-
1
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
DOI 10.1038/nature02625
-
G Egger G Liang A Aparicio PA Jones 2004 Epigenetics in human disease and prospects for epigenetic therapy Nature 429 457 463 (Pubitemid 38715140)
-
(2004)
Nature
, vol.429
, Issue.6990
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
2
-
-
67650386630
-
Epigenetics and human disease
-
Cold Spring Harbor Laboratory Press Cold Spring Harbor
-
Zoghbi HY, Beaudet AL (2007) Epigenetics and human disease. In: Allis CD, Jenuwein T, Reinberg D (eds) Epigenetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 435-456
-
(2007)
Epigenetics
, pp. 435-456
-
-
Zoghbi, H.Y.1
Beaudet, A.L.2
Allis, C.D.3
Jenuwein, T.4
Reinberg, D.5
-
3
-
-
40949093544
-
Epigenetics at the epicenter of modern medicine
-
AP Feinberg 2008 Epigenetics at the epicenter of modern medicine JAMA 299 1345 1350
-
(2008)
JAMA
, vol.299
, pp. 1345-1350
-
-
Feinberg, A.P.1
-
4
-
-
0026653420
-
The essentials of DNA methylation
-
A Bird 1992 The essentials of DNA methylation Cell 70 5 8
-
(1992)
Cell
, vol.70
, pp. 5-8
-
-
Bird, A.1
-
5
-
-
0035839136
-
Translating the histone code
-
DOI 10.1126/science.1063127
-
T Jenuwein CD Allis 2001 Translating the histone code Science 293 1074 1080 (Pubitemid 32758077)
-
(2001)
Science
, vol.293
, Issue.5532
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
6
-
-
39549083972
-
Chromatin modifications and their mechanism of action
-
Cold Spring Harbor Laboratory Press Cold Spring Harbor
-
Kouzarides T, Berger SL (2007) Chromatin modifications and their mechanism of action. In: Allis CD, Jenuwein T, Reinberg D (eds) Epigenetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 191-209
-
(2007)
Epigenetics
, pp. 191-209
-
-
Kouzarides, T.1
Berger, S.L.2
Allis, C.D.3
Jenuwein, T.4
Reinberg, D.5
-
7
-
-
34447625911
-
Epigenetics and aging: the targets and the marks
-
DOI 10.1016/j.tig.2007.05.008, PII S0168952507001862
-
MF Fraga M Esteller 2007 Epigenetics and aging: the targets and the marks Trends Genet 23 413 418 (Pubitemid 47088010)
-
(2007)
Trends in Genetics
, vol.23
, Issue.8
, pp. 413-418
-
-
Fraga, M.F.1
Esteller, M.2
-
8
-
-
22844457491
-
DNA methylation and human disease
-
DOI 10.1038/nrg1655
-
KD Robertson 2005 DNA methylation and human disease Nat Rev Genet 6 597 610 (Pubitemid 41044297)
-
(2005)
Nature Reviews Genetics
, vol.6
, Issue.8
, pp. 597-610
-
-
Robertson, K.D.1
-
10
-
-
0029926820
-
S-Adenosylmethionine and methylation
-
PK Chiang RK Gordon J Tal GC Zeng BP Doctor K Pardhasaradhi PP [tmp] McCann 1996 S-adenosylmethionine and methylation FASEB J 10 471 480 (Pubitemid 26120322)
-
(1996)
FASEB Journal
, vol.10
, Issue.4
, pp. 471-480
-
-
Chiang, P.K.1
Gordon, R.K.2
Tal, J.3
Zeng, G.C.4
Doctor, B.P.5
Pardhasaradhi, K.6
McCann, P.P.7
-
11
-
-
15744401773
-
Eukaryotic cytosine methyltransferases
-
DOI 10.1146/annurev.biochem.74.010904.153721
-
MG Goll TH Bestor 2005 Eukaryotic cytosine methyltransferases Annu Rev Biochem 74 481 514 (Pubitemid 40995515)
-
(2005)
Annual Review of Biochemistry
, vol.74
, pp. 481-514
-
-
Goll, M.G.1
Bestor, T.H.2
-
12
-
-
34249111173
-
DNA methylation in mammals
-
Cold Spring Harbor Laboratory Press Cold Spring Harbor
-
Li E, Bird A (2007) DNA methylation in mammals. In: Allis CD, Jenuwein T, Reinberg D (eds) Epigenetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 341-356
-
(2007)
Epigenetics
, pp. 341-356
-
-
Li, E.1
Bird, A.2
Allis, C.D.3
Jenuwein, T.4
Reinberg, D.5
-
13
-
-
0033601073
-
Methylation-induced repression-belts, braces, and chromatin
-
AP Bird AP Wolffe 1999 Methylation-induced repression-belts, braces, and chromatin Cell 99 451 454 (Pubitemid 129746827)
-
(1999)
Cell
, vol.99
, Issue.5
, pp. 451-454
-
-
Bird, A.P.1
Wolffe, A.P.2
-
14
-
-
0027348191
-
X-chromosome inactivation and DNA methylation
-
J Singer-Sam AD Riggs 1993 X-chromosome inactivation and DNA methylation EXS 64 358 384
-
(1993)
EXS
, vol.64
, pp. 358-384
-
-
Singer-Sam, J.1
Riggs, A.D.2
-
15
-
-
0027378582
-
Role for DNA methylation in genomic imprinting
-
E Li C Beard R Jaenisch 1993 Role for DNA methylation in genomic imprinting Nature 366 362 365
-
(1993)
Nature
, vol.366
, pp. 362-365
-
-
Li, E.1
Beard, C.2
Jaenisch, R.3
-
16
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
DOI 10.1016/S0168-9525(97)01181-5, PII S0168952597011815
-
JA Yoder CP Walsh TH Bestor 1997 Cytosine methylation and the ecology of intragenomic parasites Trends Genet 13 335 340 (Pubitemid 27309911)
-
(1997)
Trends in Genetics
, vol.13
, Issue.8
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
17
-
-
33847032960
-
The Mammalian Epigenome
-
DOI 10.1016/j.cell.2007.01.033, PII S0092867407001286
-
BE Bernstein A Meissner ES Lander 2007 The mammalian epigenome Cell 128 669 681 (Pubitemid 46273573)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 669-681
-
-
Bernstein, B.E.1
Meissner, A.2
Lander, E.S.3
-
18
-
-
0019318994
-
DNA methylation and gene function
-
A Razin AD Riggs 1980 DNA methylation and gene function Science 210 604 610
-
(1980)
Science
, vol.210
, pp. 604-610
-
-
Razin, A.1
Riggs, A.D.2
-
19
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
DOI 10.1016/S0092-8674(00)81656-6
-
M Okano DW Bell DA Haber E Li 1999 DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 247 257 (Pubitemid 29519904)
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
20
-
-
17144369504
-
Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L
-
DOI 10.1074/jbc.M413412200
-
H Gowher K Liebert A Hermann G Xu A Jeltsch 2005 Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L J Biol Chem 280 13341 13348 (Pubitemid 40517220)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13341-13348
-
-
Gowher, H.1
Liebert, K.2
Hermann, A.3
Xu, G.4
Jeltsch, A.5
-
21
-
-
31444436545
-
Lsh is involved in de novo methylation of DNA
-
DOI 10.1038/sj.emboj.7600925, PII 7600925
-
H Zhu TM Geiman S Xi Q Jiang A Schmidtmann T Chen E Li K Muegge 2006 Lsh is involved in de novo methylation of DNA EMBO J 25 335 345 (Pubitemid 43152854)
-
(2006)
EMBO Journal
, vol.25
, Issue.2
, pp. 335-345
-
-
Zhu, H.1
Geiman, T.M.2
Xi, S.3
Jiang, Q.4
Schmidtmann, A.5
Chen, T.6
Li, E.7
Muegge, K.8
-
22
-
-
35649020283
-
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
-
DOI 10.1073/pnas.0707628104
-
M Fabbri R Garzon A Cimmino Z Liu N Zanesi E Callegari S Liu H Alder S Costinean C Fernandez-Cymering S Volinia G Guler CD Morrison KK Chan G Marcucci GA Calin K Huebner CM Croce 2007 MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B Proc Natl Acad Sci USA 104 15805 15810 (Pubitemid 350035380)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.40
, pp. 15805-15810
-
-
Fabbri, M.1
Garzon, R.2
Cimmino, A.3
Liu, Z.4
Zanesi, N.5
Callegari, E.6
Liu, S.7
Alder, H.8
Costinean, S.9
Fernandez-Cymering, C.10
Volinia, S.11
Guler, G.12
Morrison, C.D.13
Chan, K.K.14
Marcucci, G.15
Calin, G.A.16
Huebner, K.17
Croce, C.M.18
-
23
-
-
52049098967
-
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
-
AA Aravin R Sachidanandam D Bouc'his C Schaefer D Pezic KF Toth T Bestor GJ Hannon 2008 A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice Mol Cell 31 785 799
-
(2008)
Mol Cell
, vol.31
, pp. 785-799
-
-
Aravin, A.A.1
Sachidanandam, R.2
Bouc'His, D.3
Schaefer, C.4
Pezic, D.5
Toth, K.F.6
Bestor, T.7
Hannon, G.J.8
-
24
-
-
0036135014
-
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
-
DOI 10.1128/MCB.22.2.480-491.2002
-
G Liang MF Chan Y Tomigahara YC Tsai FA Gonzales E Li PW Laird PA Jones 2002 Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements Mol Cell Biol 22 480 491 (Pubitemid 34027493)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.2
, pp. 480-491
-
-
Liang, G.1
Chan, M.F.2
Tomigahara, Y.3
Tsai, Y.C.4
Gonzales, F.A.5
Li, E.6
Laird, P.W.7
Jones, P.A.8
-
25
-
-
0242551379
-
DNMT cooperativity - The developing links between methylation, chromatin structure and cancer
-
DOI 10.1002/bies.10345
-
A El-Osta 2003 DNMT cooperativity - the developing links between methylation, chromatin structure and cancer Bioessays 25 1071 1084 (Pubitemid 37411767)
-
(2003)
BioEssays
, vol.25
, Issue.11
