-
1
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
IGNEY FH, KRAMMER PH: Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer (2002) 2:277-288.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
2
-
-
0032575750
-
Caspases: Enemies within
-
THORNBERRY NA, LAZEBNIK Y: Caspases: enemies within. Science (1998) 281:1312-1316.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
3
-
-
0033635733
-
BH3-only proteins- essential initiators of apoptonic cell death
-
HUANG DS, STRASSER A: BH3-only proteins- essential initiators of apoptonic cell death. Cell(2000) 103:839-842.
-
(2000)
Cell
, vol.103
, pp. 839-842
-
-
Huang, D.S.1
Strasser, A.2
-
4
-
-
0033596980
-
An APAF-1: Cytochrome c multimeric complex is a functional apoptosome that activates Procaspase-9
-
ZOU H, LI Y, LIU X, WANG X: An APAF-1: Cytochrome c multimeric complex is a functional apoptosome that activates Procaspase-9. J. Biol. Chem. (1999) 274:11549-11556.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11549-11556
-
-
Zou, H.1
Li, Y.2
Liu, X.3
Wang, X.4
-
5
-
-
0033529634
-
Caspase activation involves the formation of the aposome, a large (70 kDa) caspase-activating complex
-
CAIN K, BROWN DG, LANGLAIS C, COHEN GM: Caspase activation involves the formation of the aposome, a large (70 kDa) caspase-activating complex. J. Biol. Chem. (1999) 274:22686-22692.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 22686-22692
-
-
Cain, K.1
Brown, D.G.2
Langlais, C.3
Cohen, G.M.4
-
6
-
-
0035936797
-
The TNF and TNF receptor superfamilies: Integrating mammalian biology
-
LOCKSLEY RM, KILLEEN N, LENARDO MJ: The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell (2001) 104:487-501.
-
(2001)
Cell
, vol.104
, pp. 487-501
-
-
Locksley, R.M.1
Killeen, N.2
Lenardo, M.J.3
-
7
-
-
0025916387
-
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
-
ITOH N, YONEHARA S, ISHII A et al.: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 66:233-243.
-
(1991)
Cell
, vol.66
, pp. 233-243
-
-
Itoh, N.1
Yonehara, S.2
Ishii, A.3
-
8
-
-
0028927607
-
The Fas death factor
-
NAGATA S, GOLSTEIN P: The Fas death factor. Science (1995) 267:1449-1456.
-
(1995)
Science
, vol.267
, pp. 1449-1456
-
-
Nagata, S.1
Golstein, P.2
-
9
-
-
0028962125
-
Fas-mediated cytotoxicity by freshly isolated natural killer cells
-
ARASE H, ARASE N, SAITO T et al.: Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. (1995) 181:1235-1238.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1235-1238
-
-
Arase, H.1
Arase, N.2
Saito, T.3
-
10
-
-
0027402369
-
Fas involvement in Ca(2+) independent T cell mediated cytotoxicity
-
ROUVIER E, LUCIANI MF, GOLDSTEIN et al.: Fas involvement in Ca(2+) independent T cell mediated cytotoxicity. J. Exp. Med. (1993) 177:195-200.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 195-200
-
-
Rouvier, E.1
Luciani, M.F.2
Goldstein3
-
11
-
-
0028879109
-
Fas ligand-induced apoptosis as a mechanism of immune privilege
-
GRIFFITH TS, BRUNNER T, FLETCHER SM, GREEN DR, FERGUSON TA: Fas ligand-induced apoptosis as a mechanism of immune privilege. Science (1995) 270:1189-1192.
-
(1995)
Science
, vol.270
, pp. 1189-1192
-
-
Griffith, T.S.1
Brunner, T.2
Fletcher, S.M.3
Green, D.R.4
Ferguson, T.A.5
-
12
-
-
0029965280
-
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumour necrosis factor receptor-induced apoptosis
-
CHINNAIYAN AM, TEPPER CG, SELDIN MF et al.: FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumour necrosis factor receptor-induced apoptosis. J. Biol. Chem. (1996) 271:4961-4965.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4961-4965
-
-
Chinnaiyan, A.M.1
Tepper, C.G.2
Seldin, M.F.3
-
13
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor
-
KISCHKEL FC, HELLBARDT S, BEHRMANN I et al.: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signalling complex (DISC) with the receptor. EMB0 J. (1995) 14:5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
-
14
-
-
0035824635
-
Death receptor recruitment of endogenous Caspase-10 and apoptosis initiation in the absence of Caspase-8
-
KISCHKEL FC, LAWRENCE DA, TINEL A et al.: Death receptor recruitment of endogenous Caspase-10 and apoptosis initiation in the absence of Caspase-8, J. Biol. Chem. (2001) 276:46639-46646.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46639-46646
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Tinel, A.3
-
15
-
-
2942746419
-
Caspase activation: Rrevisiting the induced proximity model
-
SHI Y: Caspase activation: revisiting the induced proximity model. Cell (2004) 117:855-858.
