-
1
-
-
0035415869
-
Chemical genetic approaches for the elucidation of signaling pathways
-
Alaimo, P.J., Shogren-Knaak, M.A. & Shokat, K.M. Chemical genetic approaches for the elucidation of signaling pathways. Curr. Opin. Chem. Biol. 5, 360-367 (2001).
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 360-367
-
-
Alaimo, P.J.1
Shogren-Knaak, M.A.2
Shokat, K.M.3
-
2
-
-
0033636862
-
Chemical strategies for the global analysis of protein function
-
Cravatt, B.F. & Sorensen, E.J. Chemical strategies for the global analysis of protein function. Curr. Opin. Chem. Biol. 4, 663-668 (2000).
-
(2000)
Curr. Opin. Chem. Biol.
, vol.4
, pp. 663-668
-
-
Cravatt, B.F.1
Sorensen, E.J.2
-
3
-
-
0034331004
-
Chemical genetics: Ligand-based discovery of gene function
-
Stockwell, B.R. Chemical genetics: ligand-based discovery of gene function. Nat. Rev. Genet. 1, 116-125 (2000).
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 116-125
-
-
Stockwell, B.R.1
-
4
-
-
0024578338
-
Characteristics necessary for an interconvertible enzyme cascade to generate a highly sensitive response to an effector
-
Cárdenas, M.L. & Cornish-Bowden, A. Characteristics necessary for an interconvertible enzyme cascade to generate a highly sensitive response to an effector. Biochem. J. 257, 339-345 (1989).
-
(1989)
Biochem. J.
, vol.257
, pp. 339-345
-
-
Cárdenas, M.L.1
Cornish-Bowden, A.2
-
5
-
-
0020171028
-
Sensitivity amplification in biochemical systems
-
Goldbeter, A. & Koshland, D.E. Sensitivity amplification in biochemical systems. Q. Rev. Biophys. 15, 555-591 (1982).
-
(1982)
Q. Rev. Biophys.
, vol.15
, pp. 555-591
-
-
Goldbeter, A.1
Koshland, D.E.2
-
6
-
-
0026527708
-
Response coefficients of interconvertible enzyme cascades towards effectors that act on one or both modifier enzymes
-
Szedlacsek, S.E., Cárdenas, M.L. & Cornish-Bowden, A. Response coefficients of interconvertible enzyme cascades towards effectors that act on one or both modifier enzymes. Eur. J. Biochem. 204, 807-813 (1992).
-
(1992)
Eur. J. Biochem.
, vol.204
, pp. 807-813
-
-
Szedlacsek, S.E.1
Cárdenas, M.L.2
Cornish-Bowden, A.3
-
7
-
-
65149094024
-
Brought to life: Targeted activation of enzyme function with small molecules
-
Bishop, A.C. & Chen, V.L. Brought to life: targeted activation of enzyme function with small molecules. J. Chem. Biol. 2, 1-9 (2009).
-
(2009)
J. Chem. Biol.
, vol.2
, pp. 1-9
-
-
Bishop, A.C.1
Chen, V.L.2
-
8
-
-
0038360824
-
Evolution and regulatory role of the hexokinases
-
Cárdenas, M.L., Cornish-Bowden, A. & Ureta, T. Evolution and regulatory role of the hexokinases. Biochim. Biophys. Acta 1401, 242-264 (1998).
-
(1998)
Biochim. Biophys. Acta.
, vol.1401
, pp. 242-264
-
-
Cárdenas, M.L.1
Cornish-Bowden, A.2
Ureta, T.3
-
9
-
-
67349139275
-
Assessing the potential of glucokinase activators in diabetes therapy
-
Matschinsky, F. Assessing the potential of glucokinase activators in diabetes therapy. Nat. Rev. Drug Discov. 8, 399-416 (2009).
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 399-416
-
-
Matschinsky, F.1
-
10
-
-
67651213750
-
Recent advances in glucokinase activators for the treatment of type 2 diabetes
-
Pal, M. Recent advances in glucokinase activators for the treatment of type 2 diabetes. Drug Discov. Today 14, 784-792 (2009).
-
(2009)
Drug Discov. Today.
