메뉴 건너뛰기




Volumn 12, Issue 3, 2009, Pages 55-64

Targeting apoptosis as an approach for gastrointestinal cancer therapy

Author keywords

Apoptosis; Colon cancer; Gastric cancer; Therapy

Indexed keywords

AMG 655; ANTINEOPLASTIC AGENT; APO 010; APOMAB; BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FAS ANTIGEN; FAS LIGAND; FASARET; FLUOROURACIL; FOLINIC ACID; GEFITINIB; INHIBITOR OF APOPTOSIS PROTEIN 2; IRINOTECAN; LEXATUMUMAB; MAPATUMUMAB; MATUZUMAB; MITOGEN ACTIVATED PROTEIN KINASE; OBLIMERSEN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; SURVIVIN; TNFERADE; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

EID: 67349150698     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2009.02.002     Document Type: Article
Times cited : (136)

References (181)
  • 1
    • 58149335340 scopus 로고    scopus 로고
    • PPARgamma ligands, rosiglitazone and pioglitazone inhibit bFGF- and VEGF-mediated angiogenesis
    • Aljada A., O'Connor L., Fu Y.Y., and Mousa S.A. PPARgamma ligands, rosiglitazone and pioglitazone inhibit bFGF- and VEGF-mediated angiogenesis. Angiogenesis 11 (2008) 361-367
    • (2008) Angiogenesis , vol.11 , pp. 361-367
    • Aljada, A.1    O'Connor, L.2    Fu, Y.Y.3    Mousa, S.A.4
  • 4
    • 58349112979 scopus 로고    scopus 로고
    • Clinical benefit of new targeted agents in Phase I trials in patients with advanced colorectal cancer
    • Arkenau H.T., Brunetto A.T., Barriuso J., Olmos D., Eaton D., de Bono J., Judson I., et al. Clinical benefit of new targeted agents in Phase I trials in patients with advanced colorectal cancer. Oncology 76 (2009) 151-156
    • (2009) Oncology , vol.76 , pp. 151-156
    • Arkenau, H.T.1    Brunetto, A.T.2    Barriuso, J.3    Olmos, D.4    Eaton, D.5    de Bono, J.6    Judson, I.7
  • 5
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev. 19 (2008) 325-331
    • (2008) Cytokine Growth Factor Rev. , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 6
    • 56249137901 scopus 로고    scopus 로고
    • HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
    • Bachleitner-Hofmann T., Sun M.Y., Chen C.T., Tang L., Song L., Zeng Z., et al. HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol. Cancer Ther. 7 (2008) 3499-3508
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3499-3508
    • Bachleitner-Hofmann, T.1    Sun, M.Y.2    Chen, C.T.3    Tang, L.4    Song, L.5    Zeng, Z.6
  • 7
    • 43849086302 scopus 로고    scopus 로고
    • Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines
    • Bae S.H., Ryoo H.M., Kim M.K., Lee K.H., Sin J.I., and Hyun M.S. Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines. Oncol. Rep. 19 (2008) 1027-1032
    • (2008) Oncol. Rep. , vol.19 , pp. 1027-1032
    • Bae, S.H.1    Ryoo, H.M.2    Kim, M.K.3    Lee, K.H.4    Sin, J.I.5    Hyun, M.S.6
  • 8
    • 54349091392 scopus 로고    scopus 로고
    • Curcumin inhibits VEGF mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition
    • Binion D.G., Otterson M.F., and Rafiee P. Curcumin inhibits VEGF mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 57 (2008) 1509-1517
    • (2008) Gut , vol.57 , pp. 1509-1517
    • Binion, D.G.1    Otterson, M.F.2    Rafiee, P.3
  • 9
    • 65649091280 scopus 로고    scopus 로고
    • Thiazolidinediones as anti-cancer agents
    • Blanquicett C., Roman J., and Hart C.M. Thiazolidinediones as anti-cancer agents. Cancer Ther. 6 (2008) 25-34
    • (2008) Cancer Ther. , vol.6 , pp. 25-34
    • Blanquicett, C.1    Roman, J.2    Hart, C.M.3
  • 10
    • 52249121583 scopus 로고    scopus 로고
    • Isolation and extraction of circulating tumor DNA from patients with small cell lung cancer
    • Board R.E., Williams V.S., Knight L., Shaw J., Greystoke A., Ranson M., et al. Isolation and extraction of circulating tumor DNA from patients with small cell lung cancer. Ann. N.Y. Acad. Sci. 1137 (2008) 98-107
    • (2008) Ann. N.Y. Acad. Sci. , vol.1137 , pp. 98-107
    • Board, R.E.1    Williams, V.S.2    Knight, L.3    Shaw, J.4    Greystoke, A.5    Ranson, M.6
  • 12
    • 14644409675 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans
    • Bowen J.M., Gibson R.J., Keefe D.M., and Cummins A.G. Cytotoxic chemotherapy upregulates pro-apoptotic Bax and Bak in the small intestine of rats and humans. Pathology 37 (2005) 56-62
    • (2005) Pathology , vol.37 , pp. 56-62
    • Bowen, J.M.1    Gibson, R.J.2    Keefe, D.M.3    Cummins, A.G.4
  • 13
    • 48049118634 scopus 로고    scopus 로고
    • Approved monoclonal antibodies for cancer therapy
    • Boyiadzis M., and Foon K.A. Approved monoclonal antibodies for cancer therapy. Expert Opin. Biol. Ther. 8 (2008) 1151-1158
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1151-1158
    • Boyiadzis, M.1    Foon, K.A.2
  • 14
    • 0031595670 scopus 로고    scopus 로고
    • Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells
    • Brockman J.A., Gupta R.A., and Dubois R.N. Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells. Gastroenterology 115 (1998) 1049-1055
    • (1998) Gastroenterology , vol.115 , pp. 1049-1055
    • Brockman, J.A.1    Gupta, R.A.2    Dubois, R.N.3
  • 15
    • 0034025130 scopus 로고    scopus 로고
    • Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas
    • Bukholm I.K., and Nesland J.M. Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. Virchows Arch. 436 (2000) 224-228
    • (2000) Virchows Arch. , vol.436 , pp. 224-228
    • Bukholm, I.K.1    Nesland, J.M.2
  • 16
    • 0032780384 scopus 로고    scopus 로고
    • Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours
    • Cai Y.C., Jiang Z., Vittimberga F., Xu X., Savas L., and Woda B. Expression of transforming growth factor-alpha and epidermal growth factor receptor in gastrointestinal stromal tumours. Virchows Arch. 435 (1999) 112-115
    • (1999) Virchows Arch. , vol.435 , pp. 112-115
    • Cai, Y.C.1    Jiang, Z.2    Vittimberga, F.3    Xu, X.4    Savas, L.5    Woda, B.6
  • 17
    • 52749085743 scopus 로고    scopus 로고
    • Targeted manipulation of apoptosis in cancer treatment
    • Call J.A., Eckhardt S.G., and Camidge D.R. Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol. 9 (2008) 1002-1011
    • (2008) Lancet Oncol. , vol.9 , pp. 1002-1011
    • Call, J.A.1    Eckhardt, S.G.2    Camidge, D.R.3
  • 18
    • 47949092316 scopus 로고    scopus 로고
    • Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors
    • Camidge D.R. Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors. Expert Opin. Biol. Ther. 8 (2008) 1167-1176
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 1167-1176
    • Camidge, D.R.1
  • 20
    • 20844437755 scopus 로고    scopus 로고
    • Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
    • Carter B.Z., Gronda M., Wang Z., Welsh K., Pinilla C., and Andreeff M. Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. Blood 105 (2005) 4043-4050
    • (2005) Blood , vol.105 , pp. 4043-4050
    • Carter, B.Z.1    Gronda, M.2    Wang, Z.3    Welsh, K.4    Pinilla, C.5    Andreeff, M.6
  • 21
    • 43449117473 scopus 로고    scopus 로고
    • Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells
    • Chen T., and Deng C. Inhibitory effect of siRNA targeting survivin in gastric cancer MGC-803 cells. Int. Immunopharmacol. 8 (2008) 1006-1011
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 1006-1011
    • Chen, T.1    Deng, C.2
  • 22
    • 0035174504 scopus 로고    scopus 로고
    • Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    • Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 21 (2001) 2895-2900
    • (2001) Anticancer Res. , vol.21 , pp. 2895-2900
    • Cheng, A.L.1    Hsu, C.H.2    Lin, J.K.3    Hsu, M.M.4    Ho, Y.F.5    Shen, T.S.6
  • 23
    • 43649105389 scopus 로고    scopus 로고
    • Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumors
    • Chiacchiera F., and Simone C. Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumors. Cancer Lett. 265 (2008) 16-26
    • (2008) Cancer Lett. , vol.265 , pp. 16-26
    • Chiacchiera, F.1    Simone, C.2
  • 24
    • 2342615480 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells
