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Volumn 1, Issue 3, 2006, Pages 397-403

Bortezomib in the treatment of cancer

Author keywords

Anti tumor activity; Bortezomib; Proteasome inhibition

Indexed keywords

ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; BORTEZOMIB; PROTEASOME; PYRAZINE DERIVATIVE;

EID: 39049173144     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489206778776925     Document Type: Article
Times cited : (71)

References (53)
  • 1
    • 0032514684 scopus 로고    scopus 로고
    • Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1
    • Nussbaum AK, Dick TP, Keilholz W, et al. Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci USA 1998; 95: 12504.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12504
    • Nussbaum, A.K.1    Dick, T.P.2    Keilholz, W.3
  • 2
    • 0033615348 scopus 로고    scopus 로고
    • The proteasome: A macromolecular assembly designed for controlled proteolysis
    • Zwickl P, Voges D, Baumeister W. The proteasome: a macromolecular assembly designed for controlled proteolysis. Trans R Soc Lond B Biol Sci 1999; 354: 1501.
    • (1999) Trans R Soc Lond B Biol Sci , vol.354 , pp. 1501
    • Zwickl, P.1    Voges, D.2    Baumeister, W.3
  • 3
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitor: From research tools to drug candidates
    • Kisselev AF, Goldberg AL. Proteasome inhibitor: from research tools to drug candidates. Chem Biol 2001; 8: 739.
    • (2001) Chem Biol , vol.8 , pp. 739
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 4
    • 0032539702 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
    • Adams J, Behnke M, Chen S, et al. Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett 1998; 8: 333.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 333
    • Adams, J.1    Behnke, M.2    Chen, S.3
  • 5
    • 18544367201 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in multiple myeloma
    • Hideshima T, Chauhan D, Richardson P, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002; 277: 16639.
    • (2002) J Biol Chem , vol.277 , pp. 16639
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 6
    • 0029662342 scopus 로고    scopus 로고
    • Rel/NFkappaB/IkappaB proteins and cancer
    • Gilmore TD, Koedood M, Piffat KA, et al. Rel/NFkappaB/IkappaB proteins and cancer. Oncogene 1996; 13: 1367.
    • (1996) Oncogene , vol.13 , pp. 1367
    • Gilmore, T.D.1    Koedood, M.2    Piffat, K.A.3
  • 7
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: Therapeutic applications. Blood 2002; 99: 4079.
    • (2002) Blood , vol.99 , pp. 4079
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 8
    • 0033996762 scopus 로고    scopus 로고
    • Kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
    • Karin M, Delhase M, The I. kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling. Semin Immunol 2000; 12: 85.
    • (2000) Semin Immunol , vol.12 , pp. 85
    • Karin, M.1    Delhase, M.2    The, I.3
  • 9
    • 0034161929 scopus 로고    scopus 로고
    • Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells
    • Gardner RC, Assinder SJ, Christie G, et al. Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells. Biochem J 2000; 346: 447.
    • (2000) Biochem J , vol.346 , pp. 447
    • Gardner, R.C.1    Assinder, S.J.2    Christie, G.3
  • 10
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-B activity
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: The control of NF-B activity. Annu Rev Immunol 2000; 18: 621.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621
    • Karin, M.1    Ben-Neriah, Y.2
  • 11
    • 0035958517 scopus 로고    scopus 로고
    • The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: Therapeutic applications
    • Hideshima T, Chauhan D, Schlossman R, et al. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: Therapeutic applications. Oncogene 2001; 20: 4519.
    • (2001) Oncogene , vol.20 , pp. 4519
    • Hideshima, T.1    Chauhan, D.2    Schlossman, R.3
  • 12
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
    • Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 1996; 87: 1104.
    • (1996) Blood , vol.87 , pp. 1104
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3
  • 13
    • 0034618384 scopus 로고    scopus 로고
    • Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