, vol.14
, pp. 784-792
-
-
Pal, M.1
-
11
-
-
33644749337
-
The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy
-
Matschinsky, F.M. et al. The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy. Diabetes 55, 1-12 (2006).
-
(2006)
Diabetes
, vol.55
, pp. 1-12
-
-
Matschinsky, F.M.1
-
12
-
-
0027410865
-
Glucokinase mutations associated with non-insulindependent (type 2) diabetes mellitus have decreased enzymatic activity: Implications for structure/function relationships
-
Gidh-Jain, M. et al. Glucokinase mutations associated with non-insulindependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc. Natl. Acad. Sci. USA 90, 1932-1936 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 1932-1936
-
-
Gidh-Jain, M.1
-
13
-
-
0032801668
-
Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase
-
de la Iglesia, N., Veiga-da-Cunha, M., Van Schaftingen, E., Guinovart, J.J. & Ferrer, J.C. Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase. FEBS Lett. 456, 332-338 (1999).
-
(1999)
FEBS Lett
, vol.456
, pp. 332-338
-
-
De La Iglesia, N.1
Veiga-Da-Cunha, M.2
Van Schaftingen, E.3
Guinovart, J.J.4
Ferrer, J.C.5
-
14
-
-
57649133952
-
Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: Impact of physiological and pharmacological effectors
-
Anderka, O. et al. Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein: impact of physiological and pharmacological effectors. J. Biol. Chem. 283, 31333-31340 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31333-31340
-
-
Anderka, O.1
-
15
-
-
0037041034
-
Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase
-
Veiga-da-Cunha, M. & Van Schaftingen, E. Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase. J. Biol. Chem. 277, 8466-8473 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8466-8473
-
-
Veiga-Da-Cunha, M.1
Van Schaftingen, E.2
-
16
-
-
0037624071
-
Allosteric activators of glucokinase: Potential role in diabetes therapy
-
Grimsby, J. et al. Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301, 370-373 (2003).
-
(2003)
Science
, vol.301
, pp. 370-373
-
-
Grimsby, J.1
-
17
-
-
42449159741
-
Glucose modulation of glucokinase activation by small molecules
-
Ralph, E.C., Thomson, J., Almaden, J. & Sun, S. Glucose modulation of glucokinase activation by small molecules. Biochemistry 47, 5028-5036 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 5028-5036
-
-
Ralph, E.C.1
Thomson, J.2
Almaden, J.3
Sun, S.4
-
18
-
-
33745043238
-
Small molecule glucokinase activators as glucose lowering agents: A new paradigm for diabetes therapy
-
Guertin, K.R. & Grimsby, J. Small molecule glucokinase activators as glucose lowering agents: a new paradigm for diabetes therapy. Curr. Med. Chem. 13, 1839-1843 (2006).
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 1839-1843
-
-
Guertin, K.R.1
Grimsby, J.2
-
19
-
-
1542791635
-
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase
-
Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J.-I. & Nagata, Y. Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure 12, 429-438 (2004).
-
(2004)
Structure
, vol.12
, pp. 429-438
-
-
Kamata, K.1
Mitsuya, M.2
Nishimura, T.3
Eiki, J.-I.4
Nagata, Y.5
-
20
-
-
40849135481
-
The Sirtuin family: Therapeutic targets to treat diseases of aging
-
Milne, J.C. & Denu, J.M. The Sirtuin family: therapeutic targets to treat diseases of aging. Curr. Opin. Chem. Biol. 12, 11-17 (2008).
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 11-17
-
-
Milne, J.C.1
Denu, J.M.2
-
21
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
Longo, V.D. & Kennedy, B.K. Sirtuins in aging and age-related disease. Cell 126, 257-268 (2006).
-
(2006)
Cell
, vol.126
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
22
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580 (1999).
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
23
-
-
0034703217
-
Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S.J., Defossez, P.A. & Guarente, L. Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128 (2000).
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
24
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen, H.Y. et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392 (2004).
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
-
25
-
-
53249121556
-
Sirtuins-novel therapeutic targets to treat age-associated diseases
-
Lavu, S., Boss, O., Elliott, P.J. & Lambert, P.D. Sirtuins-novel therapeutic targets to treat age-associated diseases. Nat. Rev. Drug Discov. 7, 841-853 (2008).
