Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 140, Issue 3-4, 2005, Pages 403-407

  Bresolin, Taise ^a   De Freitas Rebelo, Mauro ^b   Dias Bainy, Afonso Celso ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Clotrimazole; CYP3A; Cytochrome P4503A; MDR; Multidrug resistance; Nifedipine; Pregnane X receptor; Pregnenolone 16 carboninitrile; PXR; Zebrafish

Indexed keywords

16ALPHA CYANOPREGNENOLONE; ANTIANGINA PECTORIS AGENT; ANTIFUNGAL AGENT; CLOTRIMAZOLE; CYTOCHROME P450 3A; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; NIFEDIPINE; PREGNANE X RECEPTOR; STEROID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ZEBRA FISH;

DANIO RERIO; MAMMALIA;

EID: 20444386267     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2005.04.003     Document Type: Article

References (22)

1. A.C.D. Bainy, and J.J. Stegeman Cloning and identification of a full length Pregnane X Receptor and expression in vivo in zebrafish (Danio rerio) Mar. Environ. Res. 58 2004 133 134
2. B. Bauer, A.M. Hartz, G. Fricker, and D.S. Miller Pregnane X receptor up-regulation of P-glycoprotein expression and transport at the blood-brain barrier Mol. Pharmacol. 66 2004 413 419
3. W.T. Bellamy P-glycoprotein and multidrug resistance Annu. Rev. Pharmacol. Toxicol. 36 1996 161 183
4. I. Dussault, M. Lin, K. Hollister, E.H. Wang, T.W. Synold, and B.M. Forman Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR J. Biol. Chem. 276 2001 33309 33312
5. S. Ekins, L. Mirny, and E.G. Schuetz A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRα, e LXRβ Pharm. Res. 19 2002 1788 1800
6. A. Geik, M. Eichelbaum, and O. Burk Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin J. Biol. Chem. 276 2001 14581 14587
7. P. Goldsmith Zebrafish as a pharmacological tool: the how, why and when Curr. Opin. Pharmacol. 4 2004 504 512
8. T.A. Hall BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT Nucleic Acids Symp. Ser. 41 1999 95 98
9. S.A. Kliewer, J.T. Moore, L. Wade, J.L. Staudinger, M.A. Watson, S.A. Jones, D.D. McKee, B.B. Oliver, T.M. Willson, R.H. Zetterström, T. Perlmann, and J.M. Lehmann An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 92 1998 73 82
10. J.M. Lehmann, D.D. McKee, M.A. Watson, T.M. Willson, J.T. Moore, and S.A. Kliewer The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions J. Clin. Invest. 102 1998 1016 1023
11. J.M. Maglich, J.A. Caravella, M.H. Lambert, T.M. Willson, J.T. Moore, and L. Ramamurthy The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily Nucleic Acids Res. 31 2003 4051 4058
12. L.B. Moore, D.J. Parks, S.A. Jones, R.K. Bledsoe, T.G. Consler, J.B. Stimmel, B. Goodwin, C. Liddle, S.G. Blanhard, T.M. Willson, J.L. Collins, and S.A. Kliewer Orphan nuclear receptors constitutive androstane receptor and Pregnane X Receptor share xenobiotic and steroid ligands J. Biol. Chem. 275 2000 15122 15127
13. L.B. Moore, J.M. Maglich, D.D. McKee, B. Wisely, T.M. Willson, S.A. Kliewer, M.H. Lambert, and J.T. Moore Pregnane X Receptor (PXR), Constitutive Androstane Receptor (CAR), and Benzoate X Receptor (BXR) define three pharmacologically distinct classes of nuclear receptors Mol. Endocrinol. 16 2002 977 986
14. T. Östberg, G. Bertilsson, L. Jendeberg, A. Berkenstam, and J. Uppenberg Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation Eur. J. Biochem. 269 2002 4896 4904
15. S. Rozen, and H.J. Skaletsky Primer3 on the WWW for general users and for biologist programmers S. Krawetz S. Misener Bioinformatics methods and protocols: methods in molecular biology 2000 Humana Press Totowa, NJ 365 386
16. E.G. Schuetz, W.T. Beck, and J.D. Schuetz Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells Mol. Pharmacol. 49 1996 311 318
17. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, A. LaTour, Y. Liu, C.D. Klaassen, K.K. Brown, J. Reinhard, T.M. Willson, B.H. Koller, and S.A. Kliewer The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc. Natl. Acad. Sci. U. S. A. 98 2001 3369 3374
18. S. Sumanas, and S. Lin Zebrafish as a model system for drug target screening and validation DDT: Targets 3 2004 89 96
19. T.W. Synold, I. Dussault, and B.M. Forman The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux Nat. Med. 7 2001 584 590
20. S. Teng, V. Jekerle, and M. Piquette-Miller Induction of ABCC3 (MRP3) by Pregnane X Receptor activators Drug Metab. Dispos. 31 2003 1296 1299
21. R.E. Watkins, G.B. Wisely, L.B. Moore, J.L. Collins, M.H. Lambert, S.P. Williams, T.M. Willson, S.A. Kliewer, and M.R. Redinbo The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity Science 292 2001 2329 2333
22. W. Xie, J.L. Barwick, M. Downes, B. Blumberg, C.M. Simon, M.C. Nelson, B.A. Neuschwander-Tetri, E.M. Brunt, P.S. Guzelian, and R.M Evans Humanized xenobiotic response in mice expressing nuclear receptor SXR Nature 406 2000 435 439