    • Hazlehurst LA, Damiano JS, Buyuksal I, et al. Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene 2000; 19: 4319.
    • (2000) Oncogene , vol.19 , pp. 4319
    • Hazlehurst, L.A.1    Damiano, J.S.2    Buyuksal, I.3
  • 14
    • 0035692411 scopus 로고    scopus 로고
    • Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies
    • Hazlehurst LA, Dalton WS. Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies. Cancer Metastasis Rev 2001; 20: 43.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 43
    • Hazlehurst, L.A.1    Dalton, W.S.2
  • 15
    • 0035233477 scopus 로고    scopus 로고
    • Multiple myeloma
    • in Schechter GP, Broudy VB, Williams ME (eds), Washington, DC, American Society of Hematology
    • Dalton WS, Bergsagel PL, Kuehl WM, et al. Multiple myeloma, in Schechter GP, Broudy VB, Williams ME (eds): Hematology 2001. Washington, DC, American Society of Hematology, pp 157-177.
    • (2001) Hematology , pp. 157-177
    • Dalton, W.S.1    Bergsagel, P.L.2    Kuehl, W.M.3
  • 16
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 2001; 7: 1419.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3
  • 17
    • 0242496212 scopus 로고    scopus 로고
    • Molecular sequelae of proteasome inhibition in human multiple myeloma cells
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 2002; 99: 14374.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14374
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 18
    • 0035300479 scopus 로고    scopus 로고
    • The proteaosme inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma
    • Hideshima T, Richardson P, Chauhan D, et al. The proteaosme inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma. Cancer Res 2001; 61: 3071.
    • (2001) Cancer Res , vol.61 , pp. 3071
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 19
    • 0034981649 scopus 로고    scopus 로고
    • 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer
    • Shah SA, Potter MW, McDade TP, et al. 26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J Cell Biochem 2001; 82: 110.
    • (2001) J Cell Biochem , vol.82 , pp. 110
    • Shah, S.A.1    Potter, M.W.2    McDade, T.P.3
  • 20
    • 0036690648 scopus 로고    scopus 로고
    • PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorilation and cleavage in association with GM-2 phase arrest and apoptosis
    • Ling YH, Liebes L, Mg B, et al. PS-341, a novel proteasome inhibitor, induces Bcl-2 phosphorilation and cleavage in association with GM-2 phase arrest and apoptosis. Mol Cancer Ther 2002; 1:841.
    • (2002) Mol Cancer Ther , vol.1 , pp. 841
    • Ling, Y.H.1    Liebes, L.2    Mg, B.3
  • 21
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating anti-myeloma activity of proteasome inhibitor PS-341
    • Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating anti-myeloma activity of proteasome inhibitor PS-341. Blood 2003; 101:1530.
    • (2003) Blood , vol.101 , pp. 1530
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 22
    • 0037097595 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic implications
    • Mitsiades CS, Treon SP, Mitsiades N, et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic implications. Blood 2002; 99: 4525.
    • (2002) Blood , vol.99 , pp. 4525
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3
  • 23
    • 0034647563 scopus 로고    scopus 로고
    • Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction
    • Breitschopf K, Zeiher AM, Dimmeler S. Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. J Biol Chem 2000; 275: 21648.
    • (2000) J Biol Chem , vol.275 , pp. 21648
    • Breitschopf, K.1    Zeiher, A.M.2    Dimmeler, S.3
  • 24
    • 0034635952 scopus 로고    scopus 로고
    • Bax degradation by the ubiquitin/proteasomedependent pathway: Involvement in tumor survival and progression
    • Li B, Dou QP. Bax degradation by the ubiquitin/proteasomedependent pathway: involvement in tumor survival and progression. Proc Natl Acad Sci USA 2000; 97: 3850.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3850
    • Li, B.1    Dou, Q.P.2
  • 25
    • 0033965742 scopus 로고    scopus 로고
    • Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells
    • Drexler HC, Risau W, Konerding MA. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. FASEB J 2000; 14: 65.
    • (2000) FASEB J , vol.14 , pp. 65
