메뉴 건너뛰기




Volumn 23, Issue 3, 2003, Pages 1044-1053

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN; PROTEIN LOXP; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

EID: 0037305849     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.3.1044-1053.2003     Document Type: Article
Times cited : (128)

References (54)
  • 1
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • Almasan, A., Y. Yin, R. E. Kelly, E. Y. Lee, A. Bradley, W. Li, J. R. Bertino, and G. M. Wahl. 1995. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. Natl. Acad. Sci. USA 92:5436-5440.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.4    Bradley, A.5    Li, W.6    Bertino, J.R.7    Wahl, G.M.8
  • 3
    • 0032578028 scopus 로고    scopus 로고
    • Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
    • Banasiak, K. J., and G. G. Haddad. 1998. Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res. 797:295-304.
    • (1998) Brain Res. , vol.797 , pp. 295-304
    • Banasiak, K.J.1    Haddad, G.G.2
  • 6
    • 0034720190 scopus 로고    scopus 로고
    • Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis
    • Boutillier, A. L., E. Trinh, and J. P. Loeffler. 2000. Caspase-dependent cleavage of the retinoblastoma protein is an early step in neuronal apoptosis. Oncogene 19:2171-2178.
    • (2000) Oncogene , vol.19 , pp. 2171-2178
    • Boutillier, A.L.1    Trinh, E.2    Loeffler, J.P.3
  • 8
    • 0030999788 scopus 로고    scopus 로고
    • Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding
    • Chen, W. D., G. A. Otterson, S. Lipkowitz, S. N. Khleif, A. B. Coxon, and F. J. Kaye. 1997. Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding. Oncogene 14:1243-1248.
    • (1997) Oncogene , vol.14 , pp. 1243-1248
    • Chen, W.D.1    Otterson, G.A.2    Lipkowitz, S.3    Khleif, S.N.4    Coxon, A.B.5    Kaye, F.J.6
  • 10
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson, N. 1998. The regulation of E2F by pRB-family proteins. Genes Dev. 12:2245-2262.
    • (1998) Genes Dev. , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 13
    • 0033118160 scopus 로고    scopus 로고
    • Developmental basis of retinal-specific induction of cancer by RB mutation
    • Gallie, B. L., C. Campbell, H. Devlin, A. Duckett, and J. A. Squire. 1999. Developmental basis of retinal-specific induction of cancer by RB mutation. Cancer Res, 59:1731s-1735s.
    • (1999) Cancer Res. , vol.59
    • Gallie, B.L.1    Campbell, C.2    Devlin, H.3    Duckett, A.4    Squire, J.A.5
  • 14
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 15
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber, T. G., C. Osmanian, T. Jacks, D. E. Housman, C. J. Koch, S. W. Lowe, and A. J. Giaccia. 1996. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    Housman, D.E.4    Koch, C.J.5    Lowe, S.W.6    Giaccia, A.J.7
  • 17
    • 0035576791 scopus 로고    scopus 로고
    • Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis
    • Guo, Z., S. Yikang, H. Yoshida, T. W. Mak, and E. Zacksenhaus. 2001. Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Cancer Res. 61:8395-8400.
    • (2001) Cancer Res. , vol.61 , pp. 8395-8400
    • Guo, Z.1    Yikang, S.2    Yoshida, H.3    Mak, T.W.4    Zacksenhaus, E.5
  • 18
    • 0033566792 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53
    • Halterman, M. W., C. C. Miller, and H. J. Federoff. 1999. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. J. Neurosci. 19:6818-6824.
    • (1999) J. Neurosci. , vol.19 , pp. 6818-6824
    • Halterman, M.W.1    Miller, C.C.2    Federoff, H.J.3
  • 20
    • 0030846593 scopus 로고    scopus 로고
    • Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis
    • Hu, N., M. L. Gulley, J. T. Kung, and E. Y. Lee. 1997. Retinoblastoma gene deficiency has mitogenic but not tumorigenic effects on erythropoiesis. Cancer Res. 57:4123-4129.
    • (1997) Cancer Res. , vol.57 , pp. 4123-4129
    • Hu, N.1    Gulley, M.L.2    Kung, J.T.3    Lee, E.Y.4
  • 21
    • 0028174064 scopus 로고
    • Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
    • Hu, N., A. Gutsmann, D. C. Herbert, A. Bradley, W. H. Lee, and E. Y. Lee. 1994, Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene 9:1021-1027.
