Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity

Toxicology and Applied Pharmacology

Volumn 216, Issue 1, 2006, Pages 98-107

  Cover, Cathleen ^a   Liu, Jie ^b   Farhood, Anwar ^c   Malle, Ernst ^d   Waalkes, Michael P ^b   Bajt, Mary Lynn ^a   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b NCI   (United States)

^c Brackenridge Hospital   (United States)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Cytokines; Hypochlorite; Inflammation; NAPDH oxidase; Neutrophils; Oxidant stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIBODY; ANTINEUTROPHIL ANTIBODY; APOCYNIN; DIPHENYLIODONIUM SALT; HEME OXYGENASE 1; HYPOCHLORITE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EXTRAVASATION; FEMALE; GENE; INFLAMMATION; LIVER INJURY; LIVER TOXICITY; MALE; MOUSE; NECROSIS; NEUTROPHIL COUNT; NONHUMAN; PATHOPHYSIOLOGY; TIME; TISSUE INJURY;

ACETAMINOPHEN; ACUTE DISEASE; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; DRUG-INDUCED LIVER INJURY; FEMALE; GENE EXPRESSION; HEPATITIS, TOXIC; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1BETA; LIVER; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIES SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745522546     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.04.010     Document Type: Article

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