E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

Molecular Cell

Volumn 6, Issue 3, 2000, Pages 729-735

  Gaubatz, Stefan ^a   Lindeman, Geoffrey J ^c   Ishida, Seiichi ^b   Jakoi, Laszlo ^b   Nevins, Joseph R ^b   Livingston, David M ^a   Rempel, Rachel E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; TRANSCRIPTION FACTOR E2F;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; GENE INACTIVATION; LETHALITY; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; REGULATORY MECHANISM;

ANIMALIA;

EID: 0033634869     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00071-X     Document Type: Article

References (41)

1. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo
2. Requirements for cell cycle arrest by p16INK4a
3. p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
4. Shared role of the pRB-related p130 and p107 proteins in limb development
5. Expression patterns of the E2F family of transcription factors during mouse nervous system development
6. Expression patterns of the E2F family of transcription factors during murine epithelial development
7. The regulation of E2F by pRB-family proteins
8. E2F-4, a new member of the E2F transcription factor family, interacts with p107
9. Growth suppression by p18, a p16INK4/MTS1-and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
10. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
11. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit
12. E2f3 is critical for normal cellular proliferation
13. pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes
14. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
15. Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression
16. Functions of the retinoblastoma protein
17. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
18. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
19. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
20. E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites
21. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
22. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
23. Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
24. Growth suppression by p16ink4 requires functional retinoblastoma protein
25. Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)
26. Control of pRB phosphorylation
27. Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein
28. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
29. The retinoblastoma gene family: Cousins with overlapping interests
30. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
31. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
32. Loss of E2F4 activity leads to abnormal development of multiple cellular lineages
33. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle
34. Role of the INK4a locus in tumor suppression and cell mortality
35. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
36. Cancer cell cycles
37. CDK inhibitors: Positive and negative regulators of G1-phase progression
38. Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
39. Distinct roles for cyclin-dependent kinases in cell cycle control
40. Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts
41. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFβ, and contact inhibition