Sinusoidal endothelial cells as an early target for hepatic toxicants

Clinical Hemorheology and Microcirculation

Volumn 34, Issue 1-2, 2006, Pages 5-10

  McCuskey, Robert S ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Acetaminophen; in vivo microscopy; Liver microcirculation; Sinusoidal endothelial cells; Toxicants

Indexed keywords

ALCOHOL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCEIN ISOTHIOCYANATE; GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIGAND; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR; PARACETAMOL; SCAVENGER RECEPTOR; TOXIN;

ALCOHOL CONSUMPTION; BLOOD FLOW VELOCITY; CELL FUNCTION; CELL SWELLING; CONFERENCE PAPER; CYTOSKELETON; DISEASE EXACERBATION; ENDOCYTOSIS; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ERYTHROCYTE; HUMAN; LIVER CELL DAMAGE; LIVER CIRCULATION; LIVER PARENCHYMA; LIVER SINUSOID; LIVER TOXICITY; LIVER VENOOCCLUSIVE DISEASE; NONHUMAN;

ACETAMINOPHEN; ANIMALS; DRUG TOXICITY; ENDOTHELIAL CELLS; ETHANOL; HUMANS; LIVER DISEASES; MATRIX METALLOPROTEINASES; NITRIC OXIDE DONORS;

EID: 33644810257     PISSN: 13860291     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. M. Black, Acetaminophen hepatotoxicity, Ann. Rev. Med. 35 (1984), 577-593.
2. H.J. Zimmerman and W.C. Maddrey, Acetaminophen (Paracetamol) hepatotoxicity with regular intake of alcohol: Analyis of instances of therapeutic misadventure, Hepatology 22 (1995), 767-773.
3. S.P. Lim, F.J. Andrews and P.E. O'Brien, Acetaminophen-induced microvascular injury in the rat liver: Protection with misoprostol, Hepatology 22 (1995), 1776-1781.
4. R.M. Walker, T.F. McElligott, E.M. Power and W.J. Racz, Increased acetaminophen induced hepatotoxicity after chronic ethanol consumption in mice, Toxicology 28 (1983), 193-206.
5. R.M. Walker, W.J. Racz and T.F. McElligott, Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice, Am. J. Pathol. 113 (1983), 321-330.
6. R.M. Walker, W.J. Racz and T.F. McElligott, Acetaminophen-induced hepatotoxic congestion in mice, Hepatology 5 (1985), 233-240.
7. H.H. Wacher, H.J. Radzun and M.R. Parwaresch, Kinetics of Kupffer cells as shown by parabiosis and combined autoradiographic/immunohistochemical analysis, Virchows Archiv B, Cell Pathology Including Molecular Pathology 15 (1986), 71-78.
8. H. Wechsler, G. Dowdall, G. Maenner, J. Gledhill-Hoyt and H. Lee, Changes in binge drinking and related problems amoung American college students between 1993 and 1997, J. A. Coll. Health 47 (1998), 57-68.
9. H. Wechsler, J.E. Lee, J. Gledhill-Hoyt and H. Lee, College binge drinking in the 1990s: a continuing problem: results of the Harvard School of Public Health 1999 college alcohol study, J. Am. Coll. Health 48 (2000), 199-210.
10. Y. Ito, E. Abril, N. Bethea and R.S. McCuskey, Role of nitric oxide in hepatic microvascular injury elicited by acetaminophen in mice, Am. J. Physiol. 286 (2003), G60-67.
11. Y. Ito, E. Abril, N. Bethea and R.S. McCuskey, Ethanol binging enhances hepatic microvascular responses to acetaminophen in mice, Microcirculation 11 (2004), 625-632.
12. Y. Ito, E. Abril, N. Bethea and R.S. McCuskey, Inhibition of matrix metalloproteinases minimizes hepatic microvascular injury in response to acetaminophen in mice, Toxicol. Sci. 83 (2005), 190-196.
13. Y. Ito, N.W. Machen, E.R. Abril and R.S. McCuskey, Early hepatic microvascular injury in response to acetaminophen toxicity, Microcirculation 10 (2003), 391-400.
14. R.S. McCuskey, N. Bethea, J. Wong, M.K. McCuskey, E. Abril, X. Wang and L.D. DeLeve, Ethanol binging sensitizes the liver to injury by acetaminophen with the sinusoidal endothelium being an early target, J. Hepatol. 42 (2005), 371-377.
15. R.S. McCuskey, N.W. Machen, X. Wang, M.K. McCuskey, E. Abril, D.L. Earnest and L.D. DeLeve, A single ethanol binge exacerbates early acetaminophen-induced centrilobular injury to the sinusoidal endothelium and alters sinusoidal blood flow, in: Cells of the Hepatic Sinusoid VIII, E. Wisse, D.L. Knook, R. deZanger and M.J.P. Arthur, eds, Kupffer Cell Foundation, Leiden, 2001, pp. 68-70.
16. L.D. DeLeve, Y. Ito, N.W. Machen, M.K. McCuskey, X. Wang and R.S. McCuskey, Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome (hepatic venoocclusive disease), Am. J. Physiol. 284 (2003), G1045-1052.
17. L.D. DeLeve, R.S. McCuskey, X. Wang, M.K. McCuskey, R.B. Epstein and G.C. Kanel, Characterization of a reproducible model of hepatic veno-occlusive disease, Hepatology 29 (1999), 1779-1791.
18. L.D. DeLeve, X. Wang, G. Kanel, Y. Ito, N. Bethea, M.K. McCuskey, J. Tokes, J. Tsai and R.S. McCuskey, Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome, Hepatology 38 (2003), 900-908.
19. L.D. DeLeve, X. Wang, J. Tsai, G. Kanel, S.M. Strasberg and T.A. Tokes, Sinusoidal obstruction syndrome (venoocclusive disease) in the rat is prevented by matrix metalloproteinase inhibition, Gastroenterology 125 (2003), 882-890.
20. M. Oda, H. Yokomori and Y. Han, Regulatory mechanisms of hepatic microcirculaiton, Clin. Hemorheol. Microcirc. 29 (2003), 167-182.