-
1
-
-
0027537461
-
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
-
Crook, N.E., Clem, R.J., and Miller, L.K. 1993. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif J. Virol. 67:2168-2174.
-
(1993)
J. Virol.
, vol.67
, pp. 2168-2174
-
-
Crook, N.E.1
Clem, R.J.2
Miller, L.K.3
-
2
-
-
0028274132
-
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs
-
Birnbaum, M.J., Clem, R.J., and Miller, L.K. 1994. An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs J. Virol 68:2521-2528.
-
(1994)
J. Virol.
, vol.68
, pp. 2521-2528
-
-
Birnbaum, M.J.1
Clem, R.J.2
Miller, L.K.3
-
3
-
-
0026344133
-
Prevention of apoptosis by a baculovirus gene during infection of insect cells
-
Clem, R.J., Fechheimer, M., and Miller, L.K. 1991. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science. 254:1388-1390.
-
(1991)
Science
, vol.254
, pp. 1388-1390
-
-
Clem, R.J.1
Fechheimer, M.2
Miller, L.K.3
-
4
-
-
0036088471
-
IAP proteins: Blocking the road to death's door
-
Salvesen, G.S., and Duckett, C.S. 2002. IAP proteins: blocking the road to death's door [review]. Nat. Rev. Mol. Cell Biol. 3:401-410.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 401-410
-
-
Salvesen, G.S.1
Duckett, C.S.2
-
5
-
-
0032078249
-
Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts
-
Uren, A.G., Coulson, E.J., and Vaux, D.L. 1998. Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. Trends Biochem. Sci. 23:159-162.
-
(1998)
Trends Biochem. Sci.
, vol.23
, pp. 159-162
-
-
Uren, A.G.1
Coulson, E.J.2
Vaux, D.L.3
-
6
-
-
0034282432
-
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
-
Huang, H.-K., et al. 2000. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J. Biol. Chem. 275:26661-26664.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26661-26664
-
-
Huang, H.-K.1
-
7
-
-
0242414466
-
A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation
-
Olson, M.R., et al. 2003. A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation. J. Biol. Chem. 278:44758-44768.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 44758-44768
-
-
Olson, M.R.1
-
8
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki, Y., Nakabayashi, Y., and Takahashi, R. 2001. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc. Natl. Acad. Sci. U. S. A. 98:8662-8667.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
Nakabayashi, Y.2
Takahashi, R.3
-
9
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang, Y., Fang, S., Jensen, J.P., Weissman, A.M., and Ashwell, J.D. 2000. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science. 288:874-877.
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
Weissman, A.M.4
Ashwell, J.D.5
-
11
-
-
0030746636
-
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
-
Ambrosini, G., Adida, C., and Altieri, D.C. 1997. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3:917-921.
-
(1997)
Nat. Med.
, vol.3
, pp. 917-921
-
-
Ambrosini, G.1
Adida, C.2
Altieri, D.C.3
-
12
-
-
0034597594
-
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype
-
Uren, A.G., et al. 2000. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr. Biol. 10:1319-1328.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1319-1328
-
-
Uren, A.G.1
-
13
-
-
10744219638
-
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death
-
Okada, H., et al. 2004. Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J. Exp. Med. 199:399-410.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 399-410
-
-
Okada, H.1
-
14
-
-
0033621107
-
Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division
-
Uren, A.G., et al. 1999. Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division. Proc. Natl. Acad. Sci. U. S. A. 96:10170-10175.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 10170-10175
-
-
Uren, A.G.1
-
15
-
-
0033602489
-
Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis
-
Fraser, A.G., James, C., Evan, G.I., and Hengartner, M.O. 1999. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Curr. Biol. 9:292-301.
-
(1999)
Curr. Biol.
, vol.9
, pp. 292-301
-
-
Fraser, A.G.1
James, C.2
Evan, G.I.3
Hengartner, M.O.4
-
16
-
-
0346250160
-
Survivin, versatile modulation of cell division and apoptosis in cancer
-
Alfieri, D.C. 2003. Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogens. 22:8581-8589.
-
(2003)
Oncogens
, vol.22
, pp. 8581-8589
-
-
Alfieri, D.C.1
-
17
-
-
0034905394
-
XIAP: Apoptotic brake and promising therapeutic target
-
Holcik, M., Gibson, H., and Korneluk, R.G. 2001. XIAP: apoptotic brake and promising therapeutic target. Apoptosis. 6:253-261.