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 841-853
-
-
Lavu, S.1
Boss, O.2
Elliott, P.J.3
Lambert, P.D.4
-
26
-
-
19344374925
-
Sir2-independent life span extension by calorie restriction in yeast
-
Kaeberlein, M., Kirkland, K.T., Fields, S. & Kennedy, B.K. Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol. 2, E296 (2004).
-
(2004)
PLoS Biol
, vol.2
-
-
Kaeberlein, M.1
Kirkland, K.T.2
Fields, S.3
Kennedy, B.K.4
-
27
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel, T., Deng, C.-X. & Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591 (2009).
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.-X.2
Mostoslavsky, R.3
-
28
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson, R.M., Bitterman, K.J., Wood, J.G., Medvedik, O. & Sinclair, D.A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423, 181-185 (2003).
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
29
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim, J.-E., Chen, J. & Lou, Z. DBC1 is a negative regulator of SIRT1. Nature 451, 583-586 (2008).
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.-E.1
Chen, J.2
Lou, Z.3
-
30
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao, W. et al. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-590 (2008).
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
-
31
-
-
35349011726
-
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
-
Kim, E.-J., Kho, J.-H., Kang, M.-R. & Um, S.-J. Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity. Mol. Cell 28, 277-290 (2007).
-
(2007)
Mol. Cell
, vol.28
, pp. 277-290
-
-
Kim, E.-J.1
Kho, J.-H.2
Kang, M.-R.3
Um, S.-J.4
-
32
-
-
53649086367
-
Mechanisms and molecular probes of sirtuins
-
Smith, B.C., Hallows, W.C. & Denu, J.M. Mechanisms and molecular probes of sirtuins. Chem. Biol. 15, 1002-1013 (2008).
-
(2008)
Chem. Biol.
, vol.15
, pp. 1002-1013
-
-
Smith, B.C.1
Hallows, W.C.2
Denu, J.M.3
-
33
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz, K.T. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196 (2003).
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
-
34
-
-
20444431507
-
Substrate-specific activation of sirtuins by resveratrol
-
Kaeberlein, M. et al. Substrate-specific activation of sirtuins by resveratrol. J. Biol. Chem. 280, 17038-17045 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 17038-17045
-
-
Kaeberlein, M.1
-
35
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne, J.C. et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450, 712-716 (2007).
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
-
36
-
-
77950246109
-
SRT1720 SRT2183 SRT1460 and resveratrol are not direct activators of SIRT1
-
doi:10.1074/jbc. M109.088682 8 January
-
Pacholec, M. et al. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. published online, doi:10.1074/jbc. M109.088682 (8 January 2010).
-
(2010)
J. Biol. Chem. Published Online
-
-
Pacholec, M.1
-
37
-
-
0037107414
-
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
-
Frödin, M. et al. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J. 21, 5396-5407 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 5396-5407
-
-
Frödin, M.1
-
38
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse, M. & Kuriyan, J. The conformational plasticity of protein kinases. Cell 109, 275-282 (2002).
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
39
-
-
1542286168
-
Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation
-
Biondi, R.M. Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation. Trends Biochem. Sci. 29, 136-142 (2004).
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 136-142
-
-
Biondi, R.M.1
-
40
-
-
0037102153
-
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
-
Biondi, R.M. et al. High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. EMBO J. 21, 4219-4228 (2002).
-
(2002)
EMBO J
, vol.21
, pp. 4219-4228
-
-
Biondi, R.M.1
-
41
-
-
0034161251
-
Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA
-
Biondi, R.M. et al. Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA. EMBO J. 19, 979-988 (2000).
-
(2000)
EMBO J
, vol.19
, pp. 979-988
-
-
Biondi, R.M.1
-
42
-
-
33751583820
-
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
-
Engel, M. et al. Allosteric activation of the protein kinase PDK1 with low molecular weight compounds. EMBO J. 25, 5469-5480 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 5469-5480
-
-
Engel, M.1
-
43
-
-
68549123439
-
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds
-
Stroba, A. et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J. Med. Chem. 52, 4683-4693 (2009).
