-
1
-
-
46049104223
-
-
Atlanta:American Cancer Society;, Available from
-
American Cancer Society. Cancer Facts & Figures 2008. Atlanta:American Cancer Society; 2008. Available from:www.cancer.org
-
(2008)
Cancer Facts & Figures 2008
-
-
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100(1):57-70
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
34547775831
-
The potential of DR4- and DR5-directed therapies in lung cancer
-
Camidge DR. The potential of DR4- and DR5-directed therapies in lung cancer. Clin Lung Cancer 2007;8:413-9
-
(2007)
Clin Lung Cancer
, vol.8
, pp. 413-419
-
-
Camidge, D.R.1
-
4
-
-
47949097844
-
Targeted manipulation of apoptosis in anti-cancer therapeutics [manuscript submitted]
-
Call JA, Eckhardt SG, Camidge DR. Targeted manipulation of apoptosis in anti-cancer therapeutics [manuscript submitted]. Lancet Oncol 2008
-
(2008)
Lancet Oncol
-
-
Call, J.A.1
Eckhardt, S.G.2
Camidge, D.R.3
-
5
-
-
0036598992
-
Targeting death and decoy receptors in the tumour-necrosis factor superfamily
-
Ashkenazi A. Targeting death and decoy receptors in the tumour-necrosis factor superfamily. Nat Rev Cancer 2002;2(6):420-30
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.6
, pp. 420-430
-
-
Ashkenazi, A.1
-
6
-
-
0344908231
-
Portrait of a killer:the mitochondrial apoptosome emerges from the shadows
-
Hill MM, Adrain C, Martin SJ. Portrait of a killer:the mitochondrial apoptosome emerges from the shadows. Mol Interv 2003;3(1):19-26
-
(2003)
Mol Interv
, vol.3
, Issue.1
, pp. 19-26
-
-
Hill, M.M.1
Adrain, C.2
Martin, S.J.3
-
8
-
-
33847328289
-
The bcl-2 apoptotic switch in cancer development and therapy
-
Adams JM, Cory S. The bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007;26:1324-37
-
(2007)
Oncogene
, vol.26
, pp. 1324-1337
-
-
Adams, J.M.1
Cory, S.2
-
9
-
-
47949097309
-
-
and, editors, Cancer drug discovery and development:the oncogenomics handbook. Humana Press, Inc, Totawa, NJ;
-
Humphreys RC. Development and evaluation of cancer therapeutic agents targeting TRAIL receptor 1 and 2. In:LaRochelle WJ and Shimkets RA, editors, Cancer drug discovery and development:the oncogenomics handbook. Humana Press, Inc.; Totawa, NJ; 2005. p. 659-76
-
(2005)
Development and evaluation of cancer therapeutic agents targeting TRAIL receptor 1 and 2
, pp. 659-676
-
-
Humphreys, R.C.1
-
10
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
-
Kischkel FC, Lawrence DA, Chuntharapai A, et al. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000;12:611-20
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Chuntharapai, A.3
-
11
-
-
35348881412
-
TRAIL death receptors and cancer therapeutics
-
Huang Y, Sheikh MS. TRAIL death receptors and cancer therapeutics. Toxicol Appl Pharmacol 2007;224:284-9
-
(2007)
Toxicol Appl Pharmacol
, vol.224
, pp. 284-289
-
-
Huang, Y.1
Sheikh, M.S.2
-
13
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104(2):155-62
-
(1999)
J Clin Invest
, vol.104
, Issue.2
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
-
14
-
-
40949138762
-
Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5
-
Adams C, Totpal K, Lawrence D, et al. Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5. Cell Death Differ 2008;15:751-61
-
(2008)
Cell Death Differ
, vol.15
, pp. 751-761
-
-
Adams, C.1
Totpal, K.2
Lawrence, D.3
-
16
-
-
47949121684
-
A phase I safety and pharmacokinetic study of Apomab, a human DR5 agonist antibody in patients with advanced cancer
-
abstract 3582
-
Camidge DR, Herbst RS, Gordon M, et al. A phase I safety and pharmacokinetic study of Apomab, a human DR5 agonist antibody in patients with advanced cancer [abstract 3582]. ASCO Proceedings; 2007
-
(2007)
ASCO Proceedings
-
-
Camidge, D.R.1
Herbst, R.S.2
Gordon, M.3
-
17
-
-
34248187996
-
Phase I pharmacokinetic and biological correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis inducing-ligand receptor-1
-
Tolcher AW, Mita M, Meropol NJ, et al. Phase I pharmacokinetic and biological correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis inducing-ligand receptor-1. J Clin Oncol 2007;25(11):1390-5
-
(2007)
J Clin Oncol
, vol.25
, Issue.11
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
-
18
-
-
47949093146
-
Phase I study of a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) in subjects with advanced solid malignancies or non-Hodgkin's lymphoma
-
abstract 208
-