-
(2001)
Apoptosis
, vol.6
, pp. 253-261
-
-
Holcik, M.1
Gibson, H.2
Korneluk, R.G.3
-
18
-
-
0037149542
-
TNF-RII and C-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li, X., Yang, Y., and Ashwell, J.D. 2002. TNF-RII and C-IAP1 mediate ubiquitination and degradation of TRAF2. Nature. 416:345-347.
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
19
-
-
16644375193
-
Molecular circuits of apoptosis regulation and cell division control: The survivin paradigm
-
Altieri, D.C. 2004. Molecular circuits of apoptosis regulation and cell division control: the survivin paradigm. J. Cell. Biochem. 92:656-663.
-
(2004)
J. Cell. Biochem.
, vol.92
, pp. 656-663
-
-
Altieri, D.C.1
-
20
-
-
0030810926
-
X-linked IAP is a direct inhibitor of cell-death proteases
-
Deveraux, Q.L., Takahashi, R., Salvesen, G.S., and Reed, J.C. 1997. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 388:300-304.
-
(1997)
Nature
, vol.388
, pp. 300-304
-
-
Deveraux, Q.L.1
Takahashi, R.2
Salvesen, G.S.3
Reed, J.C.4
-
21
-
-
3343011970
-
Caspase activation, inhibition, and reactivation: A mechanistic view
-
Shi, Y. 2004. Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci. 13:1979-1987.
-
(2004)
Protein Sci.
, vol.13
, pp. 1979-1987
-
-
Shi, Y.1
-
22
-
-
26444560960
-
Caspases: Pharmacological manipulation of cell death
-
doi:10.1172/JCI26252
-
Lavrik, I.N., Golks, A., and Krammer, P.H. 2005. Caspases: pharmacological manipulation of cell death. J. Clin. Invest. 115:2665-2672. doi:10.1172/JCI26252.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2665-2672
-
-
Lavrik, I.N.1
Golks, A.2
Krammer, P.H.3
-
23
-
-
4344691959
-
Caspases, IAPs and Smac/DIABLO: Mechanisms from structural biology
-
Shiozaki, E.N., and Shi, Y. 2004. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem. Sci. 29:486-494.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 486-494
-
-
Shiozaki, E.N.1
Shi, Y.2
-
24
-
-
0030698127
-
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific Caspases
-
Roy, N., Deveraux, Q.L., Takahashi, R., Salvesen, G.S., and Reed, J.C. 1997. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific Caspases. EMBO J. 16:6914-6925.
-
(1997)
EMBO J.
, vol.16
, pp. 6914-6925
-
-
Roy, N.1
Deveraux, Q.L.2
Takahashi, R.3
Salvesen, G.S.4
Reed, J.C.5
-
25
-
-
5644259587
-
Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice
-
Schimmer, A.D. 2004. Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 64:7183-7190.
-
(2004)
Cancer Res.
, vol.64
, pp. 7183-7190
-
-
Schimmer, A.D.1
-
26
-
-
0034667372
-
Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells
-
Sasaki, H., Sheng, Y., Kotsuji, F., and Tsang, B.K. 2000. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res. 60:5659-5666.
-
(2000)
Cancer Res.
, vol.60
, pp. 5659-5666
-
-
Sasaki, H.1
Sheng, Y.2
Kotsuji, F.3
Tsang, B.K.4
-
27
-
-
0142188706
-
Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: Implication for cancer specific therapy
-
Yang, L., Cao, Z., Yan, H., and Wood, W.C. 2003. Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Res. 63:6815-6824.
-
(2003)
Cancer Res.
, vol.63
, pp. 6815-6824
-
-
Yang, L.1
Cao, Z.2
Yan, H.3
Wood, W.C.4
-
28
-
-
0037211252
-
Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro
-
Bilim, V., Kasahara, T., Hara, N., Takahashi, K., and Tomita, Y. 2003. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. Int. J. Cancer. 103:29-37.