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4683-4693
-
-
Stroba, A.1
-
44
-
-
70349305603
-
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
-
Hindie, V. et al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat. Chem. Biol. 5, 758-764 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 758-764
-
-
Hindie, V.1
-
45
-
-
0035882103
-
The PIFbinding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
Biondi, R.M., Kieloch, A., Currie, R.A., Deak, M. & Alessi, D.R. The PIFbinding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20, 4380-4390 (2001).
-
(2001)
EMBO J
, vol.20
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
46
-
-
33751539464
-
Protein-protein interactions in the allosteric regulation of protein kinases
-
Pellicena, P. & Kuriyan, J. Protein-protein interactions in the allosteric regulation of protein kinases. Curr. Opin. Struct. Biol. 16, 702-709 (2006).
-
(2006)
Curr. Opin. Struct. Biol.
, vol.16
, pp. 702-709
-
-
Pellicena, P.1
Kuriyan, J.2
-
47
-
-
39149114105
-
Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site
-
Tappan, E. & Chamberlin, A.R. Activation of protein phosphatase 1 by a small molecule designed to bind to the enzyme's regulatory site. Chem. Biol. 15, 167-174 (2008).
-
(2008)
Chem. Biol.
, vol.15
, pp. 167-174
-
-
Tappan, E.1
Chamberlin, A.R.2
-
48
-
-
0037805679
-
Small molecule modulators of histone acetyltransferase p300
-
Balasubramanyam, K., Swaminathan, V., Ranganathan, A. & Kundu, T.K. Small molecule modulators of histone acetyltransferase p300. J. Biol. Chem. 278, 19134-19140 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19134-19140
-
-
Balasubramanyam, K.1
Swaminathan, V.2
Ranganathan, A.3
Kundu, T.K.4
-
49
-
-
33947502604
-
Autocatalytic cleavage of Clostridium difficile toxin B
-
Reineke, J. et al. Autocatalytic cleavage of Clostridium difficile toxin B. Nature 446, 415-419 (2007).
-
(2007)
Nature
, vol.446
, pp. 415-419
-
-
Reineke, J.1
-
50
-
-
34548472183
-
Autocatalytic cleavage of clostridium difficile toxins a and b depends on cysteine protease activity
-
Egerer, M., Giesemann, T., Jank, T., Satchell, K.J.F. & Aktories, K. Autocatalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity. J. Biol. Chem. 282, 25314-25321 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25314-25321
-
-
Egerer, M.1
Giesemann, T.2
Jank, T.3
Satchell, K.J.F.4
Aktories, K.5
-
51
-
-
63649106579
-
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate
-
Egerer, M., Giesemann, T., Herrmann, C. & Aktories, K. Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate. J. Biol. Chem. 284, 3389-3395 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3389-3395
-
-
Egerer, M.1
Giesemann, T.2
Herrmann, C.3
Aktories, K.4
-
52
-
-
53749083462
-
Small molecule-induced allosteric activation of the vibrio cholerae rtx cysteine protease domain
-
Lupardus, P.J., Shen, A., Bogyo, M. & Garcia, K.C. Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science 322, 265-268 (2008).
-
(2008)
Science
, vol.322
, pp. 265-268
-
-
Lupardus, P.J.1
Shen, A.2
Bogyo, M.3
Garcia, K.C.4
-
53
-
-
67650290548
-
Mechanistic and structural insights into the proteolytic activation of vibrio cholerae martx toxin
-
Shen, A. et al. Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nat. Chem. Biol. 5, 469-478 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 469-478
-
-
Shen, A.1
-
54
-
-
53049108644
-
Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin
-
Prochazkova, K. & Satchell, K.J.F. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin. J. Biol. Chem. 283, 23656-23664 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 23656-23664
-
-
Prochazkova, K.1
Satchell, K.J.F.2
-
55
-
-
70350351548
-
Structural and molecular mechanism for autoprocessing of martx toxin of vibrio cholerae at multiple sites
-
Prochazkova, K. et al. Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites. J. Biol. Chem. 284, 26557-26568 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26557-26568
-
-
Prochazkova, K.1
-
56
-
-
69249100500
-
Human caspases: Activation, specificity and regulation
-
Pop, C. & Salvesen, G. Human caspases: activation, specificity and regulation. J. Biol. Chem. 284, 21777-21781 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21777-21781
-
-
Pop, C.1
Salvesen, G.2
-
57
-
-
0037833742
-
Caspase-Activation pathways in apoptosis and immunity
-
Creagh, E.M., Conroy, H. & Martin, S.J. Caspase-activation pathways in apoptosis and immunity. Immunol. Rev. 193, 10-21 (2003).
