Two-state selection of conformation-specific antibodies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 9, 2009, Pages 3071-3076

  Gao, Junjun ^a   Sidhu, Sachdev S ^b,c   Wells, James A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Allostery; Caspase 1; Phage display; Protein conformational change

Indexed keywords

ANTIBODY; CASPASE 2; CONFORMATION SPECIFIC ANTIBODY; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANTIBODY AFFINITY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANTIBODIES; ANTIBODY SPECIFICITY; CASPASE 1; CELL LINE; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 62549093913     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812952106     Document Type: Article

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