, pp. 1071-1084
-
-
El-Osta, A.1
-
26
-
-
0038136913
-
Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
-
DOI 10.1074/jbc.M209923200
-
H Kimura K Shiota 2003 Methyl-CpG-binding protein, MeCP2, is target molecule for maintenance DNA methyltransferase, Dnmt1 J Biol Chem 278 4806 4812 (Pubitemid 36800984)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.7
, pp. 4806-4812
-
-
Kimura, H.1
Shiota, K.2
-
28
-
-
53649097070
-
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base flipping mechanism
-
K Arita M Ariyoshi H Tochio Y Nakamura M Shirakawa 2008 Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base flipping mechanism Nature 455 818 821
-
(2008)
Nature
, vol.455
, pp. 818-821
-
-
Arita, K.1
Ariyoshi, M.2
Tochio, H.3
Nakamura, Y.4
Shirakawa, M.5
-
29
-
-
53649088595
-
Structural basis for recognition of hemimethylated DNA by the SRA domain of human UHRF1
-
GV Avvakumov JR Walker S Xue Y Li S Duan C Bronner CH Arrowsmith S Dhe-Paganon 2008 Structural basis for recognition of hemimethylated DNA by the SRA domain of human UHRF1 Nature 455 822 825
-
(2008)
Nature
, vol.455
, pp. 822-825
-
-
Avvakumov, G.V.1
Walker, J.R.2
Xue, S.3
Li, Y.4
Duan, S.5
Bronner, C.6
Arrowsmith, C.H.7
Dhe-Paganon, S.8
-
33
-
-
32044455298
-
Large-scale structure of genomic methylation patterns
-
DOI 10.1101/gr.4362006
-
RA Rollins F Haghighi JR Edwards R Das MQ Zhang J Ju TH Bestor 2006 Large-scale structure of genomic methylation patterns Genome Res 16 157 163 (Pubitemid 43200263)
-
(2006)
Genome Research
, vol.16
, Issue.2
, pp. 157-163
-
-
Rollins, R.A.1
Haghighi, F.2
Edwards, J.R.3
Das, R.4
Zhang, M.Q.5
Ju, J.6
Bestor, T.H.7
-
34
-
-
43749098985
-
DNA methylation landscapes: Provocative insights from epigenomics
-
DOI 10.1038/nrg2341, PII NRG2341
-
MM Suzuki A Bird 2008 DNA methylation landscapes: provocative insights from epigenomics Nat Rev Genet 9 465 476 (Pubitemid 351693975)
-
(2008)
Nature Reviews Genetics
, vol.9
, Issue.6
, pp. 465-476
-
-
Suzuki, M.M.1
Bird, A.2
-
36
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
E Li TH Bestor R Jaenisch 1992 Targeted mutation of the DNA methyltransferase gene results in embryonic lethality Cell 69 915 926
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
37
-
-
45449114804
-
The Colorful History of Active DNA Demethylation
-
DOI 10.1016/j.cell.2008.06.009, PII S0092867408007617
-
SK Ooi TH Bestor 2008 The colorful history of active DNA demethylation Cell 133 1145 1148 (Pubitemid 351852922)
-
(2008)
Cell
, vol.133
, Issue.7
, pp. 1145-1148
-
-
Ooi, S.K.T.1
Bestor, T.H.2
-
38
-
-
58149156264
-
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
-
J Wang S Hevi JK Kurash H Lei F Gay J Bajko H Su W Sun H Chang G Xu F Gaudet E Li T Chen 2009 The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation Nat Genet 41 125 129
-
(2009)
Nat Genet
, vol.41
, pp. 125-129
-
-
Wang, J.1
Hevi, S.2
Kurash, J.K.3
Lei, H.4
Gay, F.5
Bajko, J.6
Su, H.7
Sun, W.8
Chang, H.9
Xu, G.10
Gaudet, F.11
Li, E.12
Chen, T.13
-
39
-
-
0036327615
-
Diet, methyl donors and DNA methylation: Interactions between dietary folate, methionine and choline
-
MD Niculescu SH Zeisel 2002 Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline J Nutr 132 2333S 2335S (Pubitemid 34848102)
-
(2002)
Journal of Nutrition
, vol.132
, Issue.SUPPL.
-
-
Niculescu, M.D.1
Zeisel, S.H.2
-
42
-
-
33847055935
-
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
-
DOI 10.1158/0008-5472.CAN-06-3123
-
V Valinluck LC Sowers 2007 Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1 Cancer Res 67 946 950 (Pubitemid 46270748)
-
(2007)
Cancer Research
, vol.67
, Issue.3
, pp. 946-950
-
-
Valinluck, V.1
Sowers, L.C.2
-
43
-
-
0027849602
-
Hypomethylation of DNA: A possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis
-
JI Goodman JL Counts 1993 Hypomethylation of DNA: a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis Environ Health Perspect 101 169 172 (Pubitemid 24096345)
-
(1993)
Environmental Health Perspectives
, vol.101
, Issue.SUPPL. 5
, pp. 169-172
-
-
Goodman, J.I.1
Counts, J.L.2
-
44
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
DOI 10.1126/science.1083558
-
F Gaudet JG Hodgson A Eden L Jackson-Grusby J Dausman JW Gray H Leonhardt R Jaenisch 2003 Induction of tumors in mice by genomic hypomethylation Science 300 489 492 (Pubitemid 36444330)
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 489-492
-
-
Gaudet, F.1
Hodgson, J.G.2
Eden, A.3
Jackson-Grusby, L.4
Dausman, J.5
Gray, J.W.6
Leonhardt, H.7
Jaenisch, R.8
-
45
-
-
0020032366
-
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2-deoxycytidine
-
F Creusot G Acs JK Christman 1982 Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2-deoxycytidine J Biol Chem 257 2041 2048
-
(1982)
J Biol Chem
, vol.257
, pp. 2041-2048
-
-
Creusot, F.1
Acs, G.2
Christman, J.K.3
-
48
-
-
25144507259
-
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
-
DOI 10.1124/mol.104.008367
-
WJ Lee JY Shim BT Zhu 2005 Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids Mol Pharmacol 68 1018 1030 (Pubitemid 41345793)
-
(2005)
Molecular Pharmacology
, vol.68
, Issue.4
, pp. 1018-1030
-
-
Won, J.L.1
Shim, J.-Y.2
Zhu, B.T.3
-
49
-
-
34547118090
-
Molecular mechanisms of alcohol-mediated carcinogenesis
-
HK Seitz F Stickel 2007 Molecular mechanisms of alcohol-mediated carcinogenesis Nat Rev Cancer 7 599 612
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 599-612
-
-
Seitz, H.K.1
Stickel, F.2
-
50
-
-
35148873511
-
Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B
-
H Liu Y Zhou SE Boggs SA Belinsky J Liu 2007 Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B Oncogene 26 5900 5910
-
(2007)
Oncogene
, vol.26
, pp. 5900-5910
-
-
Liu, H.1
Zhou, Y.2
Boggs, S.E.3
Belinsky, S.A.4
Liu, J.5
-
51
-
-
37549061829
-
LSH cooperates with DNA methyltransferases to repress transcription
-
K Myant I Stancheva 2008 LSH cooperates with DNA methyltransferases to repress transcription Mol Cell Biol 28 215 226
-
(2008)
Mol Cell Biol
, vol.28
, pp. 215-226
-
-
Myant, K.1
Stancheva, I.2
-
52
-
-
53349146471
-
Genetic polymorphisms in methyl-group metabolism and epigenetics: Lessons from humans and mouse models
-
SH Zeisel 2008 Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models Brain Res 1237 5 11
-
(2008)
Brain Res
, vol.1237
, pp. 5-11
-
-
Zeisel, S.H.1
-
53
-
-
2942700001
-
5,10-Methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C mutations are associated with DNA hypomethylation
-
R Castro I Rivera P Racasco ME Camilo C Jakobs HJ Blom IT de Almeida 2004 5, 10-methylenetetrahydrofolate reductase (MTHFR) 677C → T and 1298A → C mutations are associated with DNA hypomethylation J Med Genet 41 454 458 (Pubitemid 38788042)
-
(2004)
Journal of Medical Genetics
, vol.41
, Issue.6
, pp. 454-458
-
-
Castro, R.1
Rivera, I.2
Ravasco, P.3
Camilo, M.E.4
Jakobs, C.5
Blom, H.J.6
De Almeida, I.T.7
-
55
-
-
0026579875
-
Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression
-
E Wainfan LA Poirier 1992 Methyl groups in carcinogenesis: effects on DNA methylation and gene expression Cancer Res 52 2071S 2077S
-
(1992)
Cancer Res
, vol.52
-
-
Wainfan, E.1
Poirier, L.A.2
-
56
-
-
0029072763
-
Lipotrope deficiency and persistent changes in DNA methylation
-
JK Christman 1995 Lipotrope deficiency and persistent changes in DNA methylation Adv Exp Med Biol 375 97 106
-
(1995)
Adv Exp Med Biol
, vol.375
, pp. 97-106
-
-
Christman, J.K.1
-
59
-
-
0034071060
-
Effect of trichloroethylene and its metabolites, dichloroacetic acid and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: Prevention by methionine
-
L Tao S Yang M Xie PM Kramer MA Pereira 2000 Effect of trichloroethylene and its metabolites, dichloroacetic and trichloroacetic acid, on the methylation and expression of c-Jun and c-Myc protooncogenes in mouse liver: prevention by methionine Toxicol Sci 54 399 407 (Pubitemid 30185962)
-
(2000)
Toxicological Sciences
, vol.54
, Issue.2
, pp. 399-407
-
-
Tao, L.1
Yang, S.2
Xie, M.3
Kramer, P.M.4
Pereira, M.A.5
-
61
-
-
38049059966
-
DNA damage, cellular senescence and organismal ageing: Causal or correlative?