    • (1994) Oncogene , vol.9 , pp. 1021-1027
    • Hu, N.1    Gutsmann, A.2    Herbert, D.C.3    Bradley, A.4    Lee, W.H.5    Lee, E.Y.6
  • 23
    • 0030462563 scopus 로고    scopus 로고
    • Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis
    • Janicke, R. U., P. A. Walker, X. Y. Lin, and A. G. Porter. 1996. Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J. 15:6969-6978.
    • (1996) EMBO J. , vol.15 , pp. 6969-6978
    • Janicke, R.U.1    Walker, P.A.2    Lin, X.Y.3    Porter, A.G.4
  • 24
    • 0031992159 scopus 로고    scopus 로고
    • E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
    • Kowalik, T. F., J. DeGregori, G. Leone, L. Jakoi, and J. R. Nevins. 1998. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 9:113-118.
    • (1998) Cell Growth Differ. , vol.9 , pp. 113-118
    • Kowalik, T.F.1    DeGregori, J.2    Leone, G.3    Jakoi, L.4    Nevins, J.R.5
  • 25
    • 0034609818 scopus 로고    scopus 로고
    • Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
    • Lasorella, A., M. Noseda, M. Beyna, Y. Yokota, and A. Iavarone. 2000. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 407:592-598.
    • (2000) Nature , vol.407 , pp. 592-598
    • Lasorella, A.1    Noseda, M.2    Beyna, M.3    Yokota, Y.4    Iavarone, A.5
  • 26
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee, E. Y., C. Y. Chang, N. Hu, Y. C. Wang, C. C. Lai, K. Herrup, W. H. Lee, and A. Bradley. 1992. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359:288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6    Lee, W.H.7    Bradley, A.8
  • 27
    • 0028131540 scopus 로고
    • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
    • Lee, E. Y., N. Hu, S. S. Yuan, L. A. Cox, A. Bradley, W. H. Lee, and K. Herrup. 1994. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev, 8:2008-2021.
    • (1994) Genes Dev. , vol.8 , pp. 2008-2021
    • Lee, E.Y.1    Hu, N.2    Yuan, S.S.3    Cox, L.A.4    Bradley, A.5    Lee, W.H.6    Herrup, K.7
  • 28
    • 0028263192 scopus 로고
    • p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats
    • Li, Y., M. Chopp, Z. G. Zhang, C. Zaloga, L. Niewenhuis, and S. Gautam. 1994. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke 25:849-856.
    • (1994) Stroke , vol.25 , pp. 849-856
    • Li, Y.1    Chopp, M.2    Zhang, Z.G.3    Zaloga, C.4    Niewenhuis, L.5    Gautam, S.6
  • 29
    • 0033590071 scopus 로고    scopus 로고
    • The retinoblastoma gene family in differentiation and development
    • Lipinski, M. M., and T. Jacks. 1999. The retinoblastoma gene family in differentiation and development. Oncogene 18:7873-7882.
    • (1999) Oncogene , vol.18 , pp. 7873-7882
    • Lipinski, M.M.1    Jacks, T.2
  • 30
    • 0035796491 scopus 로고    scopus 로고
    • Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system
    • Lipinski, M. M., K. F. Macleod, B. O. Williams, T. L. Mullaney, D. Crowley, and T. Jacks. 2001. Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system. EMBO J. 20:3402-3413.
    • (2001) EMBO J. , vol.20 , pp. 3402-3413
    • Lipinski, M.M.1    Macleod, K.F.2    Williams, B.O.3    Mullaney, T.L.4    Crowley, D.5    Jacks, T.6
  • 31
    • 0035829650 scopus 로고    scopus 로고
    • Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
    • Liu, D. X., and L. A. Greene. 2001. Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32:425-438.
    • (2001) Neuron , vol.32 , pp. 425-438
    • Liu, D.X.1    Greene, L.A.2
  • 33
    • 0029910628 scopus 로고    scopus 로고
    • Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
    • Macleod, K. F., Y. Hu, and T. Jacks. 1996. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 15:6178-6188.
    • (1996) EMBO J. , vol.15 , pp. 6178-6188
    • Macleod, K.F.1    Hu, Y.2    Jacks, T.3
  • 34
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbesser, S. D., B. O. Williams, T. Jacks, and R. A. DePinho. 1994. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371:72-74.
