Inhibition of the PI3K-Akt/PKB survival pathway enhanced an ethanol extract of Rhus verniciflua Stokes-induced apoptosis via a mitochondrial pathway in AGS gastric cancer cell lines

Cancer Letters

Volumn 265, Issue 2, 2008, Pages 197-205

  Kim, Ji Hye ^a,b   Go, Ho Yeon ^c   Jin, Dong Hoon ^d   Kim, Hwang Phill ^e   Hong, Myung Hee ^a,b   Chung, Woo Yeop ^f   Park, Jong Hyeong ^f   Jang, Jun Bock ^b   Jung, Hee ^a   Shin, Yong Cheol ^a   Kim, Sung Hoon ^g   Ko, Seong Gyu ^a,b  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Semyung University   (South Korea)

^d Seoul National University   (South Korea)

^e Seoul National University College of Medicine   (South Korea)

^f Gachon University College of Medicine   (South Korea)

^g East West Medical Research Institute   (South Korea)

Author keywords

Akt PKB; Apoptosis; Caspases; Mitochondria; Rhus verniciflua Stokes

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALCOHOL DERIVATIVE; CASPASE 9; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; RHUS VERNICIFLUA EXTRACT; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RHUS VERNICIFLUA; SIGNAL TRANSDUCTION; STOMACH CANCER; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 9; CELL LINE, TUMOR; ETHANOL; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RHUS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

TOXICODENDRON VERNICIFLUUM;

EID: 43949116902     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.02.039     Document Type: Article

References (41)

1. Steller H. Mechanism and genes of cells suicide. Science 267 (1995) 1145-1149
2. Green D.R. Apoptotic pathways: paper wraps stone blunts scissors. Cell 102 (2000) 1-4
3. Meier P., Finch A., and Evan G. Apoptosis in development. Nature 407 (2000) 796-801
4. Nunez G., Benedict M.A., Hu Y., and Inohara N. Caspases: the proteases of the apoptotic pathway. Oncogene 17 (1998) 3237-3245
5. Kothakota S., Azuma T., Reinhard C., et al. Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science 278 (1997) 294-298
6. Martinou J.C., and Green D.R. Breaking the mitochondrial barrior. Nat. Rev. Mol. Cell Biol. 1 (2001) 63-67
7. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 15 (2001) 2922-2933
8. Adams J.M., and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281 (1998) 1322-1326
9. Cory S., and Adams J.M. The bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2 (2002) 647-656
10. Atan G., James M.M., and Stanley J.K. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13 (1999) 1899-1911
11. Vivanco I., and Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 7 (2002) 489-501
12. Nicholson K.M., and Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell. Signal. 5 (2002) 381-395
13. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 22 (1999) 2905-2927
14. Brazil D.P., and Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 11 (2001) 657-664
15. Hawes B.E., Luttrell L.M., van Biesen T., and Lefkowitz R.J. Phosphatidylinositol 3-kinase is an early intermediate in the Gßγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 271 (1996) 12133-12136
16. Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 2 (1998) 262-267
17. Maehama T., and Dixon J.E. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 4 (1999) 125-128
18. Sandeep R.D., Henryk D., Tao X., Shane M., Haian F., Yukiko G., and Michael E.G. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 (1997) 231-241
19. Cardone M.H., Roy N., Stennicke H.R., Salvesen G.S., Franke T.F., Stanbridge E., Frisch S., and Reed J.C. Regulation of cell death protease caspase-9 by phosphorylation. Science 5392 (1998) 1318-1321
20. N.C. Jung, Biological activity of urushiol and flavonoids from Lac tree (Rhus verniciflua Stokes). Ph.D. Thesis, Chonnam National University, Kwang-ju, Republic of Korea, 1998.
21. Lee J.C., Kim J., Lim K.T., Yang M.S., and Jang Y.S. Ethanol eluted extract of Rhus verniciflua Stokes showed both antioxidant and cytotoxic effects on mouse thymocytes depending on the dose and time of the treatment. J. Biochem. Mol. Biol. 34 (2001) 250-258
22. Kitts D.D., and Lim K.T. Antitumorigenic and cytotoxic properties of an ethanol extract derived from Rhus verniciflua Stokes (RVS). J. Toxicol. Environ. Health A 64 (2001) 357-371
23. Lee J.C., Kim J., and Jang Y.S. Ethanol-eluted extract of Rhus verniciflua Stokes inhibits cell growth and induces apoptosis in human lymphoma cells. J. Biochem. Mol. Biol. 4 (2003) 337-343
24. Lee J.C., Lee K.Y., Kim J.N., et al. Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem. Toxicol. 9 (2004) 1383-1388
25. Kip1 up-regulation and apoptosis induction by an ethanol extract of Rhus verniciflua Stokes in AGS gastric cancer cells. Int. J. Mol. Med. 18 (2006) 201-208
26. Hang D.Y., Wu J., Ye F., Xue L., Jiang S., Yi J., Zhang W., Wei H., Sung M., Wang W., and Li X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Cancer Res. 63 (2003) 4037-4043
27. Staal S.P. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2; amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. USA 84 (1987) 5034-5037
28. Cheng J.Q., Godwin A.K., Bellacosa A., Taguchi T., Franke T.F., Hamilton T.C., Tsichlis P.N., and Testa J.R. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. USA 89 (1992) 9267-9271
29. Cheng J.Q., Ruggeri B., Klein W.M., Sonoda G., Altomare D.A., Wat-son D.K., and Testa J.R. Amplication of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity antisense RNA. Proc. Natl. Acad. Sci. USA 93 (1996) 3636-3641
30. Bellacosa A., de Feo D., Godwin A.K., Bell D.W., et al. Molecular alterations of the AKT2 oncogene in ovarian breast carcinomas. Int. J. Cancer 64 (1995) 280-285
31. Nakatani K., Thompson D.A., Barthel A., Sakaue H., Liu W., Weigel R.J., and Roth R.A. Up-regulation of Akt3 in estrogen receptor deficient breast cancers and androgen-independent prostate cancer lines. J. Biol. Chem. 274 (1999) 21528-21532
32. Yamada K.M., and Araki M. Tumor suppressor PTEN: Modulator of cell signaling, growth, migration and apoptosis. J. Cell Sci. 114 (2001) 2375-2382
33. Stokoe D., Stephens L.R., Copeland T., et al. 5-trisphosphate in the activation of protein kinase B. Science 5325 (1997) 567-570
34. Alessi D.R., James S.R., Downes C.P., et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr. Biol. 4 (1997) 261-269
35. Toker A., and Alexandra C.N. Akt/Protein Kinase B Is regulated by autophosphorylation at the hypothetical PDK-2 Site. J. Biol. Chem. 12 (2000) 8271-8274
36. Kang S.S., Kwon T., Kwon D.Y., and Do S.I. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274 (1999) 13085-13090
37. Brunet A., Bonni A., Zigmond M.J., Lin M.Z., et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96 (1999) 857-868
38. Kops G.J., de Ruiter N.D., de Vries-Smits A.M., et al. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398 (1999) 630-634
39. Ozes O.N., Mayo L.D., Gustin J.A., et al. NF-κB activation by tumour necrosis factor requires the Akt serine- threonine kinase. Nature (Lond.) 401 (1999) 82-85
40. Romashkova J.A., and Makarov S.S. NF-kB is a target of AKT in anti-apoptotic PDGF signaling. Nature (Lond.) 401 (1999) 86-90
41. kip1. Nature 404 (2000) 782-787