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Volumn 58, Issue 4, 2010, Pages 377-390

Cell-context specific role of the E2F/Rb pathway in development and disease

Author keywords

Brain; Cell cycle; Differentiation; Glia; Proliferation; Tumor

Indexed keywords

CRE RECOMBINASE; CYCLIN DEPENDENT KINASE; PROTEIN P107; PROTEIN P130; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

EID: 76549105557     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20933     Document Type: Review
Times cited : (46)

References (176)
  • 5
    • 0025910802 scopus 로고
    • The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
    • Bagchi S, Weinmann R, Raychaudhuri P. 1991. The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Cell 65:1063-1072.
    • (1991) Cell , vol.65 , pp. 1063-1072
    • Bagchi, S.1    Weinmann, R.2    Raychaudhuri, P.3
  • 6
    • 0025917231 scopus 로고
    • Cyclin A and the retinoblastoma gene product complex with a common transcription factor
    • Bandara LR, Adamczewski JP, Hunt T, La Thangue NB. 1991. Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature 352:249-251.
    • (1991) Nature , vol.352 , pp. 249-251
    • Bandara, L.R.1    Adamczewski, J.P.2    Hunt, T.3    La Thangue, N.B.4
  • 7
    • 0027434084 scopus 로고
    • Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F
    • Bandara LR, Buck VM, Zamanian M, Johnston LH, La Thangue NB. 1993. Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F. EMBO J 12:4317-4324.
    • (1993) EMBO J , vol.12 , pp. 4317-4324
    • Bandara, L.R.1    Buck, V.M.2    Zamanian, M.3    Johnston, L.H.4    La Thangue, N.B.5
  • 8
    • 0027985749 scopus 로고
    • E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
    • Beijersbergen RL, Kerkhoven RM, Zhu L, Carlee L, Voorhoeve PM, Bernards R. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev 8:2680-2690.
    • (1994) Genes Dev , vol.8 , pp. 2680-2690
    • Beijersbergen, R.L.1    Kerkhoven, R.M.2    Zhu, L.3    Carlee, L.4    Voorhoeve, P.M.5    Bernards, R.6
  • 9
    • 33745140886 scopus 로고    scopus 로고
    • Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome
    • Bieda M, Xu X, Singer MA, Green R, Farnham PJ. 2006. Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res 16:595-605.
    • (2006) Genome Res , vol.16 , pp. 595-605
    • Bieda, M.1    Xu, X.2    Singer, M.A.3    Green, R.4    Farnham, P.J.5
  • 10
    • 5444240769 scopus 로고    scopus 로고
    • Hitting their targets: An emerging picture of E2F and cell cycle control
    • Blais A, Dynlacht BD. 2004. Hitting their targets: An emerging picture of E2F and cell cycle control. Curr Opin Genet Dev 14:527-532.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 527-532
    • Blais, A.1    Dynlacht, B.D.2
  • 11
    • 36749080303 scopus 로고    scopus 로고
    • E2F-associated chromatin modifiers and cell cycle control
    • Blais A, Dynlacht BD. 2007. E2F-associated chromatin modifiers and cell cycle control. Curr Opin Cell Biol 19:658-662.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 658-662
    • Blais, A.1    Dynlacht, B.D.2
  • 15
    • 0032522911 scopus 로고    scopus 로고
    • Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
    • Busser J, Geldmacher DS, Herrup K. 1998. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 18:2801-2807.
    • (1998) J Neurosci , vol.18 , pp. 2801-2807
    • Busser, J.1    Geldmacher, D.S.2    Herrup, K.3
  • 16
    • 0033559609 scopus 로고    scopus 로고
    • Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity
    • Callaghan DA, Dong L, Callaghan SM, Hou YX, Dagnino L, Slack RS. 1999. Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Dev Biol 207:257-270.
    • (1999) Dev Biol , vol.207 , pp. 257-270
    • Callaghan, D.A.1    Dong, L.2    Callaghan, S.M.3    Hou, Y.X.4    Dagnino, L.5    Slack, R.S.6
  • 17
    • 0041733054 scopus 로고    scopus 로고
    • Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters
    • Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R. 2003. Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters. J Biol Chem 278:30435-30440.
    • (2003) J Biol Chem , vol.278 , pp. 30435-30440
    • Caretti, G.1    Salsi, V.2    Vecchi, C.3    Imbriano, C.4    Mantovani, R.5
  • 18
    • 0025905183 scopus 로고
    • The E2F transcription factor is a cellular target for the RB protein
    • Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR. 1991. The E2F transcription factor is a cellular target for the RB protein. Cell 65:1053-1061.
    • (1991) Cell , vol.65 , pp. 1053-1061
    • Chellappan, S.P.1    Hiebert, S.2    Mudryj, M.3    Horowitz, J.M.4    Nevins, J.R.5
  • 19
    • 2942574955 scopus 로고    scopus 로고
    • Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma
    • Chen D, Livne-Bar I, Vanderluit JL, Slack RS, Agochiya M, Bremner R. 2004. Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 5:539-551.
    • (2004) Cancer Cell , vol.5 , pp. 539-551
    • Chen, D.1    Livne-Bar, I.2    Vanderluit, J.L.3    Slack, R.S.4    Agochiya, M.5    Bremner, R.6
  • 21
    • 0025734783 scopus 로고
    • The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
    • Chittenden T, Livingston DM, Kaelin WG Jr. 1991. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65:1073-1082.