-
(2004)
Cell
, vol.117
, pp. 855-858
-
-
Shi, Y.1
-
16
-
-
0037291871
-
A unique model for apical Caspase activation
-
BOATRIGHT KM, RENATUS M, SCOTT FL et al.: A unique model for apical Caspase activation. Mol. Cell (2003) 11:529-541.
-
(2003)
Mol. Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
-
17
-
-
0037291890
-
Insights into the regulatory mechanism for Caspase-8 activation
-
DONEPUDI M, MAC SWEENEY A, BRIAND C, GRUTTER MG: Insights into the regulatory mechanism for Caspase-8 activation. Mol. Cell (2003) 11:543-549.
-
(2003)
Mol. Cell
, vol.11
, pp. 543-549
-
-
Donepudi, M.1
Mac Sweeney, A.2
Briand, C.3
Grutter, M.G.4
-
18
-
-
0037240850
-
Nature's TRAIL -on a path to cancer immunotherapy
-
SMYTH MJ, TAKEDE K, HAYAKAWA Y et al.: Nature's TRAIL -on a path to cancer immunotherapy. Immunity (2003) 18:1-6.
-
(2003)
Immunity
, vol.18
, pp. 1-6
-
-
Smyth, M.J.1
Takede, K.2
Hayakawa, Y.3
-
19
-
-
0033667778
-
FADD/MORT1 and Caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
SPRICK MR, WEIGAND MA, REISER E et al.: FADD/MORT1 and Caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity (2000) 12:599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Reiser, E.3
-
20
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and Caspase 8 to death receptors 4 and 5
-
KISCHKEL FC, LAWRENCE DA, CHUNTHARAPAI A, SCHOW P, KIM KJ, ASHKENAZI A. Apo2L/TRAIL-dependent recruitment of endogenous FADD and Caspase 8 to death receptors 4 and 5. Immunity (2000) 12:611-620.
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Chuntharapai, A.3
Schow, P.4
Kim, K.J.5
Ashkenazi, A.6
-
21
-
-
3342894130
-
Targeting death receptors in cancer with Apo2L/TRAIL
-
KELLEY SK, ASHKENAZI A: Targeting death receptors in cancer with Apo2L/TRAIL. Curr. Opin. Pharmacol. (2004) 4:333-339.
-
(2004)
Curr. Opin. Pharmacol.
, vol.4
, pp. 333-339
-
-
Kelley, S.K.1
Ashkenazi, A.2
-
22
-
-
17744396145
-
Death to the bad guys: Targeting cancer via Apo2L/TRAIL
-
BOURALEXIS S, FINDLAY DM, EVDOKIOU A: Death to the bad guys: targeting cancer via Apo2L/TRAIL. Apoptosis (2005) 10:35-51.
-
(2005)
Apoptosis
, vol.10
, pp. 35-51
-
-
Bouralexis, S.1
Findlay, D.M.2
Evdokiou, A.3
-
23
-
-
27144503348
-
Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity
-
LIU X, YUE P, KHURI FR, SUN SY: Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity. Cancer Res. (2005) 65:9169-9175.
-
(2005)
Cancer Res.
, vol.65
, pp. 9169-9175
-
-
Liu, X.1
Yue, P.2
Khuri, F.R.3
Sun, S.Y.4
-
24
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
ASHKENAZI A: Targeting death and decoy receptors of the tumour-necrosis factor superfamily, Nat. Rev. Cancer (2002) 2:420-430.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
25
-
-
0030970013
-
Viral FLICE-inhibitory protein (FLIPs) prevents apoptosis induced by death receptors
-
THOME M, SCHNEIDER P, HOFMANN K et al.: Viral FLICE-inhibitory protein (FLIPs) prevents apoptosis induced by death receptors. Nature (1997) 386:517-521.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
Schneider, P.2
Hofmann, K.3
-
26
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
IRMLER M, THOME M, HAHNE M et al.: Inhibition of death receptor signals by cellular FLIP. Nature (1997) 388:190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
-
27
-
-
0030746740
-
Casper is a FADD- and caspase-related inducer of apoptosis
-
SHU HB, HALPIN DR, GOEDDEL DV: Casper is a FADD- and caspase-related inducer of apoptosis. Immunity (1997) 6:751-763.
