메뉴 건너뛰기




Volumn 2, Issue 2, 2010, Pages 245-269

Hypomethylation of repeated DNA sequences in cancer

Author keywords

cancer; DNA hypomethylation; epigenome; repeat sequences; retrotransposons

Indexed keywords

DNA METHYLTRANSFERASE; TRANSFER RNA;

EID: 77954137460     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.10.2     Document Type: Review
Times cited : (100)

References (250)
  • 1
    • 32044455298 scopus 로고    scopus 로고
    • Large-scale structure of genomic methylation patterns
    • Rollins RA, Haghighi F, Edwards JR et al.: Large-scale structure of genomic methylation patterns. Genome Res. 16(2), 157-163 (2006).
    • (2006) Genome Res , vol.16 , Issue.2 , pp. 157-163
    • Rollins, R.A.1    Haghighi, F.2    Edwards, J.R.3
  • 2
    • 33748122556 scopus 로고    scopus 로고
    • Cancer-linked DNA hypomethylation and its relationship to hypermethylation
    • Doerfer W, Böhm P (Eds). Springer, Berlin, Germany
    • Ehrlich M: Cancer-linked DNA hypomethylation and its relationship to hypermethylation. In: DNA Methylation: Development, Genetic Disease and Cancer. Doerfer W, Böhm P (Eds). Springer, Berlin, Germany, 251-274 (2006).
    • (2006) DNA Methylation: Development, Genetic Disease and Cancer , pp. 251-274
    • Ehrlich, M.1
  • 3
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg A P, Ohlsson R, Henikoff S: The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 7(1), 21-33 (2006).
    • (2006) Nat. Rev. Genet , vol.7 , Issue.1 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 4
    • 33845417885 scopus 로고    scopus 로고
    • The cancer epigenome-components and functional correlates
    • Ting AH, McGarvey KM, Baylin SB: The cancer epigenome-components and functional correlates. Genes Dev. 20(23), 3215-3231 (2006).
    • (2006) Genes Dev , vol.20 , Issue.23 , pp. 3215-3231
    • Ting, A.H.1    McGarvey, K.M.2    Baylin, S.B.3
  • 5
    • 24744471011 scopus 로고    scopus 로고
    • Causes and consequences of DNA hypomethylation in human cancer
    • Hoffmann MJ, Schulz WA: Causes and consequences of DNA hypomethylation in human cancer. Biochem. Cell Biol. 83(3), 296-321 (2005).
    • (2005) Biochem. Cell Biol , vol.83 , Issue.3 , pp. 296-321
    • Hoffmann, M.J.1    Schulz, W.A.2
  • 7
    • 67650462249 scopus 로고    scopus 로고
    • DNA hypomethylation in the origin and pathogenesis of human diseases
    • Pogribny IP, Beland FA: DNA hypomethylation in the origin and pathogenesis of human diseases. Cell. Mol. Life Sci. 66(14), 2249-2261 (2009).
    • (2009) Cell. Mol. Life Sci , vol.66 , Issue.14 , pp. 2249-2261
    • Pogribny, I.P.1    Beland, F.A.2
  • 8
    • 77954661906 scopus 로고    scopus 로고
    • Recent review of hypomethylation of DNA as it relates to human pathology with a particular emphasis on one carbon metabolism, nutrition and environmental factors.Ehrlich M: DNA hypomethylation in cancer cells
    • Recent review of hypomethylation of DNA as it relates to human pathology with a particular emphasis on one carbon metabolism, nutrition and environmental factors.Ehrlich M: DNA hypomethylation in cancer cells. Epigenomics 1(2), 239-259 (2009).
    • (2009) Epigenomics , vol.1 , Issue.2 , pp. 239-259
  • 10
    • 61549137178 scopus 로고    scopus 로고
    • Emerging methods for ana lysis of the cancer methylome
    • Chang JW, Huang THM, Wang YC: Emerging methods for ana lysis of the cancer methylome. Pharmacogenomics 9(12), 1869-1878 (2008).
    • (2008) Pharmacogenomics , vol.9 , Issue.12 , pp. 1869-1878
    • Chang, J.W.1    Thm, H.2    Wang, Y.C.3
  • 11
    • 70350232064 scopus 로고    scopus 로고
    • Endogenous retroviral LTRs as promoters for human genes: A critical assessment
    • Cohen CJ, Lock WM, Mager DL: Endogenous retroviral LTRs as promoters for human genes: a critical assessment. Gene 448(2), 105-114 (2009).
    • (2009) Gene , vol.448 , Issue.2 , pp. 105-114
    • Cohen, C.J.1    Lock, W.M.2    Mager, D.L.3
  • 12
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and ana lysis of the human genome
    • Lander ES, Linton LM, Birren B et al.: Initial sequencing and ana lysis of the human genome. Nature 409(6822), 860-921 (2001).
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 13
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modifcation: Patterns and paradigms
    • Cedar H, Bergman Y: Linking DNA methylation and histone modifcation: patterns and paradigms. Nat. Rev. Genet. 10(5), 295-304 (2009).
    • (2009) Nat. Rev. Genet , vol.10 , Issue.5 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 14
    • 67651031415 scopus 로고    scopus 로고
    • Cancer stem cells: A new paradigm for understanding tumor growth and progression and drug resistance
    • Gangemi R, Paleari L, Orengo AM et al.: Cancer stem cells: a new paradigm for understanding tumor growth and progression and drug resistance. Curr. Med. Chem. 16(14), 1688-1703 (2009).
    • (2009) Curr. Med. Chem , vol.16 , Issue.14 , pp. 1688-1703
    • Gangemi, R.1    Paleari, L.2    Orengo, A.M.3
  • 15
    • 77954116916 scopus 로고    scopus 로고
    • Epigenome: The program for human health and disease
    • Jirtle RL: Epigenome: the program for human health and disease. Epigenomics 1(1), 13-16 (2009).
    • (2009) Epigenomics , vol.1 , Issue.1 , pp. 13-16
    • Jirtle, R.L.1
  • 16
    • 0142247187 scopus 로고    scopus 로고
    • Mammalian DNA (cytosine-5) methyltransferases and their expression
    • Pradhan S, Esteve PO: Mammalian DNA (cytosine-5) methyltransferases and their expression. Clin. Immunol. 109(1), 6-16 (2003).
    • (2003) Clin. Immunol , vol.109 , Issue.1 , pp. 6-16
    • Pradhan, S.1    Esteve, P.O.2
  • 17
    • 9744251005 scopus 로고    scopus 로고
    • Biochemistry and biology of mammalian DNA methyltransferases
    • Hermann A, Gowher H, Jeltsch A: Biochemistry and biology of mammalian DNA methyltransferases. Cell. Mol. Life Sci. 61(19-20), 2571-2587 (2004).
    • (2004) Cell. Mol. Life Sci , vol.61 , Issue.19-20 , pp. 2571-2587
    • Hermann, A.1    Gowher, H.2    Jeltsch, A.3
  • 18
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll MG, Bestor TH: Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481-514 (2005).
    • (2005) Annu. Rev. Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 19
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose RJ, Bird AP: Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31(2), 89-97 (2006).
    • (2006) Trends Biochem. Sci , vol.31 , Issue.2 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 20
    • 34247479414 scopus 로고    scopus 로고
    • Epigenetic decisions in mammalian germ cells
    • Schaefer CB, Ooi SKT, Bestor TH, Bourc'his D: Epigenetic decisions in mammalian germ cells. Science 316(5823), 398-399 (2007).
    • (2007) Science , vol.316 , Issue.5823 , pp. 398-399
    • Schaefer, C.B.1    Skt, O.2    Bestor, T.H.3    Bourc'His, D.4
  • 21
    • 34548705374 scopus 로고    scopus 로고
    • Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
    • Kato Y, Kaneda M, Hata K et al.: Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet. 16(19), 2272-2280 (2007).
    • (2007) Hum. Mol. Genet , vol.16 , Issue.19 , pp. 2272-2280
    • Kato, Y.1    Kaneda, M.2    Hata, K.3
  • 22
    • 0037168587 scopus 로고    scopus 로고
    • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
    • Chedin F, Lieber MR, Hsieh CL: The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc. Natl Acad. Sci. USA 99(26), 16916-16921 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.26 , pp. 16916-16921
    • Chedin, F.1    Lieber, M.R.2    Hsieh, C.L.3
  • 23
    • 26444561533 scopus 로고    scopus 로고
    • Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family
    • Chen ZX, Mann JR, Hsieh CL, Riggs AD, Chedin F: Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. J. Cell. Biochem. 95(5), 902-917 (2005).
    • (2005) J. Cell. Biochem , vol.95 , Issue.5 , pp. 902-917
    • Chen, Z.X.1    Mann, J.R.2    Hsieh, C.L.3    Riggs, A.D.4    Chedin, F.5
  • 24
    • 31444436545 scopus 로고    scopus 로고
    • Lsh is involved in de novo methylation of DNA
    • Zhu H, Geiman TM, Xi S et al.: Lsh is involved in de novo methylation of DNA. EMBO J. 25(2), 335-345 (2006).
    • (2006) EMBO J , vol.25 , Issue.2 , pp. 335-345
    • Zhu, H.1    Geiman, T.M.2    Xi, S.3
  • 25
    • 33751523649 scopus 로고    scopus 로고
    • Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells
    • De la Fuente R, Baumann C, Fan T, Schmidtmann A, Dobrinski I, Muegge K: Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells. Nat. Cell Biol. 8(12), U1448-U1485 (2006).
    • (2006) Nat. Cell Biol , vol.8 , Issue.12
    • De La Fuente, R.1    Baumann, C.2    Fan, T.3    Schmidtmann, A.4    Dobrinski, I.5    Muegge, K.6
  • 26
    • 55549102967 scopus 로고    scopus 로고
    • Keeping active endogenous retroviral-like elements in check: The epigenetic perspective
    • Maksakova IA, Mager DL, Reiss D: Keeping active endogenous retroviral-like elements in check: the epigenetic perspective. Cell. Mol. Life Sci. 65(21), 3329-3347 (2008).
    • (2008) Cell. Mol. Life Sci , vol.65 , Issue.21 , pp. 3329-3347
    • Maksakova, I.A.1    Mager, D.L.2    Reiss, D.3
  • 27
    • 37349045107 scopus 로고    scopus 로고
    • Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1
    • Kurihara Y, Kawamura Y, Uchijima Y et al.: Maintenance of genomic methylation patterns during preimplantation development requires the somatic form of DNA methyltransferase 1. Dev. Biol. 313(1), 335-346 (2008).
    • (2008) Dev. Biol , vol.313 , Issue.1 , pp. 335-346
    • Kurihara, Y.1    Kawamura, Y.2    Uchijima, Y.3
  • 29
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3), 247-257 (1999).
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 30
    • 36549069302 scopus 로고    scopus 로고
    • Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages
    • Yamagata K, Yamazaki T, Miki H et al.: Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages. Dev. Biol. 312(1), 419-426 (2007).
    • (2007) Dev. Biol , vol.312 , Issue.1 , pp. 419-426
    • Yamagata, K.1    Yamazaki, T.2    Miki, H.3
  • 31
    • 0037298161 scopus 로고    scopus 로고
    • Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse
    • Lane N, Dean W, Erhardt S et al.: Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis 35(2), 88-93 (2003).
    • (2003) Genesis , vol.35 , Issue.2 , pp. 88-93
    • Lane, N.1    Dean, W.2    Erhardt, S.3
  • 32
    • 27744566944 scopus 로고    scopus 로고
    • Lsh, a guardian of heterochromatin at repeat elements
    • Muegge K: Lsh, a guardian of heterochromatin at repeat elements. Biochem. Cell Biol. 83(4), 548-554 (2005).
    • (2005) Biochem. Cell Biol , vol.83 , Issue.4 , pp. 548-554
    • Muegge, K.1
  • 33
    • 58149143278 scopus 로고    scopus 로고
    • Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fbroblasts
    • Suzuki T, Farrar JE, Yegnasubramanian S, Zahed M, Suzuki N, Arceci RJ: Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fbroblasts. Epigenetics 3(5), 281-291 (2008).