-
JH Chen CN Hales SE Ozanne 2007 DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res 35 7417 7428
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 7417-7428
-
-
Chen, J.H.1
Hales, C.N.2
Ozanne, S.E.3
-
62
-
-
0242610894
-
Mechanisms of DNA Damage, DNA Hypomethylation, and Tumor Progression in the Folate/Methyl-Deficient Rat Model of Hepatocarcinogenesis
-
SJ James IP Pogribny M Pogribna BJ Miller S Jernigan S Melnyk 2003 Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis J Nutr 133 3740S 3747S (Pubitemid 37406630)
-
(2003)
Journal of Nutrition
, vol.133
, Issue.SUPPL. 1
-
-
James, S.J.1
Pogribny, I.P.2
Pogribna, M.3
Miller, B.J.4
Jernigan, S.5
Melnyk, S.6
-
63
-
-
4043112183
-
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
-
DOI 10.1093/nar/gkh739
-
V Valinluck HH Tsai DK Rogstad A Burdzy A Bird LC Sowers 2004 Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2) Nucleic Acids Res 32 4100 4108 (Pubitemid 39232282)
-
(2004)
Nucleic Acids Research
, vol.32
, Issue.14
, pp. 4100-4108
-
-
Valinluck, V.1
Tsai, H.-H.2
Rogstad, D.K.3
Burdzy, A.4
Bird, A.5
Sowers, L.C.6
-
64
-
-
0030859713
-
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases
-
S Tommasi MF Denissenko GP Pfeifer 1997 Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases Cancer Res 57 4727 4730 (Pubitemid 27468976)
-
(1997)
Cancer Research
, vol.57
, Issue.21
, pp. 4727-4730
-
-
Tommasi, S.1
Denissenko, M.F.2
Pfeifer, G.P.3
-
67
-
-
0027310491
-
Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine
-
JP Jost 1993 Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine Proc Natl Acad Sci USA 90 4684 4688
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 4684-4688
-
-
Jost, J.P.1
-
69
-
-
0032534635
-
Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts
-
JF Swisher E Rand H Cedar A Marie Pyle 1998 Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts Nucleic Acids Res 26 5573 5580 (Pubitemid 28554724)
-
(1998)
Nucleic Acids Research
, vol.26
, Issue.24
, pp. 5573-5580
-
-
Swisher, J.F.A.1
Rand, E.2
Cedar, H.3
Pyle, A.M.4
-
70
-
-
0033580326
-
A mammalian protein with specific demethylase activity for mCpG DNA
-
SK Bhattacharya S Ramchandani N Cervoni M Szyf 1999 A mammalian protein with specific demethylase activity for mCpG DNA Nature 397 579 583
-
(1999)
Nature
, vol.397
, pp. 579-583
-
-
Bhattacharya, S.K.1
Ramchandani, S.2
Cervoni, N.3
Szyf, M.4
-
71
-
-
40449123137
-
Cyclical DNA methylation of a transcriptionally active promoter
-
DOI 10.1038/nature06544, PII NATURE06544
-
R Métivier R Gallais C Tiffoche C Le Péron RZ Jurkowska RP Carmouche D Ibberson P Barath F Demay G Reid V Benes A Jeltsch F Gannon G Salbert 2008 Cyclical DNA methylation of a transcriptionally active promoter Nature 452 45 50 (Pubitemid 351355084)
-
(2008)
Nature
, vol.452
, Issue.7183
, pp. 45-50
-
-
Metivier, R.1
Gallais, R.2
Tiffoche, C.3
Le Peron, C.4
Jurkowska, R.Z.5
Carmouche, R.P.6
Ibberson, D.7
Barath, P.8
Demay, F.9
Reid, G.10
Benes, V.11
Jeltsch, A.12
Gannon, F.13
Salbert, G.14
-
72
-
-
40449104358
-
Transient cyclical methylation of promoter DNA
-
DOI 10.1038/nature06640, PII NATURE06640
-
S Kangaspeska B Stride R Métivier M Polycarpou-Schwarz D Ibberson RP Carmouche V Benes F Gannon G Reid 2008 Transient cyclical methylation of promoter DNA Nature 452 112 115 (Pubitemid 351355094)
-
(2008)
Nature
, vol.452
, Issue.7183
, pp. 112-115
-
-
Kangaspeska, S.1
Stride, B.2
Metivier, R.3
Polycarpou-Schwarz, M.4
Ibberson, D.5
Carmouche, R.P.6
Benes, V.7
Gannon, F.8
Reid, G.9
-
73
-
-
0034614637
-
The hallmarks of cancer
-
D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57 70 (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
74
-
-
4043181214
-
Cancer genes and the pathways they control
-
DOI 10.1038/nm1087
-
B Vogelstein KW Kinzler 2004 Cancer genes and the pathways they control Nat Med 10 789 799 (Pubitemid 39070849)
-
(2004)
Nature Medicine
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
75
-
-
33847065486
-
The Epigenomics of Cancer
-
DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
-
PA Jones SB Baylin 2007 The epigenomics of cancer Cell 128 683 692 (Pubitemid 46273572)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
77
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
DOI 10.1038/301089a0
-
AP Feinberg B Vogelstein 1983 Hypomethylation distinguishes genes of some human cancers from their normal counterparts Nature 301 89 92 (Pubitemid 13154475)
-
(1983)
Nature
, vol.301
, Issue.5895
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
78
-
-
0020520688
-
Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants
-
E Flatau E Bogenmann PA Jones 1983 Variable 5-methylcytosine levels in human tumor cell lines and fresh pediatric tumor explants Cancer Res 43 4901 4905
-
(1983)
Cancer Res
, vol.43
, pp. 4901-4905
-
-
Flatau, E.1
Bogenmann, E.2
Jones, P.A.3
-
79
-
-
0023848637
-
Reduced genomic 5-methylcytosine content in human colonic neoplasia
-
AP Feinberg CW Gehrke KC Kuo M Ehrlich 1988 Reduced genomic 5-methylcytosine content in human colonic neoplasia Cancer Res 48 1159 1161 (Pubitemid 18075525)
-
(1988)
Cancer Research
, vol.48
, Issue.5
, pp. 1159-1161
-
-
Feinberg, A.P.1
Gehrke, C.W.2
Kuo, K.C.3
Ehrlich, M.4
-
80
-
-
33644825262
-
Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage
-
DOI 10.1016/j.ccr.2006.02.016, PII S1535610806000535
-
K Suzuki I Suzuki A Leodolter S Alonso S Horiuchi K Yamashita M Perucho 2006 Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage Cancer Cell 9 199 207 (Pubitemid 43357946)
-
(2006)
Cancer Cell
, vol.9
, Issue.3
, pp. 199-207
-
-
Suzuki, K.1
Suzuki, I.2
Leodolter, A.3
Alonso, S.4
Horiuchi, S.5
Yamashita, K.6
Perucho, M.7
-
81
-
-
38349135680
-
High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer
-
TA Rauch X Zhong X Wu M Wang KH Kernstine Z Wang AD Riggs GP Pfeifer 2008 High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer Proc Natl Acad Sci USA 105 252 257
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 252-257
-
-
Rauch, T.A.1
Zhong, X.2
Wu, X.3
Wang, M.4
Kernstine, K.H.5
Wang, Z.6
Riggs, A.D.7
Pfeifer, G.P.8
-
83
-
-
20544458020
-
DNA hypomethylation is prevalent even in low-grade breast cancers
-
K Jackson MC Yu K Arakawa E Fiala B Youn H Fiegl E Müller-Holzner M Widschwendter M Ehrlich 2004 DNA hypomethylation is prevalent in low-grade breast cancers Cancer Biol Ther 3 1225 1231 (Pubitemid 41350957)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.12
, pp. 1225-1231
-
-
Jackson, K.1
Yu, M.C.2
Arakawa, K.3
Fiala, E.4
Youn, B.5
Fiegl, H.6
Muller-Holzner, E.7
Widschwendter, M.8
Ehrlich, M.9
-
84
-
-
10344263962
-
DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas
-
DOI 10.1097/01.ju.0000141577.98902.49
-
T Nakagawa Y Kanai S Ushijima T Kitamura T Kakizoe S Hirohashi 2005 DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas J Urol 173 243 246 (Pubitemid 39627727)
-
(2005)
Journal of Urology
, vol.173
, Issue.1
, pp. 243-246
-
-
Nakagawa, T.1
Kanai, Y.2
Ushijima, S.3
Kitamura, T.4
Kakizoe, T.5
Hirohashi, S.6
-
85
-
-
3042822370
-
DNA hypomethylation and ovarian cancer biology
-
DOI 10.1158/0008-5472.CAN-04-0238
-
M Widschwendter G Jiang C Woods HM Müller H Fiegl G Goebel C Marth E Müller-Holzner AG Zeimet PW Laird M Ehrlich 2004 DNA hypomethylation and ovarian cancer biology Cancer Res 64 4472 4480 (Pubitemid 38856918)
-
(2004)
Cancer Research
, vol.64
, Issue.13
, pp. 4472-4480
-
-
Widschwendter, M.1
Jiang, G.2
Woods, C.3
Muller, H.M.4
Fiegl, H.5
Goebel, G.6
Marth, C.7
Muller-Holzner, E.8
Zeimet, A.G.9
Laird, P.W.10
Ehrlich, M.11
-
87
-
-
0028111446
-
Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
-
DOI 10.1002/1097-0142(19940801)74:3<893::AID-CNCR2820740316>3.0. CO;2-B
-
YI Kim A Giuliano KD Hatch A Schneider MA Nour GE Dallal J Selhub JB Mason 1994 Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma Cancer 74 893 899 (Pubitemid 24237470)
-
(1994)
Cancer
, vol.74
, Issue.SUPPL.
