Mechanisms of acetaminophen-induced liver necrosis

Handbook of Experimental Pharmacology

Volumn 196, Issue , 2010, Pages 369-405

  Hinson, Jack A ^a   Roberts, Dean W ^b   James, Laura P ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b NONE

Author keywords

Acetaminophen; Covalent binding; Glutathione; JNK; Liver; Mitochondria; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; CALCIUM; CELECOXIB; CHEMOKINE; COMPLEMENT COMPONENT C1Q; CYCLOOXYGENASE 2; CYTOCHROME P450 2E1; CYTOKINE; ENDONUCLEASE G; GAMMA INTERFERON; GLUTATHIONE; GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PARACETAMOL; PROTEIN BAX; PROTEIN BID; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNINDEXED DRUG; VASCULOTROPIN; ANALGESIC AGENT;

CALCIUM HOMEOSTASIS; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; LIVER CELL; LIVER FAILURE; LIVER NECROSIS; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOTRANSFORMATION; LIVER; LIVER CIRCULATION; LIVER MITOCHONDRION; LIVER REGENERATION; METABOLISM; NECROSIS; PATHOLOGY; TOXIC HEPATITIS; VASCULARIZATION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BIOTRANSFORMATION; CHEMOKINES; CYTOKINES; DRUG-INDUCED LIVER INJURY; HUMANS; LIVER; LIVER CIRCULATION; LIVER REGENERATION; MITOCHONDRIA, LIVER; NECROSIS; SIGNAL TRANSDUCTION;

EID: 77749262361     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-00663-0_12     Document Type: Review

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