E2F-1 Functions in mice to promote apoptosis and suppress proliferation

Cell

Volumn 85, Issue 4, 1996, Pages 549-561

  Field, Seth J ^a   Tsai, Fong Ying ^b,d   Kuo, Frank ^c   Zubiaga, Ana M ^a,e   Kaelin Jr , William G ^d   Livingston, David M ^d   Orkin, Stuart H ^a,b,d   Greenberg, Michael E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL MATURATION; CELL PROLIFERATION; EMBRYO; GENE MUTATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0029949784     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81255-6     Document Type: Article

References (65)

1. Adams, P.D., and Kaelin, W.G., Jr. (1995). Transcriptional control by E2F. Semin. Cancer Biol. 6, 99-108.
2. Bagchi, S., Weinmann, R., and Raychaudhuri, P. (1991). The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F. Cell 65, 1063-1072.
3. Bandara, L.R., Adamczewski, J.P., Hunt, T., and La Thangue, N.B. (1991). Cyclin Aand the retinoblastoma gene product complex with a common transcription factor. Nature 352, 249-251.
4. Blake, M.C., and Azizkhan, J.C. (1989). Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo. Mol. Cell. Biol. 9, 4994-5002.
5. Cao, L., Faha, B., Dembski, M., Tsai, L.H., Harlow, E., and Dyson, N. (1992). Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature 355, 176-179.
6. Chellappan, S.P., Hiebert, S., Mudryj, M., Horowitz, J.M., and Nevins, J.R. (1991). The E2F transcription factor is a cellular target for the RB protein. Cell 65, 1053-1061.
7. Chittenden, T., Livingston, D.M., and Kaelin, W.G., Jr. (1991). The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell 65, 1073-1082.
8. Chomczynski, C., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
9. Church, G.M., and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Acad. Sci. USA 81, 1991-1995.
10. Cobrinik, D., Whyte, P., Peeper, D.S., Jacks, T., and Weinberg, R.A. (1993). Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7, 2392-2404.
11. Cress, W.D., Johnson, D.G., and Nevins, J.R. (1993). Agenetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4. Mol. Cell. Biol. 13, 6314-6325.
12. DeGregori, J., Kowalik, T., and Nevins, J.R. (1995). Cellular targets for activation by the E2F1 transcription factor include DNA synthesis-and G1/S-regulatory genes. Mol. Cell. Biol. 15, 4215-4224.
13. cdk2 is a component of the E2F-cyclin A complex. Cell 68, 167-176.
14. Dou, Q.P., Markell, P.J., and Pardee, A.B. (1992). Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2kinase. Proc. Natl. Acad. Sci. USA 89, 3256-3260.
15. Duronio, R.J., and O'Farrell, P.H. (1995). Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 9, 1456-1468.
16. Duronio, R.J., O'Farrell, P.H., Xie, J.E., Brook, A., and Dyson, N. (1995). The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 9, 1445-1455.
17. Dynlacht, B.D., Flores, O., Lees, J.A., and Harlow, E. (1994). Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 8, 1772-1786.
18. Fort, P., Marty, L., Piechaczyk, M., El Sabrouty, S., Dani, C., Jeanteur, P., and Blanchard, J.M. (1985). Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphatedehydrogenase multigenic family. Nucleic Acids Res. 13, 1431-1442.
19. +8+ precursor stage. Nature 334, 620-623.
20. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S.A. (1992). Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
21. Gold, R., Schmied, M., Rothe, G., Zischler, H., Breitschopf, H., Wekerle, H., and Lassmann, H. (1993). Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections. J. Histochem. Cytochem. 41, 1023-1030.
22. Helin, K., Lees, J.A., Vidal, M., Dyson, N., Harlow, E., and Fattaey, A. (1992). A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70, 337-350.
23. Hiebert, S.W., Lipp, M., and Nevins, J.R. (1989). E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86, 3594-3598.
24. Huang, M.M., and Hearing, P. (1989). The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex. Genes Dev. 3, 1699-1710.
25. Johnson, D.G., Schwarz, J.K., Cress, W.D., and Nevins, J.R. (1993). Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352.
26. Johnson, D.G., Cress, W.D., Jakoi, L., and Nevins, J.R. (1994). Oncogenic capacity of the E2F1 gene. Proc. Natl. Acad. Sci. USA 91, 12823-12827.
27. Kaelin, W.G., Jr., Krek, W., Sellers, W.R., DeCaprio, J.A., Ajchenbaum, F., Fuchs, C.S., Chittenden, T., Li, Y., Farnham, P.J., Blanar, M.A., et al. (1992). Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70, 351-364.
28. Kisielow, P., and von Boehmer, H. (1991). Kinetics of negative and positive selection in the thymus. Adv. Exp. Med. Biol. 292, 31-42.
29. Kowalik, T.F., DeGregori, J., Schwarz, J.K., and Nevins, J.R. (1995). E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69, 2491-2500.
30. Krek, W., Ewen, M.E., Shirodkar, S., Arany, Z., Kaelin, W.G., Jr., and Livingston, D.M. (1994). Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 161-172.
31. Krek, W., Xu, G., and Livingston, D. (1995).Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149-1158.
32. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