    • Drexler, H.C.1    Risau, W.2    Konerding, M.A.3
  • 27
    • 0036735298 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    • LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002; 62:4996.
    • (2002) Cancer Res , vol.62 , pp. 4996
    • LeBlanc, R.1    Catley, L.P.2    Hideshima, T.3
  • 28
    • 79953655710 scopus 로고    scopus 로고
    • Bortezomib targets multiple myeloma endothelial cells
    • Roccaro AM, Hideshima T, Raje N, et al. Bortezomib targets multiple myeloma endothelial cells. Cancer Res. 2006; 1: 184.
    • (2006) Cancer Res , vol.1 , pp. 184
    • Roccaro, A.M.1    Hideshima, T.2    Raje, N.3
  • 30
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003; 348: 2609.
    • (2003) N Engl J Med , vol.348 , pp. 2609
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 31
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002; 20:4420.
    • (2002) J Clin Oncol , vol.20 , pp. 4420
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 32
    • 0036023407 scopus 로고    scopus 로고
    • A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
    • Aghajanian C, Soignet S, Dizon DS, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002; 8:2505.
    • (2002) Clin Cancer Res , vol.8 , pp. 2505
    • Aghajanian, C.1    Soignet, S.2    Dizon, D.S.3
  • 33
    • 7044221131 scopus 로고    scopus 로고
    • Quality-of-life (QOL) and clinical benefit assessment in patients with relapsed and refractory multiple myeloma (MM) treated with bortezomib
    • (abstr 2339)
    • Lee S, Richardson P, Barlogie B, et al. Quality-of-life (QOL) and clinical benefit assessment in patients with relapsed and refractory multiple myeloma (MM) treated with bortezomib. Proc Am Soc Clin Oncol 2003; 22: 582. (abstr 2339).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 582
    • Lee, S.1    Richardson, P.2    Barlogie, B.3
  • 34
    • 0142200670 scopus 로고    scopus 로고
    • Experience with long-term therapy using the proteasome inhibitor, bortezomib, in advanced multiple myeloma (MM)
    • (abstr 2337)
    • Berenson JR, Jagannath S, Barlogie B, et al. Experience with long-term therapy using the proteasome inhibitor, bortezomib, in advanced multiple myeloma (MM). Proc Am Soc Clin Oncol 2003; 22: 581 (abstr 2337).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 581
    • Berenson, J.R.1    Jagannath, S.2    Barlogie, B.3
  • 35
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high dose dexametasone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW, et al. Bortezomib or high dose dexametasone for relapsed multiple myeloma. N Engl J Med 2005; 352: 2487.
    • (2005) N Engl J Med , vol.352 , pp. 2487
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 36
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999; 59: 2615.
    • (1999) Cancer Res , vol.59 , pp. 2615
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 37
    • 0037342895 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines
    • Ling YH, Liebes L, Jiang JD, et al. Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines. Clin Cancer Res 2003; 9: 1145.
    • (2003) Clin Cancer Res , vol.9 , pp. 1145
    • Ling, Y.H.1    Liebes, L.2    Jiang, J.D.3
  • 38
    • 0642349188 scopus 로고    scopus 로고
    • Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts
    • Williams S, Pettaway C, Song R, et al. Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts. Mol Cancer Ther 2003; 2: 835.
    • (2003) Mol Cancer Ther , vol.2 , pp. 835
    • Williams, S.1    Pettaway, C.2    Song, R.3
  • 39
    • 0142139039 scopus 로고    scopus 로고
    • Phase I study of bortezomib in combination with docetaxel in anthracycline-pretreated advanced breast cancer
    • Albanell J, Baselga J, Guix M, et al. Phase I study of bortezomib in combination with docetaxel in anthracycline-pretreated advanced breast cancer. Proc Am Soc Clin Oncol 2003; 22: 16.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 16
    • Albanell, J.1    Baselga, J.2    Guix, M.3
  • 40
    • 0442289374 scopus 로고    scopus 로고
    • A phase II trial of PS-341 in patients with renal cell cancer
    • (abstr 1551)
    • Davis NB, Taber DA, Ansari R. H, et al. A phase II trial of PS-341 in patients with renal cell cancer. Proc Am Soc Clin Oncol 2003; 22: 386 (abstr 1551).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 386
