Requirements for cell cycle arrest by p16(INK4a)

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 737-742

  Bruce, Jacqueline L ^a   Hurford Jr , Robert K ^a   Classon, Marie ^a   Koh, James ^a   Dyson, Nicholas ^a  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; PEPTIDES AND PROTEINS; PROTEIN P107; PROTEIN P130; PROTEIN P16; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; COMPARATIVE ANATOMY; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; EMBRYO; FIBROBLAST; GENE MUTATION; MITOSIS INHIBITION; MOUSE; NONHUMAN; REGULATORY MECHANISM; TUMOR CELL;

ANIMALIA;

EID: 0033636905     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00072-1     Document Type: Article

References (59)

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3. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation
4. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
5. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F
6. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs
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8. Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma
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11. Shared role of the pRB-related p130 and p107 proteins in limb development
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13. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
14. A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
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16. The regulation of E2F by pRB-family proteins
17. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins
18. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control
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20. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
21. pRB plays an essential role in cell cycle arrest induced by DNA damage
22. CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines
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38. Control of pRB phosphorylation
39. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
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41. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
42. Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB
43. Production of high-titre helper-free retroviruses by transient transfection
44. p107 is a suppressor of retinoblastoma development in pRB-deficient mice
45. CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
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48. CDK inhibitors: Positive and negative regulators of G1-phase progression
49. Cancer cell cycles
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51. Ovarian cancer cells that coexpress endogenous Rb and p16 are insensitive to overexpression of functional p16 protein
52. E2F activity is regulated by cell cycle-dependent changes in subcellular localization
53. The retinoblastoma protein and cell cycle control
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55. p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
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57. Transcriptional repression by the Rb-related protein p107
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