    • Cummins J.M., Kohli M., Rago C., Kinzler K.W., Vogelstein B., and Bunz F. X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res. 64 (2004) 3006-3008
    • (2004) Cancer Res. , vol.64 , pp. 3006-3008
    • Cummins, J.M.1    Kohli, M.2    Rago, C.3    Kinzler, K.W.4    Vogelstein, B.5    Bunz, F.6
  • 25
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351 (2004) 337-345
    • (2004) N. Engl. J. Med. , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 26
    • 43049093730 scopus 로고    scopus 로고
    • Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo
    • Dai Y., Qiao L., Chan K.W., Zou B., Ma J., Lan H.Y., et al. Loss of XIAP sensitizes Rosiglitazone-induced growth inhibition of colon cancer in vivo. Int. J. Cancer 122 (2008) 2858-2863
    • (2008) Int. J. Cancer , vol.122 , pp. 2858-2863
    • Dai, Y.1    Qiao, L.2    Chan, K.W.3    Zou, B.4    Ma, J.5    Lan, H.Y.6
  • 28
    • 0036031772 scopus 로고    scopus 로고
    • Therapeutics targeting signal transduction for patients with colorectal carcinoma
    • de Bono J.S., and Rowinsky E.K. Therapeutics targeting signal transduction for patients with colorectal carcinoma. Br. Med. Bull. 64 (2002) 227-254
    • (2002) Br. Med. Bull. , vol.64 , pp. 227-254
    • de Bono, J.S.1    Rowinsky, E.K.2
  • 29
    • 54249157397 scopus 로고    scopus 로고
    • Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer
    • de Haas E.C., di Pietro A., Simpson K.L., Meijer C., Suurmeijer A.J., Lancashire L.J., et al. Clinical evaluation of M30 and M65 ELISA cell death assays as circulating biomarkers in a drug-sensitive tumor, testicular cancer. Neoplasia 10 (2008) 1041-1048
    • (2008) Neoplasia , vol.10 , pp. 1041-1048
    • de Haas, E.C.1    di Pietro, A.2    Simpson, K.L.3    Meijer, C.4    Suurmeijer, A.J.5    Lancashire, L.J.6
  • 30
    • 34247880415 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer
    • Durai R., Yang S.Y., Sales K.M., Seifalian A.M., Goldspink G., and Winslet M.C. Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer. Int. J. Oncol. 30 (2007) 883-888
    • (2007) Int. J. Oncol. , vol.30 , pp. 883-888
    • Durai, R.1    Yang, S.Y.2    Sales, K.M.3    Seifalian, A.M.4    Goldspink, G.5    Winslet, M.C.6
  • 31
    • 33144481343 scopus 로고    scopus 로고
    • The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer
    • Dutton A., Young L.S., and Murray P.G. The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer. Expert Opin. Ther. Targets 10 (2006) 27-35
    • (2006) Expert Opin. Ther. Targets , vol.10 , pp. 27-35
    • Dutton, A.1    Young, L.S.2    Murray, P.G.3
  • 33
    • 42149143633 scopus 로고    scopus 로고
    • Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand
    • Ebert E.C., and Groh V. Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand. Immunology 124 (2008) 33-41
    • (2008) Immunology , vol.124 , pp. 33-41
    • Ebert, E.C.1    Groh, V.2
  • 34
    • 34247390081 scopus 로고    scopus 로고
    • First steps towards molecular prevention in gastric carcinogenesis
    • Ebert M.P., and Röcken C. First steps towards molecular prevention in gastric carcinogenesis. Cancer Biol. Ther. 6 (2007) 276-277
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 276-277
    • Ebert, M.P.1    Röcken, C.2
  • 35
    • 22944479004 scopus 로고    scopus 로고
    • Modulation of anti-apoptosis by endogenous IAP expression in MKN45 human gastric cancer cells
    • Endo K., Kohnoe S., Tsujita E., Watanabe A., Nakashima H., and Baba H. Modulation of anti-apoptosis by endogenous IAP expression in MKN45 human gastric cancer cells. Anticancer Res. 25 (2005) 2713-2717
    • (2005) Anticancer Res. , vol.25 , pp. 2713-2717
    • Endo, K.1    Kohnoe, S.2    Tsujita, E.3    Watanabe, A.4    Nakashima, H.5    Baba, H.6
  • 37
    • 17844368327 scopus 로고    scopus 로고
    • The MAPK signalling pathways and colorectal cancer
    • Fang J.Y., and Richardson B.C. The MAPK signalling pathways and colorectal cancer. Lancet Oncol. 6 (2005) 322-327
    • (2005) Lancet Oncol. , vol.6 , pp. 322-327
    • Fang, J.Y.1    Richardson, B.C.2
  • 38
    • 0037396217 scopus 로고    scopus 로고
    • Oblimersen sodium (G3139 Bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia: a targeted approach to enhance apoptosis
    • Frankel S.R. Oblimersen sodium (G3139 Bcl-2 antisense oligonucleotide) therapy in Waldenstrom's macroglobulinemia: a targeted approach to enhance apoptosis. Semin. Oncol. 30 (2003) 300-304
    • (2003) Semin. Oncol. , vol.30 , pp. 300-304
    • Frankel, S.R.1
  • 39
    • 34548357028 scopus 로고    scopus 로고
    • Antitumor effects and drug interactions of the proteasome inhibitor bortezomib (PS341) in gastric cancer cells
    • Fujita T., Doihara H., Washio K., Ino H., Murakami M., Naito M., et al. Antitumor effects and drug interactions of the proteasome inhibitor bortezomib (PS341) in gastric cancer cells. Anticancer Drugs 18 (2007) 677-686
    • (2007) Anticancer Drugs , vol.18 , pp. 677-686
    • Fujita, T.1    Doihara, H.2    Washio, K.3    Ino, H.4    Murakami, M.5    Naito, M.6
  • 40
    • 2442682791 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-alpha and epidermal growth factor receptors in rat chronic reflux esophagitis
    • Fujiwara Y., Higuchi K., Hamaguchi M., Takashima T., Watanabe T., Tominaga K., et al. Increased expression of transforming growth factor-alpha and epidermal growth factor receptors in rat chronic reflux esophagitis. J. Gastroenterol. Hepatol. 9 (2004) 521-527
    • (2004) J. Gastroenterol. Hepatol. , vol.9 , pp. 521-527
    • Fujiwara, Y.1    Higuchi, K.2    Hamaguchi, M.3    Takashima, T.4    Watanabe, T.5    Tominaga, K.6
  • 41
    • 65549143792 scopus 로고    scopus 로고
    • The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
    • (Epub ahead of print)
    • Garm Spindler K.L., Pallisgaard N., Rasmussen A.A., Lindebjerg J., Andersen R.F., Crüger D., et al. The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann. Oncol. 29 (2009) (Epub ahead of print)
    • (2009) Ann. Oncol. , vol.29
    • Garm Spindler, K.L.1    Pallisgaard, N.2    Rasmussen, A.A.3    Lindebjerg, J.4    Andersen, R.F.5    Crüger, D.6
  • 43
    • 0036134344 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: a clinical perspective
    • Goel S., Mani S., and Perez-Soler R. Tyrosine kinase inhibitors: a clinical perspective. Curr. Oncol. Rep. 4 (2002) 9-19
    • (2002) Curr. Oncol. Rep. , vol.4 , pp. 9-19
    • Goel, S.1    Mani, S.2    Perez-Soler, R.3
  • 44
    • 45949083997 scopus 로고    scopus 로고
    • A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment
    • Gonçalves A., Esteyries S., Taylor-Smedra B., Lagarde A., Ayadi M., Monges G., et al. A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment. BMC Cancer 8 (2008) 169
    • (2008) BMC Cancer , vol.8 , pp. 169
    • Gonçalves, A.1    Esteyries, S.2    Taylor-Smedra, B.3    Lagarde, A.4    Ayadi, M.5    Monges, G.6
  • 45
    • 34547842484 scopus 로고    scopus 로고
    • Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model
    • Guichard S.M., Hua M.L., Kang P., Macpherson J.S., and Jodrell D.I. Short hairpin RNAs targeting Bcl-xL modulate senescence and apoptosis following SN-38 and irinotecan exposure in a colon cancer model. Cancer Chemother. Pharmacol. 60 (2007) 651-660
    • (2007) Cancer Chemother. Pharmacol. , vol.60 , pp. 651-660
    • Guichard, S.M.1    Hua, M.L.2    Kang, P.3    Macpherson, J.S.4    Jodrell, D.I.5
  • 46
    • 0035951886 scopus 로고    scopus 로고
    • Bcl-G, a novel pro-apoptotic member of the Bcl-2 family
    • Guo B., Godzik A., and Reed J.C. Bcl-G, a novel pro-apoptotic member of the Bcl-2 family. J. Biol. Chem. 276 (2001) 2780-2785
    • (2001) J. Biol. Chem. , vol.276 , pp. 2780-2785
    • Guo, B.1    Godzik, A.2    Reed, J.C.3
  • 47
    • 23844552830 scopus 로고    scopus 로고
    • New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPARγ agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy
    • Hafner C., Reichle A., and Vogt T. New indications for established drugs: combined tumor-stroma-targeted cancer therapy with PPARγ agonists, COX-2 inhibitors, mTOR antagonists and metronomic chemotherapy. Curr. Cancer Drug Targets 5 (2005) 393-419