-
(1997)
Immunity
, vol.6
, pp. 751-763
-
-
Shu, H.B.1
Halpin, D.R.2
Goeddel, D.V.3
-
28
-
-
0030841911
-
I-FLICE, a novel inhibitor of tumour necrosis factor-1 and CD-95-induced apoptosis
-
HU S, VINCENZ C, NI J, GENTZ R, DIXIT VM: I-FLICE, a novel inhibitor of tumour necrosis factor-1 and CD-95-induced apoptosis. J. Biol. Chem. (1997) 273:17255-17257.
-
(1997)
J. Biol. Chem.
, vol.273
, pp. 17255-17257
-
-
Hu, S.1
Vincenz, C.2
Ni, J.3
Gentz, R.4
Dixit, V.M.5
-
29
-
-
0030810981
-
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
-
SRINIVASULA SM, AHMAD M, OTTILIES S et al.: FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Mol. Chem. (1997) 272:18542-18545.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18542-18545
-
-
Srinivasula, S.M.1
Ahmad, M.2
Ottilies, S.3
-
30
-
-
0030877440
-
CASH, a novel caspase homolgue with death effector domains
-
GOLTSEV YV, KOVALENKO AV, ARNOLD E et al.: CASH, a novel caspase homolgue with death effector domains. J. Biol. Chem. (1997) 272:19641-19644.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19641-19644
-
-
Goltsev, Y.V.1
Kovalenko, A.V.2
Arnold, E.3
-
31
-
-
0030961084
-
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
-
INOHARA N, KOSEKI T, HU Y, CHEN S, NUNEZ G: CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc. Natl. Acad. Sci. USA (1997) 94:10717-10722.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10717-10722
-
-
Inohara, N.1
Koseki, T.2
Hu, Y.3
Chen, S.4
Nunez, G.5
-
32
-
-
0030758315
-
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death
-
HAN DK, CHAUDHARY PM, WRIGHT ME et al.: MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc. Natl. Acad. Sci. USA (1997) 94:11333-11338.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11333-11338
-
-
Han, D.K.1
Chaudhary, P.M.2
Wright, M.E.3
-
33
-
-
7344220967
-
Cell death attenuation by 'Usurpid, a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by CD-95 (Fas, APO-1) receptor complex
-
RASPER DM, VAILLANCOURT JP, HADANO S et al.: Cell death attenuation by 'Usurpid, a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by CD-95 (Fas, APO-1) receptor complex. Cell. Death. Differ. (1998) 5:271-288.
-
(1998)
Cell. Death. Differ.
, vol.5
, pp. 271-288
-
-
Rasper, D.M.1
Vaillancourt, J.P.2
Hadano, S.3
-
35
-
-
0035827569
-
Cellular FLICE-inhibitory protein splice variants inhibit different steps of Caspase 8 activation at the CD95 death induced signalling complex
-
KRUEGER A, SCHMITZ I, BAUMANN S, KRAMMER PH, KIRCHHOFF S: Cellular FLICE-inhibitory protein splice variants inhibit different steps of Caspase 8 activation at the CD95 death induced signalling complex. J. Biol. Chem. (2001) 276:20633-20640.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20633-20640
-
-
Krueger, A.1
Schmitz, I.2
Baumann, S.3
Krammer, P.H.4
Kirchhoff, S.5
-
37
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signalling complex
-
MICHEAU O, THOME M, SCHNEIDER P et al.: The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signalling complex. J. Biol. Chem. (2002) 277:45162-45171.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
-
39
-
-
0037099678
-
c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
CHANG DW, XING Z, PAN Y et al.: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J. (2002) 21:3704-3714.
-
(2002)
EMBO J.