    • Davis, N.B.1    Taber, D.A.2    Ansari, R.H.3
  • 41
    • 0000640680 scopus 로고    scopus 로고
    • PS-341 enhances chemotherapeutic effect in human xenograft models
    • Pink M, Pien CS, Worland P, et al. PS-341 enhances chemotherapeutic effect in human xenograft models. Proc Am Assoc Cancer Res 2002; 43: 158.
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 158
    • Pink, M.1    Pien, C.S.2    Worland, P.3
  • 42
    • 0035349836 scopus 로고    scopus 로고
    • New drug development in non-Hodgkin lymphomas
    • Cheson BD. New drug development in non-Hodgkin lymphomas. Curr Oncol Rep 2001; 3: 250.
    • (2001) Curr Oncol Rep , vol.3 , pp. 250
    • Cheson, B.D.1
  • 43
    • 0142200669 scopus 로고    scopus 로고
    • Report of a phase II study of proteasome inhibitor bortezomib in patients with relapsed or refractory indolent and aggressive B-cell lymphomas
    • (abstr 2291)
    • Goy AH, East K, Mesina O, et al. Report of a phase II study of proteasome inhibitor bortezomib in patients with relapsed or refractory indolent and aggressive B-cell lymphomas. Proc Am Soc Clin Oncol 2003; 22: 570 (abstr 2291).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 570
    • Goy, A.H.1    East, K.2    Mesina, O.3
  • 44
    • 0142231752 scopus 로고    scopus 로고
    • Phase II clinical experience with the proteasome inhibitor bortezomib (formerly PS-341) in patients with indolent lymphomas
    • (abstr 2277)
    • O'Connor OA, Wright J, Moskowitz C, et al. Phase II clinical experience with the proteasome inhibitor bortezomib (formerly PS-341) in patients with indolent lymphomas. Proc Am Soc Clin Oncol 2003; 22: 566 (abstr 2277).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 566
    • O'Connor, O.A.1    Wright, J.2    Moskowitz, C.3
  • 45
    • 0442273783 scopus 로고    scopus 로고
    • Phase II trial of PS-341 shows response in patients with advanced renal cell carcinoma
    • (abstr 1550)
    • Drucker BJ, Schwartz L, Bacik J, et al. Phase II trial of PS-341 shows response in patients with advanced renal cell carcinoma. Proc Am Soc Clin Oncol 2003; 22: 386 (abstr 1550).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 386
    • Drucker, B.J.1    Schwartz, L.2    Bacik, J.3
  • 46
    • 12344320797 scopus 로고    scopus 로고
    • A phase II multicenter study of proteasome inhibitor PS-341 (LDP-341, bortezomib) for untreated recurrent or metastatic soft tissue sarcoma (STS); CTEP study 1757
    • (abstr 3291)
    • Maki RG, Kraft A, Demetri GD, et al. A phase II multicenter study of proteasome inhibitor PS-341 (LDP-341, bortezomib) for untreated recurrent or metastatic soft tissue sarcoma (STS); CTEP study 1757. Proc Am Soc Clin Oncol 2003; 22: 819 (abstr 3291).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 819
    • Maki, R.G.1    Kraft, A.2    Demetri, G.D.3
  • 47
    • 1242281150 scopus 로고    scopus 로고
    • Phase II clinical/pharmacodynamic trial of the proteasome inhibitor PS-341 in advanced non-small cell lung cancer
    • (abstr 810)
    • Stevenson J, Nho CW, Schick J, et al. Phase II clinical/pharmacodynamic trial of the proteasome inhibitor PS-341 in advanced non-small cell lung cancer. Proc Am Soc Clin Oncol 2003; 22: 202 (abstr 810).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 202
    • Stevenson, J.1    Nho, C.W.2    Schick, J.3
  • 48
    • 29144514707 scopus 로고    scopus 로고
    • Treatment of relapsed or refractory Waldenstrom's macroglobulinemia with bortezomib
    • Dimopoulos MA, Anagnostopoulos A, Kyrtsonis MC, et al. Treatment of relapsed or refractory Waldenstrom's macroglobulinemia with bortezomib. Haematologica 2005; 90:1655.
    • (2005) Haematologica , vol.90 , pp. 1655
    • Dimopoulos, M.A.1    Anagnostopoulos, A.2    Kyrtsonis, M.C.3
  • 49
    • 2542481724 scopus 로고    scopus 로고
    • Phase I study of bortezomib in refractory or relapsed acute leukemias
    • Cortes J, Thomas D, Koller C, et al. Phase I study of bortezomib in refractory or relapsed acute leukemias. Clin Cancer Res 2004; 10: 3371.
    • (2004) Clin Cancer Res , vol.10 , pp. 3371
    • Cortes, J.1    Thomas, D.2    Koller, C.3
  • 50
    • 84873582457 scopus 로고    scopus 로고
    • US20026492333
    • Mundy, G.R.: US20026492333 (2002).
    • (2002)
    • Mundy, G.R.1


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