-
(2003)
Immunol. Rev.
, vol.193
, pp. 10-21
-
-
Creagh, E.M.1
Conroy, H.2
Martin, S.J.3
-
58
-
-
58149464289
-
The Jekyll and Hyde functions of caspases
-
Yi, C.H. & Yuan, J. The Jekyll and Hyde functions of caspases. Dev. Cell 16, 21-34 (2009).
-
(2009)
Dev. Cell
, vol.16
, pp. 21-34
-
-
Yi, C.H.1
Yuan, J.2
-
59
-
-
0034615555
-
Caspases - Controlling intracellular signals by protease zymogen activation
-
Stennicke, H.R. & Salvesen, G.S. Caspases - controlling intracellular signals by protease zymogen activation. Biochim. Biophys. Acta 1477, 299-306 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1477
, pp. 299-306
-
-
Stennicke, H.R.1
Salvesen, G.S.2
-
60
-
-
0032885388
-
Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
-
Earnshaw, W.C., Martins, L.M. & Kaufmann, S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68, 383-424 (1999).
-
(1999)
Annu. Rev. Biochem.
, vol.68
, pp. 383-424
-
-
Earnshaw, W.C.1
Martins, L.M.2
Kaufmann, S.H.3
-
62
-
-
14344272939
-
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "Safety catch"regulatory tripeptide
-
Roy, S. et al. Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc. Natl. Acad. Sci. USA 98, 6132-6137 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6132-6137
-
-
Roy, S.1
-
63
-
-
4344654060
-
Discovery of an allosteric site in the caspases
-
Hardy, J.A., Lam, J., Nguyen, J.T., O'Brien, T. & Wells, J.A. Discovery of an allosteric site in the caspases. Proc. Natl. Acad. Sci. USA 101, 12461-12466 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12461-12466
-
-
Hardy, J.A.1
Lam, J.2
Nguyen, J.T.3
O'Brien, T.4
Wells, J.A.5
-
64
-
-
33646727594
-
A common allosteric site and mechanism in caspases
-
Scheer, J.M., Romanowski, M.J. & Wells, J.A. A common allosteric site and mechanism in caspases. Proc. Natl. Acad. Sci. USA 103, 7595-7600 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 7595-7600
-
-
Scheer, J.M.1
Romanowski, M.J.2
Wells, J.A.3
-
65
-
-
62549093913
-
Two-state selection of conformation-specific antibodies
-
Gao, J., Sidhu, S.S. & Wells, J.A. Two-state selection of conformation-specific antibodies. Proc. Natl. Acad. Sci. USA 106, 3071-3076 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3071-3076
-
-
Gao, J.1
Sidhu, S.S.2
Wells, J.A.3
-
66
-
-
0035798361
-
Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
-
Chai, J. et al. Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell 107, 399-407 (2001).
-
(2001)
Cell
, vol.107
, pp. 399-407
-
-
Chai, J.1
-
67
-
-
0035909889
-
Structural basis for the activation of human procaspase-7
-
Riedl, S.J. et al. Structural basis for the activation of human procaspase-7. Proc. Natl. Acad. Sci. USA 98, 14790-14795 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14790-14795
-
-
Riedl, S.J.1
-
68
-
-
33748759801
-
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
-
Putt, K.S. et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat. Chem. Biol. 2, 543-550 (2006).
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 543-550
-
-
Putt, K.S.1
-
69
-
-
34548070795
-
Small molecules not direct activators of caspases
-
author reply 3, 520
-
Denault, J.-B. et al. Small molecules not direct activators of caspases. Nat. Chem. Biol. 3, 519 (2007); author reply 3, 520 (2007).
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 519
-
-
Denault, J.-B.1
-
70
-
-
63449138094
-
PAC-1 activates procaspase-3 in vitro through relief of zincmediated inhibition
-
Peterson, Q.P. et al. PAC-1 activates procaspase-3 in vitro through relief of zincmediated inhibition. J. Mol. Biol. 388, 144-158 (2009).