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
-
40
-
-
0033523670
-
Immune escape of tumours in vivo by expression of cellular FLICE-inhibitory protein
-
MEDEMA JP, DE JONG J, VAN HALL T, MALIEF CJ, OFFRINGA R. Immune escape of tumours in vivo by expression of cellular FLICE-inhibitory protein. J. Exp. Med. (1999) 190:1033-1038.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1033-1038
-
-
Medema, J.P.1
de Jong, J.2
van Hall, T.3
Malief, C.J.4
Offringa, R.5
-
41
-
-
0033523684
-
FLICE-inhibitory protein defines a new class of tumour progression factors
-
DJERBI M, SCREPANTI V, CATRINA AL, BOGEN B, BIBERFELD P, GRANDIEN A: FLICE-inhibitory protein defines a new class of tumour progression factors. J. Exp. Med. (1999) 190:1025-1032.
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1025-1032
-
-
Djerbi, M.1
Screpanti, V.2
Catrina, A.L.3
Bogen, B.4
Biberfeld, P.5
Grandien, A.6
-
42
-
-
2342588619
-
Expression of the Cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
-
DUTTON A, O'Neil JD, MILNER AE et al.: Expression of the Cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death. Proc. Natl. Acad. Sci. USA (2004) 101:6611-6616.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6611-6616
-
-
Dutton, A.1
O'Neil, J.D.2
Milner, A.E.3
-
43
-
-
2442545178
-
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis
-
MATHAS S, LIETZ A, ANAGNOSTOPOULOS et al.: c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J. Exp. Med. (2004) 199:1041-1052.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1041-1052
-
-
Mathas, S.1
Lietz, A.2
Anagnostopoulos3
-
44
-
-
4344607589
-
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
-
GANTER TM, HAAS TL, SYKORA J et al.: Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell. Death Diff. (2004) 11:S86-S96.
-
(2004)
Cell. Death Diff.
, vol.11
-
-
Ganter, T.M.1
Haas, T.L.2
Sykora, J.3
-
45
-
-
7644244878
-
FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cells
-
RIPPO MR, MORRETTI S, VESCOVI S et al.: FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cells. Oncogene (2004) 23:7753-7760.
-
(2004)
Oncogene
, vol.23
, pp. 7753-7760
-
-
Rippo, M.R.1
Morretti, S.2
Vescovi, S.3
-
46
-
-
21444446872
-
Selective knockdown of the long variant of Cellular FLICE inhibitory protein augments death receptor-mediated Caspase-8 activation and apoptosis
-
SHARP DA, LAWRENCE DA, ASHKENAZI A: Selective knockdown of the long variant of Cellular FLICE inhibitory protein augments death receptor-mediated Caspase-8 activation and apoptosis. J. Biol. Chem. (2005) 280:19401-19409.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19401-19409
-
-
Sharp, D.A.1
Lawrence, D.A.2
Ashkenazi, A.3
-
47
-
-
0042809497
-
Cellular FLICE/Caspase-8-inhibitory protein as a principle regulator of cell death and survival in human hepatocellular carcinoma
-
OKANO H, SHIRAKI K, INOUE H et al.: Cellular FLICE/Caspase-8-inhibitory protein as a principle regulator of cell death and survival in human hepatocellular carcinoma. Lab. Invest. (2003) 83:1033-1043.
-
(2003)
Lab. Invest.
, vol.83
, pp. 1033-1043
-
-
Okano, H.1
Shiraki, K.2
Inoue, H.3
-
48
-
-
0037028250
-
Loss of expression of death-inducing signalling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification
-
SHIVAPURKAR N, REDDY J, MATTA H et al.: Loss of expression of death-inducing signalling complex (DISC) components in lung cancer cell lines and the influence of MYC amplification. Oncogene (2002) 21:8510-8514.
-
(2002)
Oncogene
, vol.21
, pp. 8510-8514
-
-
Shivapurkar, N.1
Reddy, J.2
Matta, H.3
-
49
-
-
0035258678
-
Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway
-
ELNEMR A, OHTA T, YACHIE A et al.: Human pancreatic cancer cells disable function of Fas receptors at several levels in Fas signal transduction pathway. Int. J. Oncol. (2001) 18:311-316.
-
(2001)
Int. J. Oncol.
, vol.18
, pp. 311-316
-
-
Elnemr, A.1
Ohta, T.2
Yachie, A.3
-
50
-
-
0035720569
-
Selective expression of FLIP in malignant melanocytic skin lesions
-
BULLANI RR, HUARD B, VIARD-LEVEUGLE I et al.: Selective expression of FLIP in malignant melanocytic skin lesions. J. Invest. Dermatol. (2001) 117:360-364.