    • (1991) Cell , vol.65 , pp. 1073-1082
    • Chittenden, T.1    Livingston, D.M.2    Kaelin Jr., W.G.3
  • 24
    • 0026760426 scopus 로고    scopus 로고
    • Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A, te Riele H. 1992. Requirement for a functional Rb-1 gene in murine development. Nature 359:328-330.
    • Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A, te Riele H. 1992. Requirement for a functional Rb-1 gene in murine development. Nature 359:328-330.
  • 26
    • 18344383345 scopus 로고    scopus 로고
    • Pocket proteins and cell cycle control
    • Cobrinik D. 2005. Pocket proteins and cell cycle control. Oncogene 24:2796-2809.
    • (2005) Oncogene , vol.24 , pp. 2796-2809
    • Cobrinik, D.1
  • 28
    • 0027140404 scopus 로고
    • Cell cycle-specific association of E2F with the p130 E1A-binding protein
    • Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA. 1993. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev A 7:2392-2404.
    • (1993) Genes Dev A , vol.7 , pp. 2392-2404
    • Cobrinik, D.1    Whyte, P.2    Peeper, D.S.3    Jacks, T.4    Weinberg, R.A.5
  • 30
    • 43449130065 scopus 로고    scopus 로고
    • E2f6 and Bmi1 cooperate in axial skeletal development
    • Courel M, Friesenhahn L, Lees JA. 2008. E2f6 and Bmi1 cooperate in axial skeletal development. Dev Dyn 237:1232-1242.
    • (2008) Dev Dyn , vol.237 , pp. 1232-1242
    • Courel, M.1    Friesenhahn, L.2    Lees, J.A.3
  • 31
    • 0030959767 scopus 로고    scopus 로고
    • Expression patterns of the E2F family of transcription factors during mouse nervous system development
    • Dagnino L, Fry CJ, Bartley SM, Farnham P, Gallie BL, Phillips RA. 1997. Expression patterns of the E2F family of transcription factors during mouse nervous system development. Mech Dev 66:13-25.
    • (1997) Mech Dev , vol.66 , pp. 13-25
    • Dagnino, L.1    Fry, C.J.2    Bartley, S.M.3    Farnham, P.4    Gallie, B.L.5    Phillips, R.A.6
  • 32
    • 0142242213 scopus 로고    scopus 로고
    • Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation
    • de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. 2003. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem 278:42041-42049.
    • (2003) J Biol Chem , vol.278 , pp. 42041-42049
    • de Bruin, A.1    Maiti, B.2    Jakoi, L.3    Timmers, C.4    Buerki, R.5    Leone, G.6
  • 33
    • 33750920705 scopus 로고    scopus 로고
    • Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis
    • DeGregori J, Johnson DG. 2006. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6:739-748.
    • (2006) Curr Mol Med , vol.6 , pp. 739-748
    • DeGregori, J.1    Johnson, D.G.2
  • 34
    • 0029049577 scopus 로고
    • Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/ S-regulatory genes
    • DeGregori J, Kowalik T, Nevins JR. 1995a. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/ S-regulatory genes. Mol Cell Biol 15:4215-4224.
    • (1995) Mol Cell Biol , vol.15 , pp. 4215-4224
    • DeGregori, J.1    Kowalik, T.2    Nevins, J.R.3
  • 36
    • 0028826881 scopus 로고
    • E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity
    • DeGregori J, Leone G, Ohtani K, Miron A, Nevins JR. 1995b. E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity. Genes Dev 9:2873-2887.
    • (1995) Genes Dev , vol.9 , pp. 2873-2887
    • DeGregori, J.1    Leone, G.2    Ohtani, K.3    Miron, A.4    Nevins, J.R.5
  • 37
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud E, McMahon AP, Briscoe J. 2008. Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network. Development 135:2489-2503.
    • (2008) Development , vol.135 , pp. 2489-2503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 38
    • 0346874353 scopus 로고    scopus 로고
    • E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes
    • Di Stefano L, Jensen MR, Helin K. 2003. E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J 22:6289-6298.
    • (2003) EMBO J , vol.22 , pp. 6289-6298
    • Di Stefano, L.1    Jensen, M.R.2    Helin, K.3
  • 39
    • 18344393150 scopus 로고    scopus 로고
    • The E2F transcriptional network: Old acquaintances with new faces
    • Dimova DK, Dyson NJ. 2005. The E2F transcriptional network: Old acquaintances with new faces. Oncogene 24:2810-2826.
    • (2005) Oncogene , vol.24 , pp. 2810-2826
    • Dimova, D.K.1    Dyson, N.J.2
  • 40
    • 33745304849 scopus 로고    scopus 로고
    • Compensation by tumor suppressor genes during retinal development in mice and humans
    • Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA. 2006. Compensation by tumor suppressor genes during retinal development in mice and humans. BMC Biol 4:14.
    • (2006) BMC Biol , vol.4 , pp. 14
    • Donovan, S.L.1    Schweers, B.2    Martins, R.3    Johnson, D.4    Dyer, M.A.5
  • 42
    • 0030990095 scopus 로고    scopus 로고
    • Specific regulation of E2F family members by cyclin-dependent kinases
    • Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. 1997. Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol 17:3867-3875.
    • (1997) Mol Cell Biol , vol.17 , pp. 3867-3875
    • Dynlacht, B.D.1    Moberg, K.2    Lees, J.A.3    Harlow, E.4    Zhu, L.5
  • 45
    • 0032168984 scopus 로고    scopus 로고
    • The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
    • Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D. 1998. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci USA 95:10493-10498.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10493-10498
    • Ferreira, R.1    Magnaghi-Jaulin, L.2    Robin, P.3    Harel-Bellan, A.4    Trouche, D.5
  • 49
    • 0033580436 scopus 로고    scopus 로고
    • Transcriptional repression of the E2F-1 gene by interferonalpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes
    • Furukawa Y, Iwase S, Kikuchi J, Nakamura M, Yamada H, Matsuda M. 1999. Transcriptional repression of the E2F-1 gene by interferonalpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes. Oncogene 18:2003-2014.