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 393-419
    • Hafner, C.1    Reichle, A.2    Vogt, T.3
  • 48
    • 14944367957 scopus 로고    scopus 로고
    • Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis
    • Hague A., Hicks D.J., Hasan F., Smartt H., Cohen G.M., Paraskeva C., et al. Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. Br. J. Cancer 92 (2005) 736-742
    • (2005) Br. J. Cancer , vol.92 , pp. 736-742
    • Hague, A.1    Hicks, D.J.2    Hasan, F.3    Smartt, H.4    Cohen, G.M.5    Paraskeva, C.6
  • 50
    • 44449113251 scopus 로고    scopus 로고
    • Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice
    • Hecht J.R. Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice. Am. J. Health Syst. Pharm. 65 (2008) S15-S21
    • (2008) Am. J. Health Syst. Pharm. , vol.65
    • Hecht, J.R.1
  • 51
    • 34548147248 scopus 로고    scopus 로고
    • Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
    • Hecht J.R., Patnaik A., Berlin J., Venook A., Malik I., Tchekmedyian S., et al. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer 110 (2007) 980-988
    • (2007) Cancer , vol.110 , pp. 980-988
    • Hecht, J.R.1    Patnaik, A.2    Berlin, J.3    Venook, A.4    Malik, I.5    Tchekmedyian, S.6
  • 52
    • 0033590636 scopus 로고    scopus 로고
    • Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
    • Hoshino R., Chatani Y., Yamori T., Tsuruo T., Oka H., Yoshida O., et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 21 (1999) 813-822
    • (1999) Oncogene , vol.21 , pp. 813-822
    • Hoshino, R.1    Chatani, Y.2    Yamori, T.3    Tsuruo, T.4    Oka, H.5    Yoshida, O.6
  • 53
    • 54249087106 scopus 로고    scopus 로고
    • Colon cancer stem cells: implications for prevention and therapy
    • Huang E.H., and Wicha M.S. Colon cancer stem cells: implications for prevention and therapy. Trends Mol. Med. 14 (2008) 503-509
    • (2008) Trends Mol. Med. , vol.14 , pp. 503-509
    • Huang, E.H.1    Wicha, M.S.2
  • 54
    • 33645065460 scopus 로고    scopus 로고
    • Development and evaluation of cancer therapeutic agents targeting TRAIL receptor 1 and 2
    • LaRochelle W.J., and Shimkets R.A. (Eds), Humana Press, Totawa
    • Humphreys R.C. Development and evaluation of cancer therapeutic agents targeting TRAIL receptor 1 and 2. In: LaRochelle W.J., and Shimkets R.A. (Eds). Cancer Drug Discovery and Development: The Oncogenomics Handbook (2005), Humana Press, Totawa 659-676
    • (2005) Cancer Drug Discovery and Development: The Oncogenomics Handbook , pp. 659-676
    • Humphreys, R.C.1
  • 55
    • 34547126428 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) as cancer targets
    • Hunter A.M., LaCasse E.C., and Korneluk R.G. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12 (2007) 1543-1668
    • (2007) Apoptosis , vol.12 , pp. 1543-1668
    • Hunter, A.M.1    LaCasse, E.C.2    Korneluk, R.G.3
  • 56
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., Cartwright T., Hainsworth J., Heim W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350 23 (2004) 2335-2342
    • (2004) N. Engl. J. Med. , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 58
    • 0036172028 scopus 로고    scopus 로고
    • Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment
    • Ikeguchi M., Liu J., and Kaibara N. Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment. Apoptosis 7 (2002) 23-29
    • (2002) Apoptosis , vol.7 , pp. 23-29
    • Ikeguchi, M.1    Liu, J.2    Kaibara, N.3
  • 59
    • 47149084688 scopus 로고    scopus 로고
    • Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer
    • Jean G.W., and Shah S.R. Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer. Pharmacotherapy 28 (2008) 742-754
    • (2008) Pharmacotherapy , vol.28 , pp. 742-754
    • Jean, G.W.1    Shah, S.R.2
  • 61
    • 0037026663 scopus 로고    scopus 로고
    • Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β(1)-dependent pathway
    • Jiang X.H., Lam S.K., Lin M.C., Jiang S.H., Kung H.F., Slosberg E.D., et al. Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β(1)-dependent pathway. Oncogene 21 (2002) 6113-6122
    • (2002) Oncogene , vol.21 , pp. 6113-6122
    • Jiang, X.H.1    Lam, S.K.2    Lin, M.C.3    Jiang, S.H.4    Kung, H.F.5    Slosberg, E.D.6
  • 62
    • 61449154484 scopus 로고    scopus 로고
    • KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection
    • (Epub ahead of print)
    • Jimeno A., Messersmith W.A., Hirsch F.R., Franklin W.A., and Eckhardt S.G. KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J. Clin. Oncol. 5 (2009) (Epub ahead of print)
    • (2009) J. Clin. Oncol. , vol.5
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 63
    • 34547948369 scopus 로고    scopus 로고
    • Curcumin for chemoprevention of colon cancer
    • Johnson J.J., and Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 255 (2007) 170-181
    • (2007) Cancer Lett. , vol.255 , pp. 170-181
    • Johnson, J.J.1    Mukhtar, H.2
  • 64
    • 52649109068 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway in cancer onset, progression and therapy
    • Johnstone R.W., Frew A.J., and Smyth M.J. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat. Rev. Cancer 8 (2008) 782-798
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 782-798
    • Johnstone, R.W.1    Frew, A.J.2    Smyth, M.J.3
  • 65
    • 67349181817 scopus 로고    scopus 로고
    • Results of a phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC)
    • Paris, France (Abstract No: 630)
    • Kanzler S., Trarbach T., and Heinemann V. Results of a phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC). Proceedings of the 13th European Cancer Organisation Conference, October 20-November 3. Paris, France (2005) (Abstract No: 630)
    • (2005) Proceedings of the 13th European Cancer Organisation Conference, October 20-November 3
    • Kanzler, S.1    Trarbach, T.2    Heinemann, V.3
  • 66
    • 0027151835 scopus 로고
    • Expression of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in gastric and colorectal carcinomas. An immunohistological study of 63 cases
    • Karameris A., Kanavaros P., Aninos D., Gorgoulis V., Mikou G., Rokas T., Niotis M., and Kalogeropoulos N. Expression of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in gastric and colorectal carcinomas. An immunohistological study of 63 cases. Pathol. Res. Pract. 189 (1993) 133-137
    • (1993) Pathol. Res. Pract. , vol.189 , pp. 133-137
    • Karameris, A.1    Kanavaros, P.2    Aninos, D.3    Gorgoulis, V.4    Mikou, G.5    Rokas, T.6    Niotis, M.7    Kalogeropoulos, N.8
  • 67
    • 34147144169 scopus 로고    scopus 로고
    • Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
    • Karikari C.A., Roy I., Tryggestad E., Feldmann G., Pinilla C., Welsh K., et al. Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. Mol. Cancer Ther. 6 (2007) 957-966
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 957-966
    • Karikari, C.A.1    Roy, I.2    Tryggestad, E.3    Feldmann, G.4    Pinilla, C.5    Welsh, K.6
  • 68
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • Katoh M., and Katoh M. WNT signaling pathway and stem cell signaling network. Clin. Cancer Res. 13 (2007) 4042-4045
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 69
    • 33644682653 scopus 로고    scopus 로고
    • Therapeutic potential of antisense (AS) Bcl-2 as a chemosensitizer for patients with gastric and breast carcinoma
    • Kim R., Emi M., Matsuura K., and Tanabe K. Therapeutic potential of antisense (AS) Bcl-2 as a chemosensitizer for patients with gastric and breast carcinoma. Gan To Kagaku Ryoho 32 (2005) 1540-1545
    • (2005) Gan To Kagaku Ryoho , vol.32 , pp. 1540-1545
    • Kim, R.1    Emi, M.2    Matsuura, K.3    Tanabe, K.4
  • 70
    • 7644231496 scopus 로고    scopus 로고
    • Preclinical evaluation of antisense Bcl-2 as a chemosensitizer for patients with gastric carcinoma
    • Kim R., Emi M., Tanabe K., and Toge T. Preclinical evaluation of antisense Bcl-2 as a chemosensitizer for patients with gastric carcinoma. Cancer 101 (2004) 2177-2186
    • (2004) Cancer , vol.101 , pp. 2177-2186