    • (2008) Epigenetics , vol.3 , Issue.5 , pp. 281-291
    • Suzuki, T.1    Farrar, J.E.2    Yegnasubramanian, S.3    Zahed, M.4    Suzuki, N.5    Arceci, R.J.6
  • 34
    • 50849099769 scopus 로고    scopus 로고
    • Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions
    • Yehezkel S, Segev Y, Viegas-Pequignot E, Skorecki K, Selig S: Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum. Mol. Genet. 17(18), 2776-2789 (2008).
    • (2008) Hum. Mol. Genet , vol.17 , Issue.18 , pp. 2776-2789
    • Yehezkel, S.1    Segev, Y.2    Viegas-Pequignot, E.3    Skorecki, K.4    Selig, S.5
  • 35
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M, Dowen RH et al.: Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462(7271), 315-322 (2009).
    • (2009) Nature , vol.462 , Issue.7271 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 36
    • 0042311434 scopus 로고    scopus 로고
    • Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b
    • Suetake I, Miyazaki J, Murakami C, Takeshima H, Tajima S: Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b. J. Biochem. 133(6), 737-744 (2003).
    • (2003) J. Biochem , vol.133 , Issue.6 , pp. 737-744
    • Suetake, I.1    Miyazaki, J.2    Murakami, C.3    Takeshima, H.4    Tajima, S.5
  • 38
    • 4544223707 scopus 로고    scopus 로고
    • Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
    • Bourc'his D, Bestor TH: Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431(7004), 96-99 (2004).
    • (2004) Nature , vol.431 , Issue.7004 , pp. 96-99
    • Bourc'His, D.1    Bestor, T.H.2
  • 39
    • 28744442731 scopus 로고    scopus 로고
    • Meiotic and epigenetic aberrations in Dnmt3L-defcient male germ cells
    • Hata K, Kusumi M, Yokomine T, Li E, Sasaki H: Meiotic and epigenetic aberrations in Dnmt3L-defcient male germ cells. Mol. Reprod. Dev. 73(1), 116-122 (2006).
    • (2006) Mol. Reprod. Dev , vol.73 , Issue.1 , pp. 116-122
    • Hata, K.1    Kusumi, M.2    Yokomine, T.3    Li, E.4    Sasaki, H.5
  • 40
    • 0034162852 scopus 로고    scopus 로고
    • Whole-genome methylation scan in ICF syndrome: Hypomethylation of non-satellite DNA repeats D4Z4 and NBL2
    • Kondo T, Bobek MP, Kuick R et al.: Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2. Hum. Mol. Genet. 9(4), 597-604 (2000).
    • (2000) Hum. Mol. Genet , vol.9 , Issue.4 , pp. 597-604
    • Kondo, T.1    Bobek, M.P.2    Kuick, R.3
  • 41
    • 0032714089 scopus 로고    scopus 로고
    • Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes
    • Brock GJR, Charlton J, Bird A: Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene 240(2), 269-277 (1999).
    • (1999) Gene , vol.240 , Issue.2 , pp. 269-277
    • Gjr, B.1    Charlton, J.2    Bird, A.3
  • 42
    • 33645702660 scopus 로고    scopus 로고
    • DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    • Gonzalo S, Jaco I, Fraga MF et al.: DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat. Cell Biol. 8(4), 416-424 (2006).
    • (2006) Nat. Cell Biol , vol.8 , Issue.4 , pp. 416-424
    • Gonzalo, S.1    Jaco, I.2    Fraga, M.F.3
  • 43
  • 44
    • 33846590977 scopus 로고    scopus 로고
    • Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
    • Benetti R, Garcia-Cao M, Blasco MA: Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres. Nat. Genet. 39(2), 243-250 (2007).
    • (2007) Nat. Genet , vol.39 , Issue.2 , pp. 243-250
    • Benetti, R.1    Garcia-Cao, M.2    Blasco, M.A.3
  • 45
    • 65449186589 scopus 로고    scopus 로고
    • A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation
    • El-Maarri O, Kareta MS, Mikeska T et al.: A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. Hum. Mol. Genet. 18(10), 1755-1768 (2009).
    • (2009) Hum. Mol. Genet , vol.18 , Issue.10 , pp. 1755-1768
    • El-Maarri, O.1    Kareta, M.S.2    Mikeska, T.3
  • 46
    • 33645460549 scopus 로고    scopus 로고
    • How imprinting centres work
    • Lewis A, Reik W: How imprinting centres work. Cytogenet. Genome Res. 113(1-4), 81-89 (2006).
    • (2006) Cytogenet. Genome Res , vol.113 , Issue.1-4 , pp. 81-89
    • Lewis, A.1    Reik, W.2
  • 48
    • 0344961845 scopus 로고    scopus 로고
    • X chromosome inactivation: Theme and variations
    • Migeon BR: X chromosome inactivation: theme and variations. Cytogenet. Genome Res. 99(1-4), 8-16 (2002).
    • (2002) Cytogenet. Genome Res , vol.99 , Issue.1-4 , pp. 8-16
    • Migeon, B.R.1
  • 49
    • 23044437498 scopus 로고    scopus 로고
    • RNA meets chromatin
    • Bernstein E, Allis CD: RNA meets chromatin. Genes Dev. 19(14), 1635-1655 (2005).
    • (2005) Genes Dev , vol.19 , Issue.14 , pp. 1635-1655
    • Bernstein, E.1    Allis, C.D.2
  • 50
    • 22144447822 scopus 로고    scopus 로고
    • RNA interference and heterochromatin in the fssion yeast Schizosaccharomyces pombe
    • Martienssen RA, Zaratiegui M, Goto DB: RNA interference and heterochromatin in the fssion yeast Schizosaccharomyces pombe. Trends Genet. 21(8), 450-456 (2005).
    • (2005) Trends Genet , vol.21 , Issue.8 , pp. 450-456
    • Martienssen, R.A.1    Zaratiegui, M.2    Goto, D.B.3
  • 51
    • 34249304470 scopus 로고    scopus 로고
    • Transcription and RNA interference in the formation of heterochromatin
    • Grewal SI, Elgin SC: Transcription and RNA interference in the formation of heterochromatin. Nature 447(7143), 399-406 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 399-406
    • Grewal, S.I.1    Elgin, S.C.2
  • 52
    • 36749037521 scopus 로고    scopus 로고
    • The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race
    • Aravin AA, Hannon GJ, Brennecke J: The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science 318(5851), 761-764 (2007).
    • (2007) Science , vol.318 , Issue.5851 , pp. 761-764
    • Aravin, A.A.1    Hannon, G.J.2    Brennecke, J.3
  • 53
    • 70349303348 scopus 로고    scopus 로고
    • The secret message of heterochromatin: New insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription
    • Eymery A, Callanan M, Vourc'h C: The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription. Int. J. Dev. Biol. 53(2-3), 259-268 (2009).
    • (2009) Int. J. Dev. Biol , vol.53 , Issue.2-3 , pp. 259-268
    • Eymery, A.1    Callanan, M.2    Vourc'H, C.3
  • 54
    • 56449126497 scopus 로고    scopus 로고
    • KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state
    • Frescas D, Guardavaccaro D, Kuchay SM et al.: KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle 7(22), 3539-3547 (2008).
    • (2008) Cell Cycle , vol.7 , Issue.22 , pp. 3539-3547
    • Frescas, D.1    Guardavaccaro, D.2    Kuchay, S.M.3
  • 55
    • 34547628691 scopus 로고    scopus 로고
    • Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere
    • Wong LH, Brettingham-Moore KH, Chan L et al.: Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere. Genome Res. 17(8), 1146-1160 (2007).
    • (2007) Genome Res , vol.17 , Issue.8 , pp. 1146-1160
    • Wong, L.H.1    Brettingham-Moore, K.H.2    Chan, L.3
  • 56
    • 44349130233 scopus 로고    scopus 로고
    • Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
    • Watanabe T, Totoki Y, Toyoda A et al.: Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453(7194), 539-543 (2008).
    • (2008) Nature , vol.453 , Issue.7194 , pp. 539-543
    • Watanabe, T.1    Totoki, Y.2    Toyoda, A.3
  • 57
    • 33745336617 scopus 로고    scopus 로고
    • A germline-specifc class of small RNAs binds mammalian Piwi proteins
    • Girard A, Sachidanandam R, Hannon GJ, Carmell MA: A germline-specifc class of small RNAs binds mammalian Piwi proteins. Nature 442(7099), 199-202 (2006).
    • (2006) Nature , vol.442 , Issue.7099 , pp. 199-202
    • Girard, A.1    Sachidanandam, R.2    Hannon, G.J.3    Carmell, M.A.4
  • 58
    • 52049098967 scopus 로고    scopus 로고
    • A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
    • Aravin AA, Sachidanandam R, Bourc'his D et al.: A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31(6), 785-799 (2008).
    • (2008) Mol. Cell , vol.31 , Issue.6 , pp. 785-799
    • Aravin, A.A.1    Sachidanandam, R.2    Bourc'His, D.3
  • 59
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ: Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316(5825), 744-747 (2007).
    • (2007) Science , vol.316 , Issue.5825 , pp. 744-747
    • Aravin, A.A.1    Sachidanandam, R.2    Girard, A.3    Fejes-Toth, K.4    Hannon, G.J.5
  • 60
    • 33947720638 scopus 로고    scopus 로고
    • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
    • Carmell MA, Girard A, van de Kant HJG et al.: MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12(4), 503-514 (2007).
    • (2007) Dev. Cell , vol.12 , Issue.4 , pp. 503-514
    • Carmell, M.A.1    Girard, A.2    Van De Kant, H.J.G.3
  • 61
    • 41649116098 scopus 로고    scopus 로고
    • DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes
    • Kuramochi-Miyagawa S, Watanabe T, Gotoh K et al.: DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 22(7), 908-917 (2008).
    • (2008) Genes Dev , vol.22 , Issue.7 , pp. 908-917
    • Kuramochi-Miyagawa, S.1    Watanabe, T.2    Gotoh, K.3
  • 62
    • 42149171774 scopus 로고    scopus 로고
    • Small RNA guides for de novo DNA methylation in mammalian germ cells
    • Aravin AA, Bourc'his D: Small RNA guides for de novo DNA methylation in mammalian germ cells. Genes Dev. 22(8), 970-975 (2008).
    • (2008) Genes Dev , vol.22 , Issue.8 , pp. 970-975
    • Aravin, A.A.1    Bourc'His, D.2
  • 63
    • 0034015438 scopus 로고    scopus 로고
    • CpG-island methylation in aging and cancer
    • Issa JP: CpG-island methylation in aging and cancer. Curr. Top. Microbiol. Immunol. 249, 101-118 (2000).
    • (2000) Curr. Top. Microbiol. Immunol , vol.249 , pp. 101-118
    • Issa, J.P.1
  • 64
    • 4444375474 scopus 로고    scopus 로고
    • Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: An HPLC-based study
    • Fuke C, Shimabukuro M, Petronis A et al.: Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study. Ann. Hum. Genet. 68(Pt 3), 196-204 (2004).
    • (2004) Ann. Hum. Genet , vol.68 , Issue.PART 3 , pp. 196-204
    • Fuke, C.1    Shimabukuro, M.2    Petronis, A.3
  • 65
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • Bollati V, Schwartz J, Wright R et al.: Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech. Ageing Dev. 130(4), 234-239 (2009).
    • (2009) Mech. Ageing Dev , vol.130 , Issue.4 , pp. 234-239
    • Bollati, V.1    Schwartz, J.2    Wright, R.3
  • 66
    • 9944233064 scopus 로고    scopus 로고
    • Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis
    • Chalitchagorn K, Shuangshoti S, Hourpai N et al.: Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene 23(54), 8841-8846 (2004).