    • (1999) Oncogene , vol.18 , pp. 2003-2014
    • Furukawa, Y.1    Iwase, S.2    Kikuchi, J.3    Nakamura, M.4    Yamada, H.5    Matsuda, M.6
  • 54
    • 36549046563 scopus 로고    scopus 로고
    • Spatial and temporal specification of neural fates by transcription factor codes
    • Guillemot F. 2007. Spatial and temporal specification of neural fates by transcription factor codes. Development 134:3771-3780.
    • (2007) Development , vol.134 , pp. 3771-3780
    • Guillemot, F.1
  • 55
    • 0027142956 scopus 로고
    • Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins
    • Hannon GJ, Demetrick D, Beach D. 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev A 7:2378-2391.
    • (1993) Genes Dev A , vol.7 , pp. 2378-2391
    • Hannon, G.J.1    Demetrick, D.2    Beach, D.3
  • 56
    • 0027382336 scopus 로고
    • Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
    • Helin K, Harlow E, Fattaey A. 1993. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol 13:6501-6508.
    • (1993) Mol Cell Biol , vol.13 , pp. 6501-6508
    • Helin, K.1    Harlow, E.2    Fattaey, A.3
  • 57
    • 34247508686 scopus 로고    scopus 로고
    • Cell cycle regulation in the postmitotic neuron: Oxymoron or new biology?
    • Herrup K, Yang Y. 2007. Cell cycle regulation in the postmitotic neuron: Oxymoron or new biology? Nat Rev Neurosci 8:368-378.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 368-378
    • Herrup, K.1    Yang, Y.2
  • 60
    • 0036323485 scopus 로고    scopus 로고
    • Cyclin D1 and cyclin E are co-localized with cyclooxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    • Hoozemans JJ, Bruckner MK, Rozemuller AJ, Veerhuis R, Eikelenboom P, Arendt T. 2002. Cyclin D1 and cyclin E are co-localized with cyclooxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J Neuropathol Exp Neurol 61:678-688.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 678-688
    • Hoozemans, J.J.1    Bruckner, M.K.2    Rozemuller, A.J.3    Veerhuis, R.4    Eikelenboom, P.5    Arendt, T.6
  • 62
    • 0034913318 scopus 로고    scopus 로고
    • The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation
    • Hou ST, Cowan E, Walker T, Ohan N, Dove M, Rasqinha I, MacManus JP. 2001. The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation. J Neurochem 78:287-297.
    • (2001) J Neurochem , vol.78 , pp. 287-297
    • Hou, S.T.1    Cowan, E.2    Walker, T.3    Ohan, N.4    Dove, M.5    Rasqinha, I.6    MacManus, J.P.7
  • 63
    • 0028276864 scopus 로고
    • Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
    • Hsiao KM, McMahon SL, Farnham PJ. 1994. Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev 8:1526-1537.
    • (1994) Genes Dev , vol.8 , pp. 1526-1537
    • Hsiao, K.M.1    McMahon, S.L.2    Farnham, P.J.3
  • 64
    • 0026582927 scopus 로고
    • The retinoblastoma protein physically associates with the human cdc2 kinase
    • Hu QJ, Lees JA, Buchkovich KJ, Harlow E. 1992. The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol 12:971-980.
    • (1992) Mol Cell Biol , vol.12 , pp. 971-980
    • Hu, Q.J.1    Lees, J.A.2    Buchkovich, K.J.3    Harlow, E.4
  • 65
    • 0036195123 scopus 로고    scopus 로고
    • Down-regulation of the retinoblastoma protein (rb) is associated with rat oligodendrocyte differentiation
    • Huang Z, Tang XM, Cambi F. 2002. Down-regulation of the retinoblastoma protein (rb) is associated with rat oligodendrocyte differentiation. Mol Cell Neurosci 19:250-262.
    • (2002) Mol Cell Neurosci , vol.19 , pp. 250-262
    • Huang, Z.1    Tang, X.M.2    Cambi, F.3
  • 67
    • 15444353328 scopus 로고    scopus 로고
    • pRB and p107/ p130 are required for the regulated expression of different sets of E2F responsive genes
    • Hurford RK Jr, Cobrinik D, Lee MH, Dyson N. 1997. pRB and p107/ p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev 11:1447-1463.
    • (1997) Genes Dev , vol.11 , pp. 1447-1463
    • Hurford Jr, R.K.1    Cobrinik, D.2    Lee, M.H.3    Dyson, N.4
  • 68
    • 33751160409 scopus 로고    scopus 로고
    • ID proteins as targets in cancer and tools in neurobiology
    • Iavarone A, Lasorella A. 2006. ID proteins as targets in cancer and tools in neurobiology. Trends Mol Med 12:588-594.
    • (2006) Trends Mol Med , vol.12 , pp. 588-594
    • Iavarone, A.1    Lasorella, A.2
  • 69
    • 0032933352 scopus 로고    scopus 로고
    • E2F and histone deacetylase mediate transforming growth factor b repression of cdc25A during keratinocyte cell cycle arrest
    • Iavarone A, Massague J. 1999. E2F and histone deacetylase mediate transforming growth factor b repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol 19:916-922.