, pp. 893-899
-
-
Kim, Y.-I.1
Giuliano, A.2
Hatch, K.D.3
Schneider, A.4
Nour, M.A.5
Dallal, G.E.6
Selhub, J.7
Mason, J.B.8
-
89
-
-
40949160813
-
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish bladder cancer study: A case-control study
-
LE Moore RM Pfeiffer C Poscablo FX Real M Kogevinas D Silverman R García-Closas S Chanock A Tardón C Serra A Carrato M Dosemeci M García-Closas M Esteller M Fraga N Rothman N Malats 2008 Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish bladder cancer study: a case-control study Lancet Oncol 9 359 366
-
(2008)
Lancet Oncol
, vol.9
, pp. 359-366
-
-
Moore, L.E.1
Pfeiffer, R.M.2
Poscablo, C.3
Real, F.X.4
Kogevinas, M.5
Silverman, D.6
García-Closas, R.7
Chanock, S.8
Tardón, A.9
Serra, C.10
Carrato, A.11
Dosemeci, M.12
García-Closas, M.13
Esteller, M.14
Fraga, M.15
Rothman, N.16
Malats, N.17
-
90
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
DOI 10.1126/science.1083557
-
A Eden F Gaudet A Waghmare R Jaenisch 2003 Chromosomal instability and tumors promoted by DNA hypomethylation Science 300 455 (Pubitemid 36444319)
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
91
-
-
26444473234
-
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
-
DOI 10.1073/pnas.0506612102
-
Y Yamada L Jackson-Grusby H Linhart A Meissner A Eden H Lin R Jaenisch 2005 Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis Proc Natl Acad Sci USA 102 13580 13585 (Pubitemid 41420891)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.38
, pp. 13580-13585
-
-
Yamada, Y.1
Jackson-Grusby, L.2
Linhart, H.3
Meissner, A.4
Eden, A.5
Lin, H.6
Jaenisch, R.7
-
92
-
-
49249126168
-
DNA hypomethylation caused by LSH deletion promotes erythroleukemia development
-
T Fan A Schmidtmann S Xi V Briones H Zhu HC Suh J Gooya JR Keller H Xu J Roayaei M Anver S Ruscetti K Muegge 2008 DNA hypomethylation caused by LSH deletion promotes erythroleukemia development Epigenetics 3 134 142
-
(2008)
Epigenetics
, vol.3
, pp. 134-142
-
-
Fan, T.1
Schmidtmann, A.2
Xi, S.3
Briones, V.4
Zhu, H.5
Suh, H.C.6
Gooya, J.7
Keller, J.R.8
Xu, H.9
Roayaei, J.10
Anver, M.11
Ruscetti, S.12
Muegge, K.13
-
93
-
-
57349138824
-
A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
-
S Ogino K Nosho GJ Kirkner T Kawasaki AT Chan ES Schernhammer EL Giovannucci CS Fuchs 2008 A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer J Natl Cancer Inst 100 1734 1738
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1734-1738
-
-
Ogino, S.1
Nosho, K.2
Kirkner, G.J.3
Kawasaki, T.4
Chan, A.T.5
Schernhammer, E.S.6
Giovannucci, E.L.7
Fuchs, C.S.8
-
94
-
-
33645784375
-
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation
-
NC Wong LH Wong JM Quach P Canham JM Craig JZ Song SJ Clark LHA Choo 2006 Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation PLoS Genet 2 e17
-
(2006)
PLoS Genet
, vol.2
, pp. 17
-
-
Wong, N.C.1
Wong, L.H.2
Quach, J.M.3
Canham, P.4
Craig, J.M.5
Song, J.Z.6
Clark, S.J.7
Choo, L.H.A.8
-
96
-
-
50849099769
-
Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions
-
S Yehezkel Y Segev E Viegas-Péquignot K Skorecki S Selig 2008 Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions Hum Mol Genet 17 2776 2789
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2776-2789
-
-
Yehezkel, S.1
Segev, Y.2
Viegas-Péquignot, E.3
Skorecki, K.4
Selig, S.5
-
98
-
-
38049164130
-
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice
-
G Howard R Eiges F Gaudet R Jaenisch A Eden 2008 Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice Oncogene 27 404 408
-
(2008)
Oncogene
, vol.27
, pp. 404-408
-
-
Howard, G.1
Eiges, R.2
Gaudet, F.3
Jaenisch, R.4
Eden, A.5
-
99
-
-
33846581497
-
Loss of imprinting and cancer
-
DOI 10.1002/path.2116
-
P Jelinic P Shaw 2007 Loss of imprinting and cancer J Pathol 211 261 268 (Pubitemid 46172701)
-
(2007)
Journal of Pathology
, vol.211
, Issue.3
, pp. 261-268
-
-
Jelinic, P.1
Shaw, P.2
-
100
-
-
33847358273
-
Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer
-
Epigenetic Markers
-
H Cui 2007 Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer Dis Markers 23 105 112 (Pubitemid 46333644)
-
(2007)
Disease Markers
, vol.23
, Issue.1-2
, pp. 105-112
-
-
Cui, H.1
-
102
-
-
49649112211
-
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer
-
Y Ito T Koessler AE Ibrahim S Rai SL Vowler S Abu-Amero AL Silva AT Maia JE Huddleston S Uribe-Lewis K Woodfine M Jagodic R Nativio A Dunning G Moore E Klenova S Bingham PD Pharoah JD Brenton S Beck MS Sandhu A Murrell 2008 Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer Hum Mol Genet 17 2633 2643
-
(2008)
Hum Mol Genet
, vol.17
, pp. 2633-2643
-
-
Ito, Y.1
Koessler, T.2
Ibrahim, A.E.3
Rai, S.4
Vowler, S.L.5
Abu-Amero, S.6
Silva, A.L.7
Maia, A.T.8
Huddleston, J.E.9
Uribe-Lewis, S.10
Woodfine, K.11
Jagodic, M.12
Nativio, R.13
Dunning, A.14
Moore, G.15
Klenova, E.16
Bingham, S.17
Pharoah, P.D.18
Brenton, J.D.19
Beck, S.20
Sandhu, M.S.21
Murrell, A.22
more..
-
103
-
-
39049192533
-
Hypomethylation of P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population
-
SH Tang DH Yang W Huang HK Zhou XH Lu G Ye 2006 Hypomethylation of P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population Clin Cancer Res 12 4171 4177
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4171-4177
-
-
Tang, S.H.1
Yang, D.H.2
Huang, W.3
Zhou, H.K.4
Lu, X.H.5
Ye, G.6
-
104
-
-
0035510088
-
Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer
-
D Takai FA Gonzales YC Tsai MJ Thayer PA Jones 2001 Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer Hum Mol Genet 10 2619 2626 (Pubitemid 33133402)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.23
, pp. 2619-2626
-
-
Takai, D.1
Gonzales, F.A.2
Tsai, Y.C.3
Thayer, M.J.4
Jones, P.A.5
-
105
-
-
0028905376
-
Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers
-
M Kondo H Suzuki R Ueda H Osada K Takagi T Takahashi T Takahashi 1995 Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancers Oncogene 10 1193 1198
-
(1995)
Oncogene
, vol.10
, pp. 1193-1198
-
-
Kondo, M.1
Suzuki, H.2
Ueda, R.3
Osada, H.4
Takagi, K.5
Takahashi, T.6
Takahashi, T.7
-
106
-
-
85047699309
-
Loss of methylation at chromosome 11p15.5 is common in human adult tumors
-
DOI 10.1038/sj/onc/1205336
-
RA Scelfo C Schwienbacher A Veronese L Gramantieri L Bolondi P Querzoli I Nenci GA Calin A Angioni G Barbanti-Brodano M Negrini 2002 Loss of methylation at chromosome 11p15.5 is common in human adult tumors Oncogene 21 2564 2572 (Pubitemid 34438109)
-
(2002)
Oncogene
, vol.21
, Issue.16
, pp. 2564-2572
-
-
Scelfo, R.A.M.1
Schwienbacher, C.2
Veronese, A.3
Gramantieri, L.4
Bolondi, L.5
Querzoli, P.6
Nenci, I.7
Calin, G.A.8
Angioni, A.9
Barbanti-Brodano, G.10
Negrini, M.11
-
107
-
-
42449129744
-
Cytosine methylation profiling of cancer cell lines
-
DOI 10.1073/pnas.0712251105
-
M Ehrich J Turner P Gibbs L Lipton M Giovanneti C Cantor D van den Boom 2008 Cytosine methylation profiling of cancer cell lines Proc Natl Acad Sci USA 105 4844 4849 (Pubitemid 351753834)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.12
, pp. 4844-4849
-
-
Ehrich, M.1
Turner, J.2
Gibbs, P.3
Lipton, L.4
Giovanneti, M.5
Cantor, C.6
Van Den Boom, D.7
-
109
-
-
35948981875
-
Genome-wide profiling of DNA reveals a class of normally methylated CpG island promoters
-
L Shen Y Kondo Y Guo J Zhang L Zhang S Ahmed J Shu X Chen RA Waterland JP Issa 2007 Genome-wide profiling of DNA reveals a class of normally methylated CpG island promoters PLoS Genet 3 2023 2036
-
(2007)
PLoS Genet
, vol.3
, pp. 2023-2036
-
-
Shen, L.1
Kondo, Y.2
Guo, Y.3
Zhang, J.4
Zhang, L.5
Ahmed, S.6
Shu, J.7
Chen, X.8
Waterland, R.A.9
Issa, J.P.10
-
110
-
-
0032468051
-
Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
-
DOI 10.1023/A:1006589626307
-
N Nakamura K Takenaga 1998 Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines Clin Exp Metastasis 16 471 479 (Pubitemid 29098810)
-
(1998)
Clinical and Experimental Metastasis
, vol.16
, Issue.5
, pp. 471-479
-
-
Nakamura, N.1
Takenaga, K.2
-
111
-
-
34548808621
-
Hypomethylation-induced expression of S100A4 in endometrial carcinoma
-
DOI 10.1038/modpathol.3800940, PII 3800940
-
R Xie DS Loose GL Shipley S Xie RL Bassett Jr RR Broaddus 2007 Hypomethylation-induced expression of S100A4 in endometrial carcinoma Mod Pathol 20 1045 1054 (Pubitemid 47429198)
-
(2007)
Modern Pathology
, vol.20
, Issue.10
, pp. 1045-1054
-
-
Xie, R.1
Loose, D.S.2
Shipley, G.L.3
Xie, S.4
Bassett Jr., R.L.5
Broaddus, R.R.6
-
112
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
N Sato A Maitra N Fukushima NT van Heek H Matsubayashi CA Iacobuzio-Donahue C Rosty M Coggins 2003 Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma Cancer Res 63 4158 4166 (Pubitemid 36917941)
-
(2003)
Cancer Research
, vol.63
, Issue.14
, pp. 4158-4166
-
-
Sato, N.1
Maitra, A.2
Fukushima, N.3
Van Heek, N.T.4
Matsubayashi, H.5
Iacobuzio-Donahue, C.A.6
Rosty, C.7
Goggins, M.8
-
114
-
-
54249096084
-
Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo
-
A Milicic LA Harrison RA Goodlad RG Hardy AM Nicholson M Presz O Sieber S Santander JH Pringle N Mandir P East J Obszynska S Sanders E Piazuelo J Shaw R Harrison IP Tomlinson SA [tmp] McDonald NA Wright JA Jankowski 2008 Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo Cancer Res 68 7760 7768
-
(2008)
Cancer Res
, vol.68
, pp. 7760-7768
-
-
Milicic, A.1
Harrison, L.A.2
Goodlad, R.A.3
Hardy, R.G.4
Nicholson, A.M.5
Presz, M.6
Sieber, O.7
Santander, S.8
Pringle, J.H.9
Mandir, N.10
East, P.11
Obszynska, J.12
Sanders, S.13
Piazuelo, E.14
Shaw, J.15
Harrison, R.16
Tomlinson, I.P.17
McDonald, S.A.18
Wright, N.A.19
Jankowski, J.A.20
more..