    • (2004) Oncogene , vol.23 , Issue.54 , pp. 8841-8846
    • Chalitchagorn, K.1    Shuangshoti, S.2    Hourpai, N.3
  • 67
    • 33644825262 scopus 로고    scopus 로고
    • Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage
    • Suzuki K, Suzuki I, Leodolter A et al.: Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage. Cancer Cell 9(3), 199-207 (2006).
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 199-207
    • Suzuki, K.1    Suzuki, I.2    Leodolter, A.3
  • 70
    • 67650067284 scopus 로고    scopus 로고
    • Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer
    • Choi SH, Worswick S, Byun HM et al.: Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. Int. J. Cancer 125(3), 723-729 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.3 , pp. 723-729
    • Choi, S.H.1    Worswick, S.2    Byun, H.M.3
  • 71
    • 70350215746 scopus 로고    scopus 로고
    • Loss of epigenetic silencing in tumors preferentially affects primate-specifc retroelements
    • Szpakowski S, Sun XG, Lage JM et al.: Loss of epigenetic silencing in tumors preferentially affects primate-specifc retroelements. Gene 448(2), 151-167 (2009).
    • (2009) Gene , vol.448 , Issue.2 , pp. 151-167
    • Szpakowski, S.1    Sun, X.G.2    Lage, J.M.3
  • 72
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3(6), 415-428 (2002).
    • (2002) Nat. Rev. Genet , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 73
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB: The epigenomics of cancer. Cell 128(4), 683-692 (2007).
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 74
    • 70549086900 scopus 로고    scopus 로고
    • Epigenetic mechanisms in cancer
    • Banerjee HN, Verma M: Epigenetic mechanisms in cancer. Biomark. Med. 3(4), 397-410 (2009).
    • (2009) Biomark. Med , vol.3 , Issue.4 , pp. 397-410
    • Banerjee, H.N.1    Verma, M.2
  • 75
    • 29244490041 scopus 로고    scopus 로고
    • Analysis of repetitive element DNA methylation by MethyLight
    • Weisenberger DJ, Campan M, Long TI et al.: Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res. 33(21), 6823-6836 (2005).
    • (2005) Nucleic Acids Res , vol.33 , Issue.21 , pp. 6823-6836
    • Weisenberger, D.J.1    Campan, M.2    Long, T.I.3
  • 76
    • 33646338637 scopus 로고    scopus 로고
    • Quantitative ana lysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors
    • Ehrlich M, Woods CB, Yu MC et al.: Quantitative ana lysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene 18, 2636-2645 (2006).
    • (2006) Oncogene , vol.18 , pp. 2636-2645
    • Ehrlich, M.1    Woods, C.B.2    Yu, M.C.3
  • 77
    • 33749039999 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in human glioblastomas associated with specifc copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation
    • Cadieux B, Ching TT, VandenBerg SR, Costello JF: Genome-wide hypomethylation in human glioblastomas associated with specifc copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res. 66(17), 8469-8476 (2006).
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8469-8476
    • Cadieux, B.1    Ching, T.T.2    Vandenberg, S.R.3    Costello, J.F.4
  • 78
    • 72249101937 scopus 로고    scopus 로고
    • Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratifed for Helicobacter pylori infection
    • Park SY, Yoo EJ, Cho NY et al.: Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratifed for Helicobacter pylori infection. J. Pathol. 219(4), 410-416 (2009).
    • (2009) J. Pathol , vol.219 , Issue.4 , pp. 410-416
    • Park, S.Y.1    Yoo, E.J.2    Cho, N.Y.3
  • 79
    • 69449085661 scopus 로고    scopus 로고
    • Differential repetitive DNA methylation in multiple myeloma molecular subgroups
    • Bollati V, Fabris S, Pegoraro V et al.: Differential repetitive DNA methylation in multiple myeloma molecular subgroups. Carcinogenesis 30(8), 1330-1335 (2009).
    • (2009) Carcinogenesis , vol.30 , Issue.8 , pp. 1330-1335
    • Bollati, V.1    Fabris, S.2    Pegoraro, V.3
  • 80
    • 58149399844 scopus 로고    scopus 로고
    • Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer
    • Daskalos A, Nikolaidis G, Xinarianos G et al.: Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int. J. Cancer 124(1), 81-87 (2009).
    • (2009) Int. J. Cancer , vol.124 , Issue.1 , pp. 81-87
    • Daskalos, A.1    Nikolaidis, G.2    Xinarianos, G.3
  • 81
    • 38349135680 scopus 로고    scopus 로고
    • High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
    • Rauch TA, Zhong XY, Wu XW et al.: High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer. Proc. Natl Acad. Sci. USA 105(1), 252-257 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.1 , pp. 252-257
    • Rauch, T.A.1    Zhong, X.Y.2    Wu, X.W.3
  • 82
    • 33644782715 scopus 로고    scopus 로고
    • SATR-1 hypomethylation is a common and early event in breast cancer
    • Costa FF, Paixao VA, Cavalher FP et al.: SATR-1 hypomethylation is a common and early event in breast cancer. Cancer Genet. Cytogenet. 165(2), 135-143 (2006).
    • (2006) Cancer Genet. Cytogenet , vol.165 , Issue.2 , pp. 135-143
    • Costa, F.F.1    Paixao, V.A.2    Cavalher, F.P.3
  • 83
    • 1242285594 scopus 로고    scopus 로고
    • Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
    • Suter CM, Martin DI, Ward RL: Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int. J. Colorectal Dis. 19(2), 95-101 (2004).
    • (2004) Int. J. Colorectal Dis , vol.19 , Issue.2 , pp. 95-101
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 84
    • 40949160813 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: A case-control study
    • Moore LE, Pfeiffer RM, Poscablo C et al.: Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. Lancet Oncol. 9(4), 359-366 (2008).
    • (2008) Lancet Oncol , vol.9 , Issue.4 , pp. 359-366
    • Moore, L.E.1    Pfeiffer, R.M.2    Poscablo, C.3
  • 85
    • 70849112745 scopus 로고    scopus 로고
    • Association between global DNA hypomethylation in leukocytes and risk of breast cancer
    • Choi J-Y, James SR, Link PA et al.: Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis 30(11), 1889-1897 (2009).
    • (2009) Carcinogenesis , vol.30 , Issue.11 , pp. 1889-1897
    • Choi, J.-Y.1    James, S.R.2    Link, P.A.3
  • 86
    • 0038523843 scopus 로고    scopus 로고
    • Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: A case-control study
    • Pufulete M, Al-Ghnaniem R, Leather AJ et al.: Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case-control study. Gastroenterology 124(5), 1240-1248 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1240-1248
    • Pufulete, M.1    Al-Ghnaniem, R.2    Leather, A.J.3
  • 87
    • 37349088614 scopus 로고    scopus 로고
    • Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women
    • Lim U, Flood A, Choi SW et al.: Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology 134(1), 47-55 (2008).
    • (2008) Gastroenterology , vol.134 , Issue.1 , pp. 47-55
    • Lim, U.1    Flood, A.2    Choi, S.W.3
  • 88
    • 33846619807 scopus 로고    scopus 로고
    • Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma
    • Hsiung DT, Marsit CJ, Houseman EA et al.: Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol. Biomark. Prev. 16(1), 108-114 (2007).
    • (2007) Cancer Epidemiol. Biomark. Prev , vol.16 , Issue.1 , pp. 108-114
    • Hsiung, D.T.1    Marsit, C.J.2    Houseman, E.A.3
  • 89
    • 24044508252 scopus 로고    scopus 로고
    • The Genome Health Clinic and Genome Health Nutrigenomics concepts: Diagnosis and nutritional treatment of genome and epigenome damage on an individual basis
    • Fenech M: The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis 20(4), 255-269 (2005).
    • (2005) Mutagenesis , vol.20 , Issue.4 , pp. 255-269
    • Fenech, M.1
  • 90
    • 3042822370 scopus 로고    scopus 로고
    • DNA hypomethylation and ovarian cancer biology
    • Widschwendter M, Jiang G, Woods C et al.: DNA hypomethylation and ovarian cancer biology. Cancer Res. 64(13), 4472-4480 (2004).
    • (2004) Cancer Res , vol.64 , Issue.13 , pp. 4472-4480
    • Widschwendter, M.1    Jiang, G.2    Woods, C.3
  • 91
    • 57349138824 scopus 로고    scopus 로고
    • A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    • Ogino S, Nosho K, Kirkner GJ et al.: A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J. Natl. Cancer Inst. 100(23), 1734-1738 (2008).
    • (2008) J. Natl. Cancer Inst , vol.100 , Issue.23 , pp. 1734-1738
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 93
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo CB, Jones PA: Epigenetic therapy of cancer: past, present and future. Nat. Rev. Drug Discov. 5(1), 37-50 (2006).
    • (2006) Nat. Rev. Drug Discov , vol.5 , Issue.1 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 94
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • Issa PJ: DNA methylation as a therapeutic target in cancer. Clin. Cancer Res. 13(6), 1634-1637 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.6 , pp. 1634-1637
    • Issa, P.J.1
  • 95
    • 21844443820 scopus 로고    scopus 로고
    • Decitabine in chronic leukemias
    • Issa PJ, Byrd JC: Decitabine in chronic leukemias. Semin. Hematol. 42, S43-S49 (2005).
    • (2005) Semin. Hematol , vol.42
    • Issa, P.J.1    Byrd, J.C.2
  • 96
    • 61549106628 scopus 로고    scopus 로고
    • Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice
    • Yoo CB, Chuang JC, Byun HM et al.: Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev. Res. (Phila. PA). 1(4), 233-240 (2008).
    • (2008) Cancer Prev. Res. (Phila. PA) , vol.1 , Issue.4 , pp. 233-240
    • Yoo, C.B.1    Chuang, J.C.2    Byun, H.M.3
  • 97
    • 67651166778 scopus 로고    scopus 로고
    • Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines
    • Crea F, Giovannetti E, Cortesi F et al.: Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines. Mol. Cancer Ther. 8(7), 1964-1973 (2009).
    • (2009) Mol. Cancer Ther , vol.8 , Issue.7 , pp. 1964-1973
    • Crea, F.1    Giovannetti, E.2    Cortesi, F.3
  • 98
    • 34247094617 scopus 로고    scopus 로고
    • Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specifc and sensitive LC-MS/MS method
    • Liu ZF, Liu SJ, Xie ZL et al.: Characterization of in vitro and in vivo hypomethylating effects of decitabine in acute myeloid leukemia by a rapid, specifc and sensitive LC-MS/MS method. Nucleic Acids Res. 35(5), E31 (2007).
    • (2007) Nucleic Acids Res , vol.35 , Issue.5
    • Liu, Z.F.1    Liu, S.J.2    Xie, Z.L.3
  • 99
    • 33744918070 scopus 로고    scopus 로고
    • DNA methylation changes after 5-aza-2́-deoxycytidine therapy in patients with leukemia
    • Yang AS, Doshi KD, Choi SW et al.: DNA methylation changes after 5-aza-2́-deoxycytidine therapy in patients with leukemia. Cancer Res. 66(10), 5495-5503 (2006).
    • (2006) Cancer Res , vol.66 , Issue.10 , pp. 5495-5503
    • Yang, A.S.1    Doshi, K.D.2    Choi, S.W.3
  • 100
    • 1142275253 scopus 로고    scopus 로고
    • Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation
    • Kaneda A, Tsukamoto T, Takamura-Enya T et al.: Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci. 95(1), 58-64 (2004).
    • (2004) Cancer Sci , vol.95 , Issue.1 , pp. 58-64
    • Kaneda, A.1    Tsukamoto, T.2    Takamura-Enya, T.3
  • 101
    • 20144387855 scopus 로고    scopus 로고
    • Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer
    • Grunau C, Sanchez C, Ehrlich M et al.: Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. Genes Chromosomes Cancer 43(1), 11-24 (2005).
    • (2005) Genes Chromosomes Cancer , vol.43 , Issue.1 , pp. 11-24
    • Grunau, C.1    Sanchez, C.2    Ehrlich, M.3
  • 103
    • 11844302899 scopus 로고    scopus 로고
    • Promoter methylation profling of 30 genes in human malignant melanoma
    • Furuta J, Umebayashi Y, Miyamoto K et al.: Promoter methylation profling of 30 genes in human malignant melanoma. Cancer Sci. 95(12), 962-968 (2004).
