Experience-driven development: Effector/memory-like α E+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells

Journal of Immunology

Volumn 180, Issue 1, 2008, Pages 146-155

  Siewert, Christiane ^a   Lauer, Uta ^a   Cording, Sascha ^a   Bopp, Tobias ^b   Schmitt, Edgar ^b   Hamann, Alf ^a   Huehn, Jochen ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; INTEGRIN; INTEGRIN ALPHA E BETA 7; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTEGRIN ALPHAEBETA7; INTERLEUKIN 2 RECEPTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FRACTIONATION; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; HOMEOSTASIS; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMUS; TURNOVER TIME; ANIMAL; CELL PROLIFERATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; MOUSE STRAIN; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; HOMEOSTASIS; IMMUNOLOGIC MEMORY; INTEGRINS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED STRAINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 40449110125     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.1.146     Document Type: Article

References (45)

1. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
2. Annacker, O., O. Burlen-Defranoux, R. Pimenta-Araujo, A. Cumano, and A. Bandeira. 2000. Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment. J. Immunol. 164: 3573-3580.
3. + regulatory T cells. Nat. Immunol. 4: 330-336.
4. + regulatory T cells. J. Exp. Med. 199: 303-313.
5. Huehn, J., and A. Hamann. 2005. Homing to suppress: address codes for Treg migration. Trends Immunol. 26: 632-636.
6. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
7. + regulatory T cells in the steady state. J. Exp. Med. 198: 737-746.
8. + regulatory T cells in vivo. J. Exp. Med. 198: 249-258.
9. Klein, L., K. Khazaie, and H. von Boehmer. 2003. In vivo dynamics of antigenspecific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 100: 8886-8891.
10. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198: 235-247.
11. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199: 1467-1477.
12. + regulatory T cells. J. Immunol. 171: 5678-5682.
13. + regulatory T cells participate in the control of immune responses. J. Immunol. 178: 6901-6911.
14. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
15. - T cells through Foxp3 induction and down-regulation of Smad7. J. Immunol. 172: 5149-5153.
16. Sun, C. M., J. A. Hall, R. B. Blank, N. Bouladoux, M. Oukka, J. R. Mora, and Y. Belkaid. 2007. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J. Exp. Med. 204: 1775-1785.
17. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742.
18. + regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101: 4862-4869.
19. Kretschmer, K., I. Apostolou, D. Hawiger, K. Khazaie, M. C. Nussenzweig, and H. von Boehmer. 2005. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 12: 1219-1227.
20. +CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167: 188-195.
21. Unger, W. W., F. Hauet-Broere, W. Jansen, L. A. van Berkel, G. Kraal, and J. N. Samsom. 2003. Early events in peripheral regulatory T cell induction via the nasal mucosa. J. Immunol. 171: 4592-4603.
22. + mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. Eur. J. Immunol. 33: 2801-2810.
23. Hultkrantz, S., S. Ostman, and E. Telemo. 2005. Induction of antigen-specific regulatory T cells in the liver-draining celiac lymph node following oral antigen administration. Immunology 116: 362-372.
24. Apostolou, I., and H. von Boehmer. 2004. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199: 1401-1408.
25. Mayer, L., and L. Shao. 2004. Therapeutic potential of oral tolerance. Nat. Rev. Immunol. 4: 407-419.
26. Matsuno, K., K. Miyakawa, T. Ezaki, and M. Kotani. 1990. The liver lymphatics as a migratory pathway of macrophages from the sinusoids to the celiac lymph nodes in the rat. Arch. Histol. Cytol. 53 (Suppl.): 179-187.
27. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162: 5317-5326.
28. + T-cell development is regulated by at least 2 distinct mechanisms. Blood 99: 555-560.
29. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10: 1969-1980.
30. + T cell receptors. Immunity 21: 267-277.
31. + regulatory T cells. J. Exp. Med. 201: 681-686.
32. Hsieh, C. S., Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7: 401-410.
33. + natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 203: 777-788.
34. + T cells. Proc. Natl. Acad. Sci. USA 101: 14473-14478.
35. + regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J. Immunol. 172: 6003-6010.
36. + regulatory T cells in vivo requires B7 costimulation, but not the thymus. J. Exp. Med. 201: 127-137.
37. May, A. G., S. Bauer, J. P. Leddy, B. Panner, J. Vaughan, and P. S. Russell. 1969. Survival of allografts after hepatic portal venous administration of specific transplantation antigen. Ann. Surg. 170: 824-832.
38. Knolle, P. A. 2006. Involvement of the liver in the induction of CD8 T cell tolerance towards oral antigen. Z. Gastroenterol. 44: 51-56.
39. Yang, R., Q. Liu, J. L. Grosfeld, and M. D. Pescovitz. 1994. Intestinal venous drainage through the liver is a prerequisite for oral tolerance induction. J. Pediatr. Surg. 29: 1145-1148.
40. + regulatory T cells. J. Exp. Med. 201: 1061-1067.
41. + T cells. J. Immunol. 173: 6526-6531.
42. Kilshaw, P. J., and S. J. Murant. 1991. Expression and regulation of β 7(β p) integrins on mouse lymphocytes: relevance to the mucosal immune system. Eur. J. Immunol. 21: 2591-2597.
43. Von Boehmer, H. 2007. Oral tolerance: is it all retinoic acid? J. Exp. Med. 204: 1737-1739.
44. + Treg and control of Leishmania major infection. J. Immunol. 174: 5444-5455.
45. + regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation. J. Immunol. 176: 5374-5387.