-
(2009)
J. Mol. Biol.
, vol.388
, pp. 144-158
-
-
Peterson, Q.P.1
-
71
-
-
70449372265
-
Small-molecule activators of a proenzyme
-
Wolan, D.W., Zorn, J.A., Gray, D.C. & Wells, J.A. Small-molecule activators of a proenzyme. Science 326, 853-858 (2009).
-
(2009)
Science
, vol.326
, pp. 853-858
-
-
Wolan, D.W.1
Zorn, J.A.2
Gray, D.C.3
Wells, J.A.4
-
72
-
-
6044273762
-
Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel
-
Svingen, P.A. et al. Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel. Clin. Cancer Res. 10, 6807-6820 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6807-6820
-
-
Svingen, P.A.1
-
73
-
-
65349177200
-
AMPK: An emerging drug target for diabetes and the metabolic syndrome
-
Zhang, B.B., Zhou, G. & Li, C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 9, 407-416 (2009).
-
(2009)
Cell Metab
, vol.9
, pp. 407-416
-
-
Zhang, B.B.1
Zhou, G.2
Li, C.3
-
74
-
-
0344081177
-
Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
-
Hardie, D.G. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144, 5179-5183 (2003).
-
(2003)
Endocrinology
, vol.144
, pp. 5179-5183
-
-
Hardie, D.G.1
-
75
-
-
33847072201
-
AMP-activated protein kinase as a drug target
-
Hardie, D.G. AMP-activated protein kinase as a drug target. Annu. Rev. Pharmacol. Toxicol. 47, 185-210 (2007).
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 185-210
-
-
Hardie, D.G.1
-
76
-
-
34848843526
-
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
-
Amodeo, G.A., Rudolph, M.J. & Tong, L. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature 449, 492-495 (2007).
-
(2007)
Nature
, vol.449
, pp. 492-495
-
-
Amodeo, G.A.1
Rudolph, M.J.2
Tong, L.3
-
77
-
-
0032567252
-
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase
-
Crute, B.E., Seefeld, K., Gamble, J., Kemp, B.E. & Witters, L.A. Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J. Biol. Chem. 273, 35347-35354 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35347-35354
-
-
Crute, B.E.1
Seefeld, K.2
Gamble, J.3
Kemp, B.E.4
Witters, L.A.5
-
78
-
-
67649484365
-
Structural insight into the autoinhibition mechanism of AMPactivated protein kinase
-
Chen, L. et al. Structural insight into the autoinhibition mechanism of AMPactivated protein kinase. Nature 459, 1146-1149 (2009).
-
(2009)
Nature
, vol.459
, pp. 1146-1149
-
-
Chen, L.1
-
79
-
-
34848840368
-
Structural basis for AMP binding to mammalian AMP-activated protein kinase
-
Xiao, B. et al. Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature 449, 496-500 (2007).
-
(2007)
Nature
, vol.449
, pp. 496-500
-
-
Xiao, B.1
-
80
-
-
34047161436
-
Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase
-
Townley, R. & Shapiro, L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315, 1726-1729 (2007).
-
(2007)
Science
, vol.315
, pp. 1726-1729
-
-
Townley, R.1
Shapiro, L.2
-
81
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn, B.B., Alquier, T., Carling, D. & Hardie, D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15-25 (2005).
-
(2005)
Cell Metab
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
82
-
-
85047279405
-
The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP)
-
Sabina, R.L., Holmes, E.W. & Becker, M.A. The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP). Science 223, 1193-1195 (1984).
-
(1984)
Science
, vol.223
, pp. 1193-1195
-
-
Sabina, R.L.1
Holmes, E.W.2
Becker, M.A.3
-
83
-
-
85047689953
-
5-aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur
-
Corton, J.M., Gillespie, J.G., Hawley, S.A. & Hardie, D.G. 5-aminoimidazole-4- carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur. J. Biochem. 229, 558-565 (1995).
-
(1995)
J. Biochem.
, vol.229
, pp. 558-565
-
-
Corton, J.M.1
Gillespie, J.G.2
Hawley, S.A.3
Hardie, D.G.4
-
84
-
-
33744514139
-
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
-
Cool, B. et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab. 3, 403-416 (2006).