-
115
-
-
23844489449
-
P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation
-
DOI 10.1158/1078-0432.CCR-05-0059
-
J Paredes A Albergaria JT Oliveira C Jerónimo F Milanezi FC Schmidt 2005 P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation Clin Cancer Res 11 5869 5877 (Pubitemid 41170315)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.16
, pp. 5869-5877
-
-
Paredes, J.1
Albergaria, A.2
Oliveira, J.T.3
Jeronimo, C.4
Milanezi, F.5
Schmitt, F.C.6
-
116
-
-
53349119036
-
BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection
-
C Grunau ME Brun I Rivals J Selves W Hindermann M Favre-Mercuret G Granier A De Sario 2008 BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection Cancer Epidemiol Biomarkers Prev 17 1374 1379
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 1374-1379
-
-
Grunau, C.1
Brun, M.E.2
Rivals, I.3
Selves, J.4
Hindermann, W.5
Favre-Mercuret, M.6
Granier, G.7
De Sario, A.8
-
117
-
-
0025761007
-
Hypomethylation of the decorin proteoglycan gene in human colon cancer
-
R Adany RV Iozzo 1991 Hypomethylation of the decorin proteoglycan gene in human colon cancer Biochem J 276 301 306
-
(1991)
Biochem J
, vol.276
, pp. 301-306
-
-
Adany, R.1
Iozzo, R.V.2
-
118
-
-
33750120013
-
Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues
-
KH Kim JS Choi IJ Kim JL Ku JG Park 2006 Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues World J Gastroenterol 12 5651 5657
-
(2006)
World J Gastroenterol
, vol.12
, pp. 5651-5657
-
-
Kim, K.H.1
Choi, J.S.2
Kim, I.J.3
Ku, J.L.4
Park, J.G.5
-
120
-
-
22044446350
-
Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation
-
DOI 10.1002/ijc.21007
-
JH Lim SP Kim E Gabrielson YB Park JW Park TK Kwon 2005 Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation Int J Cancer 116 200 206 (Pubitemid 40967256)
-
(2005)
International Journal of Cancer
, vol.116
, Issue.2
, pp. 200-206
-
-
Lim, J.H.1
Kim, S.-P.2
Gabrielson, E.3
Park, Y.B.4
Park, J.-W.5
Kwon, T.K.6
-
122
-
-
0142182088
-
Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells
-
Y Akiyama C Maesawa S Ogasawara M Terashima T Masuda 2003 Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells Am J Pathol 163 1911 1919 (Pubitemid 37310021)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.5
, pp. 1911-1919
-
-
Akiyama, Y.1
Maesawa, C.2
Ogasawara, S.3
Terashima, M.4
Masuda, T.5
-
123
-
-
34247382565
-
Prognostic significance of maspin in pancreatic ductal adenocarcinoma: Tissue microarray analysis of 223 surgically resected cases
-
DOI 10.1038/modpathol.3800772, PII 3800772
-
D Cao Q Zhang LS Wu SN Salaria JW Winter RH Hruban MS Goggins JL Abbruzzese A Maitra L Ho 2007 Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases Mod Pathol 20 570 578 (Pubitemid 46631999)
-
(2007)
Modern Pathology
, vol.20
, Issue.5
, pp. 570-578
-
-
Cao, D.1
Zhang, Q.2
Wu, L.S.-F.3
Salaria, S.N.4
Winter, J.W.5
Hruban, R.H.6
Goggins, M.S.7
Abbruzzese, J.L.8
Maitra, A.9
Ho, L.10
-
124
-
-
10744233288
-
Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers
-
DOI 10.1038/sj.onc.1207211
-
S Ogasawara C Maesawa M Yamamoto Y Akiyama K Wada K Fujisawa T Higuchi Y Tomisawa N Sato S Endo K Saito T Masuda 2004 Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers Oncogene 23 1117 1124 (Pubitemid 38269965)
-
(2004)
Oncogene
, vol.23
, Issue.5
, pp. 1117-1124
-
-
Ogasawara, S.1
Maesawa, C.2
Yamamoto, M.3
Akiyama, Y.4
Wada, K.5
Fujisawa, K.6
Higuchi, T.7
Tomisawa, Y.8
Sato, N.9
Endo, S.10
Saito, K.11
Masuda, T.12
-
125
-
-
0037469101
-
Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas
-
DOI 10.1016/S0304-3835(02)00549-9, PII S0304383502005499
-
P Mesquita AJ Peixoto R Seruca C Hanski R Almeida F Silva C Reis L David 2003 Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinoma Cancer Lett 189 129 136 (Pubitemid 35469124)
-
(2003)
Cancer Letters
, vol.189
, Issue.2
, pp. 129-136
-
-
Mesquita, P.1
Peixoto, A.J.2
Seruca, R.3
Hanski, C.4
Almeida, R.5
Silva, F.6
Reis, C.7
David, L.8
-
126
-
-
59449088515
-
NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma
-
L Cui LY Xu ZY Shen Q Tao SY Gao Z Lv ZP Du WK Fang EM Li 2008 NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma Clin Cancer Res 14 7674 7681
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7674-7681
-
-
Cui, L.1
Xu, L.Y.2
Shen, Z.Y.3
Tao, Q.4
Gao, S.Y.5
Lv, Z.6
Du, Z.P.7
Fang, W.K.8
Li, E.M.9
-
127
-
-
53349167537
-
Promoter hypomethylation regulates CD133 expression in human gliomas
-
K Tabu K Sasai T Kimura L Wang E Aoyanagi S Kohsaka M Tanino H Nishihara S Tanaka 2008 Promoter hypomethylation regulates CD133 expression in human gliomas Cell Res 18 1037 1046
-
(2008)
Cell Res
, vol.18
, pp. 1037-1046
-
-
Tabu, K.1
Sasai, K.2
Kimura, T.3
Wang, L.4
Aoyanagi, E.5
Kohsaka, S.6
Tanino, M.7
Nishihara, H.8
Tanaka, S.9
-
128
-
-
40249118885
-
Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer
-
SJ Kim HS Kang HL Chang YC Jung HB Sim KS Lee J Ro ES Lee 2008 Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer Oncol Rep 19 663 668 (Pubitemid 351330433)
-
(2008)
Oncology Reports
, vol.19
, Issue.3
, pp. 663-668
-
-
Kim, S.J.1
Kang, H.-S.2
Chang, H.L.3
Jung, Y.C.4
Sim, H.-B.5
Lee, K.-S.6
Ro, J.7
Lee, E.S.8
-
129
-
-
56449116122
-
Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers
-
P Singh M Yang H Dai D Yu Q Huang W Tan KH Kernstine D Lin B Shen 2008 Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers Mol Cancer Res 6 1710 1717
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1710-1717
-
-
Singh, P.1
Yang, M.2
Dai, H.3
Yu, D.4
Huang, Q.5
Tan, W.6
Kernstine, K.H.7
Lin, D.8
Shen, B.9
-
130
-
-
0037310198
-
Hypomethylation of the Synuclein γ gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma
-
A Gupta AK Godwin L Vanderveer A Lu J Liu 2003 Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma Cancer Res 63 664 673 (Pubitemid 36158146)
-
(2003)
Cancer Research
, vol.63
, Issue.3
, pp. 664-673
-
-
Gupta, A.1
Godwin, A.K.2
Vanderveer, L.3
Lu, A.4
Liu, J.5
-
132
-
-
27144437605
-
Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: Prognostic and therapeutic implications
-
DOI 10.2174/156800905774574011
-
P Pakneshan M Szyf SA Rabbani 2005 Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications Curr Cancer Drug Targets 5 471 488 (Pubitemid 41502560)
-
(2005)
Current Cancer Drug Targets
, vol.5
, Issue.7
, pp. 471-488
-
-
Pakneshan, P.1
Szyf, M.2
Rabbani, S.A.3
-
133
-
-
33645237240
-
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer
-
GG van den Eynden SJ van Laere I van der Auwera SD Merajver EA van Marck PB van Dam PB Vermeulen LY Dirix KL van Golen 2006 Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer Breast Cancer Res Treat 95 219 228
-
(2006)
Breast Cancer Res Treat
, vol.95
, pp. 219-228
-
-