-
(2001)
J. Invest. Dermatol.
, vol.117
, pp. 360-364
-
-
Bullani, R.R.1
Huard, B.2
Viard-Leveugle, I.3
-
51
-
-
33144488766
-
Increased expression of cFLIP (L) in colonic adenocarcinoma
-
RYE BK, LEE MG, CHI SG et al.: Increased expression of cFLIP (L) in colonic adenocarcinoma. J. Pathol. (2001) 194:15-19.
-
(2001)
J. Pathol.
, vol.194
, pp. 15-19
-
-
Rye, B.K.1
Lee, M.G.2
Chi, S.G.3
-
52
-
-
0038203183
-
Differential recruitment of Caspase 8 to cFLIP confers sensitivity or resistance to Fas mediated apoptosis in a subset of familial lymphoma patients
-
BAUMLER C, DUAN F, ONEL K et al.: Differential recruitment of Caspase 8 to cFLIP confers sensitivity or resistance to Fas mediated apoptosis in a subset of familial lymphoma patients. Leuk. Res. (2003) 27:841-851.
-
(2003)
Leuk. Res.
, vol.27
, pp. 841-851
-
-
Baumler, C.1
Duan, F.2
Onel, K.3
-
53
-
-
0036105506
-
Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells
-
THOMAS RK, KALLENBORN A, WICKENHAUSER C: Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells. Am. J. Pathol. (2002) 160:1521-1528.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1521-1528
-
-
Thomas, R.K.1
Kallenborn, A.2
Wickenhauser, C.3
-
54
-
-
0344321886
-
Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitise tumour cells for TRAIL-induced apoptosis
-
SIEGMUND D, HADWIGER P, PFIZENMAIER K, VORNLOCHER HP, WAJANT H: Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitise tumour cells for TRAIL-induced apoptosis. Mol. Med. (2002) 8:725-732.
-
(2002)
Mol. Med.
, vol.8
, pp. 725-732
-
-
Siegmund, D.1
Hadwiger, P.2
Pfizenmaier, K.3
Vornlocher, H.P.4
Wajant, H.5
-
55
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
ASHKENAZI A, PAI RC, FONG S et al.: Safety and antitumor activity of recombinant soluble Apo2 ligand. Clin. Invest. (1999) 104:155-162.
-
(1999)
Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
-
56
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
WALCZAK H, MILLER RE, ARIAIL K et al.: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. (1999) 5:157-163.
-
(1999)
Nat. Med.
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
-
57
-
-
0032530612
-
Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
-
GRIFFITH TS, CHIN WA, JACKSON GC, LYNCH DH, KUBIN MZ: Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J. Immunol. (1998) 161:2833-2840.
-
(1998)
J. Immunol.
, vol.161
, pp. 2833-2840
-
-
Griffith, T.S.1
Chin, W.A.2
Jackson, G.C.3
Lynch, D.H.4
Kubin, M.Z.5
-
58
-
-
0033975513
-
Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes
-
LEVERKUS M, MEUMANN M, MENGLING T et al.: Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes. Cancer Res. (2000) 60:553-559.
-
(2000)
Cancer Res.
, vol.60
, pp. 553-559
-
-
Leverkus, M.1
Meumann, M.2
Mengling, T.3
-
59
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
MICHEAU O, LENS S, GOUDE O, ALEVIZOPOULAS K, TSCHOPP J: NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. (2001) 21:85299-5305.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
Lens, S.2
Goude, O.3
Alevizopoulas, K.4
Tschopp, J.5
-
60
-
-
0035816727
-
Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
-
SUHARA T, MANO T, OLIVEIRA B, WALSH K: Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP). Circ. Res. (2001) 89:13-19.
-
(2001)
Circ. Res.
, vol.89
, pp. 13-19
-
-
Suhara, T.1
Mano, T.2
Oliveira, B.3
Walsh, K.4
-
61
-
-
0032539007
-
Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression
-
YEH JH, HSU SC, HAN SH, LAI MZ: Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression. J. Exp. Med. (1998) 188:1795-802.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 1795-1802
-
-
Yeh, J.H.1
Hsu, S.C.2
Han, S.H.3
Lai, M.Z.4
-
62
-
-
0034646478
-
Activation of NF-κB by FADD, Casper, and Caspase-8
-
HU W, JOHNSON H, SHU HB: Activation of NF-κB by FADD, Casper, and Caspase-8. J. Biol. Chem. (2000) 275:10838-10844.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 10838-10844
-
-
Hu, W.1
Johnson, H.2
Shu, H.B.3
-
63
-
-
18744425429
-
The caspase-8 inhibitor FLIP promotes activation of NF-κ and Erk signaling pathways
-
KATAOKA T, BUDD RC, HOLLER N et al.: The caspase-8 inhibitor FLIP promotes activation of NF-κ and Erk signaling pathways. Curr. Biol. (2000) 10:640-648.
