The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Nature

Volumn 442, Issue 7100, 2006, Pages 307-311

  Cloos, Paul A C ^a   Christensen, Jesper ^a   Agger, Karl ^a   Maiolica, Alessio ^b   Rappsilber, Juri ^b   Antal, Torben ^a   Hansen, Klaus H ^a   Helin, Kristian ^a,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENZYMES; GENES; HYDROXYLATION; ONCOLOGY; REACTION KINETICS;

CELL PROLIFERATION; ECTOPIC EXPRESSION; HETEROCHROMATIN; OESOPHAGEAL SQUAMOUS CARCINOMAS;

AMINO ACIDS;

HISTONE H3; LYSINE; LYSINE 9; PROTEIN; PROTEIN GASC1; UNCLASSIFIED DRUG;

AMINO ACID; CANCER; DISEASE TREATMENT; GENE; GENE EXPRESSION; PROTEIN; TUMOR;

ARTICLE; CANCER THERAPY; CHROMATIN; CONTROLLED STUDY; EPIGENETICS; ESOPHAGUS CARCINOMA; GENE AMPLIFICATION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYDROXYLATION; METHYLATION; ONCOGENE; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

EID: 33746332412     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04837     Document Type: Article

References (30)

1. Fischle, W., Wang, Y. & Allis, C. D. Histone and chromatin cross-talk. Curr. Opin. Cell Biol. 15, 172-183 (2003).
2. Margueron, R., Trojer, P. & Reinberg, D. The key to development: interpreting the histone code? Curr. Opin. Genet. Dev. 15, 163-176 (2005).
3. Peterson, C. L. & Laniel, M. A. Histones and histone modifications. Curr. Biol. 14, R546-R551 (2004).
4. Bannister, A. J. et al. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124 (2001).
5. Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. & Jenuwein, T. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116-120 (2001).
6. Elgin, S. C. & Grewal, S. I. Heterochromatin: silence is golden. Curr. Biol. 13, R895-R898 (2003).
7. Kubicek, S. & Jenuwein, T. A crack in histone lysine methylation. Cell 119, 903-906 (2004).
8. Bannister, A. J. & Kouzarides, T. Reversing histone methylation. Nature 436, 1103-1106 (2005).
9. Yang, Z. Q. et al. Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. Cancer Res. 60, 4735-4739 (2000).
10. Katoh, M. & Katoh, M. Identification and characterization of JMJD2 family genes in silico. Int. J. Oncol. 24, 1623-1628 (2004).
11. Yang, Z. Q. et al. A novel amplicon at 9p23-24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB. Jpn. J. Cancer Res. 92, 423-428 (2001).
12. Hu, N. et al. Genome-wide association study in esophageal cancer using GeneChip mapping 10K array. Cancer Res. 65, 2542-2546 (2005).
13. Peters, A. H. et al. Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107, 323-337 (2001).
14. Trewick, S. C., McLaughlin, P. J. & Allshire, R. C. Methylation: lost in hydroxylation? EMBO Rep. 6, 315-320 (2005).
15. Tsukada, Y. et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 439, 811-816 (2006).
16. Elkins, J. M. et al. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α. J. Biol. Chem. 278, 1802-1806 (2003).
17. Lee, C., Kim, S. J., Jeong, D. G., Lee, S. M. & Ryu, S. E. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J. Biol. Chem. 278, 7558-7563 (2003).
18. Hegg, E. L. & Que, L. Jr. The 2-His-1-carboxylate facial triad - an emerging structural motif in mononuclear non-heme iron(II) enzymes. Eur. J. Biochem. 250, 625-629 (1997).
19. Knowles, H. J., Raval, R. R., Harris, A. L. & Ratcliffe, P. J. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Res. 63, 1764-1768 (2003).
20. Kivirikko, K. I. & Myllyharju, J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol. 16, 357-368 (1998).
21. Pidoux, A. L. & Allshire, R. C. The role of heterochromatin in centromere function. Phil. Trans. R. Soc. Lond. B 360, 569-579 (2005).
22. Ragvin, A. et al. Nucleosome binding by the bromodomain and PHD finger of the transcriptional cofactor p300. J. Mol. Biol. 337, 773-788 (2004).
23. Rhodes, D. R. et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6, 1-6 (2004).
24. Braig, M. et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (2005).
25. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005).
26. Collado, M. et al. Tumour biology: senescence in premalignant tumours. Nature 436, 642 (2005).
27. Michaloglou, C. et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436, 720-724 (2005).
28. Shi, Y. J. et al. Regulation of LSD1 histone demethylase activity by its associated factors. Mol. Cell 19, 857-864 (2005).
29. Lapointe, J. et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc. Natl Acad. Sci. USA 101, 811-816 (2004).
30. Yu, Y. P. et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J. Clin. Oncol. 22, 2790-2799 (2004).