    • Kim, R.1    Emi, M.2    Tanabe, K.3    Toge, T.4
  • 71
    • 3843128786 scopus 로고    scopus 로고
    • Technology evaluation: Matuzumab, Merck KGaA
    • Kim T. Technology evaluation: Matuzumab, Merck KGaA. Curr. Opin. Mol. Ther. 6 (2004) 96-103
    • (2004) Curr. Opin. Mol. Ther. , vol.6 , pp. 96-103
    • Kim, T.1
  • 72
    • 43949116902 scopus 로고    scopus 로고
    • Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines
    • Kim J.H., Go H.Y., Jin D.H., Kim H.P., Hong M.H., Chung W.Y., et al. Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines. Cancer Lett. 265 (2008) 197-205
    • (2008) Cancer Lett. , vol.265 , pp. 197-205
    • Kim, J.H.1    Go, H.Y.2    Jin, D.H.3    Kim, H.P.4    Hong, M.H.5    Chung, W.Y.6
  • 74
    • 0042783111 scopus 로고    scopus 로고
    • Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options
    • Kopp R., Rothbauer E., Ruge M., Arnholdt H., Spranger J., Muders M., et al. Clinical implications of the EGF receptor/ligand system for tumor progression and survival in gastrointestinal carcinomas: evidence for new therapeutic options. Recent Results Cancer Res. 162 (2003) 115-132
    • (2003) Recent Results Cancer Res. , vol.162 , pp. 115-132
    • Kopp, R.1    Rothbauer, E.2    Ruge, M.3    Arnholdt, H.4    Spranger, J.5    Muders, M.6
  • 75
    • 0142011609 scopus 로고    scopus 로고
    • Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels
    • Kopp R., Rothbauer E., Mueller E., Schildberg F.W., Jauch K.W., and Pfeiffer A. Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels. Dis. Colon Rectum 46 (2003) 1391-1399
    • (2003) Dis. Colon Rectum , vol.46 , pp. 1391-1399
    • Kopp, R.1    Rothbauer, E.2    Mueller, E.3    Schildberg, F.W.4    Jauch, K.W.5    Pfeiffer, A.6
  • 76
    • 34447515452 scopus 로고    scopus 로고
    • c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications
    • Korkolopoulou P., Saetta A.A., Levidou G., Gigelou F., Lazaris A., Thymara I., et al. c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications. Histopathology 51 (2007) 150-156
    • (2007) Histopathology , vol.51 , pp. 150-156
    • Korkolopoulou, P.1    Saetta, A.A.2    Levidou, G.3    Gigelou, F.4    Lazaris, A.5    Thymara, I.6
  • 77
    • 0029945789 scopus 로고    scopus 로고
    • Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas
    • Krajewska M., Moss S.F., Krajewski S., Song K., Holt P.R., and Reed J.C. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas. Cancer Res. 56 (1996) 2422-2427
    • (1996) Cancer Res. , vol.56 , pp. 2422-2427
    • Krajewska, M.1    Moss, S.F.2    Krajewski, S.3    Song, K.4    Holt, P.R.5    Reed, J.C.6
  • 78
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis
    • Kucharczak J., Simmons M.J., Fan Y., and Gelinas C. To be, or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 79
    • 30444440866 scopus 로고    scopus 로고
    • Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells
    • Kuniyasu H., Yoshida K., Sasaki T., Sasahira T., Fujii K., and Ohmori H. Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. Int. J. Cancer 118 (2006) 571-576
    • (2006) Int. J. Cancer , vol.118 , pp. 571-576
    • Kuniyasu, H.1    Yoshida, K.2    Sasaki, T.3    Sasahira, T.4    Fujii, K.5    Ohmori, H.6
  • 80
    • 24744456948 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan
    • Kuraoka K., Matsumura S., Sanada Y., Nakachi K., Imai K., Eguchi H., et al. A single nucleotide polymorphism in the extracellular domain of TRAIL receptor DR4 at nucleotide 626 in gastric cancer patients in Japan. Oncol. Rep. 14 (2005) 465-470
    • (2005) Oncol. Rep. , vol.14 , pp. 465-470
    • Kuraoka, K.1    Matsumura, S.2    Sanada, Y.3    Nakachi, K.4    Imai, K.5    Eguchi, H.6
  • 82
    • 33748990325 scopus 로고    scopus 로고
    • Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis
    • LaCasse E.C., Cherton-Horvat G.G., Hewitt K.E., Jerome L.J., Morris S.J., Kandimalla E.R., et al. Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis. Clin. Cancer Res. 12 (2006) 5231-5241
    • (2006) Clin. Cancer Res. , vol.12 , pp. 5231-5241
    • LaCasse, E.C.1    Cherton-Horvat, G.G.2    Hewitt, K.E.3    Jerome, L.J.4    Morris, S.J.5    Kandimalla, E.R.6
  • 83
    • 58549104540 scopus 로고    scopus 로고
    • Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen
    • Lam L.T., Davis R.E., Ngo V.N., et al. Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 20798-20803
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 20798-20803
    • Lam, L.T.1    Davis, R.E.2    Ngo, V.N.3
  • 85
    • 31544458038 scopus 로고    scopus 로고
    • Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma
    • Lee D.S., Kang S.B., Baek J.T., Nam S.W., Lee K.M., Ahn B.M., et al. Immunohistochemical expression of bcl-2, bcl-xL, bax, p53 proteins in gastric adenoma and adenocarcinoma. Korean J. Gastroenterol. 45 (2005) 394-400
    • (2005) Korean J. Gastroenterol. , vol.45 , pp. 394-400
    • Lee, D.S.1    Kang, S.B.2    Baek, J.T.3    Nam, S.W.4    Lee, K.M.5    Ahn, B.M.6
  • 86
    • 33744955317 scopus 로고    scopus 로고
    • Efficiency of recombinant human TNF in human cancer therapy
    • Lejeune F.J., Liénard D., Matter M., and Rüegg C. Efficiency of recombinant human TNF in human cancer therapy. Cancer Immun. 6 (2006) 6
    • (2006) Cancer Immun. , vol.6 , pp. 6
    • Lejeune, F.J.1    Liénard, D.2    Matter, M.3    Rüegg, C.4
  • 87
    • 1642336478 scopus 로고    scopus 로고
    • Gene transfer: Bax to the future for cancer therapy
    • Lemoine N.R., and McNeish I.A. Gene transfer: Bax to the future for cancer therapy. Gut 53 (2004) 478-479
    • (2004) Gut , vol.53 , pp. 478-479
    • Lemoine, N.R.1    McNeish, I.A.2
  • 88
    • 57649225434 scopus 로고    scopus 로고
    • First-line combination treatment of colorectal cancer with hepatic metastases: choosing a targeted agent
    • Lenz H.J. First-line combination treatment of colorectal cancer with hepatic metastases: choosing a targeted agent. Cancer Treat. Rev. 34 (2008) S3-S7
    • (2008) Cancer Treat. Rev. , vol.34
    • Lenz, H.J.1
  • 89
    • 0842310014 scopus 로고    scopus 로고
    • Fas-related apoptosis in gastric adenocarcinoma
    • Lim S.C. Fas-related apoptosis in gastric adenocarcinoma. Oncol. Rep. 10 (2003) 57-63
    • (2003) Oncol. Rep. , vol.10 , pp. 57-63
    • Lim, S.C.1
  • 90
    • 35648929217 scopus 로고    scopus 로고
    • 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer
    • Lin H.L., Yang M.H., Wu C.W., Chen P.M., Yang Y.P., Chu Y.R., et al. 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. Int. J. Cancer 121 (2007) 2547-2555
    • (2007) Int. J. Cancer , vol.121 , pp. 2547-2555
    • Lin, H.L.1    Yang, M.H.2    Wu, C.W.3    Chen, P.M.4    Yang, Y.P.5    Chu, Y.R.6
  • 91
    • 43049131769 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
    • LoPiccolo J., Blumenthal G.M., Bernstein W.B., and Dennis P.A. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist. Updates 11 (2008) 32-50
    • (2008) Drug Resist. Updates , vol.11 , pp. 32-50
    • LoPiccolo, J.1    Blumenthal, G.M.2    Bernstein, W.B.3    Dennis, P.A.4
  • 92
    • 38549123294 scopus 로고    scopus 로고
    • Therapeutic potential of AIF-mediated caspase-independent programmed cell death
    • Lorenzo H.K., and Susin S.A. Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist. Updates 10 (2007) 235-255
    • (2007) Drug Resist. Updates , vol.10 , pp. 235-255
    • Lorenzo, H.K.1    Susin, S.A.2
  • 93
    • 0032080378 scopus 로고    scopus 로고
    • Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas
    • Lu C.D., Altieri D.C., and Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas. Cancer Res. 58 (1998) 1808-1812
    • (1998) Cancer Res. , vol.58 , pp. 1808-1812
    • Lu, C.D.1    Altieri, D.C.2    Tanigawa, N.3
  • 94
    • 46449094710 scopus 로고    scopus 로고
    • Chemoprevention with special reference to inherited colorectal cancer
    • Lynch P.M. Chemoprevention with special reference to inherited colorectal cancer. Fam. Cancer 7 (2008) 59-64
    • (2008) Fam. Cancer , vol.7 , pp. 59-64
    • Lynch, P.M.1
  • 95
    • 33644776859 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) inhibitors in gastrointestinal cancer
    • Macarulla T., Casado E., Ramos F.J., Valverde C., and Tabernero J. Epidermal growth factor receptor (EGFR) inhibitors in gastrointestinal cancer. Onkologie 29 (2006) 99-105
    • (2006) Onkologie , vol.29 , pp. 99-105
    • Macarulla, T.1    Casado, E.2    Ramos, F.J.3    Valverde, C.4    Tabernero, J.5
  • 96
    • 0030897178 scopus 로고    scopus 로고
    • Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer
    • Malecka-Panas E., Kordek R., Biernat W., Tureaud J., Liberski P.P., and Majumdar A.P. Differential activation of total and EGF receptor (EGF-R) tyrosine kinase (tyr-k) in the rectal mucosa in patients with adenomatous polyps, ulcerative colitis and colon cancer. Hepatogastroenterology 44 (1997) 435-440
    • (1997) Hepatogastroenterology , vol.44 , pp. 435-440
    • Malecka-Panas, E.1    Kordek, R.2    Biernat, W.3    Tureaud, J.4    Liberski, P.P.5    Majumdar, A.P.6
  • 97
    • 4644279894 scopus 로고    scopus 로고
    • Effect of H. pylori on the expression of TRAIL, FasL and their receptor subtypes in human gastric epithelial cells and their role in apoptosis
    • Martin J.H., Potthoff A., Ledig S., Cornberg M., Jandl O., Manns M.P., et al. Effect of H. pylori on the expression of TRAIL, FasL and their receptor subtypes in human gastric epithelial cells and their role in apoptosis. Helicobacter 9 (2004) 371-386
    • (2004) Helicobacter , vol.9 , pp. 371-386
    • Martin, J.H.1    Potthoff, A.2    Ledig, S.3    Cornberg, M.4    Jandl, O.5    Manns, M.P.6
  • 98
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting
    • Matar P., Rojo F., Cassia R., Moreno-Bueno G., Di Cosimo S., and Tabernero J. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin. Cancer Res. 10 (2004) 6487-6501
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3    Moreno-Bueno, G.4    Di Cosimo, S.5    Tabernero, J.6
  • 99
    • 59749089432 scopus 로고    scopus 로고
    • Targeted therapy for advanced colorectal cancer-more is not always better
    • Mayer R. Targeted therapy for advanced colorectal cancer-more is not always better. N. Engl. J. Med. 360 (2009) 623-625
    • (2009) N. Engl. J. Med. , vol.360 , pp. 623-625
    • Mayer, R.1
  • 100
    • 53049083867 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor action and resistance in cancer
    • McConkey D.J., and Zhu K. Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist. Updates 11 (2008) 164-179
    • (2008) Drug Resist. Updates , vol.11 , pp. 164-179
    • McConkey, D.J.1    Zhu, K.2
  • 101
    • 0037838498 scopus 로고    scopus 로고
    • Signaling inhibition with radiation in colorectal cancer: clinical trials
    • McKenna W.G., Muschel R.J., Gupta A., Hahn S., and Bernhard E.J. Signaling inhibition with radiation in colorectal cancer: clinical trials. Semin. Oncol. 30 (2003) 56-67
    • (2003) Semin. Oncol. , vol.30 , pp. 56-67
    • McKenna, W.G.1    Muschel, R.J.2    Gupta, A.3    Hahn, S.4    Bernhard, E.J.5
  • 102
    • 45849097197 scopus 로고    scopus 로고
    • ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer
    • Mercier I., Vuolo M., Jasmin J.F., Medina C.M., Williams M., and Mariadason J.M. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle 7 (2008) 1640-1647
    • (2008) Cell Cycle , vol.7 , pp. 1640-1647
    • Mercier, I.1    Vuolo, M.2    Jasmin, J.F.3    Medina, C.M.4    Williams, M.5    Mariadason, J.M.6
  • 103
    • 58149340163 scopus 로고    scopus 로고
    • Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer
    • Micha D., Cummings J., Shoemaker A., Elmore S., Foster K., Greaves M., et al. Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer. Clin. Cancer Res. 14 (2008) 7304-7310
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7304-7310
    • Micha, D.1    Cummings, J.2    Shoemaker, A.3    Elmore, S.4    Foster, K.5    Greaves, M.6
  • 104
    • 27744459507 scopus 로고    scopus 로고
    • Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers
    • Michl P., and Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z. Gastroenterol. 43 (2005) 1133-1139
    • (2005) Z. Gastroenterol. , vol.43 , pp. 1133-1139
    • Michl, P.1    Downward, J.2
  • 105
    • 34247125164 scopus 로고    scopus 로고
    • The proteasome: a worthwhile target for the treatment of solid tumors?
    • Milano A., Vincenzo R., and Caponigro F. The proteasome: a worthwhile target for the treatment of solid tumors?. Eur. J. Cancer 43 (2007) 1125-1133
    • (2007) Eur. J. Cancer , vol.43 , pp. 1125-1133
    • Milano, A.1    Vincenzo, R.2    Caponigro, F.3
  • 106
    • 31544467888 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic and biologic correlative study of oblimersen sodium (Genasense, G3139) and irinotecan in patients with metastatic colorectal cancer
    • Mita M.M., Ochoa L., Rowinsky E.K., Kuhn J., Schwartz G., Hammond L.A., et al. A phase I, pharmacokinetic and biologic correlative study of oblimersen sodium (Genasense, G3139) and irinotecan in patients with metastatic colorectal cancer. Ann. Oncol. 17 (2006) 313-321
    • (2006) Ann. Oncol. , vol.17 , pp. 313-321
    • Mita, M.M.1    Ochoa, L.2    Rowinsky, E.K.3    Kuhn, J.4    Schwartz, G.5    Hammond, L.A.6
  • 107
    • 33745254719 scopus 로고    scopus 로고
    • Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy
    • Mollinedo F., and Gajate C. Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy. Drug Resist. Updates 9 (2006) 51-73
    • (2006) Drug Resist. Updates , vol.9 , pp. 51-73
    • Mollinedo, F.1    Gajate, C.2
  • 108
    • 0035002201 scopus 로고    scopus 로고
    • Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells
    • Moragoda L., Jaszewski R., and Majumdar A.P. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res. 21 (2001) 873-878
    • (2001) Anticancer Res. , vol.21 , pp. 873-878
    • Moragoda, L.1    Jaszewski, R.2    Majumdar, A.P.3
  • 109
    • 44849085132 scopus 로고    scopus 로고
    • Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality
    • Moreira J.N., Santos A., and Simões S. Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality. Rev. Recent Clin. Trials 1 (2006) 217-235
    • (2006) Rev. Recent Clin. Trials , vol.1 , pp. 217-235
    • Moreira, J.N.1    Santos, A.2    Simões, S.3
  • 110
    • 34548662911 scopus 로고    scopus 로고
    • Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells
    • Mori T., Doi R., Kida A., Nagai K., Kami K., Ito D., et al. Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. J. Surg. Res. 142 (2007) 281-286
    • (2007) J. Surg. Res. , vol.142 , pp. 281-286
    • Mori, T.1    Doi, R.2    Kida, A.3    Nagai, K.4    Kami, K.5    Ito, D.6
  • 111
    • 3042660431 scopus 로고    scopus 로고
    • The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer
    • Nachmias B., Ashhab Y., and Ben-Yehuda D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin. Cancer Biol. 14 (2004) 231-243
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 231-243
    • Nachmias, B.1    Ashhab, Y.2    Ben-Yehuda, D.3
  • 113
    • 15944387964 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim
    • Nikrad M., Johnson T., Puthalalath H., Coultas L., Adams J., and Kraft A.S. The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim. Mol. Cancer Ther. 4 (2005) 443-449
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 443-449
    • Nikrad, M.1    Johnson, T.2    Puthalalath, H.3    Coultas, L.4    Adams, J.5    Kraft, A.S.6
  • 114
    • 5644273804 scopus 로고    scopus 로고
    • ErbB2 without erbB3 expression in metaplastic columnar epithelium of Barrett's esophagus
    • Nishigaki H., Wada K., Tatsuguchi A., Sueoka N., Futagami S., Gudis K., et al. ErbB2 without erbB3 expression in metaplastic columnar epithelium of Barrett's esophagus. Digestion 70 (2004) 95-102
    • (2004) Digestion , vol.70 , pp. 95-102
    • Nishigaki, H.1    Wada, K.2    Tatsuguchi, A.3    Sueoka, N.4    Futagami, S.5    Gudis, K.6
  • 115
    • 0037010079 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy in colorectal cancer
    • O'Dwyer P.J., and Benson III A.B. Epidermal growth factor receptor-targeted therapy in colorectal cancer. Semin. Oncol. 29 (2002) 10-17
