Expression patterns of retinoblastoma protein in Parkinson disease

Journal of Neuropathology and Experimental Neurology

Volumn 62, Issue 1, 2003, Pages 68-74

  Jordan Sciutto, Kelly L ^b   Dorsey, Robert ^b   Chalovich, Elisabeth M ^b   Hammond, Robert R ^a   Achim, Cristian L ^b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b NONE

Author keywords

Brain; E2F1; Lewy bodies; Neurodegeneration; Parkinson disease; Retinoblastoma protein

Indexed keywords

CELL CYCLE PROTEIN; RETINOBLASTOMA PROTEIN;

AGED; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DOPAMINE RELEASE; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NERVE DEGENERATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOBLASTOMA; STAINING; STIMULUS RESPONSE; SUBSTANTIA NIGRA;

EID: 0037229278     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/62.1.68     Document Type: Article

References (44)

1. Cote L, Crutcher M. The basal ganglia, In: Kandel E, Schwartz J, Jessell T, eds. Principles of neural science, New York: Elsevier Science Publishing Co, Inc., 1991:653-56
2. Jenner P, Olanow C, Understanding cell death in Parkinson's disease. Ann Neurol 1998;44(suppl 1):S72-S84
3. Daily D, Barzilai A, Often D, Kamsler A, Melamed E, Ziv I. The involvement of p53 in dopamine induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53. Cell Mol Neurobiol 1999;19:261-76
4. Park D, Morris E, Greene L, Geller H, G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppression camptothecin-induced neuronal apoptosis. J Neurosci 1997;17:1256-70
5. Park D, Morris E, Bremmer R, et al, Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons by DNA damage. J Neurosci 2000;20:3104-14
6. Chellappan S, Hiebert S, Mudryj M, Horowitz J, Nevins J. The E2F transcription factor is a cellular target for the RB protein. Cell 1991;65:1053-61
7. Chellappan S, Kraus V, Droger B, et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product, Proc Natl Acad Sci, U S A 1992;89:4549-53
8. , Black AR, Azizkhan-Clifford J. Regulation of E2F: A family of transcription factors involved in proliferation control. Gene 1999; 237:281-302
9. Giovanni A, Wirtz-Bruger F, Keramaris E, Slack R, Park D. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F-DP, in β-amyloid-induced neuronal death. J Biol Chem 1999;274:19011-16
10. Giovanni A, Keramaris E, Morris E, et al. E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and Caspase 3. J Biol Chem 2000;275:11553-60
11. Hou ST, Cowan E, Walker T, et al. The transcription factor E2F1 promotes dopamine-evoked neuronal apoptosis by a mechanism independent of transcriptional activation. J Neurochem 2001;78:287-97
12. Pan H, Yin C, Dyson N, Harlow E, Yamasaki L, Van Dyke T. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell 1998;2:283-92
13. Lee EY, Hu N, Yuan SS, Cox LA, Bradley A, Lee WH, Herrup K. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev 1994;8:2008-21
14. Tsai KY, Hu Y, Macleod K, Crowley D, Yamasaki L, Jacks T. Mutation of E2F1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 1998;2:293-304
15. Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer's disease, Neurol 1995;45:461-66
16. Guy C, Zhou W, Kaufman S, Robinson M. E2F1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol Cell Biol 1996;16:685-93
17. Riley D, Nikitin A, Lee W-H. Adenovirus-mediated retinoblastoma gene therapy suppresses spontaneous pituitary melanotrophic tumors in Rb± mice, Genes Dev 1996;10:1870-79
18. Silverstein M, Poller D, Waisman J, et al. Prognostic classification of breast ductal carcinoma-in-situ, Lancet 1995;345:1154-57
19. Jordan-Sciutto K, Wang G, Murphy-Corb M, Wiley C. Induction of cell cycle regulators in simian immunodeficiency virus encephalitis. Am J Pathol 2000;157:497-507
20. Soontornniyomkij V, Wang G, Kapadia S, Achim C, Wiley C. Confocal assessment of lymphoid tissues with follicular hyperplasia from patients infected with human immunodeficiency virus type 1, Arch Pathol Lab Med 1998;122:534-38
21. Vincent I, Rosado M, Davies P. Mitotic mechanisms in Alzheimer's Disease? J Cell Biol 1996;132:413-25
22. McShea A, Wahl A, Smith M. Re-entry into the cell cycle: A mechanism for neurodegeneration in Alzheimer's disease. Med Hypoth 1999;52:525-27
23. Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998;18:2801-7
24. Yang Y, Geldmacher DS, Herrup K. DNA replication precedes neuronal cell death in Alzheimer's disease, J Neurosci 2001;21:2661-68
25. Jordan-Sciutto K, Murray B, Wiley C, Achim C. Response of cell cycle proteins to neurotrophic factor and chemokine stimulation in human neuroglia. Exp Neurol 2001;167:205-14
26. Jordan-Sciutto K, Wang G, Murphey-Corb M, Wiley C. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. J Neurosci 2002;22:2185-95
27. Rogalsky V, Todorov G, Moran D. Translocation of retinoblastoma protein associated with tumor cell growth inhibition. Biochem Biophys Res Comm 1993;192:1139-46
28. Bukovsky A, Caudle MR, Keenan JA, et al, Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract. J Assisted Reproductive Genetics 1995;12:123-31
29. Boyer SN, Wazer DE, Band V. E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway, Cancer Res 1996;56:4620-24
30. Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998;18:753-61
31. Ezhevsky SA, Ho A, Becker-Hapak M, Davis PK, Dowdy SF. Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo. Mol Cell Biol 2001;21:4773-84
32. Dickson DW. Alpha-synuclein and the Lewy body disorders. Curr Opin Neurobiol 2001;14:423-32
33. Bradbury J. Proteolysis problems implicated in neurodegenerative diseases. Lancet 2001;357:1679
34. McNaught KS, Olanow CW, Halliwell B, Isacson O, Jenner P. Failure of the ubiquitin-proteasome system in Parkinson's disease. Nat Rev Neurosci 2001;2:589-94
35. Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 1992;70:337-50
36. Kaelin WG, Jr., Krek W, Sellers WR, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 1992;70:351-64
37. Persengiev SP, Kondova II, Kilpatrick DL. E2F4 actively promotes the initiation and maintenance of nerve growth factor-induced cell differentiation. Mol Cell Biol 1999;19:6048-56
38. Azuma-Hara M, Taniura H, Uetsuki T, Niinobe M, Yoshikawa K. Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells. Exp Cell Res 1999;251:442-51
39. Ranganathan S, Scudiere S, Bowser R. Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 in Alzheimer's disease and amyotrophic lateral sclerosis. J Alzheimer's Dis 2001;3:377-85
40. Scherr C, Tumor surveillance via the ARF-p53 pathway, Genes Dev 1998;12:2984-91
41. Taniura H, Taniguchi N, Hara M, Yoshikawa K. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins an cellular transcription factor E2F1. J Biol Chem 1998;273:720-78
42. Kim TA, Lim J, Ota S, et al. NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation. J Cell Biol 1998;141:553-66
43. Lee KY, Helbing CC, Choi KS, Johnston RN, Wang JH. Neuronal Cdc2-like kinase (Nclk) binds and phosphorylates the retinoblastoma protein. J Biol Chem 1997;272:5622-26
44. Spengler D, Villalba M, Hoffmann A, et al. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J 1997;16:2814-25