E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

Genes and Development

Volumn 15, Issue 4, 2001, Pages 386-391

  Ziebold, U ^a   Reza, T ^a   Caron, A ^a   Lees, J A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Apoptosis; E2F; Erythropoiesis; Retinoblastoma protein

Indexed keywords

PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; EMBRYO; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; GENE MUTATION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL DIVISION; E2F3 TRANSCRIPTION FACTOR; EMBRYO; FEMALE; GENES, RETINOBLASTOMA; MALE; MICE; MICE, INBRED C57BL; MUTATION; PREGNANCY; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0035118893     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.858801     Document Type: Article

References (22)

1. Requirement for a functional Rb-1 gene in murine development
2. The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells
3. Distinct roles for E2F proteins in cell growth control and apoptosis
4. The regulation of E2F by pRB-family proteins
5. Heterozygous Rb-1 delta 20/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance
6. E2f3 is critical for normal cellular proliferation
7. Role for the p53 homologue p73 in E2F-1-induced apoptosis
8. Effects of an Rb mutation in the mouse
9. Id2 is a retinoblastoma protein target and mediates signalling by Myc onco-proteins
10. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
11. A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
12. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
13. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
14. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
15. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
16. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
17. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
18. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
19. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
20. Surfing the p53 network
21. The retinoblastoma gene and gene product
22. Mechanisms of carcinogenesis and the mutant mouse