    • (2004) Cancer Sci , vol.95 , Issue.12 , pp. 962-968
    • Furuta, J.1    Umebayashi, Y.2    Miyamoto, K.3
  • 105
    • 12744271900 scopus 로고    scopus 로고
    • Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer
    • Frigola J, Sole X, Paz MF et al.: Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. Hum. Mol. Genet. 14(2), 319-326 (2005).
    • (2005) Hum. Mol. Genet , vol.14 , Issue.2 , pp. 319-326
    • Frigola, J.1    Sole, X.2    Paz, M.F.3
  • 106
    • 33749037187 scopus 로고    scopus 로고
    • Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers
    • Rodriguez J, Frigola J, Vendrell E et al.: Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res. 66(17), 8462-9468 (2006).
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8462-9468
    • Rodriguez, J.1    Frigola, J.2    Vendrell, E.3
  • 107
    • 0037179870 scopus 로고    scopus 로고
    • Hypomethylation and hypermethylation of DNA in Wilms tumors
    • Ehrlich M, Jiang G, Fiala E et al.: Hypomethylation and hypermethylation of DNA in Wilms tumors. Oncogene 21(43), 6694-6702 (2002).
    • (2002) Oncogene , vol.21 , Issue.43 , pp. 6694-6702
    • Ehrlich, M.1    Jiang, G.2    Fiala, E.3
  • 108
    • 4043057968 scopus 로고    scopus 로고
    • Evidence that general genomic hypomethylation and focal hypermethylation are two independent molecular events of non-Hodgkin's lymphoma
    • Pini JT, Franchina M, Taylor JM, Kay PH: Evidence that general genomic hypomethylation and focal hypermethylation are two independent molecular events of non-Hodgkin's lymphoma. Oncol. Res. 14(7-8), 399-405 (2004).
    • (2004) Oncol. Res , vol.14 , Issue.7-8 , pp. 399-405
    • Pini, J.T.1    Franchina, M.2    Taylor, J.M.3    Kay, P.H.4
  • 109
    • 43049130760 scopus 로고    scopus 로고
    • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • DOI 10.1002/ijc.23470
    • Ogino S, Kawasaki T, Nosho K et al.: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int. J. Cancer 122(12), 2767-2773 (2008). (Pubitemid 351631379)
    • (2008) International Journal of Cancer , vol.122 , Issue.12 , pp. 2767-2773
    • Ogino, S.1    Kawasaki, T.2    Nosho, K.3    Ohnishi, M.4    Suemoto, Y.5    Kirkner, G.J.6    Fuchs, C.S.7
  • 110
    • 29344455676 scopus 로고    scopus 로고
    • The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer
    • Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS: The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin. Cancer Res. 11(24), 8564-8569 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.24 , pp. 8564-8569
    • Matsuzaki, K.1    Deng, G.2    Tanaka, H.3    Kakar, S.4    Miura, S.5    Kim, Y.S.6
  • 111
    • 36849059066 scopus 로고    scopus 로고
    • LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability
    • Estecio MR, Gharibyan V, Shen L et al.: LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS ONE 2(5), E399 (2007).
    • (2007) PLoS ONE , vol.2 , Issue.5
    • Estecio, M.R.1    Gharibyan, V.2    Shen, L.3
  • 112
    • 34547812688 scopus 로고    scopus 로고
    • Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa
    • Iacopetta B, Grieu F, Phillips M et al.: Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. Cancer Sci. 98(9), 1454-1460 (2007).
    • (2007) Cancer Sci , vol.98 , Issue.9 , pp. 1454-1460
    • Iacopetta, B.1    Grieu, F.2    Phillips, M.3
  • 113
    • 66649097032 scopus 로고    scopus 로고
    • DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer
    • Nosho K, Shima K, Irahara N et al.: DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. Clin. Cancer Res. 15(11), 3663-3671 (2009).
    • (2009) Clin. Cancer Res , vol.15 , Issue.11 , pp. 3663-3671
    • Nosho, K.1    Shima, K.2    Irahara, N.3
  • 114
    • 49249126168 scopus 로고    scopus 로고
    • DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development
    • Fan T, Schmidtmann A, Xi S et al.: DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development. Epigenetics 3(3), 134-142 (2008).
    • (2008) Epigenetics , vol.3 , Issue.3 , pp. 134-142
    • Fan, T.1    Schmidtmann, A.2    Xi, S.3
  • 115
    • 0036232616 scopus 로고    scopus 로고
    • DNA methyltransferase defciency modifes cancer susceptibility in mice lacking DNA mismatch repair
    • Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW: DNA methyltransferase defciency modifes cancer susceptibility in mice lacking DNA mismatch repair. Mol. Cell. Biol. 22(9), 2906-2917 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , Issue.9 , pp. 2906-2917
    • Trinh, B.N.1    Long, T.I.2    Nickel, A.E.3    Shibata, D.4    Laird, P.W.5
  • 116
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F, Hodgson JG, Eden A et al.: Induction of tumors in mice by genomic hypomethylation. Science 300(5618), 489-492 (2003).
    • (2003) Science , vol.300 , Issue.5618 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Eden, A.3
  • 117
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A, Gaudet F, Waghmare A, Jaenisch R: Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300(5618), 455 (2003).
    • (2003) Science , vol.300 , Issue.5618 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 118
    • 26444473234 scopus 로고    scopus 로고
    • Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
    • Yamada Y, Jackson-Grusby L, Linhart H et al.: Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl Acad. Sci. USA 102(38), 13580-13585 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.38 , pp. 13580-13585
    • Yamada, Y.1    Jackson-Grusby, L.2    Linhart, H.3
  • 119
    • 25444475765 scopus 로고    scopus 로고
    • Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells
    • Karpf AR, Matsui S: Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res. 65(19), 8635-8639 (2005).
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8635-8639
    • Karpf, A.R.1    Matsui, S.2
  • 120
    • 0034880162 scopus 로고    scopus 로고
    • Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma
    • Wong N, Lam WC, Lai PBS, Pang E, Lau WY, Johnson PJ: Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma. Am. J. Pathol. 159(2), 465-471 (2001).
    • (2001) Am. J. Pathol , vol.159 , Issue.2 , pp. 465-471
    • Wong, N.1    Lam, W.C.2    Pbs, L.3    Pang, E.4    Lau, W.Y.5    Johnson, P.J.6
  • 121
    • 0142216231 scopus 로고    scopus 로고
    • The ICF syndrome, a DNA methyltransferase 3B defciency and immunodefciency disease
    • Ehrlich M: The ICF syndrome, a DNA methyltransferase 3B defciency and immunodefciency disease. Clin. Immunol. 109(1), 17-28 (2003).
    • (2003) Clin. Immunol , vol.109 , Issue.1 , pp. 17-28
    • Ehrlich, M.1
  • 122
    • 10344263962 scopus 로고    scopus 로고
    • DNA hypomethylation on pericentromeric satellite regions signifcantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas
    • Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S: DNA hypomethylation on pericentromeric satellite regions signifcantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas. J. Urol. 173(1), 243-246 (2005).
    • (2005) J. Urol , vol.173 , Issue.1 , pp. 243-246
    • Nakagawa, T.1    Kanai, Y.2    Ushijima, S.3    Kitamura, T.4    Kakizoe, T.5    Hirohashi, S.6
  • 123
    • 0036731869 scopus 로고    scopus 로고
    • Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas
    • Tsuda H, Takarabe T, Kanai Y, Fukutomi T, Hirohashi S: Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas. Am. J. Pathol. 161(3), 859-866 (2002).
    • (2002) Am. J. Pathol , vol.161 , Issue.3 , pp. 859-866
    • Tsuda, H.1    Takarabe, T.2    Kanai, Y.3    Fukutomi, T.4    Hirohashi, S.5
  • 124
    • 34548427346 scopus 로고    scopus 로고
    • Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3
    • Davidsson J, Andersson A, Paulsson K et al.: Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. Hum. Mol. Genet. 16(18), 2215-2225 (2007).
    • (2007) Hum. Mol. Genet , vol.16 , Issue.18 , pp. 2215-2225
    • Davidsson, J.1    Andersson, A.2    Paulsson, K.3
  • 125
    • 0028564951 scopus 로고
    • Specifc association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR et al.: Specifc association of human telomerase activity with immortal cells and cancer. Science 266(5193), 2011-2015 (1994).
    • (1994) Science , vol.266 , Issue.5193 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3
  • 126
    • 56649115881 scopus 로고    scopus 로고
    • Epigenetic regulation of telomeres in human cancer
    • Vera E, Canela A, Fraga MF, Esteller M, Blasco MA: Epigenetic regulation of telomeres in human cancer. Oncogene 27(54), 6817-6833 (2008).
    • (2008) Oncogene , vol.27 , Issue.54 , pp. 6817-6833
    • Vera, E.1    Canela, A.2    Fraga, M.F.3    Esteller, M.4    Blasco, M.A.5
  • 127
    • 67349268468 scopus 로고    scopus 로고
    • Subtelomeric DNA methylation and telomere length in human cancer cells
    • Lee ME, Rha SY, Jeung HC, Chung HC, Oh BK: Subtelomeric DNA methylation and telomere length in human cancer cells. Cancer Lett. 281(1), 82-91 (2009).
    • (2009) Cancer Lett , vol.281 , Issue.1 , pp. 82-91
    • Lee, M.E.1    Rha, S.Y.2    Jeung, H.C.3    Chung, H.C.4    Oh, B.K.5
  • 128
    • 64949116602 scopus 로고    scopus 로고
    • Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells
    • Tilman G, Loriot A, Van Beneden A et al.: Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells. Oncogene 28(14), 1682-1693 (2009).
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1682-1693
    • Tilman, G.1    Loriot, A.2    Van Beneden, A.3
  • 129
    • 33646419009 scopus 로고    scopus 로고
    • Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer
    • Deng GR, Nguyen A, Tanaka H et al.: Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int. J. Cancer 118(12), 2999-3005 (2006).
    • (2006) Int. J. Cancer , vol.118 , Issue.12 , pp. 2999-3005
    • Deng, G.R.1    Nguyen, A.2    Tanaka, H.3
  • 130
    • 0036022068 scopus 로고    scopus 로고
    • Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
    • Schulz WA, Elo JP, Florl AR et al.: Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer 35(1), 58-65 (2002).
    • (2002) Genes Chromosomes Cancer , vol.35 , Issue.1 , pp. 58-65
    • Schulz, W.A.1    Elo, J.P.2    Florl, A.R.3
  • 131
    • 33847236985 scopus 로고    scopus 로고
    • Factor interaction ana lysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer
    • Schulz WA, Alexa A, Jung V et al.: Factor interaction ana lysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer. Mol. Cancer 6, 14 (2007).
    • (2007) Mol. Cancer , vol.6 , pp. 14
    • Schulz, W.A.1    Alexa, A.2    Jung, V.3
  • 132
    • 0036778597 scopus 로고    scopus 로고
    • The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors
    • Kolomietz E, Meyn MS, Pandita A, Squire JA: The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors. Genes Chromosomes Cancer 35(2), 97-112 (2002).
    • (2002) Genes Chromosomes Cancer , vol.35 , Issue.2 , pp. 97-112
    • Kolomietz, E.1    Meyn, M.S.2    Pandita, A.3    Squire, J.A.4
  • 133
    • 0038746982 scopus 로고    scopus 로고
    • Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells
    • Florl AR, Schulz WA: Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells. Genes Chromosomes Cancer 37(2), 141-148 (2003).
    • (2003) Genes Chromosomes Cancer , vol.37 , Issue.2 , pp. 141-148
    • Florl, A.R.1    Schulz, W.A.2
  • 134
    • 26944433502 scopus 로고    scopus 로고
    • High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma
    • Hsieh SY, Chen WY, Yeh TS, Sheen IS, Huang SF: High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma. Oncogene 24(43), 6584-6589 (2005).