    • (1999) Mol Cell Biol , vol.19 , pp. 916-922
    • Iavarone, A.1    Massague, J.2
  • 70
    • 0029868367 scopus 로고    scopus 로고
    • A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
    • Ikeda MA, Jakoi L, Nevins JR. 1996. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc Natl Acad Sci USA 93:3215-3220.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3215-3220
    • Ikeda, M.A.1    Jakoi, L.2    Nevins, J.R.3
  • 72
    • 0030922363 scopus 로고    scopus 로고
    • The retinoblastoma gene family is differentially expressed during embryogenesis
    • Jiang Z, Zacksenhaus E, Gallie BL, Phillips RA. 1997. The retinoblastoma gene family is differentially expressed during embryogenesis. Oncogene 14:1789-1797.
    • (1997) Oncogene , vol.14 , pp. 1789-1797
    • Jiang, Z.1    Zacksenhaus, E.2    Gallie, B.L.3    Phillips, R.A.4
  • 73
    • 0028364529 scopus 로고
    • Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
    • Johnson DG, Ohtani K, Nevins JR. 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev 8:1514-1525.
    • (1994) Genes Dev , vol.8 , pp. 1514-1525
    • Johnson, D.G.1    Ohtani, K.2    Nevins, J.R.3
  • 74
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson DG, Schwarz JK, Cress WD, Nevins JR. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 76
    • 0027288908 scopus 로고    scopus 로고
    • Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclinD-dependent kinase CDK4.Genes Dev 7:331-342.
    • Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclinD-dependent kinase CDK4.Genes Dev 7:331-342.
  • 77
    • 36448947971 scopus 로고    scopus 로고
    • Specification of CNS glia from neural stem cells in the embryonic neuroepithelium
    • Kessaris N, Pringle N, Richardson WD. 2008. Specification of CNS glia from neural stem cells in the embryonic neuroepithelium. Philos Trans R Soc Lond B Biol Sci 363:71-85.
    • (2008) Philos Trans R Soc Lond B Biol Sci , vol.363 , pp. 71-85
    • Kessaris, N.1    Pringle, N.2    Richardson, W.D.3
  • 78
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG Jr. 1971. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 79
    • 0022454147 scopus 로고
    • Identification of a cellular transcription factor involved in E1A trans-activation
    • Kovesdi I, Reichel R, Nevins JR. 1986. Identification of a cellular transcription factor involved in E1A trans-activation. Cell 45:219-228.
    • (1986) Cell , vol.45 , pp. 219-228
    • Kovesdi, I.1    Reichel, R.2    Nevins, J.R.3
  • 80
    • 0035862540 scopus 로고    scopus 로고
    • Expression of the E2F and retinoblastoma families of proteins during neural differentiation
    • Kusek JC, Greene RM, Pisano MM. 2001. Expression of the E2F and retinoblastoma families of proteins during neural differentiation. Brain Res Bull 54:187-198.
    • (2001) Brain Res Bull , vol.54 , pp. 187-198
    • Kusek, J.C.1    Greene, R.M.2    Pisano, M.M.3
  • 81
    • 33645512796 scopus 로고    scopus 로고
    • The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
    • Lasorella A, Iavarone A. 2006. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Proc Natl Acad Sci USA 103:4976-4981.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4976-4981
    • Lasorella, A.1    Iavarone, A.2
  • 82
    • 0031782695 scopus 로고    scopus 로고
    • Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene
    • LeCouter JE, Kablar B, Hardy WR, Ying C, Megeney LA, May LL, Rudnicki MA. 1998a. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol Cell Biol 18:7455-7465.
    • (1998) Mol Cell Biol , vol.18 , pp. 7455-7465
    • LeCouter, J.E.1    Kablar, B.2    Hardy, W.R.3    Ying, C.4    Megeney, L.A.5    May, L.L.6    Rudnicki, M.A.7
  • 83
    • 0032433267 scopus 로고    scopus 로고
    • Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
    • LeCouter JE, Kablar B, Whyte PF, Ying C, Rudnicki MA. 1998b. Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene. Development 125:4669-4679.
    • (1998) Development , vol.125 , pp. 4669-4679
    • LeCouter, J.E.1    Kablar, B.2    Whyte, P.F.3    Ying, C.4    Rudnicki, M.A.5
  • 84
  • 86
    • 33846657121 scopus 로고    scopus 로고
    • Cell cycle-specific and cell type-specific expression of Rb in the developing human retina
    • Lee TC, Almeida D, Claros N, Abramson DH, Cobrinik D. 2006. Cell cycle-specific and cell type-specific expression of Rb in the developing human retina. Invest Ophthalmol Vis Sci 47:5590-5598.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 5590-5598
    • Lee, T.C.1    Almeida, D.2    Claros, N.3    Abramson, D.H.4    Cobrinik, D.5
  • 87
    • 0026701339 scopus 로고
    • Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner
    • Lees E, Faha B, Dulic V, Reed SI, Harlow E. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev 6:1874-1885.
    • (1992) Genes Dev , vol.6 , pp. 1874-1885
    • Lees, E.1    Faha, B.2    Dulic, V.3    Reed, S.I.4    Harlow, E.5
  • 89
    • 0032528027 scopus 로고    scopus 로고
    • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
    • Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. 1998. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev 12:2120-2130.
