Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth

Cell Growth and Differentiation

Volumn 9, Issue 4, 1998, Pages 297-303

  Smith, Eric J ^a   Leone, Gustave ^a   Nevins, Joseph R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL STIMULATION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; TRANSCRIPTION REGULATION;

EID: 0031815206     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Nevins, J. R. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (Washington DC), 258: 424-429, 1992.
2. Helin, K., and Harlow, E. The retinoblastoma protein as a transcriptional represser. Trends Cell Biol., 3: 43-46, 1993.
3. La Thangue, N. B. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci., 19: 108-114, 1994.
4. 1 cell state. Mol. Cell. Biol., 16; 6965-6976, 1996.
5. Beijersbergen, R. L., Kerkhoven, R. M., Zhu, L., Carlee, L., Voorhoeve, P. M., and Bernards, R. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev., 8: 2680-2690, 1994.
6. Vairo, G., Livingston, D. M., and Ginsberg, D. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9: 869-881, 1995.
7. Ginsberg, D., Vairo, G., Chittenden, T., Xiao, Z-X., Xu, G., Wydner, K. L., DeCaprio, J. A., Lawrence, J. B., and Livingston, D. M. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev., 8: 2665-2679, 1994.
8. Ikeda, M-A., Jakoi, L., and Nevins, J. R. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA, 93: 3215-3220, 1996.
9. Moberg, K., Starz, M. A., and Lees, J. A. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Mol. Cell. Biol., 16: 1436-1449, 1996.
10. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T., and Weinberg, R. A. Cell cycle specific association of E2F with the p130 E1A-binding protein. Genes Dev., 7: 2392-2404, 1993.
11. Johnson, D. G., Ohtani, K., and Nevins, J. R. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev., 8: 1514-1525, 1994.
12. Hsiao, K-M., McMahon, S. L., and Farnham, P. J. Multiple DMA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev., 8: 1526-1537, 1994.
13. Lam, E. W., and Watson, R. J. An E2F-binding site mediates cell-cycle-regulated repression of mouse B-myb transcription. EMBO J., 12: 2705-2713, 1993.
14. Neuman, E., Flemington, E. K., Sellers, W. R., and Kaelin, W. G., Jr. Transcription of the E2F-1 gene is rendered cell cycle-dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol., 14: 6607-6615, 1994.
15. Sears, R., Ohtani, K., and Nevins, J. R. Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signais. Mol. Cell. Biol., 17: 5227-5235, 1997.
16. Ohtani, K., DeGregori, J., Leone, G., Herendeen, D. R., Kelly, T. J., and Nevins, J. R. Expression of the HsOrc1 gene, a human ORC homolog, is regulated by cell proliferation via the E2F transcription factor. Mol. Cell. Biol., 16: 6977-6984, 1996.
17. Zwicker, J., Liu, N., Engeland, K., Lucibello, F. C., and Muller, R. Cell cycle regulation of E2F site occupation in vivo. Science {Washington DC), 271: 1595-1596, 1996.
18. Hurford, R. K., Jr., Cobrinik, D., Lee, M-H., and Dyson, N. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev., 11: 1447-1463, 1997.
19. Lander, E. S. The new genomics: global views of biology. Science (Washington DC), 274: 536-539, 1996.
20. Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M., and Roberts, J. M. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev., 10:1979-1990, 1996.
21. Tsai, D. E., Harper, D. S., and Keene, J. D. U1-snRNP-A protein selects a ten-nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts. Nucleic Acids Res., 19: 4931-4936, 1991.
22. Tsai, D. E., Kenan, D. J., and Keene, J. D. In vitro selection of an RNA epitope immunologically cross-reactive with a peptide. Proc. Natl. Acad. Sci. USA, 89: 8864-8868, 1992.
23. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell, 75: 495-505, 1993.
24. Thompson, J. B., Ayers, D. F., Malmstrom, T. A., McKenzie, T. L., Ganousis, L., Chowrira, B. M., Couture, L., and Stinchcomb, D. T. Improved accumulation and activity of ribozymes expressed from a tRNA- based RNA polymerase III promoter. Nucleic Acids Res., 23: 2259-2268, 1995.
25. Adachi, M., Suematsu, S., Suda, T., Watanabe, D., Fukuyama, H., Ogasawara, J., Tanaka, T., Yoshida, N., and Nagata, S. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad. Sci. USA, 93: 2131-2136, 1996.
26. Kenan, D. J., Tsai, D. E., and Keene, J. D. Exploring molecular diversity with combinatorial shape libraries. Trends Biochem. Sci., 19: 57-64, 1994.
27. Nagata, S. Apoptosis by death factor. Cell, 88: 355-365, 1997.
28. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, R. D. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (Washington DC), 268: 726-731, 1995.
29. Zhu, L., Xie, E., and Chang, L-S. Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. Mol. Cell. Biol., 15: 3552-3562, 1995.
30. Won, K-A., and Reed, S. I. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J., 15: 4182-4193, 1996.
31. Cobrinik, D., Lee, M-H., Hannon, G., Mulligan, G., Bronson, R. T., Dyson, N., Harlow, E., Beach, D., Weinberg, R. A., and Jacks, T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev., 10: 1633-1644, 1996.
32. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T., and Weinberg, R. A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev., 7: 2392-2404, 1993.
33. Johnson, D. G. Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene, 11: 1685-1692, 1995.
34. Shiyanov, P., Bagchi, S., Adami, G., Kokontis, J., Hay, N., Arroyo, M., Morozov, A., and Raychaudhuri, P. p21 disrupts the interaction between cdk2 and the E2F-p130 complex, Mol. Cell. Biol., 16: 737-744, 1996.
35. Tommasi, S., and Pfeifer, G. P. In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol., 15: 6901-6913, 1995.
36. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
37. 6 myoblast differentiation. Cell Growth Differ., 6: 1287-1298, 1995.
38. 1-S regulatory genes. Mol. Cell. Biol., 15: 4215-4224, 1995.
39. DeCaprio, J. A., Ludlow, J. W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica Worms, H., Huang, C. M., and Livingston, D. M. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell, 58: 1085-1095, 1989.
40. Hiebert, S. W., Chellappan, S. P., Horowitz, J. M., and Nevins, J. R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev., 6: 177-185, 1992.