33. La Thangue, N.B. (1994). DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci. 19, 108-114.
34. Lees, E., Faha, B., Dulic, V., Reed, S.I., and Harlow, E. (1992). Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 6, 1874-1885.
35. Lees, J.A., Saito, M., Vidal, M., Valentine, M., Look, T., Harlow, E., Dyson, N., and Helin, K. (1993). The retinoblastoma protein binds to a family of E2Ftranscription factors. Mol. Cell. Biol. 13, 7813-7825.
36. Li, E., Bestor, T.H., and Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926.
37. Li, Y., Slansky, J.E., Myers, D.J., Drinkwater, N.R., Kaelin, W.G., and Farnham, P.J. (1994). Cloning, chromosomal location, and characterization of mouse E2F1. Mol. Cell. Biol. 14, 1861-1869.
38. Motokura, T., and Arnold, A. (1993). PRAD1/cyclin D1 proto-oncogene: genomic organization, 5′ DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosom. Cancer 7, 89-95.
39. Mudryj, M., Hiebert, S.W., and Nevins, J.R. (1990). A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J. 9, 2179-2184.
40. Neuman, E., Flemington, E.K., Sellers, W.R., and Kaelin, W.G., Jr. (1995). Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 15, 4660.
41. Ogris, E., Rotheneder, H., Mudrak, I., Pichler, A., and Wintersberger, E. (1993). A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J. Virol. 67, 1765-1771.
42. + lymphocytes in embryonic thymus organ cultures. Immunology 63, 639-642.
43. Pagano, M., Draetta, G., and Jansen-Durr, P. (1992a). Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255, 1144-1147.
44. Pagano, M., Pepperkok, R., Verde, F., Ansorge, W., and Draetta, G. (1992b). Cyclin A is required at two points in the human cell cycle. EMBO J. 11, 961-971.
45. Pearson, B.E., Nasheuer, H.P., and Wang, T.S. (1991). Human DNA polymerase α gene: sequences controlling expression in cycling and serum-stimulated cells. Mol. Cell. Biol. 11, 2081-2095.
46. Qin, X.Q., Livingston, D.M., Kaelin, W.G., Jr., and Adams, P.D. (1994). Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922.
47. Robertson, E.J. (1987). Embryo-derived stem cells. In Teratocarcinomas and Embryonic Stem Cells: a Practical Approach, E.J. Robertson, ed. (Oxford: IRL Press), pp. 104-108.
48. Sala, A., Nicolaides, N.C., Engelhard, A., Bellon, T., Lawe, D.C., Arnold, A., Grana, X., Giordano, A., and Calabretta, B. (1994). Correlation between E2F-1 requirement in the S phase and E2F-1 transactivation of cell cycle-related genes in human cells. Cancer Res. 54, 1402-1406.
49. Scollay, R., Wilson, A., D'Amico, A., Kelly, K., Egerton, M., Pearse, M., Wu, L., and Shortman, K. (1988). Developmental status and reconstitution potential of subpopulations of murine thymocytes. Immunological Rev. 104, 81-120.
50. Sellers, W., Rodgers, J., and Kaelin, W. (1995). A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92, 11544-11548.
51. Shan, B., and Lee, W.H. (1994). Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol. 14, 8166-8173.
52. Shan, B., Zhu, X., Chen, P.L., Durfee, T., Yang, Y., Sharp, D., and Lee, W.H. (1992). Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12, 5620-5631.
53. Shi, Y.F., Bissonnette, R.P., Parfrey, N., Szalay, M., Kubo, R.T., and Green, D.R. (1991). In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 146, 3340-3346.
54. Shirodkar, S., Ewen, M., DeCaprio, J.A., Morgan, J., Livingston, D.M., and Chittenden, T. (1992). The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68, 157-166.
55. Smith, C.A., Williams, G.T., Kingston, R., Jenkinson, E.J., and Owen, J.J. (1989). Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337, 181-184.
56. Thalmeier, K., Synovzik, H., Mertz, R., Winnacker, E.L., and Lipp, M. (1989). Nuclear factor E2F mediates basic transcription and transactivation by E1a of the human MYC promoter. Genes Dev. 3, 527-536.
57. Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T., and Mulligan, R.C. (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163.
58. Weinberg, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
59. Weintraub, S.J., Prater, C.A., and Dean, D.C. (1992). Retinoblastoma protein switches the E2F site from positive to negative element. Nature 358, 259-261.
60. Weintraub, S.J., Chow, K.N., Luo, R.X., Zhang, S.H., He, S., and Dean, D.C. (1995). Mechanism of active transcriptional repression by the retinoblastoma protein. Nature 375, 812-815.
61. Wu, X., and Levine, A.J. (1994). p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91, 3602-3606.
62. Xu, M., Sheppard, K.A., Peng, C.Y., Yee, A.S., and Piwnica-Worms, H. (1994). Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol. Cell. Biol. 14, 8420-8431.
63. Xu, G., Livingston, D.M., and Krek, W. (1995). Multiple members of the E2F transcription factor family are the products of oncogenes. Proc. Natl. Acad. Sci. USA 92, 1357-1361.
64. Yamasaki, L., Tyler, J., Roderick, B., Goillot, E., Harlow, E., and Dyson, N.J. (1996). Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, this issue.
65. Yang, X.H., and Sladek, T.L. (1995). Overexpression of the E2F-1 transcription factor gene mediates cell transformation. Gene Expr. 4, 195-204.