Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid β-protein

Journal of Alzheimer's Disease

Volumn 3, Issue 1, 2001, Pages 75-81

  Selkoe, Dennis J ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; BEHAVIOR DISORDER; COGNITIVE DEFECT; CYTOPATHOGENIC EFFECT; GENETIC DISORDER; HUMAN; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVIEW;

EID: 0035081475     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2001-3111     Document Type: Review

References (21)

1. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
2. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
3. Image analysis of β-amyloid load in Alzheimcr's disease and relation to dementia severity
4. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
5. Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
6. Aging renders the brain vulnerable to amyloid betaprotein neurotoxicity
7. 42 accumulation in human brain
8. The Alzheimer family or diseases: Many etiologies, one pathogenesis?
9. Association of missense and 5′-splice-site mutations in tau with the inherited FTDP- 17
10. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
11. Reduction of beta-amyloid peptide 42 in the cerebrospinal fluid of patients with Alzheimer's disease
12. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
13. Apolipoprotein E, dementia, and cortical deposition of β-amyloid protein
14. Molecular mapping of Alzheimer-type dementia in Down's syndrome
15. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
16. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
17. Alzheimer's disease: Genotypes, phenotype, and treatments
18. Detection of a novel intraneuronal pool of insoluble amyloid β protein that accumulates with time in culture
19. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
20. Detection of intracellular oligomers of amyloid β-protein in cells derived from human brain
21. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity