Induction of nuclear receptors and drug resistance in the brain microvascular endothelial cells treated with antiepileptic drugs

Current Neurovascular Research

Volumn 5, Issue 2, 2008, Pages 82-92

  Lombardo, Laura ^a   Pellitteri, Rosalia ^b   Balazy, Michael ^c   Cardile, Venera ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b INSTITUTE OF NEUROLOGICAL SCIENCES   (Italy)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Androstane receptor; Cerebral microvascular endothelial cells; Cytochrome P450; Drug resistance; Epilepsy; Multidrug resistance associated proteins; P glycoprotein; Pregnane X receptor

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; ETIRACETAM; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; TIAGABINE; TOPIRAMATE;

ANIMAL CELL; ARTICLE; CELL IMMORTALIZATION; DRUG RESISTANCE; ENDOTHELIUM CELL; IMMUNOCYTOCHEMISTRY; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; ANTICONVULSANTS; BRAIN; CELL LINE, TRANSFORMED; ENDOTHELIAL CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

EID: 45249089239     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720208784310196     Document Type: Article

References (55)

1. Altman, DG, Royston, P. (2006) The cost of dichotomizing continuous variables. BMJ 332: 1080.
2. Ambudkar, SV, Kim, I-W, Sauna, ZE. (2006) The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1). Eur J Pharm Sci 27: 392-400.
3. Ayrton, A, Morgan, P. (2001) Role of transport proteins in drug absorption, distribution and excretion. Xenobiotica 31: 469-497.
4. Baes, M, Gilick, T, Choi, HS, Martinoli, MG, Simha, D, Moore, DD. (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14: 1544-1552.
5. Baltes, S, Gastens, AM, Fedrowitz, M, Potschka, H, Kaever, V, Löscher, W. (2007) Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology 52: 333-346.
6. Bauer, B, Hartz, AMS, Fricker, G, Miller, DS. (2004) Pregnane X Receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol 66: 413-419.
7. Bertilsson, G, Heidrich, J, Svensson, K, Asman, M, Jendeberg, L, Sydow-Backman, M, Ohlsson, R, Postlind, H, Blomquist, P, Berkenstam, A. (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci 95: 12208-12213.
8. Borst, P, Evers, R, Kool, M, Wijnholds, J. (1999) The multidrug resistance protein family. Biochim. Biophys Acta 1461: 347-357.
9. Chang, CS, Yang, SS, Yeh, HZ, Kao, CH, Chen, GH. (2004) Tc-99m MIBI liver imaging for hepatocellular carcinoma: correlation with P-glycoprotein- multidrug-resistance gene expression. Hepatogastroenterology 51: 211-214.
10. Choi, HS, Chung, M, Tzameli, I, Simha, D, Lee, YK, Seol, W, Moore, DD. (1997) Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J Biol Chem 272: 23565-23571.
11. Cordon-Cardo, C, O'Brien, JP, Casals, D, Rittman-Grauer, L, Biedler, JL, Melamed, MR, Bertino, JR. (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci 86: 695-698.
12. Dombrowski, SM, Desai, SY, Marroni, M, Cucullo, L, Goodrich, K, Bingaman, W, Mayberg, MR, Bengez, L, Janigro, D. (2001) Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42: 1501-1506.
13. Dussault, I, Forman, BM. (2002) The nuclear receptor PXR: a master regulator of "homeland" defense. Crit Rev Eukaryot Gene Expr 12: 53-64.
14. Fraser, CM, Sills, GJ, Forrest, G, Thompson, GG, Brodie, MJ. (1999) Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain. Br Pharmacol 126: 1634-1638.
15. Geick, A, Eichelbaum, M, Burk, O. (2001) Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276: 14581-14587.
16. Gerk, PM, Vore, M. (2002) Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 302: 407-415.
17. Giessmann, T, May, K, Modess, C, Wegner, D, Hecker, U, Zschiesche, M, Dazert, P, Grube, M, Schroeder, E, Warzok, R, Cascorbi, I, Kroemer, HK, Siegmund, W. (2004) Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans. Clin Pharmacol Ther 76: 192-200.
18. Jones, PM, George, AM. (2004) The ABC transporter structure and mechanism: perspectives on recent research. Cell Mol Life Sci 61: 682-699.
19. Kassam, A, Winrow, CJ, Fernandez-Rachubinski, F, Capone, JP, Rachubinski, RA. (2000) The peroxisome proliferator response element of the gene encoding the peroxisomal β-oxidation enzyme enoyl-CoA hydrotase/3-hydroxyacyl-CoA dehydrogenase in a target for constitutive androstane receptor β/9-cis retinoic acid receptor-mediated transactivation. J Biol Chem 275: 4345-4350.
20. Kast, HR, Goodwin, B, Tarr, PT, Jones, SA, Anisfeld, AM, Stoltz, CM, Tontonoz, P, Kliewer, S, Willson, TM, Edwards, PA. (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277: 2908-2915.
21. Kawamoto, T, Sueyoshi, T, Zelko, I, Moore, R, Washburn, K, Negishi, M. (1999) Phenobarbital responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene. Mol Cell Biol 19: 6318-6322.
22. Kawamoto, T, Kakizaki, S, Yoshinari, K, Negishi, M. (2000) Estrogen activation of the nuclear orphan receptor CAR (Constitutive Active Receptor) in induction of the mouse CYP2B10 gene. Mol Endocrinol 14: 1897-1905.