-
(2000)
Curr. Biol.
, vol.10
, pp. 640-648
-
-
Kataoka, T.1
Budd, R.C.2
Holler, N.3
-
64
-
-
0034648529
-
Activation of the NF-κB pathway by caspase 8 and its homologs
-
CHAUDHARY PM, EBY MT, JASMIN A, KUMAR A, LIU L, HOOD L: Activation of the NF-κB pathway by caspase 8 and its homologs. Oncogene (2000) 19:4451-4460.
-
(2000)
Oncogene
, vol.19
, pp. 4451-4460
-
-
Chaudhary, P.M.1
Eby, M.T.2
Jasmin, A.3
Kumar, A.4
Liu, L.5
Hood, L.6
-
65
-
-
1642386039
-
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway
-
KATAOKA T, TSCHOPP J: N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway. Mol. Cell. Biol. (2004) 24:2627-2636.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2627-2636
-
-
Kataoka, T.1
Tschopp, J.2
-
66
-
-
3543096349
-
NfkappaB activation by Fas is mediated through FADD, Caspase-8, and RIP and is inhibited by FLIP
-
KREUZ S, SIEGMUND D, RUMPF JJ et al.: NfkappaB activation by Fas is mediated through FADD, Caspase-8, and RIP and is inhibited by FLIP. J. Cell. Biol. (2004) 166:369-380.
-
(2004)
J. Cell. Biol.
, vol.166
, pp. 369-380
-
-
Kreuz, S.1
Siegmund, D.2
Rumpf, J.J.3
-
67
-
-
11144224085
-
L inhibits tumour necrosis factor-related apoptosis-inducing ligand-mediated NF-κB activation at the death signaling complex in human keratinocytes
-
L inhibits tumour necrosis factor-related apoptosis-inducing ligand-mediated NF-κB activation at the death signaling complex in human keratinocytes. J. Biol. Chem. (2004) 51:52824-52834.
-
(2004)
J. Biol. Chem.
, vol.51
, pp. 52824-52834
-
-
Watcher, T.1
Sricks, M.2
Hausmann, D.3
Kerstan, A.4
-
68
-
-
23744456144
-
An essential role for c-FLIP in the efficient development of T lymphocytes
-
ZHANG N, HE YW: An essential role for c-FLIP in the efficient development of T lymphocytes. J. Exp. Med. (2005) 202:395-404.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 395-404
-
-
Zhang, N.1
He, Y.W.2
-
69
-
-
0020078040
-
The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male
-
WHITEHEAD E, SHALET SM, BLACKLEDGE G: The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer (1982) 49:418-422.
-
(1982)
Cancer
, vol.49
, pp. 418-422
-
-
Whitehead, E.1
Shalet, S.M.2
Blackledge, G.3
-
70
-
-
0020572583
-
The effect of combination chemotherapy on ovarian function in women treated for Hodgkin's disease
-
WHITEHEAD E, SHALET SM, BLACKLEDGE G et al.: The effect of combination chemotherapy on ovarian function in women treated for Hodgkin's disease. Cancer (1983) 52:988-992.
-
(1983)
Cancer
, vol.52
, pp. 988-992
-
-
Whitehead, E.1
Shalet, S.M.2
Blackledge, G.3
-
71
-
-
0027386156
-
Factors affecting late mortality from heart disease after treatment of Hodgkin's disease
-
HANCOCK SL, TUCKER MA, HOPPE RT: Factors affecting late mortality from heart disease after treatment of Hodgkin's disease. JAMA (1993) 270:1949-1955.