    • (2005) Oncogene , vol.24 , Issue.43 , pp. 6584-6589
    • Hsieh, S.Y.1    Chen, W.Y.2    Yeh, T.S.3    Sheen, I.S.4    Huang, S.F.5
  • 135
    • 33645284007 scopus 로고    scopus 로고
    • Methylation of endogenous human retroelements in health and disease
    • Schulz WA, Steinhoff C, Florl AR: Methylation of endogenous human retroelements in health and disease. Curr. Top. Microbiol. Immunol. 310, 211-250 (2006).
    • (2006) Curr. Top. Microbiol. Immunol , vol.310 , pp. 211-250
    • Schulz, W.A.1    Steinhoff, C.2    Florl, A.R.3
  • 136
    • 10244278087 scopus 로고    scopus 로고
    • Dnmt1 defciency leads to enhanced microsatellite instability in mouse embryonic stem cells
    • Kim M, Trinh BN, Long TI, Oghamian S, Laird PW: Dnmt1 defciency leads to enhanced microsatellite instability in mouse embryonic stem cells. Nucleic Acids Res. 32(19), 5742-5749 (2004).
    • (2004) Nucleic Acids Res , vol.32 , Issue.19 , pp. 5742-5749
    • Kim, M.1    Trinh, B.N.2    Long, T.I.3    Oghamian, S.4    Laird, P.W.5
  • 137
    • 3042531072 scopus 로고    scopus 로고
    • Mismatch repair genes identifed using genetic screens in Blm-defcient embryonic stem cells
    • Guo G, Wang W, Bradley A: Mismatch repair genes identifed using genetic screens in Blm-defcient embryonic stem cells. Nature 429(6994), 891-895 (2004).
    • (2004) Nature , vol.429 , Issue.6994 , pp. 891-895
    • Guo, G.1    Wang, W.2    Bradley, A.3
  • 138
    • 38049164130 scopus 로고    scopus 로고
    • Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice
    • Howard G, Eiges R, Gaudet F, Jaenisch R, Eden A: Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene 27(3), 404-408 (2008).
    • (2008) Oncogene , vol.27 , Issue.3 , pp. 404-408
    • Howard, G.1    Eiges, R.2    Gaudet, F.3    Jaenisch, R.4    Eden, A.5
  • 139
    • 0030615218 scopus 로고    scopus 로고
    • LINE-I element insertion at the t(11;22) translocation breakpoint of a desmoplastic small round cell tumor
    • Liu J, Nau MM, Zucman-Rossi J, Powell JI, Allegra CJ, Wright JJ: LINE-I element insertion at the t(11;22) translocation breakpoint of a desmoplastic small round cell tumor. Genes Chromosomes Cancer 18(3), 232-239 (1997).
    • (1997) Genes Chromosomes Cancer , vol.18 , Issue.3 , pp. 232-239
    • Liu, J.1    Nau, M.M.2    Zucman-Rossi, J.3    Powell, J.I.4    Allegra, C.J.5    Wright, J.J.6
  • 140
    • 2442671716 scopus 로고    scopus 로고
    • A highly active synthetic mammalian retrotransposon
    • Han JS, Boeke JD: A highly active synthetic mammalian retrotransposon. Nature 429(6989), 314-318 (2004).
    • (2004) Nature , vol.429 , Issue.6989 , pp. 314-318
    • Han, J.S.1    Boeke, J.D.2
  • 141
    • 0037965788 scopus 로고    scopus 로고
    • Hot L1s account for the bulk of retrotransposition in the human population
    • Brouha B, Schustak J, Badge RM et al.: Hot L1s account for the bulk of retrotransposition in the human population. Proc. Natl Acad. Sci. USA 100(9), 5280-5285 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.9 , pp. 5280-5285
    • Brouha, B.1    Schustak, J.2    Badge, R.M.3
  • 142
    • 67349173665 scopus 로고    scopus 로고
    • The regulated retrotransposon transcriptome of mammalian cells
    • Faulkner GJ, Kimura Y, Daub CO et al.: The regulated retrotransposon transcriptome of mammalian cells. Nat. Genet. 41(5), 563-571 (2009).
    • (2009) Nat. Genet , vol.41 , Issue.5 , pp. 563-571
    • Faulkner, G.J.1    Kimura, Y.2    Daub, C.O.3
  • 143
    • 38549133553 scopus 로고    scopus 로고
    • Human cis natural antisense transcripts initiated by transposable elements
    • Conley AB, Miller WJ, Jordan IK: Human cis natural antisense transcripts initiated by transposable elements. Trends Genet. 24(2), 53-56 (2008).
    • (2008) Trends Genet , vol.24 , Issue.2 , pp. 53-56
    • Conley, A.B.1    Miller, W.J.2    Jordan, I.K.3
  • 144
    • 33746658129 scopus 로고    scopus 로고
    • L1 antisense promoter drives tissue-specifc transcription of human genes
    • Matlik K, Redik K, Speek M: L1 antisense promoter drives tissue-specifc transcription of human genes. J. Biomed. Biotech. 2006(1), 71753 (2006).
    • (2006) J. Biomed. Biotech. , vol.2006 , Issue.1 , pp. 71753
    • Matlik, K.1    Redik, K.2    Speek, M.3
  • 145
    • 70349279977 scopus 로고    scopus 로고
    • Altruistic functions for selfsh DNA
    • Faulkner GJ, Carninci P: Altruistic functions for selfsh DNA. Cell Cycle 8(18), 2895-2900 (2009).
    • (2009) Cell Cycle , vol.8 , Issue.18 , pp. 2895-2900
    • Faulkner, G.J.1    Carninci, P.2
  • 146
    • 34250743796 scopus 로고    scopus 로고
    • Transcriptional interferences in cis natural antisense transcripts of humans and mice
    • Osato N, Suzuki Y, Ikeo K, Gojobori T: Transcriptional interferences in cis natural antisense transcripts of humans and mice. Genetics 176(2), 1299-1306 (2007).
    • (2007) Genetics , vol.176 , Issue.2 , pp. 1299-1306
    • Osato, N.1    Suzuki, Y.2    Ikeo, K.3    Gojobori, T.4
  • 147
    • 70449107061 scopus 로고    scopus 로고
    • Isolation of cancer-specifc chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter
    • Cruickshanks HA, Tufarelli C: Isolation of cancer-specifc chimeric transcripts induced by hypomethylation of the LINE-1 antisense promoter. Genomics 94(6), 397-406 (2009).
    • (2009) Genomics , vol.94 , Issue.6 , pp. 397-406
    • Cruickshanks, H.A.1    Tufarelli, C.2
  • 148
    • 33644755464 scopus 로고    scopus 로고
    • Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma
    • Lin L, Wang Z W, Prescott MS et al.: Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes Chromosomes Cancer 45(4), 319-331 (2006).
    • (2006) Genes Chromosomes Cancer , vol.45 , Issue.4 , pp. 319-331
    • Lin, L.1    Wang, Z.W.2    Prescott, M.S.3
  • 149
    • 27944504788 scopus 로고    scopus 로고
    • Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
    • Roman-Gomez J, Jimenez-Velasco A, Agirre X et al.: Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia. Oncogene 24(48), 7213-7223 (2005).
    • (2005) Oncogene , vol.24 , Issue.48 , pp. 7213-7223
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Agirre, X.3
  • 150
    • 7244221348 scopus 로고    scopus 로고
    • DNA methylation, cancer susceptibility, and nutrient interactions
    • Davis CD, Uthus EO: DNA methylation, cancer susceptibility, and nutrient interactions. Exp. Biol. Med. (Maywood) 229(10), 988-995 (2004).
    • (2004) Exp. Biol. Med. (Maywood) , vol.229 , Issue.10 , pp. 988-995
    • Davis, C.D.1    Uthus, E.O.2
  • 151
    • 4444370528 scopus 로고    scopus 로고
    • Alcohol, one-carbon metabolism, and colorectal cancer: Recent insights from molecular studies
    • Giovannucci E: Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. J. Nutr. 134(9), S2475-S2481 (2004).
    • (2004) J. Nutr , vol.134 , Issue.9
    • Giovannucci, E.1
  • 152
    • 30944437615 scopus 로고    scopus 로고
    • Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl defciency
    • Pogribny IP, Ross SA, Wise C et al.: Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl defciency. Mutat. Res. 593(1-2), 80-87 (2006).
    • (2006) Mutat. Res , vol.593 , Issue.1-2 , pp. 80-87
    • Pogribny, I.P.1    Ross, S.A.2    Wise, C.3
  • 153
    • 33751355257 scopus 로고    scopus 로고
    • Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk
    • Lewis SJ, Harbord RM, Harris R, Smith GD: Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J. Natl. Cancer Inst. 98(22), 1607-1622 (2006).
    • (2006) J. Natl. Cancer Inst , vol.98 , Issue.22 , pp. 1607-1622
    • Lewis, S.J.1    Harbord, R.M.2    Harris, R.3    Smith, G.D.4
  • 154
    • 33847026146 scopus 로고    scopus 로고
    • Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    • Bollati V, Baccarelli A, Hou L et al.: Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res. 67(3), 876-880 (2007).
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 876-880
    • Bollati, V.1    Baccarelli, A.2    Hou, L.3
  • 155
    • 23144451094 scopus 로고    scopus 로고
    • Mechanisms of alcohol-associated cancers: Introduction and summary of the symposium
    • Purohit V, Khalsa J, Serrano J: Mechanisms of alcohol-associated cancers: introduction and summary of the symposium. Alcohol 35(3), 155-160 (2005).
    • (2005) Alcohol , vol.35 , Issue.3 , pp. 155-160
    • Purohit, V.1    Khalsa, J.2    Serrano, J.3
  • 156
    • 34548671396 scopus 로고    scopus 로고
    • DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage
    • Smith IM, Mydlarz WK, Mithani SK, Califano JA: DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int. J. Cancer 121(8), 1724-1728 (2007).
    • (2007) Int. J. Cancer , vol.121 , Issue.8 , pp. 1724-1728
    • Smith, I.M.1    Mydlarz, W.K.2    Mithani, S.K.3    Califano, J.A.4
  • 157
    • 66649109098 scopus 로고    scopus 로고
    • Global DNA hypomethyation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors
    • Figueiredo JC, Grau MV, Wallace K et al.: Global DNA hypomethyation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol. Biomark. Prev. 18(4), 1041-1049 (2009).
    • (2009) Cancer Epidemiol. Biomark. Prev , vol.18 , Issue.4 , pp. 1041-1049
    • Figueiredo, J.C.1    Grau, M.V.2    Wallace, K.3
  • 158
    • 63449109908 scopus 로고    scopus 로고
    • Microbe-induced epigenetic alterations in host cells: The coming era of patho-epigenetics of microbial infections; A review
    • Minarovits J: Microbe-induced epigenetic alterations in host cells: the coming era of patho-epigenetics of microbial infections; a review. Acta Microbiol. Immunol. Hung. 56(1), 1-19 (2009).
    • (2009) Acta Microbiol. Immunol. Hung , vol.56 , Issue.1 , pp. 1-19
    • Minarovits, J.1
  • 159
    • 34247190634 scopus 로고    scopus 로고
    • Aberrant epigenetic modifcations in hepatocarcinogenesis induced by hepatitis B virus X protein
    • Park IY, Sohn BH, Yu E et al.: Aberrant epigenetic modifcations in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology 132(4), 1476-1494 (2007).
    • (2007) Gastroenterology , vol.132 , Issue.4 , pp. 1476-1494
    • Park, I.Y.1    Sohn, B.H.2    Yu, E.3
  • 160
    • 0033566973 scopus 로고    scopus 로고
    • Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis
    • De Marzo AM, Marchi VL, Yang ES, Veeraswamy R, Lin X, Nelson WG: Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res. 59(16), 3855-3860 (1999).
