Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins

Oncogene

Volumn 26, Issue 38, 2007, Pages 5553-5563

  Ostler, K R ^a   Davis, E M ^a   Payne, S L ^a,c   Gosalia, B B ^a   Exposito Cespedes J ^a   Beau, M M Le ^a,b   Godley, L A ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b University of Chicago   (United States)

^c ELMHURST COLLEGE   (United States)

Author keywords

Aberrant mRNA splicing; DNA methylation; DNMT3B; Epigenetics

Indexed keywords

DNA METHYLTRANSFERASE 3B; NUCLEAR PROTEIN;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME ABERRATION; DNA METHYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; LEUKEMIA; LEUKEMIA CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLICEOSOME; WESTERN BLOTTING;

ALTERNATIVE SPLICING; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CLUSTER ANALYSIS; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 34547935029     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210351     Document Type: Article

References (52)

1. Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. (2006). Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol 76: 23-32.
2. Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB et al. (2003). Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3: 89-95.
3. Bartel F, Taubert H, Harris LC. (2002). Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2: 9-15.
4. Beaulieu N, Morin S, Chute IC, Robert M-F, Nguyen H, MacLeod AR. (2002). An essential role for DNA methyltransferase DNMT3B in cancer cell survival. J Biol Chem 277: 28176-28181.
5. Bestor TH. (2000). The DNA methyltransferases of mammals. Hum Molec Genet 9: 2395-2402.
6. Chan AO. (2006). E-cadherin in gastric cancer. World J Gastroenterol 12: 199-203.
7. Charlet-B N, Savkur RS, Singh G, Philips AV, Grice EA, Cooper TA. (2002). Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Molecular Cell 10: 45-53.
8. Clark SJ, Harrison J, Paul CL, Frommer M. (1994). High sensitivity mapping of methylatedcytosines. Nucleic Acids Res 22: 2990-2997.
9. Cowin P, Rowlands TM, Hatsell SJ. (2005). Cadherins and catenins in breast cancer. Curr Opin Cell Biol 17: 499-508.
10. Culbertson MR. (1999). RNA surveillance: unforeseen consequences for gene expression, inherited genetic disorders andcancer. Trends Genet 15: 74-80.
11. Eden A, Gaudet F, Waghmare A, Jaenisch R. (2003). Chromosomal instability and tumors promotedby DNA hypomethylation. Science 300: 455.
12. Ehrlich M. (2003). The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease. Clin Immunol 109: 17-28.
13. Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M et al. (2006). Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. Oncogene 25: 2636-2645.
14. Fan Y, Nikitina T, Zhao J, Fleury TJ, Bhattacharyya R, Bouhassira EE et al. (2005). Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell 123: 1199-1212.
15. Gaudet F, Hodgson JG, Eden A, Jackson-Grusby L, Dausman J, Gray JW et al. (2003). Induction of tumors in mice by genomic hypomethylation. Science 300: 489-492.
16. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT et al. (2004a). Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res 32: 2716-2729.
17. Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Robertson KD. (2004b). DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun 318: 544-555.
18. Gore SD, Baylin S, Sugar E, Carraway H, Miller CB, Carducci M et al. (2006). Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 66: 6361-6369.
19. Hansen RS. (2003). X inactivation-specific methylation of LINE-1 elements by DNMT3B: implications for the Lyon repeat hypothesis. Hum Mol Genet 12: 2559-2567.
20. Hansen RS, Wijmenga C, Luo P, Stanek AM, Canfield TK, Weemaes CMR et al. (1999). The DNMT3B DNA methyltransferase gene is mutatedin the ICF immunodeficiency syndrome. Proc Natl Acad Sci USA 96: 14412-14417.
21. Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A et al. (2003). Deficiency of the adaptor SLP-65 in pre-B-cell lymphoblastic leukaemia. Nature 423: 452-456.
22. Kanai Y, Ushijima S, Nakanishi Y, Sakamoto M, Hirohashi S. (2003). Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers. Cancer Lett 192: 75-82.
23. Kang ES, Park CW, Chung JH. (2001). Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. Biochem & Biophys Res Comm 289: 862-868.