Van Den Eynden, G.G.1
Van Laere, S.J.2
Van Der Auwera, I.3
Merajver, S.D.4
Van Marck, E.A.5
Van Dam, P.B.6
Vermeulen, P.B.7
Dirix, L.Y.8
Van Golen, K.L.9
-
135
-
-
22344453665
-
Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas
-
H Okada MT Kimura D Tan K Fujiwara J Igarashi M Makuuchi AM Hui M Tsurumaru H Nagase 2005 Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas Int J Oncol 2005 26 369 377
-
(2005)
Int J Oncol
, vol.2005
, Issue.26
, pp. 369-377
-
-
Okada, H.1
Kimura, M.T.2
Tan, D.3
Fujiwara, K.4
Igarashi, J.5
Makuuchi, M.6
Hui, A.M.7
Tsurumaru, M.8
Nagase, H.9
-
136
-
-
34247241526
-
Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin
-
DOI 10.1593/neo.07118
-
B Litkouci J Kwong CM Lo JG Smedley 3rd BA [tmp] McClane M Aponte Z Gao JL Sarno J Hinners WR Welch RS Berkowitz SC Mok EI Garner 2007 Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using C-terminal fragment of Clostridium perfringens enterotoxin Neoplasia 9 304 314 (Pubitemid 46608297)
-
(2007)
Neoplasia
, vol.9
, Issue.4
, pp. 304-314
-
-
Litkouhi, B.1
Kwong, J.2
Lo, C.-M.3
Smedley III, J.G.4
McClane, B.A.5
Aponte, M.6
Gao, Z.7
Sarno, J.L.8
Hinners, J.9
Welch, W.R.10
Berkowitz, R.S.11
Mok, S.C.12
Garner, E.I.O.13
-
137
-
-
30144433414
-
Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
-
DOI 10.1038/nature04225, PII NATURE04225
-
H Wu Y Chen J Liang B Shi G Wu Y Zhang D Wang R Li X Yi H Zhang L Sun Y Shang 2005 Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis Nature 438 981 987 (Pubitemid 43093965)
-
(2005)
Nature
, vol.438
, Issue.7070
, pp. 981-987
-
-
Wu, H.1
Chen, Y.2
Liang, J.3
Shi, B.4
Wu, G.5
Zhang, Y.6
Wang, D.7
Li, R.8
Yi, X.9
Zhang, H.10
Sun, L.11
Shang, Y.12
-
138
-
-
38449115628
-
DNA methylation profile at the DNMT3L promoter: A potential biomarker for cervical cancer
-
G Gokul B Gautami S Malathi AP Sowjanya UR Poli M Jain G Ramarkrishna S Khosla 2007 DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer Epigenetics 2 80 85 (Pubitemid 351682000)
-
(2007)
Epigenetics
, vol.2
, Issue.2
, pp. 80-85
-
-
Gokul, G.1
Gautami, B.2
Malathi, S.3
Sowjanya, A.P.4
Poli, U.R.5
Jain, M.6
Ramakrishna, G.7
Khosla, S.8
-
140
-
-
53049107302
-
Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation
-
H Asada Y Yamagata T Taketani A Matsuoka H Tamura N Hattori J Ohgane N Hattori K Shiota N Sugino 2008 Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation Mol Hum Reprod 14 539 545
-
(2008)
Mol Hum Reprod
, vol.14
, pp. 539-545
-
-
Asada, H.1
Yamagata, Y.2
Taketani, T.3
Matsuoka, A.4
Tamura, H.5
Hattori, N.6
Ohgane, J.7
Hattori, N.8
Shiota, K.9
Sugino, N.10
-
141
-
-
39149128757
-
Hypomethylation of hepatocyte factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary
-
N Kato G Tamura T Motoyama 2008 Hypomethylation of hepatocyte factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary Virchows Arch 452 175 180
-
(2008)
Virchows Arch
, vol.452
, pp. 175-180
-
-
Kato, N.1
Tamura, G.2
Motoyama, T.3
-
143
-
-
0035902856
-
Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
-
DOI 10.1054/bjoc.2001.1951
-
M Cho H Uemura SC Kim Y Kawada K Yoshida Y Hirao N Konishi S Saga K Yoshikawa 2001 Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma Br J Cancer 85 563 567 (Pubitemid 32808282)
-
(2001)
British Journal of Cancer
, vol.85
, Issue.4
, pp. 563-567
-
-
Cho, M.1
Uemura, H.2
Kim, S.-C.3
Kawada, Y.4
Yoshida, K.5
Hirao, Y.6
Konishi, N.7
Saga, S.8
Yoshikawa, K.9
-
144
-
-
36049007134
-
Hypomethylation and aberrant expression of the glioma pathogenesis-related 1 gene in Wilms tumors
-
DOI 10.1593/neo.07661
-
L Chilukamarri AL Hancock S Malik J Zabkiewicz JA Baker A Greenhough AR Dallosso THM Huang B Royer-Pokora KW Brown K Malik 2007 Hypomethylation and aberrant expression of the glioma pathogenesis-related gene in Wilms tumors Neoplasia 9 970 978 (Pubitemid 350086442)
-
(2007)
Neoplasia
, vol.9
, Issue.11
, pp. 970-978
-
-
Chilukamarri, L.1
Hancock, A.L.2
Malik, S.3
Zabkiewicz, J.4
Baker, J.A.5
Greenhough, A.6
Dallosso, A.R.7
Huang, T.H.-M.8
Royer-Pokora, B.9
Brown, K.W.10
Malik, K.11
-
145
-
-
19944432186
-
Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer
-
T Ogishima H Shiina JE Breault L Tabatabai WW Bassett H Enokida LC Li T Kawakami S Urakami LA Ribeiro-Filho M Terashima M Fujime M Igawa R Dahiya 2005 Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer Clin Cancer Res 11 1028 1036 (Pubitemid 40175750)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.3
, pp. 1028-1036
-
-
Ogishima, T.1
Shiina, H.2
Breault, J.E.3
Tabatabai, L.4
Bassett, W.W.5
Enokida, H.6
Li, L.-C.7
Kawakami, T.8
Urakami, S.9
Ribeiro-Filho, L.A.10
Terashima, M.11
Fujime, M.12
Igawa, M.13
Dahiya, R.14
-
147
-
-
33947546035
-
Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
-
J Roman-Gomez A Jimenez-Velasco X Agirre JA Castillejo G Navarro E San Jose-Eneriz L Garate L Cordeu F Cervantes F Prosper A Heiniger A Torres 2007 Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia Haematologica 92 153 162
-
(2007)
Haematologica
, vol.92
, pp. 153-162
-
-
Roman-Gomez, J.1
Jimenez-Velasco, A.2
Agirre, X.3
Castillejo, J.A.4
Navarro, G.5
San Jose-Eneriz, E.6
Garate, L.7
Cordeu, L.8
Cervantes, F.9
Prosper, F.10
Heiniger, A.11
Torres, A.12
-
148
-
-
1642398688
-
Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells
-
DOI 10.1182/blood-2003-07-2482
-
M Yoshida K Nosaka J Yasunaga I Nishikata K Morishita M Matsuoka 2004 Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells Blood 103 2753 2760 (Pubitemid 38393034)
-
(2004)
Blood
, vol.103
, Issue.7
, pp. 2753-2760
-
-
Yoshida, M.1
Nosaka, K.2
Yasunaga, J.-I.3
Nishikata, I.4
Morishita, K.5
Matsuoka, M.6
-
149
-
-
0027239823
-
bcl-2 Gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
-
M Hanada D Delia A Aiello E Stadtmauer JC Reed 1993 Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia Blood 82 1820 1828 (Pubitemid 23278773)
-
(1993)
Blood
, vol.82
, Issue.6
, pp. 1820-1828
-
-
Hanada, M.1
Delia, D.2
Aiello, A.3
Stadtmauer, E.4
Reed, J.C.5
-
150
-
-
0035100284
-
TCL1 is activated by chromosomal rearrangement or by hypomethylation
-
DOI 10.1002/gcc.1099
-
MR Yuille A Condie EM Stone J Wilsher PS Bradshaw L Brooks D Catovsky 2001 TCL1 is activated by chromosomal rearrangement or by hypomethylation Genes Chromosomes Cancer 30 336 341 (Pubitemid 32216324)
-
(2001)
Genes Chromosomes and Cancer
, vol.30
, Issue.4
, pp. 336-341
-
-
Yuille, M.R.1
Condie, A.2
Stone, E.M.3
Wilsher, J.4
Bradshaw, P.S.5
Brooks, L.6
Catovsky, D.7
-
151
-
-
34848916733
-
FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5′ CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes
-
DOI 10.1002/gcc.20489
-
