Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2

American Journal of Pathology

Volumn 156, Issue 4, 2000, Pages 1245-1252

  Hogaboam, Cory M ^a   Bone Larson, Cynthia L ^a   Steinhauser, Matthew L ^a   Matsukawa, Akihiro ^a   Gosling, Jennifa ^b   Boring, Landin ^b   Charo, Israel F ^c   Simpson, Kenneth J ^b   Lukacs, Nicholas W ^a   Kunkel, Steven L ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR2; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; PARACETAMOL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; LIVER BIOPSY; LIVER FUNCTION; LIVER INJURY; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033848060     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64995-4     Document Type: Article

References (47)

1. Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration
2. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type 1 tumor necrosis factor receptor
3. Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatoxicity
4. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
5. Proliferative effects of CXC chemokines in rat hepatocytes in vitro and in vivo
6. Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated liver injury
7. Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines
8. Gene transfer with IL-4 and IL-13 improves survival in lethal endotoxemia in the mouse and ameliorates peritoneal macrophages immune competence
9. IL-6, IFN-gamma and TNF-alpha production by liver-associated T cells and acute liver injury in rats administered concanavalin A
10. Hepatoprotective effect of propagermanium on Corynebacterium parvum and lipopolysaccharide-induced liver injury in mice
11. High inflammatory activity is associated with an increased amount of IFN-gamma transcripts in peripheral blood cells of patients with chronic hepatitis C virus infection
12. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis
13. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor
14. Chemokine involvement in hepatic ischemia/reperfusion injury in mice: Roles for macrophage inflammatory protein-2 and KC (corrected and republished article originally printed in Hepatology 1998, 27:507-512)
15. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
16. Role of proinflammatory cytokines in acetaminophen hepatotoxicity
17. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins
18. Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC
19. Differential CC chemokine-induced enhancement of T helper cell cytokine production
20. + T cell activation
21. MCP-1 protects mice in lethal endotoxemia
22. Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion
23. Cytokine expression in hepatocytes: Role of oxidant stress
24. Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: Correlation with monocyte infiltration
25. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
26. Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis
27. Differential expression of monocyte chemotactic protein-1 (MCP-1) in transforming rat hepatic stellate cells
28. Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E
29. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
30. A sensitive ELISA for the detection of human monocyte chemoattractant protein-1 (MCP-1)
31. A role for C-C chemokines in fibrotic lung disease
32. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice
33. Effect of CCR2 knockout on type-2 (Schistosomal antigen-elicited) pulmonary granuloma formation: Analysis of cellular recruitment and cytokine responses
34. Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
35. 2+ accumulation and early DNA fragmentation with cell death
36. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment
37. Histopathology of acetaminophen-induced liver changes: Role of interleukin 1 alpha and tumor necrosis factor alpha
38. Monocyte chemoattractant protein-1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease
39. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats
40. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat
41. Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury
42. Production and role of interleukin-10 in concanavalin-A-induced hepatitis in mice
43. Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice
44. Role of macrophages in acetaminophen (paracetamol)-induced hepatotoxicity
45. Impairment of TNF-alpha expression and secretion in primary rat liver cell cultures by acetaminophen treatment
46. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 and not type 2 tumor necrosis factor receptor
47. Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4R alpha and Stat6 phosphorylation