Hotte S, Oza AM, Le LH, et al. Phase I study of a fully human monoclonal antibody to the tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) in subjects with advanced solid malignancies or non-Hodgkin's lymphoma [abstract 208]. EORTC-NCI-AACR Proceedings; 2004
-
(2004)
EORTC-NCI-AACR Proceedings
-
-
Hotte, S.1
Oza2
AM, L.L.3
-
19
-
-
47949111590
-
Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL)
-
abstract 489
-
Younes A, Vose J, Zelenetz A, et al. Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (NHL) [abstract 489]. ASH Proceedings; 2005
-
(2005)
ASH Proceedings
-
-
Younes, A.1
Vose, J.2
Zelenetz, A.3
-
20
-
-
45649084324
-
Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
-
5 February, doi:10.1016/j.lungcan.2007.12.011
-
Greco FA, Bonomi P, Crawford J, et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 2008; published online 5 February 2008, doi:10.1016/j.lungcan.2007.12.011
-
(2008)
Lung Cancer 2008; published online
-
-
Greco, F.A.1
Bonomi, P.2
Crawford, J.3
-
21
-
-
45749149222
-
Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC)
-
abstract 630
-
Kanzler S, Trarbach T, Heinemann V, et al. Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed or refractory colorectal cancer (CRC) [abstract 630]. ECCO 13 - the European Cancer Conference; 2005
-
(2005)
ECCO 13 - the European Cancer Conference
-
-
Kanzler, S.1
Trarbach, T.2
Heinemann, V.3
-
22
-
-
47949106929
-
-
Chow LQ, Eckhardt SG, Gustafson DL, et al. HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies. Results of a Phase I and PK study [abstract 2525]. ASCO Proceedings; 2006
-
Chow LQ, Eckhardt SG, Gustafson DL, et al. HGS-ETR1, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies. Results of a Phase I and PK study [abstract 2525]. ASCO Proceedings; 2006
-
-
-
-
24
-
-
35948952826
-
Phase I and pharmacokinetic study of lexatumumab in patients with advanced cancers
-
Plummer R, Attard G, Pacey S, et al. Phase I and pharmacokinetic study of lexatumumab in patients with advanced cancers. Clin Cancer Res 2007;13(20):6187-6194
-
(2007)
Clin Cancer Res
, vol.13
, Issue.20
, pp. 6187-6194
-
-
Plummer, R.1
Attard, G.2
Pacey, S.3
-
25
-
-
47949114199
-
-
LoRusso P, Hong D, Heath E, et al. First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors [abstract 3534]. ASCO Proceedings; 2007
-
LoRusso P, Hong D, Heath E, et al. First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors [abstract 3534]. ASCO Proceedings; 2007
-
-
-
-
26
-
-
47949122492
-
-
Sikic BI, Wakelee HA, Mehren MV, et al. A Phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine pemetrexed, doxorubicin, or FOLFIRI. [abstract 14006]. ASCO Proceedings; 2007
-
Sikic BI, Wakelee HA, Mehren MV, et al. A Phase Ib study to assess the safety of lexatumumab, a human monoclonal antibody that activates TRAIL-R2, in combination with gemcitabine pemetrexed, doxorubicin, or FOLFIRI. [abstract 14006]. ASCO Proceedings; 2007
-
-
-
-
27
-
-
47949123255
-
A Phase I safety and pharmacokinetic study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer
-
abstract 3013
-
Herbst RS, Mendolson DS, Ebbinghaus S, et al. A Phase I safety and pharmacokinetic study of recombinant Apo2L/TRAIL, an apoptosis-inducing protein in patients with advanced cancer [abstract 3013]. ASCO Proceedings; 2006
-
(2006)
ASCO Proceedings
-
-
Herbst, R.S.1
Mendolson, D.S.2
Ebbinghaus, S.3
-
28
-
-
47949112109
-
Apo2L/TRAIL pharmacokinetics in a Phase Ia trial in advanced cancer and lymphoma
-
abstract 3047
-
Ling J, Herbst RS, Mendelson DS, et al. Apo2L/TRAIL pharmacokinetics in a Phase Ia trial in advanced cancer and lymphoma [abstract 3047]. ASCO Proceedings; 2006
-
(2006)
ASCO Proceedings
-
-
Ling, J.1
Herbst, R.S.2
Mendelson, D.S.3
-
29
-
-
47949119621
-
Application of pharmacodynamic assays in a Phase Ia trial of Apo2L/TRAIL in patients with advanced tumors
-
abstract 3535
-
Pan Y, Xu R, Peach M, et al. Application of pharmacodynamic assays in a Phase Ia trial of Apo2L/TRAIL in patients with advanced tumors [abstract 3535]. ASCO Proceedings; 2007
-
(2007)
ASCO Proceedings
-
-
Pan, Y.1
Xu, R.2
Peach, M.3
-
30
-
-
27344456844
-
The anti-tumor effect of Apo2L/TRAJL on patient pancreatic adenocarciomas grown as xenografts in SCID mice
-
Hylander BL, Pitoniak R, Pentrante RB, et al. The anti-tumor effect of Apo2L/TRAJL on patient pancreatic adenocarciomas grown as xenografts in SCID mice. J Transl Med 2005;3:22-35
