Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: A personal account and progress report on transferring academic discoveries to the clinic

Biochemical Society Transactions

Volumn 35, Issue 5, 2007, Pages 1021-1026

  Budas, G R ^a   Koyanagi, T ^a   Churchill, E N ^a   Mochly Rosen, D ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allosteric agonist; C2 domain; Inhibitor peptide; Protein protein interaction; Protem kinase C isoenzyme (PKC isoenzyme); Receptor for activated C kinase (RACK)

Indexed keywords

KAI 9803; PLACEBO; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ALLOSTERISM; AMINO ACID SEQUENCE; CELLULAR DISTRIBUTION; CLINICAL TRIAL; CONFERENCE PAPER; DRUG SAFETY; DRUG TOLERABILITY; HEART INFARCTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

AMINO ACID SEQUENCE; ENZYME ACTIVATORS; HUMANS; ISOENZYMES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 36749081143     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0351021     Document Type: Conference Paper

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