    • (1998) Genes Dev , vol.12 , pp. 2120-2130
    • Leone, G.1    DeGregori, J.2    Yan, Z.3    Jakoi, L.4    Ishida, S.5    Williams, R.S.6    Nevins, J.R.7
  • 90
    • 0034011378 scopus 로고    scopus 로고
    • Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins
    • Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR. 2000. Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. Mol Cell Biol 20:3626-3632.
    • (2000) Mol Cell Biol , vol.20 , pp. 3626-3632
    • Leone, G.1    Nuckolls, F.2    Ishida, S.3    Adams, M.4    Sears, R.5    Jakoi, L.6    Miron, A.7    Nevins, J.R.8
  • 92
    • 28544433252 scopus 로고    scopus 로고
    • Polycystin-1 and polycystin-2 regulate the cell cycle through the helixloop-helix inhibitor Id2
    • Li X, Luo Y, Starremans PG, McNamara CA, Pei Y, Zhou J. 2005. Polycystin-1 and polycystin-2 regulate the cell cycle through the helixloop-helix inhibitor Id2. Nat Cell Biol 7:1202-1212.
    • (2005) Nat Cell Biol , vol.7 , pp. 1202-1212
    • Li, X.1    Luo, Y.2    Starremans, P.G.3    McNamara, C.A.4    Pei, Y.5    Zhou, J.6
  • 93
    • 0027135209 scopus 로고
    • The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A, E
    • Li Y, Graham C, Lacy S, Duncan AM, Whyte P. 1993. The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A, E. Genes Dev A 7:2366-2377.
    • (1993) Genes Dev A , vol.7 , pp. 2366-2377
    • Li, Y.1    Graham, C.2    Lacy, S.3    Duncan, A.M.4    Whyte, P.5
  • 95
    • 15444379011 scopus 로고    scopus 로고
    • Regulation of neuron survival and death by p130 and associated chromatin modifiers
    • Liu DX, Nath N, Chellappan SP, Greene LA. 2005. Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev 19:719-732.
    • (2005) Genes Dev , vol.19 , pp. 719-732
    • Liu, D.X.1    Nath, N.2    Chellappan, S.P.3    Greene, L.A.4
  • 96
    • 0344851640 scopus 로고    scopus 로고
    • Neuronal expression of cell cycle-related proteins after brain ischaemia in man
    • Love S. 2003. Neuronal expression of cell cycle-related proteins after brain ischaemia in man. Neurosci Lett 353:29-32.
    • (2003) Neurosci Lett , vol.353 , pp. 29-32
    • Love, S.1
  • 97
    • 0030053130 scopus 로고    scopus 로고
    • Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
    • Lukas J, Petersen BO, Holm K, Bartek J, Helin K. 1996. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol 16:1047-1057.
    • (1996) Mol Cell Biol , vol.16 , pp. 1047-1057
    • Lukas, J.1    Petersen, B.O.2    Holm, K.3    Bartek, J.4    Helin, K.5
  • 98
    • 0032549001 scopus 로고    scopus 로고
    • Rb interacts with histone deacetylase to repress transcription
    • Luo RX, Postigo AA, Dean DC. 1998. Rb interacts with histone deacetylase to repress transcription. Cell 92:463-473.
    • (1998) Cell , vol.92 , pp. 463-473
    • Luo, R.X.1    Postigo, A.A.2    Dean, D.C.3
  • 99
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod KF, Hu Y, Jacks T. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J 15:6178-6188.
    • (1996) EMBO J , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 100
    • 0037305849 scopus 로고    scopus 로고
    • Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system
    • MacPherson D, Sage J, Crowley D, Trumpp A, Bronson RT, Jacks T. 2003. Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system. Mol Cell Biol 23:1044-1053.
    • (2003) Mol Cell Biol , vol.23 , pp. 1044-1053
    • MacPherson, D.1    Sage, J.2    Crowley, D.3    Trumpp, A.4    Bronson, R.T.5    Jacks, T.6
  • 103
  • 104
    • 0030113694 scopus 로고    scopus 로고
    • E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest
    • Mann DJ, Jones NC. 1996. E2F-1 but not E2F-4 can overcome p16-induced G1 cell-cycle arrest. Curr Biol 6:474-483.
    • (1996) Curr Biol , vol.6 , pp. 474-483
    • Mann, D.J.1    Jones, N.C.2
  • 105
    • 0042977676 scopus 로고    scopus 로고
    • Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence
    • Marino S, Hoogervoorst D, Brandner S, Berns A. 2003. Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence. Development 130:3359-3368.
    • (2003) Development , vol.130 , pp. 3359-3368
    • Marino, S.1    Hoogervoorst, D.2    Brandner, S.3    Berns, A.4
  • 106
    • 0032996623 scopus 로고    scopus 로고
    • c-Myc regulates cyclin DCdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points
    • Mateyak MK, Obaya AJ, Sedivy JM. 1999. c-Myc regulates cyclin DCdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points. Mol Cell Biol 19:4672-4683.
    • (1999) Mol Cell Biol , vol.19 , pp. 4672-4683
    • Mateyak, M.K.1    Obaya, A.J.2    Sedivy, J.M.3
  • 107
    • 0029118035 scopus 로고
    • Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130
    • Mayol X, Garriga J, Grana X. 1995. Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130. Oncogene 11:801-808.
    • (1995) Oncogene , vol.11 , pp. 801-808
    • Mayol, X.1    Garriga, J.2    Grana, X.3
  • 109
    • 33750625694 scopus 로고    scopus 로고
    • In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates
    • McLear JA, Garcia-Fresco G, Bhat MA, Van Dyke TA. 2006. In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates. Mol Cell Neurosci 33:260-273.
