Structural basis for recognition of 2′,5′-linked oligoadenylates by human ribonuclease L

EMBO Journal

Volumn 23, Issue 20, 2004, Pages 3929-3938

  Tanaka, Nobutada ^a   Nakanishi, Masayuki ^b   Kusakabe, Yoshio ^a   Goto, Yoshikuni ^b   Kitade, Yukio ^b   Nakamura, Kazuo T ^a  

^a SHOWA UNIVERSITY   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

2 5A system; Ankyrin repeat; Crystal structure; Drug design; Interferon

Indexed keywords

2',5' OLIGOADENYLIC ACID; ANKYRIN; INTERFERON; NUCLEIC ACID; RIBONUCLEASE; RIBONUCLEASE L; RNA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA STABILITY;

ADENINE NUCLEOTIDES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANKYRINS; CONSENSUS SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; ENDORIBONUCLEASES; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; OLIGORIBONUCLEOTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SPECTRUM ANALYSIS, RAMAN; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

ANIMALIA; MAMMALIA;

EID: 8144225873     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600420     Document Type: Article

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