    • (2002) Semin. Oncol. , vol.29 , pp. 10-17
    • O'Dwyer, P.J.1    Benson III, A.B.2
  • 116
    • 24644523517 scopus 로고    scopus 로고
    • The role of caspases in cell death and differentiation
    • Oliver L., and Vallette F.M. The role of caspases in cell death and differentiation. Drug Resist. Updates 8 (2005) 163-170
    • (2005) Drug Resist. Updates , vol.8 , pp. 163-170
    • Oliver, L.1    Vallette, F.M.2
  • 117
    • 0035720399 scopus 로고    scopus 로고
    • Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis
    • Osaki M., Kase S., Kodani I., Watanabe M., Adachi H., and Ito H. Expression of Fas and Fas ligand in human gastric adenomas and intestinal-type carcinomas: correlation with proliferation and apoptosis. Gastric Cancer 4 (2001) 198-205
    • (2001) Gastric Cancer , vol.4 , pp. 198-205
    • Osaki, M.1    Kase, S.2    Kodani, I.3    Watanabe, M.4    Adachi, H.5    Ito, H.6
  • 118
    • 0742269398 scopus 로고    scopus 로고
    • Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45
    • Osaki M., Kase S., Adachi K., Takeda A., Hashimoto K., and Ito H. Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45. J. Cancer Res. Clin. Oncol. 130 (2004) 8-14
    • (2004) J. Cancer Res. Clin. Oncol. , vol.130 , pp. 8-14
    • Osaki, M.1    Kase, S.2    Adachi, K.3    Takeda, A.4    Hashimoto, K.5    Ito, H.6
  • 119
    • 56349112359 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system: a novel target for anticancer and anti-inflammatory drug research
    • Ostrowska H. The ubiquitin-proteasome system: a novel target for anticancer and anti-inflammatory drug research. Cell. Mol. Biol. Lett. 13 (2008) 353-365
    • (2008) Cell. Mol. Biol. Lett. , vol.13 , pp. 353-365
    • Ostrowska, H.1
  • 120
    • 25144432015 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas
    • Papouchado B., Erickson L.A., Rohlinger A.L., Hobday T.J., Erlichman C., Ames M.M., et al. Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas. Mod. Pathol. 18 (2005) 1329-1335
    • (2005) Mod. Pathol. , vol.18 , pp. 1329-1335
    • Papouchado, B.1    Erickson, L.A.2    Rohlinger, A.L.3    Hobday, T.J.4    Erlichman, C.5    Ames, M.M.6
  • 122
    • 55549105059 scopus 로고    scopus 로고
    • Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer
    • Patel D.K. Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. Pharmacotherapy 28 (2008) 31S-41S
    • (2008) Pharmacotherapy , vol.28
    • Patel, D.K.1
  • 124
    • 35948952826 scopus 로고    scopus 로고
    • Phase 1 and pharmacokinetic study of lexatumumab in patients with advanced cancers
    • Plummer R., Attard G., Pacey S., Li L., Razak A., Perrett R., et al. Phase 1 and pharmacokinetic study of lexatumumab in patients with advanced cancers. Clin. Cancer Res. 13 (2007) 6187-6194
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6187-6194
    • Plummer, R.1    Attard, G.2    Pacey, S.3    Li, L.4    Razak, A.5    Perrett, R.6
  • 125
    • 54049145194 scopus 로고    scopus 로고
    • Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma
    • Pro B., Leber B., Smith M., Fayad L., Romaguera J., Hagemeister F., et al. Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma. Br. J. Haematol. 143 (2008) 355-360
    • (2008) Br. J. Haematol. , vol.143 , pp. 355-360
    • Pro, B.1    Leber, B.2    Smith, M.3    Fayad, L.4    Romaguera, J.5    Hagemeister, F.6
  • 126
    • 21044441651 scopus 로고    scopus 로고
    • HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumor types in vitro and in vivo
    • Pukac L., Kanakaraj P., Humphreys R., Alderson R., Bloom M., Sung C., et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumor types in vitro and in vivo. Br. J. Cancer 92 (2005) 1430-1441
    • (2005) Br. J. Cancer , vol.92 , pp. 1430-1441
    • Pukac, L.1    Kanakaraj, P.2    Humphreys, R.3    Alderson, R.4    Bloom, M.5    Sung, C.6
  • 127
    • 59649112825 scopus 로고    scopus 로고
    • Gene expression profile in colon cancer cells with respect to XIAP expression status
    • Qiao L., Li G.H., Dai Y., Wang J., Li Z., Zou B., et al. Gene expression profile in colon cancer cells with respect to XIAP expression status. Int. J. Colorectal Dis. 24 (2009) 245-260
    • (2009) Int. J. Colorectal Dis. , vol.24 , pp. 245-260
    • Qiao, L.1    Li, G.H.2    Dai, Y.3    Wang, J.4    Li, Z.5    Zou, B.6
  • 128
    • 51049118824 scopus 로고    scopus 로고
    • XIAP deficiency sensitizes PPARγ ligand-induced killing of colon cancer cells
    • Qiao L., Dai Y., Chan K.W., Ma J., Lin M.C.M., Lan H.Y., et al. XIAP deficiency sensitizes PPARγ ligand-induced killing of colon cancer cells. Mol. Cancer Ther. 7 (2008) 2203-2211
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2203-2211
    • Qiao, L.1    Dai, Y.2    Chan, K.W.3    Ma, J.4    Lin, M.C.M.5    Lan, H.Y.6
  • 129
    • 48549105519 scopus 로고    scopus 로고
    • Loss of XIAP sensitizes colon cancer cells to PPARγ independent antitumor effects of troglitazone and 15-PGJ2
    • Qiao L., Dai Y., Gu Q., Chan K.W., Ma J., Lan H.Y., et al. Loss of XIAP sensitizes colon cancer cells to PPARγ independent antitumor effects of troglitazone and 15-PGJ2. Cancer Lett. 268 (2008) 260-271
    • (2008) Cancer Lett. , vol.268 , pp. 260-271
    • Qiao, L.1    Dai, Y.2    Gu, Q.3    Chan, K.W.4    Ma, J.5    Lan, H.Y.6
  • 130
    • 0035167269 scopus 로고    scopus 로고
    • Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis
    • Qiao L., Studer E., Leach K., McKinstry R., Gupta S., Decker R., et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis. Mol. Biol. Cell 12 (2001) 2629-2645
    • (2001) Mol. Biol. Cell , vol.12 , pp. 2629-2645
    • Qiao, L.1    Studer, E.2    Leach, K.3    McKinstry, R.4    Gupta, S.5    Decker, R.6
  • 131
    • 17844392101 scopus 로고    scopus 로고
    • Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL
    • Rashmi R., Kumar S., and Karunagaran D. Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 26 (2005) 713-723
    • (2005) Carcinogenesis , vol.26 , pp. 713-723
    • Rashmi, R.1    Kumar, S.2    Karunagaran, D.3
  • 132
    • 0033026714 scopus 로고    scopus 로고
    • Mechanisms of apoptosis avoidance in cancer
    • Reed J.C. Mechanisms of apoptosis avoidance in cancer. Curr. Opin. Oncol. 11 (1999) 68-75
    • (1999) Curr. Opin. Oncol. , vol.11 , pp. 68-75
    • Reed, J.C.1
  • 134
    • 33748987894 scopus 로고    scopus 로고
    • Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma
    • 4309-4016
    • Rojo F., Tabernero J., Albanell J., Van Cutsem E., Ohtsu A., Doi T., et al. Pharmacodynamic studies of gefitinib in tumor biopsy specimens from patients with advanced gastric carcinoma. J. Clin. Oncol. 24 (2006) 4309-4016
    • (2006) J. Clin. Oncol. , vol.24
    • Rojo, F.1    Tabernero, J.2    Albanell, J.3    Van Cutsem, E.4    Ohtsu, A.5    Doi, T.6
  • 135
    • 24344482476 scopus 로고    scopus 로고
    • Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)
    • Rychahou P.G., Murillo C.A., and Evers B.M. Targeted RNA interference of PI3K pathway components sensitizes colon cancer cells to TNF-related apoptosis-inducing ligand (TRAIL). Surgery 138 (2005) 391-397
    • (2005) Surgery , vol.138 , pp. 391-397
    • Rychahou, P.G.1    Murillo, C.A.2    Evers, B.M.3
  • 136
    • 34249894171 scopus 로고    scopus 로고
    • Gastrointestinal perforation due to bevacizumab in colorectal cancer
    • Saif M.W., Elfiky A., and Salem R.R. Gastrointestinal perforation due to bevacizumab in colorectal cancer. Ann. Surg. Oncol. 14 (2007) 1860-1869
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 1860-1869
    • Saif, M.W.1    Elfiky, A.2    Salem, R.R.3
  • 137
    • 33645534034 scopus 로고    scopus 로고
    • Peritoneal metastasis inhibition by linoleic acid with activation of PPARγ in human gastrointestinal cancer cells
    • Sasaki T., Fujii K., Yoshida K., Shimura H., Sasahira T., Ohmori H., and Kuniyasu H. Peritoneal metastasis inhibition by linoleic acid with activation of PPARγ in human gastrointestinal cancer cells. Virchows Arch. 16 (2005) 1-6
    • (2005) Virchows Arch. , vol.16 , pp. 1-6