    • (2006) Mol Cell Neurosci , vol.33 , pp. 260-273
    • McLear, J.A.1    Garcia-Fresco, G.2    Bhat, M.A.3    Van Dyke, T.A.4
  • 110
    • 0029769681 scopus 로고    scopus 로고
    • Overexpression of E2F1 in astrocytes leads to neoplastic transformation and changes in expression of retinoblastoma family members
    • Miyajima M, Nornes HO, Sato K, Neuman T. 1996. Overexpression of E2F1 in astrocytes leads to neoplastic transformation and changes in expression of retinoblastoma family members. J Neurosci Res 46:108-113.
    • (1996) J Neurosci Res , vol.46 , pp. 108-113
    • Miyajima, M.1    Nornes, H.O.2    Sato, K.3    Neuman, T.4
  • 111
    • 0029978325 scopus 로고    scopus 로고
    • E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
    • Moberg K, Starz MA, Lees JA. 1996. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol Cell Biol 16:1436-1449.
    • (1996) Mol Cell Biol , vol.16 , pp. 1436-1449
    • Moberg, K.1    Starz, M.A.2    Lees, J.A.3
  • 112
    • 0028918028 scopus 로고
    • Transcriptional regulation during the mammalian cell cycle
    • Muller R. 1995. Transcriptional regulation during the mammalian cell cycle. Trends Genet 11:173-178.
    • (1995) Trends Genet , vol.11 , pp. 173-178
    • Muller, R.1
  • 114
    • 0028136903 scopus 로고
    • Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
    • Neuman E, Flemington EK, Sellers WR, Kaelin WG Jr. 1994. Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol Cell Biol 14:6607-6615.
    • (1994) Mol Cell Biol , vol.14 , pp. 6607-6615
    • Neuman, E.1    Flemington, E.K.2    Sellers, W.R.3    Kaelin Jr., W.G.4
  • 115
    • 0037444453 scopus 로고    scopus 로고
    • Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1
    • Nguyen MD, Boudreau M, Kriz J, Couillard-Despres S, Kaplan DR, Julien JP. 2003. Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1. J Neurosci 23:2131-2140.
    • (2003) J Neurosci , vol.23 , pp. 2131-2140
    • Nguyen, M.D.1    Boudreau, M.2    Kriz, J.3    Couillard-Despres, S.4    Kaplan, D.R.5    Julien, J.P.6
  • 118
    • 34447562894 scopus 로고    scopus 로고
    • Expression of HOXC9 and E2F2 are up-regulated in CD133(1) cells isolated from human astrocytomas and associate with transformation of human astrocytes
    • Okamoto OK, Oba-Shinjo SM, Lopes L, Marie SKN. 2007. Expression of HOXC9 and E2F2 are up-regulated in CD133(1) cells isolated from human astrocytomas and associate with transformation of human astrocytes. Biochim Biophys Acta 1769:437-442.
    • (2007) Biochim Biophys Acta , vol.1769 , pp. 437-442
    • Okamoto, O.K.1    Oba-Shinjo, S.M.2    Lopes, L.3    Marie, S.K.N.4
  • 120
    • 0030860227 scopus 로고    scopus 로고
    • Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector
    • Parr MJ, Manome Y, Tanaka T, Wen P, Kufe DW, Kaelin WG Jr, Fine HA. 1997. Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nat Med 3:1145-1149.
    • (1997) Nat Med , vol.3 , pp. 1145-1149
    • Parr, M.J.1    Manome, Y.2    Tanaka, T.3    Wen, P.4    Kufe, D.W.5    Kaelin Jr, W.G.6    Fine, H.A.7
  • 121
    • 0032795614 scopus 로고    scopus 로고
    • E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation
    • Persengiev SP, Kondova II, Kilpatrick DL. 1999. E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. Mol Cell Biol 19:6048-6056.
    • (1999) Mol Cell Biol , vol.19 , pp. 6048-6056
    • Persengiev, S.P.1    Kondova II, K.D.L.2
  • 122
    • 0026440512 scopus 로고
    • Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding
    • Qian Y, Luckey C, Horton L, Esser M, Templeton DJ. 1992. Biological function of the retinoblastoma protein requires distinct domains for hyperphosphorylation and transcription factor binding. Mol Cell Biol 12:5363-5372.
    • (1992) Mol Cell Biol , vol.12 , pp. 5363-5372
    • Qian, Y.1    Luckey, C.2    Horton, L.3    Esser, M.4    Templeton, D.J.5
  • 123
    • 0034849106 scopus 로고    scopus 로고
    • Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis
    • Ranganathan S, Scudiere S, Bowser R. 2001. Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis. J Alzheimers Dis 3:377-385.
    • (2001) J Alzheimers Dis , vol.3 , pp. 377-385
    • Ranganathan, S.1    Scudiere, S.2    Bowser, R.3
  • 125
    • 0023652362 scopus 로고
    • Developmental control of a promoter-specific factor that is also regulated by the E1A gene product
    • Reichel R, Kovesdi I, Nevins JR. 1987. Developmental control of a promoter-specific factor that is also regulated by the E1A gene product. Cell 48:501-506.
    • (1987) Cell , vol.48 , pp. 501-506
    • Reichel, R.1    Kovesdi, I.2    Nevins, J.R.3
  • 131
    • 0037968010 scopus 로고    scopus 로고
    • Basic helix-loop-helix factors in cortical development
    • Ross SE, Greenberg ME, Stiles CD. 2003. Basic helix-loop-helix factors in cortical development. Neuron 39:13-25.