    • (1994) Nature , vol.371 , pp. 72-74
    • Morgenbesser, S.D.1    Williams, B.O.2    Jacks, T.3    DePinho, R.A.4
  • 35
    • 0028334011 scopus 로고
    • Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
    • Pan, H., and A. E. Griep. 1994. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev. 8:1285-1299.
    • (1994) Genes Dev. , vol.8 , pp. 1285-1299
    • Pan, H.1    Griep, A.E.2
  • 36
    • 0032160407 scopus 로고    scopus 로고
    • Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
    • Pan, H., C. Yin, N. J. Dyson, E. Harlow, L. Yamasaki, and T. Van Dyke. 1998. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol. Cell 2:283-292.
    • (1998) Mol. Cell , vol.2 , pp. 283-292
    • Pan, H.1    Yin, C.2    Dyson, N.J.3    Harlow, E.4    Yamasaki, L.5    Van Dyke, T.6
  • 40
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X. Q., D. M. Livingston, W. G. Kaelin, Jr., and P. D. Adams. 1994. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91:10918-10922.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin W.G., Jr.3    Adams, P.D.4
  • 42
    • 0030899360 scopus 로고    scopus 로고
    • Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death
    • Tan, X., S. J. Martin, D. R. Green, and J. Y. Wang. 1997. Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death. J. Biol. Chem. 272:9613-9616.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9613-9616
    • Tan, X.1    Martin, S.J.2    Green, D.R.3    Wang, J.Y.4
  • 43
    • 0033397681 scopus 로고    scopus 로고
    • Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    • Trumpp, A., M. J. Depew, J. L. Rubenstein, J. M. Bishop, and G. R. Martin. 1999. Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev. 13:3136-3148.
    • (1999) Genes Dev. , vol.13 , pp. 3136-3148
    • Trumpp, A.1    Depew, M.J.2    Rubenstein, J.L.3    Bishop, J.M.4    Martin, G.R.5
  • 44
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-I suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai, K. Y., Y. Hu, K. F. Macleod, D. Crowley, L. Yamasaki, and T. Jacks. 1998. Mutation of E2f-I suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol. Cell 2:293-304.
    • (1998) Mol. Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 46
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 48
    • 0027968207 scopus 로고
    • Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences
    • Williams, B. O., E. M. Schmitt, L. Remington, R. T. Bronson, D. M. Albert, R. A. Weinberg, and T. Jacks. 1994. Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 13:4251-4259.
    • (1994) EMBO J. , vol.13 , pp. 4251-4259
    • Williams, B.O.1    Schmitt, E.M.2    Remington, L.3    Bronson, R.T.4    Albert, D.M.5    Weinberg, R.A.6    Jacks, T.7
  • 49
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X., and A. J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 51
    • 0034214304 scopus 로고    scopus 로고
    • Nestin expression during mouse eye and lens development
    • Yang, J., W. Bian, X. Gao, L. Chen, and N. Jing. 2000. Nestin expression during mouse eye and lens development. Mech. Dev. 94:287-291.
    • (2000) Mech. Dev. , vol.94 , pp. 287-291
    • Yang, J.1    Bian, W.2    Gao, X.3    Chen, L.4    Jing, N.5
  • 52
    • 0029819994 scopus 로고    scopus 로고
    • pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
    • Zacksenhaus, E., Z. Jiang, D. Chung, J. D. Marth, R. A. Phillips, and B. L. Gallie. 1996. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 10:3051-3064.
    • (1996) Genes Dev. , vol.10 , pp. 3051-3064
    • Zacksenhaus, E.1    Jiang, Z.2    Chung, D.3    Marth, J.D.4    Phillips, R.A.5    Gallie, B.L.6
  • 53
    • 0037151032 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
    • Zhu, Y., X. O. Mao, Y. Sun, Z. Xia, and D. A. Greenberg. 2002. p38 mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J. Biol. Chem. 277:22909-22914.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22909-22914
    • Zhu, Y.1    Mao, X.O.2    Sun, Y.3    Xia, Z.4    Greenberg, D.A.5
  • 54
    • 0035118893 scopus 로고    scopus 로고
    • E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
    • Ziebold, U., T. Reza, A. Caron, and J. A. Lees. 2001. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev. 15:386-391.
    • (2001) Genes Dev. , vol.15 , pp. 386-391
    • Ziebold, U.1    Reza, T.2    Caron, A.3    Lees, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.