-
(2005)
J Transl Med
, vol.3
, pp. 22-35
-
-
Hylander, B.L.1
Pitoniak, R.2
Pentrante, R.B.3
-
31
-
-
34547819299
-
The promise of TRAIL - potential and risks of a novel anticancer therapy
-
Koschny R, Walczak H, Ganten TM. The promise of TRAIL - potential and risks of a novel anticancer therapy. J Mol Med 2007;85:923-35
-
(2007)
J Mol Med
, vol.85
, pp. 923-935
-
-
Koschny, R.1
Walczak, H.2
Ganten, T.M.3
-
32
-
-
0037050235
-
TRAIL and inhibitors of apoptosis are opposing determinants of NF-κB-dependent, genotoxin-induced apoptosis of cancer cells
-
Spalding AC, Jotte RM, Scheinman RI, et al. TRAIL and inhibitors of apoptosis are opposing determinants of NF-κB-dependent, genotoxin-induced apoptosis of cancer cells. Oncogene 2002;21:260271
-
(2002)
Oncogene
, vol.21
, pp. 260271
-
-
Spalding, A.C.1
Jotte, R.M.2
Scheinman, R.I.3
-
33
-
-
34250862069
-
Expression of anti-apoptotic factors modulates Apo2L/TRAIL resistance in colon carcinoma cells
-
Epub ahead of print
-
Lippa MS, Strockbine LD, Le TT, et al. Expression of anti-apoptotic factors modulates Apo2L/TRAIL resistance in colon carcinoma cells. Apoptosis 2007 [Epub ahead of print]
-
(2007)
Apoptosis
-
-
Lippa, M.S.1
Strockbine2
LD, L.T.3
-
34
-
-
34247897233
-
Targeting TRAIL agonistic receptors for cancer therapy
-
Carlo-Stella C, Lavazza C, Locatelli A, et al. Targeting TRAIL agonistic receptors for cancer therapy. Clin Cancer Res 2007;13(8):2313-7
-
(2007)
Clin Cancer Res
, vol.13
, Issue.8
, pp. 2313-2317
-
-
Carlo-Stella, C.1
Lavazza, C.2
Locatelli, A.3
-
35
-
-
33747623259
-
Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL
-
Cheng J, Hylander BL, Baer MR, et al. Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL. Mol Cancer Ther 2006;5:1844-53
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 1844-1853
-
-
Cheng, J.1
Hylander, B.L.2
Baer, M.R.3
-
36
-
-
34948822418
-
Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through DR4 receptor by competing for ligand binding
-
Bin L, Thorburn J, Thomas LR, et al. Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through DR4 receptor by competing for ligand binding. J Biol Chem 2007;282:28189-94
-
(2007)
J Biol Chem
, vol.282
, pp. 28189-28194
-
-
Bin, L.1
Thorburn, J.2
Thomas, L.R.3
-
37
-
-
42749092258
-
TRAIL receptor-targeted therapeutics:resistance mechanisms and strategies to avoid them
-
Thorburn A, Behbakht K, Ford H. TRAIL receptor-targeted therapeutics:resistance mechanisms and strategies to avoid them. Drug Resist Updat 2008;11:17-24
-
(2008)
Drug Resist Updat
, vol.11
, pp. 17-24
-
-
Thorburn, A.1
Behbakht, K.2
Ford, H.3
-
38
-
-
34948894931
-
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
-
Wagner K, Punnoose E, Januario T et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med 2007;13(9):1070-7
-
(2007)
Nat Med
, vol.13
, Issue.9
, pp. 1070-1077
-
-
Wagner, K.1
Punnoose, E.2
Januario, T.3
-
39
-
-
34248162523
-
Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival
-
Behbakht K, Qamar L, Aldridge CS, et al. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res 2007;67:3036-42
-
(2007)
Cancer Res
, vol.67
, pp. 3036-3042
-
-
Behbakht, K.1
Qamar, L.2
Aldridge, C.S.3
-
40
-
-
38549132880
-
The role of TRAIL death receptors in the treatment of hematological malignancies
-
Henson ES, Johnston JB, Gibson SB. The role of TRAIL death receptors in the treatment of hematological malignancies. Leuk Lymphoma 2008;49:27-35
-
(2008)
Leuk Lymphoma
, vol.49
, pp. 27-35
-
-
Henson, E.S.1
Johnston, J.B.2
Gibson, S.B.3
-
41
-
-
27544432516
-
Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
-
Park S-M, Schickel R, Peter ME. Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 2005;17:610-6
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 610-616
-
-
Park, S.-M.1
Schickel, R.2
Peter, M.E.3
-
42
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D, Shahrokh Z, Marsters S, et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 2001;7:383-5
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
-
43
-
-
33644832724
-
Targeted induction of apoptosis in cancer management:The emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents
-
Rowinsky EK. Targeted induction of apoptosis in cancer management:The emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents. J Clin Oncol 2005;23(36):9394-407
-
(2005)
J Clin Oncol
, vol.23
, Issue.36
, pp. 9394-9407
-
-
Rowinsky, E.K.1
|