M Goldstein I Meller A Orr-Urtreger 2007 FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5 CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes Genes Chromosomes Cancer 46 1028 1038 (Pubitemid 47502842)
-
(2007)
Genes Chromosomes and Cancer
, vol.46
, Issue.11
, pp. 1028-1038
-
-
Goldstein, M.1
Meller, I.2
Orr-Urtreger, A.3
-
152
-
-
37549004061
-
Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma
-
M Watanabe Y Ogawa K Itoh T Koiwa ME Kadin T Watanabe I Okayasu M Higashihara R Horie 2008 Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma Lab Invest 88 48 57
-
(2008)
Lab Invest
, vol.88
, pp. 48-57
-
-
Watanabe, M.1
Ogawa, Y.2
Itoh, K.3
Koiwa, T.4
Kadin, M.E.5
Watanabe, T.6
Okayasu, I.7
Higashihara, M.8
Horie, R.9
-
153
-
-
34547792388
-
Epigenetic gene silencing in cancer: The DNA hypermethylome
-
M Esteller 2007 Epigenetic gene silencing in cancer: the DNA hypermethylome Hum Mol Genet 16 R50 R59
-
(2007)
Hum Mol Genet
, vol.16
-
-
Esteller, M.1
-
154
-
-
56949101217
-
Breast cancer epigenetics: Normal human mammary epithelial cells as a model system
-
RA Hinshelwood SJ Clark 2008 Breast cancer epigenetics: normal human mammary epithelial cells as a model system J Mol Med 86 1315 1328
-
(2008)
J Mol Med
, vol.86
, pp. 1315-1328
-
-
Hinshelwood, R.A.1
Clark, S.J.2
-
155
-
-
61649092274
-
Environmental exposure measurement in cancer epidemiology
-
CP Wild 2009 Environmental exposure measurement in cancer epidemiology Mutagenesis 24 117 125
-
(2009)
Mutagenesis
, vol.24
, pp. 117-125
-
-
Wild, C.P.1
-
156
-
-
3543129379
-
Chemical-induced DNA damage and human cancer risk
-
MC Poirier 2004 Chemical-induced DNA damage and human cancer risk Nat Rev Cancer 4 630 637 (Pubitemid 39025057)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.8
, pp. 630-637
-
-
Poirier, M.C.1
-
157
-
-
33947310031
-
Environmental epigenomics and disease susceptibility
-
RL Jirtle MK Skinner 2007 Environmental epigenomics and disease susceptibility Nat Rev Genet 8 53 262
-
(2007)
Nat Rev Genet
, vol.8
, pp. 53-262
-
-
Jirtle, R.L.1
Skinner, M.K.2
-
158
-
-
1942471702
-
Epigenetics and cancer: Implications for drug discovery and safety assessment
-
DOI 10.1016/j.taap.2004.01.009, PII S0041008X04000596
-
JG Moggs JI Goodman JE Trosko RA Roberts 2004 Epigenetics and cancer: implications for drug discovery and safety assessment Toxicol Appl Pharmacol 196 422 430 (Pubitemid 38496465)
-
(2004)
Toxicology and Applied Pharmacology
, vol.196
, Issue.3
, pp. 422-430
-
-
Moggs, J.G.1
Goodman, J.I.2
Trosko, J.E.3
Roberts, R.A.4
-
159
-
-
24944575366
-
Tumorigenesis: The adaptation of mammalian cells to sustained stress environment by epigenetic alterations and succeeding matched mutations
-
DOI 10.1093/carcin/bgi079
-
TV Karpinets BD Foy 2005 Tumorigenesis: the adaptation of mammalian cells to sustained stress environment by epigenetic alterations and succeeding matched mutations Carcinogenesis 26 1323 1334 (Pubitemid 41417874)
-
(2005)
Carcinogenesis
, vol.26
, Issue.8
, pp. 1323-1334
-
-
Karpinets, T.V.1
Foy, B.D.2
-
160
-
-
49649128638
-
Epigenetic drivers and genetic passengers on the road to cancer
-
C Sawan T Vaissière R Murr Z Herceg 2008 Epigenetic drivers and genetic passengers on the road to cancer Mutat Res 642 1 13
-
(2008)
Mutat Res
, vol.642
, pp. 1-13
-
-
Sawan, C.1
Vaissière, T.2
Murr, R.3
Herceg, Z.4
-
161
-
-
33847026146
-
Changes in DNA methylation patterns in subjects exposed to low-dose benzene
-
DOI 10.1158/0008-5472.CAN-06-2995
-
V Bollati A Baccarelli L Hou M Bonzini S Fustinoni D Cavallo HM Byun J Jiang B Marinelli AC Pesatori PA Bertazzi AS Yang 2007 Changes in DNA methylation patterns in subjects exposed to low-dose benzene Cancer Res 67 876 880 (Pubitemid 46270740)
-
(2007)
Cancer Research
, vol.67
, Issue.3
, pp. 876-880
-
-
Bollati, V.1
Baccarelli, A.2
Hou, L.3
Bonzini, M.4
Fustinoni, S.5
Cavallo, D.6
Byun, H.-M.7
Jiang, J.8
Marinelli, B.9
Pesatori, A.C.10
Bertazzi, P.A.11
Yang, A.S.12
-
163
-
-
35148901501
-
Genomic methylation of peripheral blood leukocyte DNA: Influences of arsenic and folate in Bangladeshi adults
-
JR Pisner X Liu H Ahsan V Ilievski V Slavkovich D Levy P Factor-Litvak JH Graziano MV Gamble 2007 Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Banglageshi adults Am J Clin Nutr 86 1179 1186 (Pubitemid 47538325)
-
(2007)
American Journal of Clinical Nutrition
, vol.86
, Issue.4
, pp. 1179-1186
-
-
Pilsner, J.R.1
Liu, X.2
Ahsan, H.3
Ilievski, V.4
Slavkovich, V.5
Levy, D.6
Factor-Litvak, P.7
Graziano, J.H.8
Gamble, M.V.9
-
164
-
-
65249142729
-
Rapid DNA methylation changes after exposure to traffic particles
-
doi:10.1164/rccm.200807-1097OC
-
Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J (2009) Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med. doi: 10.1164/rccm.200807-1097OC
-
(2009)
Am J Respir Crit Care Med
-
-
Baccarelli, A.1
Wright, R.O.2
Bollati, V.3
Tarantini, L.4
Litonjua, A.A.5
Suh, H.H.6
Zanobetti, A.7
Sparrow, D.8
Vokonas, P.S.9
Schwartz, J.10
-
165
-
-
33846690772
-
An overview of cardiovascular disease burden in the United States
-
GA Mensah DW Brown 2007 An overview of cardiovascular disease burden in the United States Health Aff (Millwood) 26 38 48
-
(2007)
Health Aff (Millwood)
, vol.26
, pp. 38-48
-
-
Mensah, G.A.1
Brown, D.W.2
-
166
-
-
0028861741
-
Biology of atherosclerotic plaque formation: Possible role of growth factor lesion development and the potential impact of soy
-
EW Raines R Ross 1995 Biology of atherosclerotic plaque formation: possible role of growth factor lesion development and the potential impact of soy J Nutr 125 624S 630S
-
(1995)
J Nutr
, vol.125
-
-
Raines, E.W.1
Ross, R.2
-
167
-
-
0032744380
-
Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis?
-
PE Newman 1999 Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis? Med Hypothesis 53 421 424
-
(1999)
Med Hypothesis
, vol.53
, pp. 421-424
-
-
Newman, P.E.1
-
168
-
-
0031543485
-
Homocysteinemia as a risk factor for atherosclerosis: A review
-
DOI 10.1016/S0967-2109(97)00062-8, PII S0967210997000628
-
MR Nehler LM Taylor Jr JM Porter 1997 Homocysteinemia as a risk factor for atherosclerosis: a review Cardiovasc Surg 5 559 567 (Pubitemid 27502100)
-
(1997)
Cardiovascular Surgery
, vol.5
, Issue.6
, pp. 559-567
-
-
Nehler, M.R.1
Taylor Jr., L.M.2
Porter, J.M.3
-
170
-
-
17344378331
-
DNA methylation, smooth muscle cells, and atherogenesis
-
DOI 10.1161/01.ATV.0000092871.30563.41
-
MO Hiltunen S Ylä-Herttuala 2003 DNA methylation, smooth muscle cells, and atherogenesis Arterioscler Thromb Vasc Biol 23 1750 1753 (Pubitemid 37254858)
-
(2003)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.23
, Issue.10
, pp. 1750-1753
-
-
Hiltunen, M.O.1
Yla-Herttuala, S.2
-
171
-
-
11844286970
-
Nutrition and aberrant DNA methylation patterns in atherosclerosis: More than just hyperhomocysteinemia?