    • Sasaki, T.1    Fujii, K.2    Yoshida, K.3    Shimura, H.4    Sasahira, T.5    Ohmori, H.6    Kuniyasu, H.7
  • 139
    • 21344454231 scopus 로고    scopus 로고
    • MAPK pathway activation in colorectal cancer: a therapeutic opportunity for GRP receptor antagonists
    • Schwartsmann G., Di Leone L.P., Dal Pizzol F., and Roesler R. MAPK pathway activation in colorectal cancer: a therapeutic opportunity for GRP receptor antagonists. Lancet Oncol. 6 (2005) 444-445
    • (2005) Lancet Oncol. , vol.6 , pp. 444-445
    • Schwartsmann, G.1    Di Leone, L.P.2    Dal Pizzol, F.3    Roesler, R.4
  • 140
    • 67449146560 scopus 로고    scopus 로고
    • A phase I escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors
    • (Epub ahead of print)
    • Shirao K., Yoshino T., Boku N., Kato K., Hamaguchi T., Yasui H., et al. A phase I escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors. Cancer Chemother. Pharmacol. 24 (2009) (Epub ahead of print)
    • (2009) Cancer Chemother. Pharmacol. , vol.24
    • Shirao, K.1    Yoshino, T.2    Boku, N.3    Kato, K.4    Hamaguchi, T.5    Yasui, H.6
  • 141
    • 33744490370 scopus 로고    scopus 로고
    • Biological effects of curcumin and its role in cancer chemoprevention and therapy
    • Singh S., and Khar A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med. Chem. 6 (2006) 259-370
    • (2006) Anticancer Agents Med. Chem. , vol.6 , pp. 259-370
    • Singh, S.1    Khar, A.2
  • 142
    • 11144230279 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
    • Sinicrope F.A., Penington R.C., and Tang X.M. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin. Cancer Res. 10 (2004) 8284-8292
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8284-8292
    • Sinicrope, F.A.1    Penington, R.C.2    Tang, X.M.3
  • 143
    • 0037355877 scopus 로고    scopus 로고
    • CD95 (Fas/APO-1)/CD95L in the gastrointestinal tract: fictions and facts
    • Sträter J., and Möller P. CD95 (Fas/APO-1)/CD95L in the gastrointestinal tract: fictions and facts. Virchows Arch. 442 (2003) 218-225
    • (2003) Virchows Arch. , vol.442 , pp. 218-225
    • Sträter, J.1    Möller, P.2
  • 144
    • 41049097824 scopus 로고    scopus 로고
    • NF-kappa B: a new player in angiostatic therapy
    • Tabruyn S.P., and Griffioen A.W. NF-kappa B: a new player in angiostatic therapy. Angiogenesis 11 (2008) 101-106
    • (2008) Angiogenesis , vol.11 , pp. 101-106
    • Tabruyn, S.P.1    Griffioen, A.W.2
  • 145
    • 8344229890 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for gastrointestinal cancer therapy
    • Tedesco K.L., Lockhart A.C., and Berlin J.D. The epidermal growth factor receptor as a target for gastrointestinal cancer therapy. Curr. Treat. Options Oncol. 5 (2004) 393-403
    • (2004) Curr. Treat. Options Oncol. , vol.5 , pp. 393-403
    • Tedesco, K.L.1    Lockhart, A.C.2    Berlin, J.D.3
  • 146
    • 42749092258 scopus 로고    scopus 로고
    • TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them
    • Thorburn A., Behbakht K., and Ford H. TRAIL receptor-targeted therapeutics: resistance mechanisms and strategies to avoid them. Drug Resist. Updates 11 (2008) 17-24
    • (2008) Drug Resist. Updates , vol.11 , pp. 17-24
    • Thorburn, A.1    Behbakht, K.2    Ford, H.3
  • 149
    • 18244401090 scopus 로고    scopus 로고
    • Down-regulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells
    • Tong Q.S., Zheng L.D., Wang L., Zeng F.Q., Chen F.M., Dong J.H., et al. Down-regulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells. Cancer Gene Ther. 12 (2005) 509-514
    • (2005) Cancer Gene Ther. , vol.12 , pp. 509-514
    • Tong, Q.S.1    Zheng, L.D.2    Wang, L.3    Zeng, F.Q.4    Chen, F.M.5    Dong, J.H.6
  • 150
    • 34447104400 scopus 로고    scopus 로고
    • Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
    • Tortora G., Bianco R., Daniele G., et al. Overcoming resistance to molecularly targeted anticancer therapies: rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies. Drug Resist. Updates 10 (2007) 81-100
    • (2007) Drug Resist. Updates , vol.10 , pp. 81-100
    • Tortora, G.1    Bianco, R.2    Daniele, G.3
  • 151
    • 1642355989 scopus 로고    scopus 로고
    • Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer
    • Tsunemitsu Y., Kagawa S., Tokunaga N., Otani S., Umeoka T., Roth J.A., et al. Molecular therapy for peritoneal dissemination of xenotransplanted human MKN-45 gastric cancer cells with adenovirus mediated Bax gene transfer. Gut 53 (2004) 554-560
    • (2004) Gut , vol.53 , pp. 554-560
    • Tsunemitsu, Y.1    Kagawa, S.2    Tokunaga, N.3    Otani, S.4    Umeoka, T.5    Roth, J.A.6
  • 152
    • 14944359615 scopus 로고    scopus 로고
    • Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant
    • Tu S.P., Cui J.T., Liston P., Huajiang X., Xu R., Lin M.C., et al. Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. Gastroenterology 128 (2005) 361-375
    • (2005) Gastroenterology , vol.128 , pp. 361-375
    • Tu, S.P.1    Cui, J.T.2    Liston, P.3    Huajiang, X.4    Xu, R.5    Lin, M.C.6
  • 153
    • 10744232690 scopus 로고    scopus 로고
    • Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer
    • Tu S.P., Jiang X.H., Lin M.C., Cui J.T., Yang Y., Lum C.T., et al. Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer. Cancer Res. 63 (2003) 7724-7732
    • (2003) Cancer Res. , vol.63 , pp. 7724-7732
    • Tu, S.P.1    Jiang, X.H.2    Lin, M.C.3    Cui, J.T.4    Yang, Y.5    Lum, C.T.6
  • 154
    • 14844288360 scopus 로고    scopus 로고
    • Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy
    • Van Geelen C.M.M., de Vries E.G.E., and de Jong S. Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy. Drug Resist. Updates 7 (2004) 345-358
    • (2004) Drug Resist. Updates , vol.7 , pp. 345-358
    • Van Geelen, C.M.M.1    de Vries, E.G.E.2    de Jong, S.3
  • 155
    • 0034616942 scopus 로고    scopus 로고
    • Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
    • Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102 (2000) 43-53
    • (2000) Cell , vol.102 , pp. 43-53
    • Verhagen, A.M.1    Ekert, P.G.2    Pakusch, M.3    Silke, J.4    Connolly, L.M.5    Reid, G.E.6
  • 156
    • 0037016686 scopus 로고    scopus 로고
    • HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins
    • Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., et al. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 (2002) 445-454
    • (2002) J. Biol. Chem. , vol.277 , pp. 445-454
    • Verhagen, A.M.1    Silke, J.2    Ekert, P.G.3    Pakusch, M.4    Kaufmann, H.5    Connolly, L.M.6
  • 157
    • 40449136380 scopus 로고    scopus 로고
    • Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors
    • Vucic D. Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors. Curr. Cancer Drug Targets 8 (2008) 110-117
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 110-117
    • Vucic, D.1
  • 158
    • 33846203835 scopus 로고    scopus 로고
    • Association of IL1B polymorphisms with gastric cancer in a Chinese population
    • Wang P., Ni K.Y., and Zhou G.H. Association of IL1B polymorphisms with gastric cancer in a Chinese population. Clin. Biochem. 40 (2007) 218-225
    • (2007) Clin. Biochem. , vol.40 , pp. 218-225
    • Wang, P.1    Ni, K.Y.2    Zhou, G.H.3
  • 159
    • 6044220227 scopus 로고    scopus 로고
    • Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status
    • Wang Z., Li Y., Liu E.T., and Yu Q. Susceptibility to cell death induced by blockade of MAPK pathway in human colorectal cancer cells carrying Ras mutations is dependent on p53 status. Biochem. Biophys. Res. Commun. 322 (2004) 609-613
    • (2004) Biochem. Biophys. Res. Commun. , vol.322 , pp. 609-613
    • Wang, Z.1    Li, Y.2    Liu, E.T.3    Yu, Q.4
  • 160
    • 34547691667 scopus 로고    scopus 로고
    • Modulation of tumor radiation response with G3139, a Bcl-2 antisense oligonucleotide
    • Wiedenmann N., Koto M., Raju U., Milas L., and Mason K.A. Modulation of tumor radiation response with G3139, a Bcl-2 antisense oligonucleotide. Invest. New Drugs 25 (2007) 411-416
    • (2007) Invest. New Drugs , vol.25 , pp. 411-416