-
(2003)
Int. J. Cancer
, vol.103
, pp. 29-37
-
-
Bilim, V.1
Kasahara, T.2
Hara, N.3
Takahashi, K.4
Tomita, Y.5
-
29
-
-
7944229824
-
Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics
-
McManus, D.C., et al. 2004. Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics. Oncogene. 23:8105-8117.
-
(2004)
Oncogene
, vol.23
, pp. 8105-8117
-
-
McManus, D.C.1
-
30
-
-
0034698053
-
Activation of NF-κB by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
-
Hofer-Warbinek, R., et al. 2000. Activation of NF-κB by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J. Biol. Chem. 275:22064-22068.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 22064-22068
-
-
Hofer-Warbinek, R.1
-
31
-
-
0035854738
-
X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling
-
Birkey Reffey, S., Wurthner, J.U., Parks, W.T., Roberts, A.B., and Duckett, C.S. 2001. X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-β signaling. J. Biol. Chem. 276:26542-26549.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26542-26549
-
-
Birkey Reffey, S.1
Wurthner, J.U.2
Parks, W.T.3
Roberts, A.B.4
Duckett, C.S.5
-
32
-
-
0030885421
-
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-IAP2 is under NF-κB control
-
Chu, Z.-L., et al. 1997. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. U.S.A. 94:10057-10062.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 10057-10062
-
-
Chu, Z.-L.1
-
33
-
-
0036309455
-
Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma
-
Gordon, G.J., et al. 2002. Inhibitor of apoptosis protein-1 promotes tumor cell survival in mesothelioma. Carcinogenesis. 23:1017-1024.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1017-1024
-
-
Gordon, G.J.1
-
34
-
-
0034597630
-
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas
-
Vucic, D., Stennicke, H.R., Pisabarro, M.T., Salvesen, G.S., and Dixit, V.M. 2000. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr. Biol. 10:1359-1366.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1359-1366
-
-
Vucic, D.1
Stennicke, H.R.2
Pisabarro, M.T.3
Salvesen, G.S.4
Dixit, V.M.5
-
35
-
-
0033151510
-
The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
-
Dierlamm, J., et al. 1999. The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood. 93:3601-3609.
-
(1999)
Blood
, vol.93
, pp. 3601-3609
-
-
Dierlamm, J.1
-
36
-
-
0033638182
-
Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
-
Uren, A.G., et al. 2000. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol. Cell. 6:961-967.
-
(2000)
Mol. Cell
, vol.6
, pp. 961-967
-
-
Uren, A.G.1
-
37
-
-
17144438370
-
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
-
Tamm, I., et al. 2000. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin. Cancer Res. 6:1796-1803.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1796-1803
-
-
Tamm, I.1
-
38
-
-
0034885949
-
Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients
-
Ferreira, C.G., et al. 2001. Expression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patients. Clin. Cancer Res. 7:2468-2474.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2468-2474
-
-
Ferreira, C.G.1
-
39
-
-
0344394469
-
Caspase-independent cell death in AML: Caspase inhibition in vitro with pancaspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis
-
Carter, B.Z., et al. 2003. Caspase-independent cell death in AML: caspase inhibition in vitro with pancaspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood. 102:4179-4186.
-
(2003)
Blood
, vol.102
, pp. 4179-4186
-
-
Carter, B.Z.1
-
40
-
-
0035884398
-
Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas
-
Imoto, I., et al. 2001. Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer Res. 61:6629-6634.
-
(2001)
Cancer Res.
, vol.61
, pp. 6629-6634
-
-
Imoto, I.1
-
41
-
-
0033280669
-
Biochemical pathways of caspase activation during apoptosis
-
Budihardjo, I., Oliver, H., Lutter, M., Luo, X., and Wang, X. 1999. Biochemical pathways of caspase activation during apoptosis. Annu. Rev. Cell Dev. Biol. 15:269-290.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 269-290
-
-
Budihardjo, I.1
Oliver, H.2
Lutter, M.3
Luo, X.4
Wang, X.5
-
42
-
-
0030032106
-
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
-
Hsu, H., Shu, H.-B., Pan, M.-G., and Goeddel, D.V. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 84:299-308.
-
(1996)
Cell
, vol.84
, pp. 299-308
-
-
Hsu, H.1
Shu, H.-B.2
Pan, M.-G.3
Goeddel, D.V.4
-
43
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel, F.C., et al. 199S. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14:5579-5588.