24. Karpf AR, Matsui S. (2005). Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 65: 8635-8639.
25. Kim G-D, Ni J, Kelesoglu N, Roberts RJ, Pradhan S. (2002). Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J 21: 4183-4195.
26. Kumar R, Wang R-A, Mazumdar A, Talukder AH, Mandal M, Yang Z et al. (2002). A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 418: 654-657.
27. Li E. (2002). Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3: 662-673.
28. Li E, Bestor TH, Jaenisch R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
29. Lin H, Yamada Y, Nguyen S, Linhart H, Jackson-Grusby L, Meissner A et al. (2006). Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol Cell Biol 26: 2976-2983.
30. Okano M, Bell DW, Haber DA, Li E. (1999). DNA methyltranferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
31. Parolini O, Weinhausel A, Kagerbauer B, Sassmann J, Holter W, Gadner H et al. (2003). Differential methylation pattern of the X-linked lymphopoliferative (XLP) disease gene SH2D1A correlates with the cell lineage-specific transcription. Immunogenetics 55: 116-121.
32. Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ. (2002). RasGRP4 is a novel ras activator isolated from acute myeloid leukemia. J Biol Chem 277: 30508-30514.
33. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE et al. (2002). DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416: 552-556.
34. Rhee I, Jair K-W, Yen R-WC, Lengauer C, Herman JG, Kinzler KW et al. (2000). CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404: 1003-1007.
35. Robert M-F, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A et al. (2003). DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet 33: 61-65.
36. Robertson KD. (2002). DNA methylation and chromatin - unraveling the tangled web. Oncogene 21: 5361-5379.
37. Robertson KD. (2005). DNA methylation and human disease. Nat Rev Genet 6: 597-610.
38. Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA et al. (1999). The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucl Acids Res 27: 2291-2298.
39. Rountree MR, Bachman KE, Herman JG, Baylin SB. (2001). DNA methylation, chromatin inheritance, and cancer. Oncogene 20: 3156-3165.
40. Saito Y, Kanai Y, Sakamoto M, Saito H, Ishii H, Hirohashi S. (2002). Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci USA 99: 10060-10065.
41. Shirohzu H, Kubota T, Kumazawa A, Sado T, Chijiwa T, Inagaki K et al. (2002). Three novel DNMT3B mutations in Japanese patients with ICF Syndrome. Am J Med Genet 112: 31-37.
42. Sigalotti L, Coral S, Nardi G, Spessotto A, Cortini E, Cattarossi I et al. (2002). Promoter methylation controls the expression of MAGE2, 3 and 4 genes in human cutaneous melanoma. J Immunother 25: 16-26.
43. Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E. (2006). Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development 133: 1183-1192.
44. Venables JP. (2004). Aberrant and alternative splicing in cancer. Cancer Res 64: 7647-7654.
45. Wang J, Walsh G, Liu DD, Lee JJ, Mao L. (2006a). Expression of ΔDNMT3B variants and its association with promoter methylation of p16 and RASSF1A in primary non-small cell lung cancer. Cancer Res 66: 8361-8366.
46. Wang L, Wang J, Sun S, Rodriguez M, Yue P, Jang SJ et al. (2006b). A novel DNMT3B subfamily, ΔDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer. Int J Oncol 29: 201-207.
47. Watermann DO, Tang Y, Zur Hausen A, Jager M, Stamm S, Stickeler E. (2006). Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene. Cancer Res 66: 4774-4780.
48. Wilkinson MF, Shyu A-B. (2002). RNA surveillance by nuclear scanning? Nat Cell Biol 4: 144-147.
49. Xu G-L, Bestor TH, Bourc'his D, Hsieh C-L, Tommerup N, Bugge M et al. (1999). Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 402: 187-191.
50. Yamada Y, Jackson-Grusby L, Linhart H, Meissner A, Eden A, Lin H et al. (2005). Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci USA 102: 13580-13585.
51. Yanagisawa Y, Ito E, Yuasa Y, Maruyama K. (2002). The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents. Biochim Biophys Acta 1577: 457-465.
52. Yang Y, Li L, Wong GW, Krilis SA, Madhusudhan MS, Sali A et al. (2002). RasGRP4, a new mast cell-restricted ras guanine nucleotide-releasing protein with calcium and diacylglycerol-binding motifs. J Biol Chem 277: 25756-25774.