-
(1993)
JAMA
, vol.270
, pp. 1949-1955
-
-
Hancock, S.L.1
Tucker, M.A.2
Hoppe, R.T.3
-
72
-
-
0031941707
-
Second cancers following pediatric Hodgkin's disease
-
WOLDEN S, LAMBOURN KR. CLEARY SF et al.: Second cancers following pediatric Hodgkin's disease. J. Clin. Oncol. (1998) 16:536-544.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 536-544
-
-
Wolden, S.1
Lambourn, K.R.2
Cleary, S.F.3
-
73
-
-
0037099626
-
Treatment of unfavourable childhood Hodgkins disease with VEPA and low dose, involved-field radiation
-
FRIEDMANN AM, HUDSON MM, WEINSTEIN HJ et al.: Treatment of unfavourable childhood Hodgkins disease with VEPA and low dose, involved-field radiation. J. Clin. Oncol. (2002) 20:3088-3094.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3088-3094
-
-
Friedmann, A.M.1
Hudson, M.M.2
Weinstein, H.J.3
-
75
-
-
0029952779
-
Hodgkin and Reed/Sternberg cells in Hodgkins disease represent the outgrowth of a dominant tumour done derived from (crippled) germinal centre B cells
-
KANZLER H, KUPPERS R, HANSMANN ML, RAJEWSKY K: Hodgkin and Reed/Sternberg cells in Hodgkins disease represent the outgrowth of a dominant tumour done derived from (crippled) germinal centre B cells. J. Exp. Med. (1996) 184:1495-1505.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1495-1505
-
-
Kanzler, H.1
Kuppers, R.2
Hansmann, M.L.3
Rajewsky, K.4
-
78
-
-
0027161266
-
Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction
-
HOLDER MJ WANG H, MILNER AE et al.: Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. (1993) 23:2368-2371.
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 2368-2371
-
-
Holder, M.J.1
Wang, H.2
Milner, A.E.3
-
79
-
-
0028961779
-
CD40 and its ligand: Central players in B lymphocyte survival, growth and differentiation
-
GORDON J: CD40 and its ligand: central players in B lymphocyte survival, growth and differentiation. Blood Rev. (1995) 9:53-56.
-
(1995)
Blood Rev.
, vol.9
, pp. 53-56
-
-
Gordon, J.1
-
80
-
-
33144469052
-
CD40-mediated signalling in B cells. Balancing cell survival, growth and death
-
KEHRY MR: CD40-mediated signalling in B cells. Balancing cell survival, growth and death. J. Immunol. (1996) 56:345-348.
-
(1996)
J. Immunol.
, vol.56
, pp. 345-348
-
-
Kehry, M.R.1
-
81
-
-
0030894985
-
Maintenance of human germinal centre B cells in vitro
-
POUND JD, GORDON J: Maintenance of human germinal centre B cells in vitro. Blood (1997) 89:919-928.
-
(1997)
Blood
, vol.89
, pp. 919-928
-
-
Pound, J.D.1
Gordon, J.2
-
82
-
-
0029127749
-
Opposing roles of CD95 (Fas/APO-1) and CD40 in death and rescue of human low density tonsillar B cells
-
CLEARY AM, FORTUNE SM, YELLIN MJ, CHESS L, LEDERMAN S: Opposing roles of CD95 (Fas/APO-1) and CD40 in death and rescue of human low density tonsillar B cells. J. Immunol. (1995) 155:3329-3337.
-
(1995)
J. Immunol.
, vol.155
, pp. 3329-3337
-
-
Cleary, A.M.1
Fortune, S.M.2
Yellin, M.J.3
Chess, L.4
Lederman, S.5
-
83
-
-
0035099037
-
Fas is required for clonal selection in germinal centres and the subsequent establishment of the memory B cell repertoire
-
TAKAHASHI Y, OHTA H, TAKEMORI T: Fas is required for clonal selection in germinal centres and the subsequent establishment of the memory B cell repertoire. Immunity (2001) 14:181-192.
-
(2001)
Immunity
, vol.14
, pp. 181-192
-
-
Takahashi, Y.1
Ohta, H.2
Takemori, T.3
-
84
-
-
0035868704
-
Regulation of CD40 and CD40 ligand by AT-hook transcription factor ANKA
-
SIDDIQA A, SIMS-MOURTADA JC, GUZMAN-ROJAS L et al.: Regulation of CD40 and CD40 ligand by AT-hook transcription factor ANKA. Nature (2001) 410:383-387.