-
(1995)
EMBO J.
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
-
44
-
-
0030011398
-
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced death
-
Boldin, M.P., Goncharov, T.M., Goltsev, Y.V., and Wallach, D. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced death. Cell. 85:803-815.
-
(1996)
Cell
, vol.85
, pp. 803-815
-
-
Boldin, M.P.1
Goncharov, T.M.2
Goltsev, Y.V.3
Wallach, D.4
-
45
-
-
0034284637
-
Mitochondria as the central control point of apoptosis
-
Desagher, S., and Martinou, J.C. 2000. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10:369-377.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 369-377
-
-
Desagher, S.1
Martinou, J.C.2
-
46
-
-
0030715323
-
Cytochrome cand dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li, P., et al. 1997. Cytochrome cand dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 91:479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
-
47
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou, H., Henzel, W.J., Liu, X., Lutschg, A., and Wang, X. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 90:405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
-
48
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490.
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
49
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li, H., Zhu, H., Xu, C.J., and Yuan, J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 94:491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
50
-
-
2442547741
-
Caspase activation: Stepping on the gas or releasing the brakes? Lessons from humans and flies
-
Salvesen, G.S., and Abrams, J.M. 2004. Caspase activation: stepping on the gas or releasing the brakes? Lessons from humans and flies [review]. Oncogene. 23:2774-2784.
-
(2004)
Oncogene
, vol.23
, pp. 2774-2784
-
-
Salvesen, G.S.1
Abrams, J.M.2
-
51
-
-
0036718393
-
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis
-
Bratton, S.B., Lewis, J., Butterworth, M., Duckett, C.S., and Cohen, G.M. 2002. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ. 9:881-892.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 881-892
-
-
Bratton, S.B.1
Lewis, J.2
Butterworth, M.3
Duckett, C.S.4
Cohen, G.M.5
-
52
-
-
0036470319
-
Reprieval from execution: The molecular basis of caspase inhibition
-
Stennicke, H.R., Ryan, C.A., and Salvesen, G.S. 2002. Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem. Sci. 27:94-101.
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 94-101
-
-
Stennicke, H.R.1
Ryan, C.A.2
Salvesen, G.S.3
-
53
-
-
0034616942
-
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
-
Verhagen, A.M., et al.2000.Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 102:43-53.
-
(2000)
Cell
, vol.102
, pp. 43-53
-
-
Verhagen, A.M.1
-
54
-
-
0034616945
-
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
-
Du, C., Fang, M., Li, Y., Li, L., and Wang, X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102:33-42.
-
(2000)
Cell
, vol.102
, pp. 33-42
-
-
Du, C.1
Fang, M.2
Li, Y.3
Li, L.4
Wang, X.5
-
55
-
-
0034886271
-
Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
-
Wu, J.W., Cocina, A.E., Chai, J., Hay, B.A., and Shi, Y. 2001. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Mol. Cell. 8:95-104.
-
(2001)
Mol. Cell
, vol.8
, pp. 95-104
-
-
Wu, J.W.1
Cocina, A.E.2
Chai, J.3
Hay, B.A.4
Shi, Y.5
-
56
-
-
0037169556
-
Sequence requirements for hid binding and apoptosis regulation in the anti-apoptotic baculovirus protein Op-IAP: Hid binds Op-IAP in a manner similar to Smac binding of XIAP
-
Wright, C.W., and Clem, R.J. 2001. Sequence requirements for hid binding and apoptosis regulation in the anti-apoptotic baculovirus protein Op-IAP: hid binds Op-IAP in a manner similar to Smac binding of XIAP. J. Biol. Chem. 277:2454-2462.
-
(2001)
J. Biol. Chem.
, vol.277
, pp. 2454-2462
-
-
Wright, C.W.1
Clem, R.J.2
-
57
-
-
0036163042
-
A conserved tetrapeptide motif: Potentiating apoptosis through IAP-binding
-
Shi, Y. 2002. A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding. Cell Death Differ. 9:93-95.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 93-95
-
-
Shi, Y.1
-
58
-
-
18544386724
-
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction
-
Hegde, R., et al. 2001. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction. J. Biol. Chem. 277:432-438.
