A protective role for cyclooxygenase-2 in drug-induced liver injury in mice

Chemical Research in Toxicology

Volumn 14, Issue 12, 2001, Pages 1620-1628

  Reilly, T P ^a   Brady, J N ^b   Marchick, M R ^a,c   Bourdi, M ^a   George, J W ^a   Radonovich, M F ^b   Pise Masison, C A ^b   Pohl, L R ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; MESSENGER RNA; PARACETAMOL; PROSTAGLANDIN D2; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DRUG INDUCED DISEASE; DRUG PROTEIN BINDING; ENZYME DEFICIENCY; HUMAN; LETHALITY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROSTAGLANDIN SYNTHESIS; RISK ASSESSMENT;

ACETAMINOPHEN; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DISEASE MODELS, ANIMAL; DNA PRIMERS; GENE EXPRESSION PROFILING; HEPATITIS, TOXIC; IMMUNOBLOTTING; ISOENZYMES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES; SURVIVAL RATE;

ANIMALIA; MURINAE;

EID: 0035663287     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0155505     Document Type: Article

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