996;8(2):195-203.
    • (1996) Int Psychogeriatr , vol.8 , Issue.2 , pp. 195-203
    • Mohs, R.C.1
  • 26
    • 0023095275 scopus 로고
    • Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease
    • Becker JT, Boller F, Saxton J, Gonigle-Gibson KL. Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease. Cortex. 1987;23(1):59-72.
    • (1987) Cortex , vol.23 , Issue.1 , pp. 59-72
    • Becker, J.T.1    Boller, F.2    Saxton, J.3    Gonigle-Gibson, K.L.4
  • 28
    • 0026050589 scopus 로고
    • Development and validation of a model for estimating premorbid verbal intelligence in the elderly
    • Grober E, Sliwinski M. Development and validation of a model for estimating premorbid verbal intelligence in the elderly. J Clin Exp Neuropsychol. 1991;13(6):933-949.
    • (1991) J Clin Exp Neuropsychol , vol.13 , Issue.6 , pp. 933-949
    • Grober, E.1    Sliwinski, M.2
  • 29
    • 32344442907 scopus 로고    scopus 로고
    • Neuropsychological characteristics of mild cognitive impairment subgroups
    • Lopez OL, Becker JT, Jagust WJ, et al. Neuropsychological characteristics of mild cognitive impairment subgroups. J Neurol Neurosurg Psychiatry. 2006;77(2):159-165.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , Issue.2 , pp. 159-165
    • Lopez, O.L.1    Becker, J.T.2    Jagust, W.J.3
  • 31
    • 0001392453 scopus 로고
    • The relation of the trail making test to organic brain damage
    • Reitan RM. The relation of the trail making test to organic brain damage. J Consult Psychol. 1955;19(5):393-394.
    • (1955) J Consult Psychol , vol.19 , Issue.5 , pp. 393-394
    • Reitan, R.M.1
  • 32
    • 0034328702 scopus 로고    scopus 로고
    • Normative data on the Boston Naming Test and two equivalent 30-item short forms
    • Saxton J, Ratcliff G, Munro CA, et al. Normative data on the Boston Naming Test and two equivalent 30-item short forms. Clin Neuropsychol. 2000;14(4):526-534.
    • (2000) Clin Neuropsychol , vol.14 , Issue.4 , pp. 526-534
    • Saxton, J.1    Ratcliff, G.2    Munro, C.A.3
  • 36
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939-944.
    • (1984) Neurology , vol.34 , Issue.7 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 37
    • 0028240447 scopus 로고
    • Clinical criteria for vascular dementia: The NINDS-AIREN criteria
    • Erkinjuntti T. Clinical criteria for vascular dementia: the NINDS-AIREN criteria. Dementia. 1994;5(3-4):189-192.
    • (1994) Dementia , vol.5 , Issue.3-4 , pp. 189-192
    • Erkinjuntti, T.1
  • 38
    • 0028116512 scopus 로고
    • Diagnosis of vascular dementia: Consortium of Canadian Centres for Clinical Cognitive Research consensus statement
    • Rockwood K, Parhad I, Hachinski V, et al. Diagnosis of vascular dementia: Consortium of Canadian Centres for Clinical Cognitive Research consensus statement. Can J Neurol Sci. 1994;21(4):358-364.
    • (1994) Can J Neurol Sci , vol.21 , Issue.4 , pp. 358-364
    • Rockwood, K.1    Parhad, I.2    Hachinski, V.3
  • 39
    • 12944268985 scopus 로고    scopus 로고
    • Clinical criteria for the diagnosis of vascular dementia: A multicenter study of comparability and interrater reliability
    • Chui HC, Mack W, Jackson JE, et al. Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability. Arch Neurol. 2000;57(2):191-196.
    • (2000) Arch Neurol , vol.57 , Issue.2 , pp. 191-196
    • Chui, H.C.1    Mack, W.2    Jackson, J.E.3
  • 41
    • 0020072605 scopus 로고
    • Effects of Ginkgo biloba on arterial smooth muscle responses to vasoactive stimuli
    • Auguet M, DeFeudis FV, Clostre F. Effects of Ginkgo biloba on arterial smooth muscle responses to vasoactive stimuli. Gen Pharmacol. 1982;13(2):169-171.
    • (1982) Gen Pharmacol , vol.13 , Issue.2 , pp. 169-171
    • Auguet, M.1    DeFeudis, F.V.2    Clostre, F.3
  • 42
    • 0034121829 scopus 로고    scopus 로고
    • The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid
    • Bastianetto S, Ramassamy C, Dore S, Christen Y, Poirier J, Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur J Neurosci. 2000;12(6):1882-1890.
    • (2000) Eur J Neurosci , vol.12 , Issue.6 , pp. 1882-1890
    • Bastianetto, S.1    Ramassamy, C.2    Dore, S.3    Christen, Y.4    Poirier, J.5    Quirion, R.6
  • 43
    • 33845270999 scopus 로고    scopus 로고
    • Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro
    • Brunetti L, Orlando G, Menghini L, Ferrante C, Chiavaroli A, Vacca M. Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro. Planta Med. 2006;72(14):1296-1299.
    • (2006) Planta Med , vol.72 , Issue.14 , pp. 1296-1299
    • Brunetti, L.1    Orlando, G.2    Menghini, L.3    Ferrante, C.4    Chiavaroli, A.5    Vacca, M.6
  • 44
    • 0030784465 scopus 로고    scopus 로고
    • Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway
    • Chen X, Salwinski S, Lee TJ. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin Exp Pharmacol Physiol. 1997;24(12):958-959.
    • (1997) Clin Exp Pharmacol Physiol , vol.24 , Issue.12 , pp. 958-959
    • Chen, X.1    Salwinski, S.2    Lee, T.J.3
  • 45
    • 0035849120 scopus 로고    scopus 로고
    • Aging and the public health effects of dementia
    • Kawas CH, Brookmeyer R. Aging and the public health effects of dementia. N Engl J Med. 2001;344(15):1160-1161.
    • (2001) N Engl J Med , vol.344 , Issue.15 , pp. 1160-1161
    • Kawas, C.H.1    Brookmeyer, R.2
  • 46
    • 85026143490 scopus 로고    scopus 로고
    • Ginkgo biloba for the prevention and treatment of cardiovascular disease: A review of the literature
    • Mahady GB. Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. J Cardiovasc Nurs. 2002;16(4):21-32.
    • (2002) J Cardiovasc Nurs , vol.16 , Issue.4 , pp. 21-32
    • Mahady, G.B.1
  • 48
    • 0025831464 scopus 로고
    • Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: Final results of the Systolic Hypertension in the Elderly Program (SHEP)
    • SHEP Cooperative Research Group
    • SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. 1991;265(24):3255-3264.
    • (1991) JAMA , vol.265 , Issue.24 , pp. 3255-3264
  • 49
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group
    • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA. 2002;288(23):2981-2997.
    • (2002) JAMA , vol.288 , Issue.23 , pp. 2981-2997


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.