    • (2003) Neuron , vol.39 , pp. 13-25
    • Ross, S.E.1    Greenberg, M.E.2    Stiles, C.D.3
  • 136
    • 0030747725 scopus 로고    scopus 로고
    • Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals
    • Sears R, Ohtani K, Nevins JR. 1997. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. Mol Cell Biol 17:5227-5235.
    • (1997) Mol Cell Biol , vol.17 , pp. 5227-5235
    • Sears, R.1    Ohtani, K.2    Nevins, J.R.3
  • 137
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr CJ, Roberts JM. 1999. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 138
    • 8644219655 scopus 로고    scopus 로고
    • Living with or without cyclins and cyclindependent kinases
    • Sherr CJ, Roberts JM. 2004. Living with or without cyclins and cyclindependent kinases. Genes Dev 18:2699-2711.
    • (2004) Genes Dev , vol.18 , pp. 2699-2711
    • Sherr, C.J.1    Roberts, J.M.2
  • 139
    • 0032559849 scopus 로고    scopus 로고
    • A critical temporal requirement for the retinoblastoma protein family during neuronal determination
    • Slack RS, El-Bizri H, Wong J, Belliveau DJ, Miller FD. 1998. A critical temporal requirement for the retinoblastoma protein family during neuronal determination. J Cell Biol 140:1497-1509.
    • (1998) J Cell Biol , vol.140 , pp. 1497-1509
    • Slack, R.S.1    El-Bizri, H.2    Wong, J.3    Belliveau, D.J.4    Miller, F.D.5
  • 140
    • 0027280578 scopus 로고
    • Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells
    • Slack RS, Hamel PA, Bladon TS, Gill RM, McBurney MW. 1993. Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells. Oncogene 8:1585-1591.
    • (1993) Oncogene , vol.8 , pp. 1585-1591
    • Slack, R.S.1    Hamel, P.A.2    Bladon, T.S.3    Gill, R.M.4    McBurney, M.W.5
  • 141
    • 0031815206 scopus 로고    scopus 로고
    • Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth
    • Smith EJ, Leone G, Nevins JR. 1998. Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth. Cell Growth Differ 9:297-303.
    • (1998) Cell Growth Differ , vol.9 , pp. 297-303
    • Smith, E.J.1    Leone, G.2    Nevins, J.R.3
  • 142
    • 0036023975 scopus 로고    scopus 로고
    • Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6
    • Storre J, Elsasser HP, Fuchs M, Ullmann D, Livingston DM, Gaubatz S. 2002. Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6. EMBO Rep 3:695-700.
    • (2002) EMBO Rep , vol.3 , pp. 695-700
    • Storre, J.1    Elsasser, H.P.2    Fuchs, M.3    Ullmann, D.4    Livingston, D.M.5    Gaubatz, S.6
  • 144
    • 27144547207 scopus 로고    scopus 로고
    • Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development
    • Swetloff A, Ferretti P. 2005. Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. Int J Dev Biol 49:859-865.
    • (2005) Int J Dev Biol , vol.49 , pp. 859-865
    • Swetloff, A.1    Ferretti, P.2
  • 145
    • 0034175616 scopus 로고    scopus 로고
    • Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
    • Takahashi Y, Rayman JB, Dynlacht BD. 2000. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression. Genes Dev 14:804-816.
    • (2000) Genes Dev , vol.14 , pp. 804-816
    • Takahashi, Y.1    Rayman, J.B.2    Dynlacht, B.D.3
  • 146
    • 0034114458 scopus 로고    scopus 로고
    • Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
    • Tallquist MD, Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26:113-115.
    • (2000) Genesis , vol.26 , pp. 113-115
    • Tallquist, M.D.1    Soriano, P.2
  • 147
    • 0028841550 scopus 로고
    • In vivo structure of the human cdc2 promoter: Release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression
    • Tommasi S, Pfeifer GP. 1995. In vivo structure of the human cdc2 promoter: Release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol Cell Biol 15:6901-6913.
    • (1995) Mol Cell Biol , vol.15 , pp. 6901-6913
    • Tommasi, S.1    Pfeifer, G.P.2
  • 149
    • 0035852632 scopus 로고    scopus 로고
    • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
    • Trimarchi JM, Fairchild B, Wen J, Lees JA. 2001. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci USA 98:1519-1524.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1519-1524
    • Trimarchi, J.M.1    Fairchild, B.2    Wen, J.3    Lees, J.A.4
  • 151
    • 0029997146 scopus 로고    scopus 로고
    • The CBP co-activator stimulates E2F1/DP1 activity
    • Trouche D, Cook A, Kouzarides T. 1996. The CBP co-activator stimulates E2F1/DP1 activity. Nucleic Acids Res 24:4139-4145.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4139-4145
    • Trouche, D.1    Cook, A.2    Kouzarides, T.3
  • 152
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai KY, Hu Y, Macleod KF, Crowley D, Yamasaki L, Jacks T. 1998. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 2:293-304.
    • (1998) Mol Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 154
    • 0028902381 scopus 로고
    • Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members
    • Vairo G, Livingston DM, Ginsberg D. 1995. Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev 9:869-881.
    • (1995) Genes Dev , vol.9 , pp. 869-881
    • Vairo, G.1    Livingston, D.M.2    Ginsberg, D.3
  • 155
    • 50149108858 scopus 로고    scopus 로고
    • Conserved functions of the pRB and E2F families
    • van den Heuvel S, Dyson NJ. 2008. Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol 9:713-724.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 713-724
    • van den Heuvel, S.1    Dyson, N.J.2
  • 158
    • 0030062245 scopus 로고    scopus 로고
    • Mitotic mechanisms in Alzheimer's disease?
