A common allosteric site and mechanism in caspases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 20, 2006, Pages 7595-7600

  Scheer, Justin M ^a,b   Romanowski, Michael J ^b   Wells, James A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Allosteric regulation; Apoptosis; Fragment based discovery; Inflammation; Procaspase

Indexed keywords

CASPASE 7; CYSTEINE; DIMER; DISULFIDE; ENZYME PRECURSOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEINASE; THIOL DERIVATIVE;

ALLOSTERISM; APOPTOSIS; ARTICLE; BINDING SITE; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; INFLAMMATION; MUTATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; TECHNIQUE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITES; CASPASES; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; HUMANS; INFLAMMATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SULFHYDRYL COMPOUNDS;

EID: 33646727594     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0602571103     Document Type: Article

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