Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis

Archives of Toxicology

Volumn 82, Issue 12, 2008, Pages 959-964

  Fisher, Craig D ^a   Jackson, Jonathan P ^a   Lickteig, Andrew J ^a   Augustine, Lisa M ^a   Cherrington, Nathan J ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cytochrome P450 enzymes and NAD(P)H:quinone oxidoreductase 1; Drug metabolizing enzyme induction; Non alcoholic fatty liver disease; Xenobiotic activated receptors

Indexed keywords

1,4 BIS [2 (3,5 DICHOLOROPYRIDYLOXYL)]BENZENE; 16ALPHA CYANOPREGNENOLONE; BENZENE DERIVATIVE; BETA NAPHOFLAVONE; CHOLINE; CLOFIBRATE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B10; CYTOCHROME P450 3A11; CYTOCHROME P450 4A; CYTOCHROME P450 4A14; DRUG METABOLIZING ENZYME; FLAVONE DERIVATIVE; MESSENGER RNA; METHIONINE; OLTIPRAZ; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYP2B10 PROTEIN, MOUSE; CYP3A11 PROTEIN, MOUSE; CYP4A14 PROTEIN, MOUSE; CYTOCHROME P450 3A; DRUG; MEMBRANE PROTEIN; NQO1 PROTEIN, MOUSE; PREGNANE X RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; STEROID MONOOXYGENASE; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECT; ENZYMOLOGY; FATTY LIVER; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM;

MUS; RODENTIA;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FATTY LIVER; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; NADPH DEHYDROGENASE; NF-E2-RELATED FACTOR 2; PHARMACEUTICAL PREPARATIONS; PPAR ALPHA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; STEROID HYDROXYLASES; TRANSCRIPTION FACTORS;

EID: 59849098860     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0312-z     Document Type: Article

References (29)

1. S Anakk A Kalsotra Y Kikuta W Huang J Zhang JL Staudinger DD Moore HW Strobel 2004 CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11 Pharmacogenomics J 4 91 101
2. JD Browning JD Horton 2004 Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 147 152
3. S Chitturi GC Farrell 2001 Etiopathogenesis of nonalcoholic steatohepatitis Semin Liver Dis 21 27 41
4. E Elias CO Mills 2007 Coordinated defence and the liver Clin Med 7 180 184
5. GC Farrell WG Cooksley P Hart LW Powell 1978 Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism Gastroenterology 75 580 588
6. CD Fisher LM Augustine JM Maher DM Nelson AL Slitt CD Klaassen LD Lehman-McKeeman NJ Cherrington 2007 Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive and rostane receptor and nuclear factor E2-related factor 2 Drug Metab Dispos 35 995 1000
7. S Harmsen I Meijerman JH Beijnen JH Schellens 2007 The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology Cancer Treat Rev 33 369 380
8. P Honkakoski M Negishi 2000 Regulation of cytochrome P450 (CYP) genes by nuclear receptors Biochem J 347 321 337
9. SJ Karpen 2002 Nuclear receptor regulation of hepatic function J Hepatol 36 832 850
10. HR Kast B Goodwin PT Tarr SA Jones AM Anisfeld CM Stoltz P Tontonoz S Kliewer TM Willson PA Edwards 2002 Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane x receptor, farnesoid x-activated receptor, and constitutive androstane receptor J Biol Chem 277 2908 2915
11. CD Klaassen AL Slitt 2005 Regulation of hepatic transporters by xenobiotic receptors Curr Drug Metab 6 309 328
12. C Koike R Moore M Negishi 2007 Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes Mol Pharmacol 71 1217 1221
13. AJ Lickteig CD Fisher LM Augustine NJ Cherrington 2007 Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis J Biochem Mol Toxicol 21 216 220
14. M McMahon K Itoh M Yamamoto SA Chanas CJ Henderson LI McLellan CR Wolf C Cavin JD Hayes 2001 The cap'n'collar basic leucine zipper transcription factor Nrf2 (NF-E2 P45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes Cancer Res 61 3299 3307
15. T Nagasawa Y Inada S Nakano T Tamura T Takahashi K Maruyama Y Yamazaki J Kuroda N Shibata 2006 Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARdelta agonist, on development of steatohepatitis in mice fed a methionine- and choline-deficient diet Eur J Pharmacol 536 182 191
16. BA Neuschwander-Tetri SH Caldwell 2003 Nonalcoholic steatohepatitis: summary of an AASLD single topic conference Hepatology 37 1202 1219
17. JM Pascussi S Gerbal-Chaloin L Drocourt E Assenat D Larrey L Pichard-Garcia MJ Vilarem P Maurel 2004 Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences Xenobiotica 34 633 664
18. JS Petrick CD Klaassen 2007 Importance of hepatic induction of constitutive androstane receptor (CAR) and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos Drug Metab Dispos 35 10 1806 1815
19. VO Pustylnyak AN Lebedev LF Gulyaeva VV Lyakhovich NM Slynko 2007 Comparative study of CYP2B induction in the liver of rats and mice by different compounds Life Sci 80 324 328
20. M Qatanani DD Moore 2005 CAR, the continuously advancing receptor, in drug metabolism and disease Curr Drug Metab 6 329 339
21. H Reynaert A Geerts J Henrion 2005 Review article: the treatment of non-alcoholic steatohepatitis with thiazolidinediones Aliment Pharmacol Ther 22 897 905
22. N Tanaka T Aoyama 2006 PPAR and NASH Nippon Rinsho 64 1089 1094
23. YE Timsit M Negishi 2007 CAR and PXR: the xenobiotic-sensing receptors Steroids 72 231 246
24. R Venugopal AK Jaiswal 1996 Nrf1 and Nrf2 positively and C-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H: quinone oxidoreductase1 gene Proc Natl Acad Sci USA 93 14960 14965
25. DJ Waxman 1999 P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR Arch Biochem Biophys 369 11 23
26. JF Westphal JM Brogard 1997 Drug administration in chronic liver disease Drug Saf 17 47 73
27. GR Wilkinson 1997 The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans Adv Drug Deliv Rev 27 129 159
28. LQ Yang SJ Li YF Cao XB Man WF Yu HY Wang MC Wu 2003 Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases World J Gastroenterol 9 359 363
29. F Zandbergen J Plutzky 2007 PPARalpha in atherosclerosis and inflammation Biochim Biophys Acta 1771 8 972 982