    • Vincent I, Rosado M, Davies P. 1996. Mitotic mechanisms in Alzheimer's disease? J Cell Biol 132:413-425.
    • (1996) J Cell Biol , vol.132 , pp. 413-425
    • Vincent, I.1    Rosado, M.2    Davies, P.3
  • 159
    • 0037063164 scopus 로고    scopus 로고
    • Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells
    • Vooijs M, te Riele H, van der Valk M, Berns A. 2002. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene 21: 4635-4645.
    • (2002) Oncogene , vol.21 , pp. 4635-4645
    • Vooijs, M.1    te Riele, H.2    van der3    Valk, M.4    Berns, A.5
  • 160
    • 36248982140 scopus 로고    scopus 로고
    • E2F1 works as a cell cycle suppressor in mature neurons
    • Wang L, Wang R, Herrup K. 2007. E2F1 works as a cell cycle suppressor in mature neurons. J Neurosci 27:12555-12564.
    • (2007) J Neurosci , vol.27 , pp. 12555-12564
    • Wang, L.1    Wang, R.2    Herrup, K.3
  • 161
    • 0033857983 scopus 로고    scopus 로고
    • Target gene specificity of E2F and pocket protein family members in living cells
    • Wells J, Boyd KE, Fry CJ, Bartley SM, Farnham PJ. 2000. Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol 20:5797-5807.
    • (2000) Mol Cell Biol , vol.20 , pp. 5797-5807
    • Wells, J.1    Boyd, K.E.2    Fry, C.J.3    Bartley, S.M.4    Farnham, P.J.5
  • 162
    • 0030042598 scopus 로고    scopus 로고
    • Regulation of the cell cycle machinery by oncogenic ras
    • Winston JT, Coats SR, Wang YZ, Pledger WJ. 1996. Regulation of the cell cycle machinery by oncogenic ras. Oncogene 12:127-134.
    • (1996) Oncogene , vol.12 , pp. 127-134
    • Winston, J.T.1    Coats, S.R.2    Wang, Y.Z.3    Pledger, W.J.4
  • 163
    • 1842413645 scopus 로고    scopus 로고
    • p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
    • Woo MS, Sanchez I, Dynlacht BD. 1997. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity. Mol Cell Biol 17:3566-3579.
    • (1997) Mol Cell Biol , vol.17 , pp. 3566-3579
    • Woo, M.S.1    Sanchez, I.2    Dynlacht, B.D.3
  • 166
    • 0030015264 scopus 로고    scopus 로고
    • Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases
    • Xiao ZX, Ginsberg D, Ewen M, Livingston DM. 1996. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc Natl Acad Sci USA 93:4633-4637.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4633-4637
    • Xiao, Z.X.1    Ginsberg, D.2    Ewen, M.3    Livingston, D.M.4
  • 167
    • 35949000033 scopus 로고    scopus 로고
    • A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members
    • Xu X, Bieda M, Jin VX, Rabinovich A, Oberley MJ, Green R, Farnham PJ. 2007. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res 17:1550-1561.
    • (2007) Genome Res , vol.17 , pp. 1550-1561
    • Xu, X.1    Bieda, M.2    Jin, V.X.3    Rabinovich, A.4    Oberley, M.J.5    Green, R.6    Farnham, P.J.7
  • 169
    • 0035871660 scopus 로고    scopus 로고
    • DNA replication precedes neuronal cell death in Alzheimer's disease
    • Yang Y, Geldmacher DS, Herrup K. 2001. DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 21:2661-2668.
    • (2001) J Neurosci , vol.21 , pp. 2661-2668
    • Yang, Y.1    Geldmacher, D.S.2    Herrup, K.3
  • 170
    • 0023372582 scopus 로고
    • Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex
    • Yee AS, Reichel R, Kovesdi I, Nevins JR. 1987. Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multi-component complex. EMBO J 6:2061-2068.
    • (1987) EMBO J , vol.6 , pp. 2061-2068
    • Yee, A.S.1    Reichel, R.2    Kovesdi, I.3    Nevins, J.R.4
  • 172
    • 0035924692 scopus 로고    scopus 로고
    • Id proteins in cell cycle control and cellular senescence
    • Zebedee Z, Hara E. 2001. Id proteins in cell cycle control and cellular senescence. Oncogene 20:8317-8325.
    • (2001) Oncogene , vol.20 , pp. 8317-8325
    • Zebedee, Z.1    Hara, E.2
  • 174
    • 0028983384 scopus 로고
    • p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
    • Zhu L, Harlow E, Dynlacht BD. 1995a. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev 9:1740-1752.
    • (1995) Genes Dev , vol.9 , pp. 1740-1752
    • Zhu, L.1    Harlow, E.2    Dynlacht, B.D.3
  • 175
    • 0029054133 scopus 로고
    • Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins
    • Zhu L, Zhu L, Xie E, Chang LS. 1995b. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol Cell Biol 15:3552-3562.
    • (1995) Mol Cell Biol , vol.15 , pp. 3552-3562
    • Zhu, L.1    Zhu, L.2    Xie, E.3    Chang, L.S.4
  • 176
    • 0035118893 scopus 로고    scopus 로고
    • E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
    • Ziebold U, Reza T, Caron A, Lees JA. 2001. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev 15:386-391.
    • (2001) Genes Dev , vol.15 , pp. 386-391
    • Ziebold, U.1    Reza, T.2    Caron, A.3    Lees, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.