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 3855-3860
    • De Marzo, A.M.1    Marchi, V.L.2    Yang, E.S.3    Veeraswamy, R.4    Lin, X.5    Nelson, W.G.6
  • 161
    • 0037486949 scopus 로고    scopus 로고
    • DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma
    • Li S, Chiang TC, Richard-Davis G, Barrett JC, McLachlan JA: DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma. Gynecol. Oncol. 90(1), 123-130 (2003).
    • (2003) Gynecol. Oncol , vol.90 , Issue.1 , pp. 123-130
    • Li, S.1    Chiang, T.C.2    Richard-Davis, G.3    Barrett, J.C.4    McLachlan, J.A.5
  • 162
    • 1542319832 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates signifcantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
    • Etoh T, Kanai Y, Ushijima S et al.: Increased DNA methyltransferase 1 (DNMT1) protein expression correlates signifcantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol. 164(2), 689-699 (2004).
    • (2004) Am. J. Pathol , vol.164 , Issue.2 , pp. 689-699
    • Etoh, T.1    Kanai, Y.2    Ushijima, S.3
  • 163
    • 24044493602 scopus 로고    scopus 로고
    • Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer
    • Agoston AT, Argani P, Yegnasubramanian S et al.: Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. J. Biol. Chem. 280(18), 18302-18310 (2005).
    • (2005) J. Biol. Chem , vol.280 , Issue.18 , pp. 18302-18310
    • Agoston, A.T.1    Argani, P.2    Yegnasubramanian, S.3
  • 164
    • 23844472366 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    • Peng DF, Kanai Y, Sawada M et al.: Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci. 96(7), 403-408 (2005).
    • (2005) Cancer Sci , vol.96 , Issue.7 , pp. 403-408
    • Peng, D.F.1    Kanai, Y.2    Sawada, M.3
  • 165
    • 33744507681 scopus 로고    scopus 로고
    • Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells
    • Loriot A, De Plaen E, Boon T, De Smet C: Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells. J. Biol. Chem. 281(15), 10118-10126 (2006).
    • (2006) J. Biol. Chem , vol.281 , Issue.15 , pp. 10118-10126
    • Loriot, A.1    De Plaen, E.2    Boon, T.3    De Smet, C.4
  • 166
    • 0035863455 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers
    • Kanai Y, Ushijima S, Kondo Y, Nakanishi Y, Hirohashi S: DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. Int. J. Cancer 91(2), 205-212 (2001).
    • (2001) Int. J. Cancer , vol.91 , Issue.2 , pp. 205-212
    • Kanai, Y.1    Ushijima, S.2    Kondo, Y.3    Nakanishi, Y.4    Hirohashi, S.5
  • 167
    • 0035127794 scopus 로고    scopus 로고
    • Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S: Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. Hepatology 33(3), 561-568 (2001).
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 561-568
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 168
    • 0037162542 scopus 로고    scopus 로고
    • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3B4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S: Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3B4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc. Natl Acad. Sci. USA 99(15), 10060-10065 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.15 , pp. 10060-10065
    • Saito, Y.1    Kanai, Y.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6
  • 169
    • 20344386954 scopus 로고    scopus 로고
    • Genome-wide gene expression profling of testicular carcinoma in situ progression into overt tumours
    • Almstrup K, Hoei-Hansen CE, Nielsen JE et al.: Genome-wide gene expression profling of testicular carcinoma in situ progression into overt tumours. Br. J. Cancer 92(10), 1934-1941 (2005).
    • (2005) Br. J. Cancer , vol.92 , Issue.10 , pp. 1934-1941
    • Almstrup, K.1    Hoei-Hansen, C.E.2    Nielsen, J.E.3
  • 170
    • 34547935029 scopus 로고    scopus 로고
    • Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins
    • Ostler K, Davis E, Payne S et al.: Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene 26(38), 5553-5563 (2007).
    • (2007) Oncogene , vol.26 , Issue.38 , pp. 5553-5563
    • Ostler, K.1    Davis, E.2    Payne, S.3
  • 172
    • 0035831505 scopus 로고    scopus 로고
    • The dynamics of myogenin site-specifc demethylation is strongly correlated with its expression and with muscle differentiation
    • Lucarelli M, Fuso A, Strom R, Scarpa S: The dynamics of myogenin site-specifc demethylation is strongly correlated with its expression and with muscle differentiation. J. Biol. Chem. 276(10), 7500-7506 (2001).
    • (2001) J. Biol. Chem , vol.276 , Issue.10 , pp. 7500-7506
    • Lucarelli, M.1    Fuso, A.2    Strom, R.3    Scarpa, S.4
  • 173
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
    • Bruniquel D, Schwartz RH: Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process. Nat. Immunol. 4(3), 235-240 (2003).
    • (2003) Nat. Immunol , vol.4 , Issue.3 , pp. 235-240
    • Bruniquel, D.1    Schwartz, R.H.2
  • 174
    • 60749094831 scopus 로고    scopus 로고
    • Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis
    • Ma DK, Jang MH, Guo JU et al.: Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323(5917), 1074-1077 (2009).
    • (2009) Science , vol.323 , Issue.5917 , pp. 1074-1077
    • Ma, D.K.1    Jang, M.H.2    Guo, J.U.3
  • 175
    • 34347352117 scopus 로고    scopus 로고
    • Epigenetic programming of the rRNA promoter by MBD3
    • Brown SE, Szyf M: Epigenetic programming of the rRNA promoter by MBD3. Mol. Cell. Biol. 27(13), 4938-4952 (2007).
    • (2007) Mol. Cell. Biol , vol.27 , Issue.13 , pp. 4938-4952
    • Brown, S.E.1    Szyf, M.2
  • 176
    • 59849090498 scopus 로고    scopus 로고
    • TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
    • Schmitz KM, Schmitt N, Hoffmann-Rohrer U, Schafer A, Grummt I, Mayer C: TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol. Cell 33(3), 344-353 (2009).
    • (2009) Mol. Cell , vol.33 , Issue.3 , pp. 344-353
    • Schmitz, K.M.1    Schmitt, N.2    Hoffmann-Rohrer, U.3    Schafer, A.4    Grummt, I.5    Mayer, C.6
  • 177
    • 60549088692 scopus 로고    scopus 로고
    • Active DNA demethylation and DNA repair
    • Niehrs C: Active DNA demethylation and DNA repair. Differentiation 77(1), 1-11 (2009).
    • (2009) Differentiation , vol.77 , Issue.1 , pp. 1-11
    • Niehrs, C.1
  • 178
    • 41949136533 scopus 로고    scopus 로고
    • GADD45A does not promote DNA demethylation
    • Jin SG, Guo C, Pfeifer GP: GADD45A does not promote DNA demethylation. PLoS Genet. 4(3), E1000013 (2008).
    • (2008) PLoS Genet , vol.4 , Issue.3
    • Jin, S.G.1    Guo, C.2    Pfeifer, G.P.3
  • 179
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A et al.: Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37(4), 391-400 (2005).
    • (2005) Nat. Genet , vol.37 , Issue.4 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3
  • 180
    • 34548424626 scopus 로고    scopus 로고
    • Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation
    • Gallais R, Demay F, Barath P et al.: Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol. Endocrinol. 21(9), 2085-2098 (2007).
    • (2007) Mol. Endocrinol , vol.21 , Issue.9 , pp. 2085-2098
    • Gallais, R.1    Demay, F.2    Barath, P.3
  • 181
    • 0042346416 scopus 로고    scopus 로고
    • Valproate induces replication-independent active DNA demethylation
    • Detich N, Bovenzi V, Szyf M: Valproate induces replication-independent active DNA demethylation. J. Biol. Chem. 278(30), 27586-27592 (2003).
    • (2003) J. Biol. Chem , vol.278 , Issue.30 , pp. 27586-27592
    • Detich, N.1    Bovenzi, V.2    Szyf, M.3
  • 182
    • 10644282845 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues-implications for epigenetic reprogramming
    • Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK: Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues-implications for epigenetic reprogramming. J. Biol. Chem. 279(50), 52353-52360 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.50 , pp. 52353-52360
    • Morgan, H.D.1    Dean, W.2    Coker, H.A.3    Reik, W.4    Petersen-Mahrt, S.K.5
  • 183
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifcations and their function
    • Kouzarides T: Chromatin modifcations and their function. Cell 128(4), 693-705 (2007).
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 185
    • 27544505676 scopus 로고    scopus 로고
    • Chromatin modifer enzymes, the histone code and cancer
    • Santos-Rosa H, Caldas C: Chromatin modifer enzymes, the histone code and cancer. Eur. J. Cancer 41(16), 2381-2402 (2005).
    • (2005) Eur. J. Cancer , vol.41 , Issue.16 , pp. 2381-2402
    • Santos-Rosa, H.1    Caldas, C.2
  • 186
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modifcation maps
    • Esteller M: Cancer epigenomics: DNA methylomes and histone-modifcation maps. Nat. Rev. Genet. 8(4), 286-298 (2007).
    • (2007) Nat. Rev. Genet , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 187
    • 35348924169 scopus 로고    scopus 로고
    • Genetics and epigenetics of the multifunctional protein CTCF
    • Filippova GN: Genetics and epigenetics of the multifunctional protein CTCF. Curr. Top. Dev. Biol. 80, 337-360 (2008).
    • (2008) Curr. Top. Dev. Biol , vol.80 , pp. 337-360
    • Filippova, G.N.1
  • 188
    • 48949102889 scopus 로고    scopus 로고
    • DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specifc role involving CTCF and antisense transcripts
    • Chadwick BP: DXZ4 chromatin adopts an opposing conformation to that of
    • (2008) Genome Res , vol.18 , Issue.8 , pp. 1259-1269
    • Chadwick, B.P.1
  • 189
    • 61449143604 scopus 로고    scopus 로고
    • The D4Z4 macrosatellite repeat Acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy
    • Ottaviani A, Rival-Gervier S, Boussouar A et al.: The D4Z4 macrosatellite repeat Acts as a CTCF and A-type lamins-dependent insulator in facio-scapulo-humeral dystrophy. PLoS Genet. 5(2), E1000394 (2009).
    • (2009) PLoS Genet , vol.5 , Issue.2
    • Ottaviani, A.1    Rival-Gervier, S.2    Boussouar, A.3
  • 190
    • 18244412628 scopus 로고    scopus 로고
    • Proliferation-associated SNF2-like gene (PASG): A SNF2 family member altered in leukemia
    • Lee DW, Zhang K, Ning Z-Q et al.: Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia. Cancer Res. 60(13), 3612-3622 (2000).
    • (2000) Cancer Res , vol.60 , Issue.13 , pp. 3612-3622
    • Lee, D.W.1    Zhang, K.2    Ning, Z.-Q.3
  • 191
    • 4544268388 scopus 로고    scopus 로고
    • Tumor-specifc exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer
    • Yano M, Ouchida M, Shigematsu H et al.: Tumor-specifc exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer. Int. J. Cancer 112(1), 8-13 (2004).
    • (2004) Int. J. Cancer , vol.112 , Issue.1 , pp. 8-13
    • Yano, M.1    Ouchida, M.2    Shigematsu, H.3
  • 192
    • 10744230544 scopus 로고    scopus 로고
    • Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
    • Lehnertz B, Ueda Y, Derijck AA et al.: Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13(14), 1192-1200 (2003).
    • (2003) Curr. Biol , vol.13 , Issue.14 , pp. 1192-1200
    • Lehnertz, B.1    Ueda, Y.2    Derijck, A.A.3
  • 193
    • 59949085939 scopus 로고    scopus 로고
    • H3K27me3 forms BLOCs over silent genes and intergenic regions and specifes a histone banding pattern on a mouse autosomal chromosome
    • Pauler FM, Sloane MA, Huang R et al.: H3K27me3 forms BLOCs over silent genes and intergenic regions and specifes a histone banding pattern on a mouse autosomal chromosome. Genome Res. 19(2), 221-233 (2009).