-
(2006)
Cell Metab.
, vol.3
, pp. 403-416
-
-
Cool, B.1
-
85
-
-
36348998521
-
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
-
Göransson, O. et al. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J. Biol. Chem. 282, 32549-32560 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32549-32560
-
-
Göransson, O.1
-
86
-
-
56049112796
-
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
-
Scott, J.W. et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem. Biol. 15, 1220-1230 (2008).
-
(2008)
Chem. Biol.
, vol.15
, pp. 1220-1230
-
-
Scott, J.W.1
-
87
-
-
36348978499
-
Defining the mechanism of activation of AMPactivated protein kinase by the small molecule A-769662, a member of the thienopyridone family
-
Sanders, M.J. et al. Defining the mechanism of activation of AMPactivated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J. Biol. Chem. 282, 32539-32548 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32539-32548
-
-
Sanders, M.J.1
-
88
-
-
34249301362
-
Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators
-
Zhao, G. et al. Discovery and SAR development of thienopyridones: a class of small molecule AMPK activators. Bioorg. Med. Chem. Lett. 17, 3254-3257 (2007).
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 3254-3257
-
-
Zhao, G.1
-
89
-
-
47049103144
-
Small molecule antagonizes autoinhibition and activates AMPactivated protein kinase in cells
-
Pang, T. et al. Small molecule antagonizes autoinhibition and activates AMPactivated protein kinase in cells. J. Biol. Chem. 283, 16051-16060 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16051-16060
-
-
Pang, T.1
-
90
-
-
34548611290
-
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation
-
Kim, C., Cheng, C.Y., Saldanha, S.A. & Taylor, S.S. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell 130, 1032-1043 (2007).
-
(2007)
Cell
, vol.130
, pp. 1032-1043
-
-
Kim, C.1
Cheng, C.Y.2
Saldanha, S.A.3
Taylor, S.S.4
-
91
-
-
38149061122
-
Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design
-
Taylor, S.S. et al. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim. Biophys. Acta 1784, 16-26 (2008).
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 16-26
-
-
Taylor, S.S.1
-
92
-
-
65249108791
-
Contribution of non-catalytic core residues to activity and regulation in protein kinase
-
Yang, J. et al. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J. Biol. Chem. 284, 6241-6248 (2009).
-
(2009)
A. J. Biol. Chem.
, vol.284
, pp. 6241-6248
-
-
Yang, J.1
-
93
-
-
33845524054
-
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase
-
Saldanha, S.A., Kaler, G., Cottam, H.B., Abagyan, R. & Taylor, S.S. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal. Chem. 78, 8265-8272 (2006).
-
(2006)
A. Anal. Chem.
, vol.78
, pp. 8265-8272
-
-
Saldanha, S.A.1
Kaler, G.2
Cottam, H.B.3
Abagyan, R.4
Taylor, S.S.5
-
94
-
-
36749081143
-
Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: A personal account and progress report on transferring academic discoveries to the clinic
-
Budas, G.R., Koyanagi, T., Churchill, E.N. & Mochly-Rosen, D. Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem. Soc. Trans. 35, 1021-1026 (2007).
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1021-1026
-
-
Budas, G.R.1
Koyanagi, T.2
Churchill, E.N.3
Mochly-Rosen, D.4
-
95
-
-
0033119158
-
Pharmacologic modulation of protein kinase C isozymes: The role of RACKs and subcellular localisation
-
Csukai, M. & Mochly-Rosen, D. Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation. Pharmacol. Res. 39, 253-259 (1999).
-
(1999)
Pharmacol. Res.
, vol.39
, pp. 253-259
-
-
Csukai, M.1
Mochly-Rosen, D.2
-
96
-
-
58149175775
-
Rationally designed peptide regulators of protein kinase C
-
Churchill, E.N., Qvit, N. & Mochly-Rosen, D. Rationally designed peptide regulators of protein kinase C. Trends Endocrinol. Metab. 20, 25-33 (2009).
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 25-33
-
-
Churchill, E.N.1
Qvit, N.2
Mochly-Rosen, D.3
-
97
-
-
0037465342
-
Implications for RNase L in prostate cancer biology
-
Silverman, R.H. Implications for RNase L in prostate cancer biology. Biochemistry 42, 1805-1812 (2003).