23. Laemli, UK. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 277: 680-685.
24. Lautier, D, Canitrot, Y, Deeley, RG, Cole, SP. (1996) Multidrug resistance mediated by multidrug resistance protein (MRP) gene. Biochem Pharmacol 52: 967-977.
25. Lehmann, JM, McKee, DD, Watson, MA, Willson, TM, Moore, JT, Kliewer, SA. (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102: 1016-1023.
26. Leschziner, G, Jorgensen, A, Andrew, T, Pirmohamed, M, Williamson, PR, Marson, AG, Coffey, AJ, Middleditch, C, Rogers, J, Bentley, DR, Chadwick, DW, Balding, DJ, Johnson, MR. (2006) Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort epilepsy. Lancet Neurol 5: 668-676.
27. Löscher, W, Potschka, H. (2002) Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 301: 7-14.
28. Lu, Y, Yan Y, Wang, X. (2004) Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes cultured from rat brains. Chin Med J 117: 1682-1686.
29. Miller, DS, Nobmann, SN, Gutmann, H, Török, M, Drewe, J, Fricker, G. (2000) Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol Pharmacol 58: 1357-1367.
30. Moore, LB, Parks, DJ, Jones, SA, Bledsoe, RK, Consler, TG, Stimmel, JB, Goodwin, B, Liddle, C, Blanchard, SG, Willson, TM. (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275: 15122-15127.
31. Morrow, CS, Cowan, KH. (1988) Mechanisms and clinical significance of multidrug resistance. Oncology 2: 55-63.
32. Owen, A, Pirmohamed, M, Tettey, JN, Morgan, P, Chadwick, D, Park, BK. (2001) Carbamazepine is not a substrate for P-glycoprotein. Br J Clin Pharmacol 51: 345-49.
33. Park, Y, Li, H, Kemper, B. (1996) Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J Biol Chem 271: 23725-23728.
34. Potschka, H, Löscher, W. (2001) Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain. Neuroreport 12: 2387-2389.
35. Potschka, H, Fedrowitz, M, Löscher, W. (2002) P-glycoprotein- mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neurosci Lett 327: 173-176.
36. Potschka, H, Fedrowitz, M, Löscher, W. (2003) Multidrug resistance protein Mrp2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. J Pharmacol Exp Ther 306: 124-131.
37. Quilichini, PP, Diabira, D, Chiron, C, Milh, M, Ben-Ari, Y, Gozlan, H. (2003) Effects of antiepileptic drugs on refractory seizure in the intact immature corticohippocampal formation in vitro. Epilepsia 44: 1365-1374.
38. Rao, VV, Dahlheimer, JL, Bardgett, ME, Snyder, AZ, Finch, RA, Sartorelli, AC, Piwnica-Worms, D. (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug permeability barrier. Proc Natl Acad Sci 96: 3900-3905.
39. Regina, A, Koman, A, Piciotti, M, El Hafny, B, Center, MS, Bergmann, R, Couraud, PO, Roux, F. (1998) Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J Neurochem 71: 705-715.
40. Regina, A, Romero, IA, Greenwood, J, Adamson P, Borre, JM, Couraud, PO, Roux, F. (1999) Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J Neurochem 73: 1959-1963.
41. Remy, S, Beck, H. (2006) Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain 129: 18-35.
42. Royston, P. (2004) Multiple imputation of missing values. Stata J 4: 227-41.
43. Salphati, L, Benet, LZ. (1998) Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem Pharmacol 55: 387-395.
44. Schinkel, AH, Wagenaar, E, van Deemter, L, Mol, CA, Borst, P. (1995) Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 96: 1698-1705.
45. Schinkel, AH. (1999) P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36: 179-194.
46. Schmidt, D, Löscher, W. (2005) Drug resistance in epilepsy: putative neurobiological and clinical mechanisms. Epilepsia 46: 858-877.
47. Schuetz, EG, Beck, WT, Schuetz, JD. (1996) Modulators and substrates of P-glycoprotein and cytochrome P450 3A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 49: 311-318.
48. Sisodiya, SM, Lin, WR, Harding, BN, Squier, MV, Thom, M. (2002) Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 125: 22-31.
49. Sisodiya, S. (2003) Drug resistance in epilepsy: not futile, but complex? Lancet Neurol 2: 331.
50. Synold, TW, Dussault, I, Forman, BM. (2001) The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 7: 584-590.
51. Szoeke, CE, Newton, M, Wood, JM, Goldstein, D, Berkovic, SF, Obrien, TJ, Sheffield, LD. (2006) Update on pharmacogenetics in epilepsy: a brief review. Lancet Neurol 5: 189-96.
52. Tatsuta, T, Naito, M, Oh-hara, T, Sugarawa, I, Tsuruo, T. (1992) Functional involvement of P-glycoprotein in blood- brain barrier. J Biol Chem 267: 20383-20391.
53. Taylor, EM. (2002) The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clin Pharmacokinet 41: 81-92.
54. Weiss, J, Kerpen, CJ, Lindenmaier, H, Dormann, SM, Haefeli, WE. (2003) Interaction of antiepileptic drugs with human p-glycoprotein in vitro. J Pharmacol Exp Ther 307: 262-267.
55. Zhang, Y, Han, H, Elmquist, WF, Miller, DW. (2000) Expression of various multidrug resistance associated protein homologues in brain microvessel endothelial cells. Brain Res 876: 148-153.