    • (2009) Genome Res , vol.19 , Issue.2 , pp. 221-233
    • Pauler, F.M.1    Ma, S.2    Huang, R.3
  • 194
    • 15444372817 scopus 로고    scopus 로고
    • The profle of repeat-associated histone lysine methylation states in the mouse epigenome
    • Martens JHA, O'Sullivan RJ, Braunschweig U et al.: The profle of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J. 24(4), 800-812 (2005).
    • (2005) EMBO J , vol.24 , Issue.4 , pp. 800-812
    • Jha, M.1    O'Sullivan, R.J.2    Braunschweig, U.3
  • 195
    • 72849148472 scopus 로고    scopus 로고
    • Global levels of histone modifcations predict prostate cancer recurrence
    • Ellinger J, Kahl P, von der Gathen J et al.: Global levels of histone modifcations predict prostate cancer recurrence. Prostate 70(1), 61-69 (2010).
    • (2010) Prostate , vol.70 , Issue.1 , pp. 61-69
    • Ellinger, J.1    Kahl, P.2    Von Der Gathen, J.3
  • 196
    • 65649142216 scopus 로고    scopus 로고
    • Global levels of histone modifcations predict prognosis in different cancers
    • Seligson DB, Horvath S, McBrian MA et al.: Global levels of histone modifcations predict prognosis in different cancers. Am. J. Pathol. 174(5), 1619-1628 (2009).
    • (2009) Am. J. Pathol , vol.174 , Issue.5 , pp. 1619-1628
    • Seligson, D.B.1    Horvath, S.2    McBrian, M.A.3
  • 197
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A et al.: Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37(4):391-400 (2005).
    • (2005) Nat. Genet , vol.37 , Issue.4 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3
  • 198
    • 34250201468 scopus 로고    scopus 로고
    • The role of microRNAs in cancer: No small matter
    • Wiemer EAC: The role of microRNAs in cancer: no small matter. Eur. J. Cancer 43(10), 1529-1544 (2007).
    • (2007) Eur. J. Cancer , vol.43 , Issue.10 , pp. 1529-1544
    • Eac, W.1
  • 200
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD et al.: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl Acad. Sci. USA 101(9), 2999-3004 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.9 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 201
    • 19444367079 scopus 로고    scopus 로고
    • Mammalian microRNAs derived from genomic repeats
    • Smalheiser NR, Torvik VI: Mammalian microRNAs derived from genomic repeats. Trends Genet. 21(6), 322-326 (2005).
    • (2005) Trends Genet , vol.21 , Issue.6 , pp. 322-326
    • Smalheiser, N.R.1    Torvik, V.I.2
  • 203
    • 68749097208 scopus 로고    scopus 로고
    • MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
    • Ng EKO, Tsang WP, Ng SSM et al.: MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br. J. Cancer 101(4), 699-706 (2009).
    • (2009) Br. J. Cancer , vol.101 , Issue.4 , pp. 699-706
    • Eko, N.1    Tsang, W.P.2    Ssm, N.3
  • 204
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A et al.: MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl Acad. Sci. USA 104(40), 15805-15810 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.40 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 205
    • 0035863870 scopus 로고    scopus 로고
    • +) stem cells express the HIWI gene, a human homologue of the Drosophila gene piwi
    • +) stem cells express the HIWI gene, a human homologue of the Drosophila gene piwi. Blood 97(2), 426-434 (2001).
    • (2001) Blood , vol.97 , Issue.2 , pp. 426-434
    • Sharma, A.K.1    Nelson, M.C.2    Brandt, J.E.3
  • 206
    • 33847044299 scopus 로고    scopus 로고
    • Expression of the stem cell self-renewal gene HIWI and risk of tumour-related death in patients with soft-tissue sarcoma
    • Taubert H, Greither T, Kaushal D et al.: Expression of the stem cell self-renewal gene HIWI and risk of tumour-related death in patients with soft-tissue sarcoma. Oncogene 26(7), 1098-1100 (2007).
    • (2007) Oncogene , vol.26 , Issue.7 , pp. 1098-1100
    • Taubert, H.1    Greither, T.2    Kaushal, D.3
  • 207
    • 53049109462 scopus 로고    scopus 로고
    • The stem cell-associated HIWI gene in human adenocarcinoma of the pancreas: Expression and risk of tumour-related death
    • Grochola LF, Greither T, Taubert H et al.: The stem cell-associated HIWI gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death. Br. J. Cancer 99(7), 1083-1088 (2008).
    • (2008) Br. J. Cancer , vol.99 , Issue.7 , pp. 1083-1088
    • Grochola, L.F.1    Greither, T.2    Taubert, H.3
  • 208
    • 0037030522 scopus 로고    scopus 로고
    • Molecular characterization of HIWI, a human member of the piwi gene family whose overexpression is correlated to seminomas
    • Qiao D, Zeeman AM, Deng W, Looijenga LH, Lin HF: Molecular characterization of HIWI, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 21(25), 3988-3999 (2002).
    • (2002) Oncogene , vol.21 , Issue.25 , pp. 3988-3999
    • Qiao, D.1    Zeeman, A.M.2    Deng, W.3    Looijenga, L.H.4    Lin, H.F.5
  • 209
    • 31144460828 scopus 로고    scopus 로고
    • Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-X-L pathway
    • Lee JH, Schutte D, Wulf G et al.: Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-X-L pathway. Hum. Mol. Genet. 15(2), 201-211 (2006).
    • (2006) Hum. Mol. Genet , vol.15 , Issue.2 , pp. 201-211
    • Lee, J.H.1    Schutte, D.2    Wulf, G.3
  • 210
    • 41149129199 scopus 로고    scopus 로고
    • Cancer stem cells: The lessons from pre-cancerous stem cells
    • Gao JX: Cancer stem cells: the lessons from pre-cancerous stem cells. J. Cell. Mol. Med. 12(1), 67-96 (2008).
    • (2008) J. Cell. Mol. Med , vol.12 , Issue.1 , pp. 67-96
    • Gao, J.X.1
  • 211
    • 70349329849 scopus 로고    scopus 로고
    • The association between Piwil2 expression and LINE-1 methylation in cancer cells
    • Thanasupawat T, Phokaew C, Mutirangura A: The association between Piwil2 expression and LINE-1 methylation in cancer cells. Asian Biomed. 3(3), 279-285 (2009).
    • (2009) Asian Biomed , vol.3 , Issue.3 , pp. 279-285
    • Thanasupawat, T.1    Phokaew, C.2    Mutirangura, A.3
  • 212
    • 10344250458 scopus 로고    scopus 로고
    • Components of the DNA methylation system of chromatin control are RNA-binding proteins
    • Jeffery L, Nakielny S: Components of the DNA methylation system of chromatin control are RNA-binding proteins. J. Biol. Chem. 279(47), 49479-49487 (2004).
    • (2004) J. Biol. Chem , vol.279 , Issue.47 , pp. 49479-49487
    • Jeffery, L.1    Nakielny, S.2
  • 213
    • 34250160256 scopus 로고    scopus 로고
    • RNA maps reveal new RNA classes and a possible function for pervasive transcription
    • Kapranov P, Cheng J, Dike S et al.: RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316(5830), 1484-1488 (2007).
    • (2007) Science , vol.316 , Issue.5830 , pp. 1484-1488
    • Kapranov, P.1    Cheng, J.2    Dike, S.3
  • 214
  • 215
    • 69949098322 scopus 로고    scopus 로고
    • Global ana lysis of DNA methylation and transcription of human repetitive sequences
    • Horard B, Eymery A, Fourel G et al.: Global ana lysis of DNA methylation and transcription of human repetitive sequences. Epigenetics 4(5), 339-350 (2009).
    • (2009) Epigenetics , vol.4 , Issue.5 , pp. 339-350
    • Horard, B.1    Eymery, A.2    Fourel, G.3
  • 216
    • 33645319220 scopus 로고    scopus 로고
    • L1 retrotransposons in human cancers
    • Schulz WA: L1 retrotransposons in human cancers. J. Biomed. Biotech. 2006(1), 83672 (2006).
    • (2006) J. Biomed. Biotech. , vol.2006 , Issue.1 , pp. 83672
    • Schulz, W.A.1
  • 217
    • 0036250811 scopus 로고    scopus 로고
    • Alu repeats and human genomic diversity
    • Batzer MA, Deininger PL: Alu repeats and human genomic diversity. Nat. Rev. Genet. 3(5), 370-379 (2002).
    • (2002) Nat. Rev. Genet , vol.3 , Issue.5 , pp. 370-379
    • Blasco, M.A.1    Deininger, P.L.2
  • 218
    • 34147105638 scopus 로고    scopus 로고
    • The evolutionary history of human DNA transposons: Evidence for intense activity in the primate lineage
    • Pace JK, Feschotte C: The evolutionary history of human DNA transposons: evidence for intense activity in the primate lineage. Genome Res. 17(4), 422-432 (2007).
    • (2007) Genome Res , vol.17 , Issue.4 , pp. 422-432
    • Pace, J.K.1    Feschotte, C.2
  • 219
    • 0033017956 scopus 로고    scopus 로고
    • CORE-SINEs: Eukaryotic short interspersed retroposing elements with common sequence motifs
    • Gilbert N, Labuda D: CORE-SINEs: eukaryotic short interspersed retroposing elements with common sequence motifs. Proc. Natl Acad. Sci. USA 96(6), 2869-2874 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.6 , pp. 2869-2874
    • Gilbert, N.1    Labuda, D.2
  • 220
    • 0028804572 scopus 로고
    • MIRs are classic, tRNA-derived SINEs that amplifed before the mammalian radiation
    • Smit AF, Riggs AD: MIRs are classic, tRNA-derived SINEs that amplifed before the mammalian radiation. Nucleic Acids Res. 23(1), 98-102 (1995).
    • (1995) Nucleic Acids Res , vol.23 , Issue.1 , pp. 98-102
    • Smit, A.F.1    Riggs, A.D.2
  • 221
    • 0036230566 scopus 로고    scopus 로고
    • A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes
    • Strichman-Almashanu LZ, Lee RS, Onyango PO et al.: A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Res. 12(4), 543-554 (2002).
    • (2002) Genome Res , vol.12 , Issue.4 , pp. 543-554
    • Strichman-Almashanu, L.Z.1    Lee, R.S.2    Onyango, P.O.3
  • 222
    • 0345636604 scopus 로고    scopus 로고
    • SVA elements are nonautonomous retrotransposons that cause disease in humans
    • Ostertag EM, Goodier JL, Zhang Y, Kazazian HH Jr: SVA elements are nonautonomous retrotransposons that cause disease in humans. Am. J. Hum. Genet. 73(6), 1444-1451 (2003).
    • (2003) Am. J. Hum. Genet , vol.73 , Issue.6 , pp. 1444-1451
    • Ostertag, E.M.1    Goodier, J.L.2    Zhang, Y.3    Kazazian Jr., H.H.4
  • 223
    • 28444448708 scopus 로고    scopus 로고
    • SVA elements: A hominid-specifc retroposon family
    • Wang H, Xing J, Grover D et al.: SVA elements: a hominid-specifc retroposon family. J. Mol. Biol. 354(4), 994-1007 (2005).
    • (2005) J. Mol. Biol , vol.354 , Issue.4 , pp. 994-1007
    • Wang, H.1    Xing, J.2    Grover, D.3
  • 225
    • 0030464040 scopus 로고    scopus 로고
    • Demethylation of repetitive DNA sequences in neuroblastoma
    • Thoraval D, Asakawa J, Wimmer K et al.: Demethylation of repetitive DNA sequences in neuroblastoma. Genes Chromosomes Cancer 17(4), 234-244 (1996).
    • (1996) Genes Chromosomes Cancer , vol.17 , Issue.4 , pp. 234-244
    • Thoraval, D.1    Asakawa, J.2    Wimmer, K.3
  • 226
    • 0030305457 scopus 로고    scopus 로고
    • R: A language for data ana lysis and graphics
    • Ihaka R, Gentleman R: R: A language for data ana lysis and graphics. J. Comput. Graph. Stat. 5, 299-314 (1996).