-
(2003)
Biochemistry
, vol.42
, pp. 1805-1812
-
-
Silverman, R.H.1
-
98
-
-
0019423024
-
Interferon action- sequence specificity of the ppp(A2′p)nA- dependent ribonuclease
-
Wreschner, D.H., McCauley, J.W., Skehel, J.J. & Kerr, I.M. Interferon action- sequence specificity of the ppp(A2′p)nA-dependent ribonuclease. Nature 289, 414-417 (1981).
-
(1981)
Nature
, vol.289
, pp. 414-417
-
-
Wreschner, D.H.1
McCauley, J.W.2
Skehel, J.J.3
Kerr, I.M.4
-
99
-
-
8144225873
-
Structural basis for recognition of 2′,5′-linked oligoadenylates by human ribonuclease L
-
Tanaka, N. et al. Structural basis for recognition of 2′,5′-linked oligoadenylates by human ribonuclease L. EMBO J. 23, 3929-3938 (2004).
-
(2004)
EMBO J.
, vol.23
, pp. 3929-3938
-
-
Tanaka, N.1
-
100
-
-
39049178243
-
Molecular basis for recognition of 2′,5′-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease
-
Tanaka, N. et al. Molecular basis for recognition of 2′,5′- linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L. Nucleic Acids Symp. Ser. (Oxf) 323-324 (2005).
-
(2005)
L. Nucleic Acids Symp. Ser. (Oxf)
, pp. 323-324
-
-
Tanaka, N.1
-
101
-
-
19544367765
-
2-5A induces a conformational change in the ankyrin-repeat domain of RNase L
-
Nakanishi, M., Goto, Y. & Kitade, Y. 2-5A induces a conformational change in the ankyrin-repeat domain of RNase L. Proteins 60, 131-138 (2005).
-
(2005)
Proteins
, vol.60
, pp. 131-138
-
-
Nakanishi, M.1
Goto, Y.2
Kitade, Y.3
-
102
-
-
29244447137
-
Functional characterization of 2′,5′-linked oligoadenylate binding determinant of human RNase L
-
Nakanishi, M. et al. Functional characterization of 2′,5′- linked oligoadenylate binding determinant of human RNase L. J. Biol. Chem. 280, 41694-41699 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41694-41699
-
-
Nakanishi, M.1
-
103
-
-
34547407661
-
Small-molecule activators of RNase L with broad-spectrum antiviral activity
-
Thakur, C.S. et al. Small-molecule activators of RNase L with broad-spectrum antiviral activity. Proc. Natl. Acad. Sci. USA 104, 9585-9590 (2007).
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 9585-9590
-
-
Thakur, C.S.1
-
104
-
-
0344395603
-
Bypassing a kinase activity with an ATP-competitive drug
-
Papa, F.R., Zhang, C., Shokat, K. & Walter, P. Bypassing a kinase activity with an ATP-competitive drug. Science 302, 1533-1537 (2003).
-
(2003)
Science
, vol.302
, pp. 1533-1537
-
-
Papa, F.R.1
Zhang, C.2
Shokat, K.3
Walter, P.4
-
105
-
-
0035865087
-
A physical map of the human genome
-
McPherson, J.D. et al. A physical map of the human genome. Nature 409, 934-941 (2001).
-
(2001)
Nature
, vol.409
, pp. 934-941
-
-
McPherson, J.D.1
-
106
-
-
0035895505
-
The sequence of the human genome
-
Venter, J.C. et al. The sequence of the human genome. Science 291, 1304-1351 (2001).
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
-
107
-
-
51749104191
-
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
-
Chen, C.-H. et al. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321, 1493-1495 (2008).
-
(2008)
Science
, vol.321
, pp. 1493-1495
-
-
Chen, C.-H.1
-
108
-
-
67650337799
-
Inhibitor hijacking of Akt activation
-
Okuzumi, T. et al. Inhibitor hijacking of Akt activation. Nat. Chem. Biol. 5, 484-493 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 484-493
-
-
Okuzumi, T.1
-
109
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
Sergina, N.V. et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445, 437-441 (2007).
-
(2007)
Nature
, vol.445
, pp. 437-441
-
-
Sergina, N.V.1
|