-
(2001)
J. Biol. Chem.
, vol.277
, pp. 432-438
-
-
Hegde, R.1
-
59
-
-
0037016707
-
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
-
Martins, L.M., et al. 2001. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif. J. Biol. Chem. 277:439-444.
-
(2001)
J. Biol. Chem.
, vol.277
, pp. 439-444
-
-
Martins, L.M.1
-
60
-
-
0034785591
-
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
-
Suzuki, Y., et al. 2001. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell. 8:613-621.
-
(2001)
Mol. Cell
, vol.8
, pp. 613-621
-
-
Suzuki, Y.1
-
61
-
-
18244386261
-
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
-
van Loo, G., et al. 2002. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 9:20-26.
-
(2002)
Cell Death Differ.
, vol.9
, pp. 20-26
-
-
Van Loo, G.1
-
62
-
-
0037427441
-
Mammalian mitochondrial IAP binding proteins
-
Vaux, D.L., and Silke, J. 2003. Mammalian mitochondrial IAP binding proteins. Biochem. Biophys. Res. Commun. 304:499-504.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.304
, pp. 499-504
-
-
Vaux, D.L.1
Silke, J.2
-
63
-
-
0141643236
-
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein
-
Hegde, R., et al. 2003. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. J. Biol. Chem. 278:38699-38706.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38699-38706
-
-
Hegde, R.1
-
64
-
-
7644230386
-
Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
-
Martins, L.M., et al. 2004. Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24:9848-9862.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9848-9862
-
-
Martins, L.M.1
-
65
-
-
1642512653
-
Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers?
-
review
-
Huang, Y., Lu, M., and Wu, H. 2004. Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers? [review]. Cancer Cell. 5:1-2.
-
(2004)
Cancer Cell
, vol.5
, pp. 1-2
-
-
Huang, Y.1
Lu, M.2
Wu, H.3
-
66
-
-
0036341291
-
Smac agonists sensitize for Apo2L/TRAIL-or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
-
Fulda, S., Wick, W., Weller, M., and Debatin, K.M. 2002. Smac agonists sensitize for Apo2L/TRAIL-or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med. 8:808-815.
-
(2002)
Nat. Med.
, vol.8
, pp. 808-815
-
-
Fulda, S.1
Wick, W.2
Weller, M.3
Debatin, K.M.4
-
67
-
-
0347895102
-
Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ
-
Arnt, C.R., Chiorean, M.V., Heldebrant, M.P., Gores, G.J., and Kaufmann, S.H. 2002. Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. J Biol. Chem. 277:44236-44243.
-
(2002)
J Biol. Chem.
, vol.277
, pp. 44236-44243
-
-
Arnt, C.R.1
Chiorean, M.V.2
Heldebrant, M.P.3
Gores, G.J.4
Kaufmann, S.H.5
-
68
-
-
0029062573
-
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
-
Li, C.J., Friedman, D.J., Wang, C., Metelev, V., and Pardee, A.B. 1995. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science. 268:429-431.
-
(1995)
Science
, vol.268
, pp. 429-431
-
-
Li, C.J.1
Friedman, D.J.2
Wang, C.3
Metelev, V.4
Pardee, A.B.5
-
69
-
-
3843086358
-
Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site
-
Sun, H., et al. 2004. Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. J. Med. Chem. 47:4147-4150.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4147-4150
-
-
Sun, H.1
-
70
-
-
4143099131
-
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
-
Oost, T.K., et al. 2004. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J. Med. Chem. 47:4417-4426.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 4417-4426
-
-
Oost, T.K.1
-
71
-
-
4444243683
-
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death
-
Li, L., et al. 2004. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science. 305:1471-1474.
-
(2004)
Science
, vol.305
, pp. 1471-1474
-
-
Li, L.1
-
72
-
-
0041913978
-
Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction
-
Wu, T.Y., Wagner, K.W., Bursulaya, B., Schultz, P.G., and Deveraux, Q.L. 2003. Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction. Chem. Biol. 10:759-767.
-
(2003)
Chem. Biol.
, vol.10
, pp. 759-767
-
-
Wu, T.Y.1
Wagner, K.W.2
Bursulaya, B.3
Schultz, P.G.4
Deveraux, Q.L.5
-
73
-
-
9144234685
-
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad and tumor activity
-
Schimmer, A.D., et al. 2004. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad and tumor activity. Cancer Cell. 5:25-35.
