Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

Nature

Volumn 459, Issue 7250, 2009, Pages 1146-1149

  Chen, Lei ^a   Jiao, Zhi Hao ^a   Zheng, Li Sha ^b   Zhang, Yuan Yuan ^a   Xie, Shu Tao ^a   Wang, Zhi Xin ^a,b   Wu, Jia Wei ^a  

^a TSINGHUA UNIVERSITY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ADENOSINE PHOSPHATE;

BIOCHEMISTRY; CANCER; CRYSTAL STRUCTURE; DIABETES; ENZYME ACTIVITY; EUKARYOTE; INHIBITION; MODEL; OBESITY; PROTEIN; REACTION KINETICS; YEAST;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBUNIT; HINGE REGION; IN VITRO STUDY; INHIBITION KINETICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; RAT; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SCHIZOSACCHAROMYCES; SEQUENCE ALIGNMENT;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

ADENOSINE MONOPHOSPHATE; AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RATS; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SEQUENCE ALIGNMENT;

EID: 67649484365     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08075     Document Type: Article

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