-
S Zaina MW Lindholm G Lund 2005 Nutrition and aberrant DNA methylation patterns in atherosclerosis: more than just hyperhomocysteinemia? J Nutr 135 5 8 (Pubitemid 40094312)
-
(2005)
Journal of Nutrition
, vol.135
, Issue.1
, pp. 5-8
-
-
Zaina, S.1
Lindholm, M.W.2
Lund, G.3
-
172
-
-
0041866794
-
Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
-
DOI 10.1373/49.8.1292
-
R Castro I Rivera EA Struys EEW Jansen P Ravasco ME Camilo HJ Blom C Jakobs IT de Almeida 2003 Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease Clin Chem 49 1292 1296 (Pubitemid 36900615)
-
(2003)
Clinical Chemistry
, vol.49
, Issue.8
, pp. 1292-1296
-
-
Castro, R.1
Rivera, I.2
Struys, E.A.3
Jansen, E.E.W.4
Ravasco, P.5
Camilo, M.E.6
Blom, H.J.7
Jakobs, C.8
De Almeida, I.T.9
-
173
-
-
34547870843
-
Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs
-
DOI 10.1089/dna.2007.0584
-
J Yideng Z Jianzhong H Ying S Juan Z Jinge W Shenglan H Xiaoqun W Shuren 2007 Homocysteine-mediated expression of SAHH, DMNTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs DNA Cell Biol 26 603 611 (Pubitemid 47263207)
-
(2007)
DNA and Cell Biology
, vol.26
, Issue.8
, pp. 603-611
-
-
Yideng, J.1
Jianzhong, Z.2
Ying, H.3
Juan, S.4
Jinge, Z.5
Shenglan, W.6
Xiaoqun, H.7
Shuren, W.8
-
174
-
-
0035989528
-
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions
-
DOI 10.1191/1358863x02vm418oa
-
MO Hiltunen MP Turunen TP Häkkinen J Rutanen M Hedman K Mäkinen AM Turunen K Aalto-Setälä S Ylä-Herttuala 2002 DNA hypomethylation and methyltransferase expression in atherosclerotic lesions Vasc Med 7 5 11 (Pubitemid 34654067)
-
(2002)
Vascular Medicine
, vol.7
, Issue.1
, pp. 5-11
-
-
Hiltunen, M.O.1
Turunen, M.P.2
Hakkinen, T.P.3
Rutanen, J.4
Hedman, M.5
Makinen, K.6
Turunen, A.-M.7
Aalto-Setala, K.8
Yla-Herttuala, S.9
-
175
-
-
3142672297
-
DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E
-
DOI 10.1074/jbc.M403618200
-
G Lund L Andersson M Lauria M Lindholm MF Fraga A Villar-Garea E Ballestar M Esteller S Zaina 2004 DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E J Biol Chem 279 29147 29154 (Pubitemid 38915787)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.28
, pp. 29147-29154
-
-
Lund, G.1
Andersson, L.2
Lauria, M.3
Lindholm, M.4
Fraga, M.F.5
Villar-Garea, A.6
Ballestar, E.7
Esteller, M.8
Zaina, S.9
-
176
-
-
3242712279
-
Lipoxygenase pathways in atherosclerosis
-
L Zhao CD Funk 2004 Lipoxygenase pathways in atherosclerosis Trends Cardiovasc Med 14 191 195
-
(2004)
Trends Cardiovasc Med
, vol.14
, pp. 191-195
-
-
Zhao, L.1
Funk, C.D.2
-
178
-
-
2942575047
-
Transcriptional regulation of 15-lipoxygenase expression by promoter methylation
-
DOI 10.1016/j.yexcr.2004.02.014, PII S0014482704000928
-
C Liu D Xu J Sjöberg P Forsell M Björkholm HE Claesson 2004 Transcriptional regulation of 15-lipoxygenase expression by promoter methylation Exp Cell Res 297 61 67 (Pubitemid 38759562)
-
(2004)
Experimental Cell Research
, vol.297
, Issue.1
, pp. 61-67
-
-
Liu, C.1
Xu, D.2
Sjoberg, J.3
Forsell, P.4
Bjorkholm, M.5
Claesson, H.-E.6
-
179
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
J Hardy DJ Selkoe 2002 The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 353 356 (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
180
-
-
33947242870
-
When loss is gain: Reduced presenilin proteolytic function leads to increased Aβ42/Aβ40
-
MS Wolfe 2007 When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40 EMBO Rep 8 136 140
-
(2007)
EMBO Rep
, vol.8
, pp. 136-140
-
-
Wolfe, M.S.1
-
181
-
-
0029440466
-
Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient
-
RL West JM Lee LE Maroun 1995 Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient J Mol Neurosci 6 141 146
-
(1995)
J Mol Neurosci
, vol.6
, pp. 141-146
-
-
West, R.L.1
Lee, J.M.2
Maroun, L.E.3
-
182
-
-
0033052929
-
Reduction with age in methylcytosine in the promoter region -224~-101 of the amyloid precursor protein gene in autopsy human cortex
-
DOI 10.1016/S0169-328X(99)00163-1, PII S0169328X99001631
-
H Tohgi K Utsugisawa Y Nagane M Yoshimura Y Genda M Ukitsu 1999 Reduction with age in methylcytosine in the promoter region -224 ~ -101 of the amyloid precursor protein gene in autopsy human cortex Brain Res Mol Brain Res 70 288 292 (Pubitemid 29317643)
-
(1999)
Molecular Brain Research
, vol.70
, Issue.2
, pp. 288-292
-
-
Tohgi, H.1
Utsugisawa, K.2
Nagane, Y.3
Yoshimura, M.4
Genda, Y.5
Ukitsu, M.6
-
183
-
-
10644237168
-
S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
-
DOI 10.1016/j.mcn.2004.09.007, PII S1044743104002209
-
A Fuso L Seminara RA Cavallaro F D'Anselmi S Scarpa 2005 S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production Mol Cell Neurosci 28 195 204 (Pubitemid 39656023)
-
(2005)
Molecular and Cellular Neuroscience
, vol.28
, Issue.1
, pp. 195-204
-
-
Fuso, A.1
Seminara, L.2
Cavallaro, R.A.3
D'Anselmi, F.4
Scarpa, S.5
-
184
-
-
22244471085
-
Genetics and epigenetics in major psychiatric disorders: Dilemmas, achievements, applications, and future scope
-
DOI 10.2165/00129785-200505030-00002
-
HM Abdolmaleky S Thiagalingam M Wilcox 2005 Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope Am J Pharmacogenomics 5 149 160 (Pubitemid 40994274)
-
(2005)
American Journal of PharmacoGenomics
, vol.5
, Issue.3
, pp. 149-160
-
-
Abdolmaleky, H.M.1
Thiagalingam, S.2
Wilcox, M.3
-
185
-
-
21544433777
-
Reelin promoter hypermethylation in schizophrenia
-
DOI 10.1073/pnas.0503736102
-
DR Grayson X Jia Y Chen RP Sharma CP Michell A Guidotti E Costa 2005 Reelin promoter hypermethylation in schizophrenia Proc Natl Acad Sci USA 102 9341 9346 (Pubitemid 40923565)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.26
, pp. 9341-9346
-
-
Grayson, D.R.1
Jia, X.2
Chen, Y.3
Sharma, R.P.4
Mitchell, C.P.5
Guidotti, A.6
Costa, E.7
-
186
-
-
33750244045
-
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
-
DOI 10.1093/hmg/ddl253
-
HM Abdolmaleky KH Cheng SV Faraone M Wilcox SJ Glatt F Gao CL Smith R Shafa B Aeali J Carnevale H Pan P Papageorgis JF Ponte V Sivaraman MT Tsuang S Thiagalingam 2006 Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder Hum Mol Genet 15 3132 3145 (Pubitemid 44607800)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.21
, pp. 3132-3145
-
-
Abdolmaleky, H.M.1
Cheng, K.-H.2
Faraone, S.V.3
Wilcox, M.4
Glatt, S.J.5
Gao, F.6
Smith, C.L.7
Shafa, R.8
Aeali, B.9
Carnevale, J.10
Pan, H.11
Papageorgis, P.12
Ponte, J.F.13
Sivaraman, V.14
Tsuang, M.T.15
Thiagalingam, S.16
-
187
-
-
34548130797
-
Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia
-
DOI 10.1016/j.jpsychires.2006.08.006, PII S0022395606001750
-
M Shimabukuro T Sasaki A Imamura T Tsujita C Fuke T Umekage M Tochigi K Hiramatsu T Miyazaki T Oda J Sugimoto Y Jinno Y Okazaki 2007 Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia J Psychiatr Res 41 1042 1046 (Pubitemid 47301941)
-
(2007)
Journal of Psychiatric Research
, vol.41
, Issue.12
, pp. 1042-1046
-
-
Shimabukuro, M.1
Sasaki, T.2
Imamura, A.3
Tsujita, T.4
Fuke, C.5
Umekage, T.6
Tochigi, M.7
Hiramatsu, K.8
Miyazaki, T.9
Oda, T.10
Sugimoto, J.11
Jinno, Y.12
Okazaki, Y.13
-
188
-
-
0038663165
-
Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia
-
DOI 10.1016/S0140-6736(03)13372-7
-
D Ingrosso A Cimmino AF Perna L Masella NG De Santo ML De Bonis M Vacca M D'Esposito M D'Urso P Galetti V Zappia 2003 Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinemia in patients with uraemia Lancet 361 1693 1699 (Pubitemid 36577442)
-
(2003)
Lancet
, vol.361
, Issue.9370
, pp. 1693-1699
-
-
Ingrosso, D.1
Cimmino, A.2
Perna, A.F.3
Masella, L.4
De Santo, N.G.5
De Bonis, M.L.6
Vacca, M.7
D'Esposito, M.8
D'Urso, M.9
Galletti, P.10
Zappia, V.11
-
189
-
-
0142247168
-
DNA methylation and autoimmune disease
-
DOI 10.1016/S1521-6616(03)00206-7
-
B Richardson 2003 DNA methylation and autoimmune disease Clin Immunol 109 72 79 (Pubitemid 37324744)
-
(2003)
Clinical Immunology
, vol.109
, Issue.1
, pp. 72-79
-
-
Richardson, B.1
-
190
-
-
33750335132
-
DNA methylation: Its contribution to systemic lupus erythematosus
-
DOI 10.1007/s10238-006-0103-x
-
I Sekigawa M Kawasaki H Ogasawara K Kaneda H Kaneko Y Takasaki H Ogawa 2006 DNA methylation: its contribution to systemic lupus erythematosus Clin Exp Med 6 99 106 (Pubitemid 44630739)
-
(2006)
Clinical and Experimental Medicine
, vol.6
, Issue.3
, pp. 99-106
-
-
Sekigawa, I.1
Kawasaki, M.2
Ogasawara, H.3
Kaneda, K.4
Kaneko, H.5
Takasaki, Y.6
Ogawa, H.7
-
191
-
-
0034541591
-
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: Association with genomic DNA hypomethylation and influence on gene expression
-
DOI 10.1002/1529-0131(200012)43:12<2634::AID-ANR3>3.0.CO;2-1
-
M Neidhart J Rethage S Kuchen P Künzler RM Crowl ME Billingham RE Gay S Gay 2000 Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression Arthritis Rheum 43 2634 2647 (Pubitemid 32001729)
-
(2000)
Arthritis and Rheumatism
, vol.43
, Issue.12
, pp. 2634-2647
-
-
Neidhart, M.1
Rethage, J.2
Kuchen, S.3
Knzler, P.4
Crowl, R.M.5
Billingham, M.E.6
Gay, R.E.7
Gay, S.8
-
192
-
-
49449106856
-
Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis
-
CJ Nile RC Read M Akil GW Duff AG Wilson 2008 Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis Arthritis Rheum 58 2686 2693
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2686-2693
-
-
Nile, C.J.1
Read, R.C.2
Akil, M.3
Duff, G.W.4
Wilson, A.G.5
|