-
(2004)
Cancer Cell
, vol.5
, pp. 25-35
-
-
Schimmer, A.D.1
-
74
-
-
4844231863
-
XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
-
Cao, C., Mu, Y., Hallahan, D.E., and Lu, B. 2004. XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. Oncogens. 23:7047-7052.
-
(2004)
Oncogens
, vol.23
, pp. 7047-7052
-
-
Cao, C.1
Mu, Y.2
Hallahan, D.E.3
Lu, B.4
-
75
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin, H., Reffey, S.B., Duckett, C.S., Lindsten, T., and Thompson, C.B. 2001. Characterization of XIAP-deficient mice. Mol. Cell. Biol. 21:3604-3608.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
Reffey, S.B.2
Duckett, C.S.3
Lindsten, T.4
Thompson, C.B.5
-
76
-
-
0344304552
-
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis
-
Potts, P.R., Singh, S., Knezek, M., Thompson, C.B., and Deshmukh, M. 2003. Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163:789-799.
-
(2003)
J. Cell Biol.
, vol.163
, pp. 789-799
-
-
Potts, P.R.1
Singh, S.2
Knezek, M.3
Thompson, C.B.4
Deshmukh, M.5
-
77
-
-
0842307058
-
A novel role for XIAP in copper homeostasis through regulation of MURR1
-
Burstein, E., et al. 2004. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J. 23:244-254.
-
(2004)
EMBO J.
, vol.23
, pp. 244-254
-
-
Burstein, E.1
-
78
-
-
11844275937
-
XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland
-
Olayioye, M.A., et al. 2005. XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland. Cell Death Differ. 12:87-90.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 87-90
-
-
Olayioye, M.A.1
-
79
-
-
0032568528
-
Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP
-
Sanna, M.G., Duckett, C.S., Richter, B.W.M., Thompson, C.B., and Ulevitch, R.J. 1998. Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP. Proc. Natl. Acad. Sci. U. S. A. 95:6015-6020.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 6015-6020
-
-
Sanna, M.G.1
Duckett, C.S.2
Richter, B.W.M.3
Thompson, C.B.4
Ulevitch, R.J.5
-
80
-
-
0035266318
-
XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
-
Asselin, E., Mills, G.B., and Tsang, B.K. 2001. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. 61:1862-1868.
-
(2001)
Cancer Res.
, vol.61
, pp. 1862-1868
-
-
Asselin, E.1
Mills, G.B.2
Tsang, B.K.3
-
81
-
-
0037081771
-
Identification of a new copper metabolism gene by positional cloning in a purebred dog population
-
van De Sluis, B., Rothuizen, J., Pearson, P.L., van Oost, B.A., and Wijmenga, C. 2002. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. Hum. Mol. Genet. 11:165-173.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 165-173
-
-
Van De Sluis, B.1
Rothuizen, J.2
Pearson, P.L.3
Van Oost, B.A.4
Wijmenga, C.5
-
82
-
-
0037291737
-
Mechanism of XIAP-mediated inhibition of caspase-9
-
Shiozaki, E.N., et al. 2003. Mechanism of XIAP-mediated inhibition of caspase-9. Mol. Cell. 11:519-527.
-
(2003)
Mol. Cell
, vol.11
, pp. 519-527
-
-
Shiozaki, E.N.1
-
83
-
-
0034700495
-
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
-
Liu, Z., et al. 2000. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature. 408:1004-1008.
-
(2000)
Nature
, vol.408
, pp. 1004-1008
-
-
Liu, Z.1
-
84
-
-
0034700491
-
Structural basis of IAP recognition by Smac/DIABLO
-
Wu, G., et al. 2000. Structural basis of IAP recognition by Smac/DIABLO. Nature. 408:1008-1012.
-
(2000)
Nature
, vol.408
, pp. 1008-1012
-
-
Wu, G.1
-
85
-
-
0036470051
-
Protein explorer: Easy yet powerful macromolecular visualization
-
Martz, E. 2002, Protein explorer: easy yet powerful macromolecular visualization. Trends Biochem. Sci. 27:107-109.
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 107-109
-
-
Martz, E.1
-
86
-
-
26444613182
-
-
Protein Explorer, http://proteinexplorer.org.
-
-
-
|