    • (1996) J. Comput. Graph. Stat , vol.5 , pp. 299-314
    • Ihaka, R.1    Gentleman, R.2
  • 227
    • 84936916896 scopus 로고
    • Robust locally weighted regression and smoothing scatterplots
    • Cleveland WS: Robust locally weighted regression and smoothing scatterplots. J. Am. Stat. Assoc. 74, 829-836 (1979).
    • (1979) J. Am. Stat. Assoc , vol.74 , pp. 829-836
    • Cleveland, W.S.1
  • 228
    • 0001992028 scopus 로고    scopus 로고
    • Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential
    • Qu G, Dubeau L, Narayan A, Yu MC, Ehrlich M: Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential. Mutat. Res. 423(1-2), 91-101 (1999).
    • (1999) Mutat. Res , vol.423 , Issue.1-2 , pp. 91-101
    • Qu, G.1    Dubeau, L.2    Narayan, A.3    Yu, M.C.4    Ehrlich, M.5
  • 229
    • 0031816567 scopus 로고    scopus 로고
    • Hypomethylation of pericentromeric DNA in breast adenocarcinomas
    • Narayan A, Ji WZ, Zhang XY et al.: Hypomethylation of pericentromeric DNA in breast adenocarcinomas. Int. J. Cancer 77(6), 833-838 (1998).
    • (1998) Int. J. Cancer , vol.77 , Issue.6 , pp. 833-838
    • Narayan, A.1    Ji, W.Z.2    Zhang, X.Y.3
  • 230
    • 20544458020 scopus 로고    scopus 로고
    • DNA hypomethylation is prevalent even in low-grade breast cancers
    • Jackson K, Yu MC, Arakawa K et al.: DNA hypomethylation is prevalent even in low-grade breast cancers. Cancer Biol. Ther. 3(12), 1225-1231 (2004).
    • (2004) Cancer Biol. Ther , vol.3 , Issue.12 , pp. 1225-1231
    • Jackson, K.1    Yu, M.C.2    Arakawa, K.3
  • 231
    • 38049148239 scopus 로고    scopus 로고
    • Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment
    • Fanelli M, Caprodossi S, Ricci-Vitiani L et al.: Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment. Oncogene 27(3), 358-365 (2008).
    • (2008) Oncogene , vol.27 , Issue.3 , pp. 358-365
    • Fanelli, M.1    Caprodossi, S.2    Ricci-Vitiani, L.3
  • 232
    • 77954138653 scopus 로고    scopus 로고
    • DNA methylation changes in multistep gastric carcinogenesis and their relationship with H-pylori infection and association of gastric cancer
    • Park SY, Kim N, Yoo EJ, Cho NY, Kang GH: DNA methylation changes in multistep gastric carcinogenesis and their relationship with H-pylori infection and association of gastric cancer. Lab. Investig. 89, 648 (2009).
    • (2009) Lab. Investig , vol.89 , pp. 648
    • Park, S.Y.1    Kim, N.2    Yoo, E.J.3    Cho, N.Y.4    Kang, G.H.5
  • 233
    • 42449109111 scopus 로고    scopus 로고
    • Epigenetics of a tandem DNA repeat: Chromatin DNaseI sensitivity and opposite methylation changes in cancers
    • Tsumagari K, Qi L, Jackson K et al.: Epigenetics of a tandem DNA repeat: chromatin DNaseI sensitivity and opposite methylation changes in cancers. Nucleic Acids Res. 36(7), 2196-2207 (2008).
    • (2008) Nucleic Acids Res , vol.36 , Issue.7 , pp. 2196-2207
    • Tsumagari, K.1    Qi, L.2    Jackson, K.3
  • 234
    • 67650733262 scopus 로고    scopus 로고
    • Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer
    • Katargin A, Pavlova L, Kisseljov F, Kisseljova N: Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer. BMC Med. Genomics 2(1), 30 (2009).
    • (2009) BMC Med. Genomics , vol.2 , Issue.1 , pp. 30
    • Katargin, A.1    Pavlova, L.2    Kisseljov, F.3    Kisseljova, N.4
  • 235
    • 0032819322 scopus 로고    scopus 로고
    • A novel sperm-specifc hypomethylation sequence is a demethylation hotspot in human hepatocellular carcinomas
    • Nagai H, Kim YS, Yasuda T et al.: A novel sperm-specifc hypomethylation sequence is a demethylation hotspot in human hepatocellular carcinomas. Gene 237(1), 15-20 (1999).
    • (1999) Gene , vol.237 , Issue.1 , pp. 15-20
    • Nagai, H.1    Kim, Y.S.2    Yasuda, T.3
  • 236
    • 0037165224 scopus 로고    scopus 로고
    • Correlation of postoperative recurrence in hepatocellular carcinoma with demethylation of repetitive sequences
    • Itano O, Ueda M, Kikuchi K et al.: Correlation of postoperative recurrence in hepatocellular carcinoma with demethylation of repetitive sequences. Oncogene 21(5), 789-797 (2002).
    • (2002) Oncogene , vol.21 , Issue.5 , pp. 789-797
    • Itano, O.1    Ueda, M.2    Kikuchi, K.3
  • 237
    • 28844450700 scopus 로고    scopus 로고
    • Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer
    • Nishiyama R, Qi LX, Lacey M, Ehrlich M: Both hypomethylation and hypermethylation in a 0.2-kb region of a DNA repeat in cancer. Mol. Cancer Res. 3(11), 617-626 (2005).
    • (2005) Mol. Cancer Res , vol.3 , Issue.11 , pp. 617-626
    • Nishiyama, R.1    Qi, L.X.2    Lacey, M.3    Ehrlich, M.4
  • 238
    • 25144463972 scopus 로고    scopus 로고
    • A DNA repeat, NBL-2, is hypermethylated in some cancers but hypomethylated in others
    • Nishiyama R, Qi LX, Tsumagari K et al.: A DNA repeat, NBL-2, is hypermethylated in some cancers but hypomethylated in others. Cancer Biol. Ther. 4(4), 440-448 (2005).
    • (2005) Cancer Biol. Ther , vol.4 , Issue.4 , pp. 440-448
    • Nishiyama, R.1    Qi, L.X.2    Tsumagari, K.3
  • 239
    • 33846639662 scopus 로고    scopus 로고
    • Hypermethylation of CpG island loci and hypomethylation of LINE-I and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features
    • Cho NY, Kim BH, Yoo EJ et al.: Hypermethylation of CpG island loci and hypomethylation of LINE-I and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. J. Pathol. 211(3), 269-277 (2007).
    • (2007) J. Pathol , vol.211 , Issue.3 , pp. 269-277
    • Cho, N.Y.1    Kim, B.H.2    Yoo, E.J.3
  • 240
    • 0032987773 scopus 로고    scopus 로고
    • DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
    • Florl AR, Lower R, Schmitz-Drager BJ, Schulz WA: DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. Br. J. Cancer 80(9), 1312-1321 (1999).
    • (1999) Br. J. Cancer , vol.80 , Issue.9 , pp. 1312-1321
    • Florl, A.R.1    Lower, R.2    Schmitz-Drager, B.J.3    Schulz, W.A.4
  • 241
    • 2942596268 scopus 로고    scopus 로고
    • L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas
    • Menendez L, Benigno BB, McDonald JF: L1 and HERV-W retrotransposons are hypomethylated in human ovarian carcinomas. Mol. Cancer 3, 12 (2004).
    • (2004) Mol. Cancer , vol.3 , pp. 12
    • Menendez, L.1    Benigno, B.B.2    McDonald, J.F.3
  • 242
    • 0033814412 scopus 로고    scopus 로고
    • Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis
    • Takai D, Yagi Y, Habib N, Sugimura T, Ushijima T: Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn. J. Clin. Oncol. 30(7), 306-309 (2000).
    • (2000) Jpn. J. Clin. Oncol , vol.30 , Issue.7 , pp. 306-309
    • Takai, D.1    Yagi, Y.2    Habib, N.3    Sugimura, T.4    Ushijima, T.5
  • 243
    • 66149167311 scopus 로고    scopus 로고
    • Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation
    • Hervouet E, Debien E, Campion L et al.: Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation. Clin. Cancer Res. 15(10), 3519-3529 (2009).
    • (2009) Clin. Cancer Res , vol.15 , Issue.10 , pp. 3519-3529
    • Hervouet, E.1    Debien, E.2    Campion, L.3
  • 244
    • 67650401865 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage
    • Watts G, Futscher B, Holtan N, DeGeest K, Domann F, Rose S: DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage. BMC Med. Genomics 1(1), 47 (2008).
    • (2008) BMC Med. Genomics , vol.1 , Issue.1 , pp. 47
    • Watts, G.1    Futscher, B.2    Holtan, N.3    Degeest, K.4    Domann, F.5    Rose, S.6
  • 245
    • 10044239471 scopus 로고    scopus 로고
    • Global hypomethylation is common in prostate cancer cells: A quantitative predictor for clinical outcome? Cancer Genet
    • Brothman AR, Swanson G, Maxwell TM et al.: Global hypomethylation is common in prostate cancer cells: a quantitative predictor for clinical outcome? Cancer Genet. Cytogenet. 156(1), 31-36 (2005).
    • (2005) Cytogenet , vol.156 , Issue.1 , pp. 31-36
    • Brothman, A.R.1    Swanson, G.2    Maxwell, T.M.3
  • 246
    • 17144413410 scopus 로고    scopus 로고
    • DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis
    • Nakagawa T, Kanai Y, Ushijima S, Kitamura T, Kakizoe T, Hirohashi S: DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis. J. Urol. 173(5), 1767-1771 (2005).
    • (2005) J. Urol , vol.173 , Issue.5 , pp. 1767-1771
    • Nakagawa, T.1    Kanai, Y.2    Ushijima, S.3    Kitamura, T.4    Kakizoe, T.5    Hirohashi, S.6
  • 247
    • 33847789490 scopus 로고    scopus 로고
    • Serum LINE-1 hypomethylation as a potential prognostic marker for hepatocellular carcinoma
    • DOI 10.1016/j.cca.2006.12.029, PII S0009898107000216
    • Tangkijvanich P, Hourpai N, Rattanatanyong P, Wisedopas N, Mahachai V, Mutirangura A: Serum LINE-1 hypomethylation as a potential prognostic marker for hepatocellular carcinoma. Clin. Chim. Acta 379(1-2), 127-133 (2007). (Pubitemid 46389509)
    • (2007) Clinica Chimica Acta , vol.379 , Issue.1-2 , pp. 127-133
    • Tangkijvanich, P.1    Hourpai, N.2    Rattanatanyong, P.3    Wisedopas, N.4    Mahachai, V.5    Mutirangura, A.6
  • 248
    • 0033081639 scopus 로고    scopus 로고
    • Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16
    • Qu GZ, Grundy PE, Narayan A, Ehrlich M: Frequent hypomethylation in Wilms tumors of pericentromeric DNA in chromosomes 1 and 16. Cancer Genet. Cytogenet. 109(1), 34-39 (1999).
    • (1999) Cancer Genet. Cytogenet , vol.109 , Issue.1 , pp. 34-39
    • Qu, G.Z.1    Grundy, P.E.2    Narayan, A.3    Ehrlich, M.4
  • 249
    • 0037371987 scopus 로고    scopus 로고
    • Satellite DNA hypomethylation in karyotyped Wilms tumors
    • Ehrlich M, Hopkins NE, Jiang G et al.: Satellite DNA hypomethylation in karyotyped Wilms tumors. Cancer Genet. Cytogenet. 141(2), 97-105 (2003).
    • (2003) Cancer Genet. Cytogenet , vol.141 , Issue.2 , pp. 97-105
    • Ehrlich, M.1    Hopkins, N.E.2    Jiang, G.3
  • 250
    • 57149090084 scopus 로고    scopus 로고
    • Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally
    • Wiemels JL, Hofmann J, Kang M et al.: Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res. 68(23), 9935-9944 (2008).
    • (2008) Cancer Res , vol.68 , Issue.23 , pp. 9935-9944
    • Wiemels, J.L.1    Hofmann, J.2    Kang, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.