    • Wiedenmann, N.1    Koto, M.2    Raju, U.3    Milas, L.4    Mason, K.A.5
  • 161
    • 18844429786 scopus 로고    scopus 로고
    • Molecularly targeted therapy for gastrointestinal cancer
    • Wiedmann M.W., and Caca K. Molecularly targeted therapy for gastrointestinal cancer. Curr. Cancer Drug Targets 5 (2005) 171-193
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 171-193
    • Wiedmann, M.W.1    Caca, K.2
  • 162
    • 0037468255 scopus 로고    scopus 로고
    • Suppression of RelA/p65 nuclear translocation independent of IκBα degradation by cyclooxygenase-2 inhibitor in gastric cancer
    • Wong B.C., Jiang X., Fan X.M., Lin M.C., Jiang S.H., Lam S.K., et al. Suppression of RelA/p65 nuclear translocation independent of IκBα degradation by cyclooxygenase-2 inhibitor in gastric cancer. Oncogene 22 (2003) 1189-1197
    • (2003) Oncogene , vol.22 , pp. 1189-1197
    • Wong, B.C.1    Jiang, X.2    Fan, X.M.3    Lin, M.C.4    Jiang, S.H.5    Lam, S.K.6
  • 164
    • 27744607673 scopus 로고    scopus 로고
    • Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer
    • Wong S.F. Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer. Clin. Ther. 27 (2005) 684-694
    • (2005) Clin. Ther. , vol.27 , pp. 684-694
    • Wong, S.F.1
  • 165
    • 26444470888 scopus 로고    scopus 로고
    • Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function
    • Wright C.W., and Duckett C.S. Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function. J. Clin. Invest. 115 (2005) 2673-2678
    • (2005) J. Clin. Invest. , vol.115 , pp. 2673-2678
    • Wright, C.W.1    Duckett, C.S.2
  • 166
    • 0037328659 scopus 로고    scopus 로고
    • 5-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
    • Wu J., Xia H.H., Tu S.P., Fan D.M., Lin M.C., Kung H.F., et al. 5-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. Carcinogenesis 24 (2003) 243-247
    • (2003) Carcinogenesis , vol.24 , pp. 243-247
    • Wu, J.1    Xia, H.H.2    Tu, S.P.3    Fan, D.M.4    Lin, M.C.5    Kung, H.F.6
  • 167
    • 44949249814 scopus 로고    scopus 로고
    • miR-15b and miR-16 modulate multidrug resistance by targeting Bcl2 in human gastric cancer cells
    • Xia L., Zhang D., Du R., Pan Y., Zhao L., Sun S., et al. miR-15b and miR-16 modulate multidrug resistance by targeting Bcl2 in human gastric cancer cells. Int. J. Cancer 123 (2008) 372-379
    • (2008) Int. J. Cancer , vol.123 , pp. 372-379
    • Xia, L.1    Zhang, D.2    Du, R.3    Pan, Y.4    Zhao, L.5    Sun, S.6
  • 168
    • 2342440601 scopus 로고    scopus 로고
    • Survivin antisense oligodeoxynucleotide inhibits growth of gastric cancer cells
    • Yang J.H., Zhang Y.C., and Qian H.Q. Survivin antisense oligodeoxynucleotide inhibits growth of gastric cancer cells. World J. Gastroenterol. 10 (2004) 1121-1124
    • (2004) World J. Gastroenterol. , vol.10 , pp. 1121-1124
    • Yang, J.H.1    Zhang, Y.C.2    Qian, H.Q.3
  • 169
    • 0345305311 scopus 로고    scopus 로고
    • Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition
    • Yano S., Kondo K., Yamaguchi M., Richmond G., Hutchison M., Wakeling A., et al. Distribution and function of EGFR in human tissue and the effect of EGFR tyrosine kinase inhibition. Anticancer Res. 23 (2003) 3639-3650
    • (2003) Anticancer Res. , vol.23 , pp. 3639-3650
    • Yano, S.1    Kondo, K.2    Yamaguchi, M.3    Richmond, G.4    Hutchison, M.5    Wakeling, A.6
  • 170
    • 39649123058 scopus 로고    scopus 로고
    • Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk
    • Yoshida T., Okamoto I., Okabe T., Iwasa T., Satoh T., Nishio K., et al. Matuzumab and cetuximab activate the epidermal growth factor receptor but fail to trigger downstream signaling by Akt or Erk. Int. J. Cancer 122 (2008) 1530-1538
    • (2008) Int. J. Cancer , vol.122 , pp. 1530-1538
    • Yoshida, T.1    Okamoto, I.2    Okabe, T.3    Iwasa, T.4    Satoh, T.5    Nishio, K.6
  • 172
    • 36849015047 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
    • Yu H.G., Ai Y.W., Yu L.L., Zhou X.D., Liu J., Li J.H., et al. Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death. Int. J. Cancer 122 (2008) 433-443
    • (2008) Int. J. Cancer , vol.122 , pp. 433-443
    • Yu, H.G.1    Ai, Y.W.2    Yu, L.L.3    Zhou, X.D.4    Liu, J.5    Li, J.H.6
  • 173
    • 34248335752 scopus 로고    scopus 로고
    • XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer
    • Yu L.F., Wang J., Zou B., Lin M.C., Wu Y.L., Xia H.H., et al. XAF1 mediates apoptosis through an extracellular signal-regulated kinase pathway in colon cancer. Cancer 109 (2007) 1996-2003
    • (2007) Cancer , vol.109 , pp. 1996-2003
    • Yu, L.F.1    Wang, J.2    Zou, B.3    Lin, M.C.4    Wu, Y.L.5    Xia, H.H.6
  • 174
    • 57749188479 scopus 로고    scopus 로고
    • MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells
    • Zhang W., Tong Q., Li S., Wang X., and Wang Q. MG-132 inhibits telomerase activity, induces apoptosis and G(1) arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells. Cancer Invest. 26 (2008) 1032-1036
    • (2008) Cancer Invest. , vol.26 , pp. 1032-1036
    • Zhang, W.1    Tong, Q.2    Li, S.3    Wang, X.4    Wang, Q.5
  • 175
    • 38549130324 scopus 로고    scopus 로고
    • BH3 mimetics to improve cancer therapy; mechanisms and examples
    • Zhang L., Ming L., and Yu J. BH3 mimetics to improve cancer therapy; mechanisms and examples. Drug Resist. Updates 10 (2007) 207-217
    • (2007) Drug Resist. Updates , vol.10 , pp. 207-217
    • Zhang, L.1    Ming, L.2    Yu, J.3
  • 176
    • 0034806996 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of Bax and Bak
    • Zhou X.M., Wong B.C., Fan X.M., Zhang H.B., Lin M.C., Kung H.F., et al. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of Bax and Bak. Carcinogenesis 22 (2001) 1393-1397
    • (2001) Carcinogenesis , vol.22 , pp. 1393-1397
    • Zhou, X.M.1    Wong, B.C.2    Fan, X.M.3    Zhang, H.B.4    Lin, M.C.5    Kung, H.F.6
  • 177
    • 31544457665 scopus 로고    scopus 로고
    • Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis
    • Zhou Y., Li S., Hu Y.P., Wang J., Hauser J., Conway A.N., et al. Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis. Cancer Res. 66 (2006) 404-411
    • (2006) Cancer Res. , vol.66 , pp. 404-411
    • Zhou, Y.1    Li, S.2    Hu, Y.P.3    Wang, J.4    Hauser, J.5    Conway, A.N.6
  • 178
    • 34247365049 scopus 로고    scopus 로고
    • Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer
    • Zhou Y., Ran J., Tang C., Wu J., Honghua L., Xingwen L., et al. Effect of celecoxib on E-cadherin, VEGF, microvessel density and apoptosis in gastric cancer. Cancer Biol. Ther. 6 (2007) 269-275
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 269-275
    • Zhou, Y.1    Ran, J.2    Tang, C.3    Wu, J.4    Honghua, L.5    Xingwen, L.6
  • 179
    • 30644481120 scopus 로고    scopus 로고
    • Mechanism of counterattack of colorectal cancer cell by Fas/Fas ligand system
    • Zhu Q., Liu J.Y., Xu H.W., Yang C.M., Zhang A.Z., Cui Y., et al. Mechanism of counterattack of colorectal cancer cell by Fas/Fas ligand system. World J. Gastroenterol. 11 (2005) 6125-6129
    • (2005) World J. Gastroenterol. , vol.11 , pp. 6125-6129
    • Zhu, Q.1    Liu, J.Y.2    Xu, H.W.3    Yang, C.M.4    Zhang, A.Z.5    Cui, Y.6
  • 180
    • 0032928422 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc
    • Zhu G.H., Wong B.C., Eggo M.C., Ching C.K., Yuen S.T., Chan E.Y., et al. Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. Br. J. Cancer 79 (1999) 393-400
    • (1999) Br. J. Cancer , vol.79 , pp. 393-400
    • Zhu, G.H.1    Wong, B.C.2    Eggo, M.C.3    Ching, C.K.4    Yuen, S.T.5    Chan, E.Y.6
  • 181
    • 0034056322 scopus 로고    scopus 로고
    • Overexpression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells
    • Zhu G.H., Wong B.C., Slosberg E.D., Eggo M.C., Ching C.K., Yuen S.T., et al. Overexpression of protein kinase C-β1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology 118 (2000) 507-514
    • (2000) Gastroenterology , vol.118 , pp. 507-514
    • Zhu, G.H.1    Wong, B.C.2    Slosberg, E.D.3    Eggo, M.C.4    Ching, C.K.5    Yuen, S.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.