-
(2001)
Nature
, vol.410
, pp. 383-387
-
-
Siddiqa, A.1
Sims-Mourtada, J.C.2
Guzman-Rojas, L.3
-
85
-
-
0029917123
-
Human germinal centre B cells express die apoptosis inducing gcnes fas, c-myc, p53 and Bax but not the survival gene bck-2
-
MARTINEZ-VALDEZ H, GURET C, DE BOUTEILLER O, FUGIER I BANCHEREAU J, LIU YJ: Human germinal centre B cells express die apoptosis inducing gcnes fas, c-myc, p53 and Bax but not the survival gene bck-2. J. Exp. Med. (1996) 183:971-977.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 971-977
-
-
Martinez-Valdez, H.1
Guret, C.2
de Bouteiller, O.3
Fugier, I.4
Banchereau, J.5
Liu, Y.J.6
-
87
-
-
0029146709
-
Frequent expression of Fas/APO-1 in Hodgkin's disease and anaplastic large cell lymphomas
-
XERRI L, CARBUCCIA N, PARC P, HASSOUN J, BIRG F: Frequent expression of Fas/APO-1 in Hodgkin's disease and anaplastic large cell lymphomas. Histopathology (1995) 27:235-241.
-
(1995)
Histopathology
, vol.27
, pp. 235-241
-
-
Xerri, L.1
Carbuccia, N.2
Parc, P.3
Hassoun, J.4
Birg, F.5
-
88
-
-
0032958287
-
Expression of Fas and Fas ligand in Hodgkins disease
-
METKAR SS, NARESH KN, REDKAR AA, SOMAN CS, ADVANI SH, NADKARNI JJ: Expression of Fas and Fas ligand in Hodgkins disease. Leuk. Lymphoma (1999) 33:521-530.
-
(1999)
Leuk. Lymphoma
, vol.33
, pp. 521-530
-
-
Metkar, S.S.1
Naresh, K.N.2
Redkar, A.A.3
Soman, C.S.4
Advani, S.H.5
Nadkarni, J.J.6
-
89
-
-
0034667371
-
Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells
-
MUSCHEN M, RE D, BRAUNIGER A et al.: Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells. Cancer Res. (2000) 60:5640-5643.
-
(2000)
Cancer Res.
, vol.60
, pp. 5640-5643
-
-
Muschen, M.1
Re, D.2
Brauniger, A.3
-
90
-
-
0037221962
-
Low frequency of Fas mutations I Reed-Sternberg cells of Hodgkin's lymphoma
-
MAGGIO EM, VAN DEN BERG A, DE JONG D, DIEPSTRA A, POPPEMA S: Low frequency of Fas mutations I Reed-Sternberg cells of Hodgkin's lymphoma. Am. J. Pathol. (2003) 162:29-35.
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 29-35
-
-
Maggio, E.M.1
van den Berg, A.2
de Jong, D.3
Diepstra, A.4
Poppema, S.5
-
91
-
-
25144511023
-
siRNA delivery in vivo
-
SIOUD M: siRNA delivery in vivo. Methods Mol. Biol. (2005) 309:237-249.
-
(2005)
Methods Mol. Biol.
, vol.309
, pp. 237-249
-
-
Sioud, M.1
-
92
-
-
2442668068
-
Small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics
-
TAKEI Y, KADOMATSU K, YUZAWA Y et al.: Small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res. (2004) 64:3365-3370.
-
(2004)
Cancer Res.
, vol.64
, pp. 3365-3370
-
-
Takei, Y.1
Kadomatsu, K.2
Yuzawa, Y.3
-
93
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
MORRISSEY DV, LOCKRIDGE JA, SHAW L et al.: Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat. Biotechnol. (2005) 23:1002-1007.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
-
94
-
-
14544298301
-
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
-
SCHIFFELERS RM, ANSARI A, XU J et al.: Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. (2004) 32:e149.
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Schiffelers, R.M.1
Ansari, A.2
Xu, J.3
-
95
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
SONG E, ZHU P, LEE SK et al.: Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat. Biotech. (2005) 23:709-717.
-
(2005)
Nat. Biotech.
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
-
96
-
-
24944516000
-
RNA interference and potential therapeutic applications of short interfering RNAs
-
KARAGIANNIS TC, EL-OSTA A: RNA interference and potential therapeutic applications of short interfering RNAs. Cancer Gene Ther. (2005) 12:787-795.
-
(2005)
Cancer Gene Ther.
, vol.12
, pp. 787-795
-
-
Karagiannis, T.C.1
El-Osta, A.2
|