MG-132 inhibits telomerase activity, induces apoptosis and G1 arrest associated with upregulated p27kip1 expression and downregulated survivin expression in gastric carcinoma cells

Cancer Investigation

Volumn 26, Issue 10, 2008, Pages 1032-1036

  Zhang, Weiguo ^a   Tong, Qiang ^a   Li, Shengbao ^a   Wang, Xiaohu ^a   Wang, Qiang ^a  

^a HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Apoptosis; Gastric carcinoma cell; P27kip1; Survivin; Telomerase; Ubiquitin proteasome

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIN DEPENDENT KINASE INHIBITOR 1B; SURVIVIN; TELOMERASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DETERMINATION; DNA SYNTHESIS; DOWN REGULATION; ELECTROPHORESIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; DNA REPLICATION; DOWN-REGULATION; FLOW CYTOMETRY; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUPEPTINS; MICROTUBULE-ASSOCIATED PROTEINS; STOMACH NEOPLASMS; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 57749188479     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900802104997     Document Type: Article

References (19)

1. Fuchs, S.Y. The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol Ther 2002, 1(4), 337-341.
2. Romero-Perez, L.; Chen, L.; Lambertson, D.; Madura, K. Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway. J Biol Chem 2007, 282(49), 35574-35582.
3. Li, W.; Zhang, X.; Olumi, A.F. MG-132 sensitizes TRAIL-resistant prostate cancer cells by activating c-Fos/c-Jun heterodimers and repressing c-FLIP(L). Cancer Res 2007, 67(5), 2247-2255.
4. Aoyama, T.; Okamoto, T.; Nagayama, S.; Nishijo, K.; Ishibe, T.; Yasura, K.; Nakayama, T.; Nakamura, T.; Toguchida, J. Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. J Biol Chem 2004, 279(27), 28789-28797.
5. Hellmann, H.; Estelle, M. Plant development: regulation by protein degradation. Science 2002, 297(5582), 793-797.
6. Wang, X.; Guerrero, C.; Kaiser, P.; Huang, L. Proteomics of proteasome complexes and ubiquitinated proteins. Expert Rev Proteomics 2007, 4(5), 649-665.
7. Li, M.; Chen, D.; Shiloh, A.; Luo, J.; Nikolaev, A.Y.; Qin, J.; Gu, W. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002, 416(6881), 648-653.
8. Gregory, M.A.; Hann, S.R. c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol Cell Biol 2000, 20(7), 2423-2435.
9. Butler, M.W.; Robertson, I.; Greene, C.M.; O'Neill, S.J.; Taggart, C.C.; McElvaney NG. Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem 2006, 281(46), 34730-34735.
10. Qi, X.; Pohl, N.M.; Loesch, M.; Hou, S.; Li, R.; Qin, J.Z.; Cuenda, A.; Chen G. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. J Biol Chem 2007, 282(43), 31398-31408.
11. Mailhes, J.B.; Hilliard, C.; Lowery, M.; London, S.N. MG-132, an inhibitor of proteasomes and calpains, induced inhibition of oocyte maturation and aneuploidy in mouse oocytes. Cell Chromosome 2002, 1(1), 2.
12. Polyak, K.; Kato, J.Y.; Solomon, M.J.; Sherr, C.J.; Massague, J.; Roberts, J.M.; Koff, A. p27kip1, a cyclin-CDK inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 1994, 8(1), 9-22.
13. Manne, U.; Jhala, N.C.; Jones, J.; Weiss, H.L.; Chatla, C.; Meleth, S.; Suarez-Cuervo, C.; Grizzle, W.E. Prognostic significance of p27kip1 expression in colorectal adenocarcinomas is associated with tumor stage. Clin Cancer Res 2004, 10(5), 1743-1752.
14. 1 arrest. Nat Med 2002, 8(10), 1153-1160.
15. Wu, Q.M.; Yu, J.P.; Tong, Q.; Wang, X.H.; Xie, G.J. Inhibition of adenovirus-mediated p27kip1 gene on growth of esophageal carcinoma cell strain. World J Gastroenterol 2003, 9(11), 2404-2408.
16. Zhang, W.G.; Wu, Q.M.; Yu, J.P.; Tong, Q.; Xie, G.J.; Wang, X.H.; Li, S.B. Adenovirus expressing p27kip1 suppresses growth of established esophageal carcinoma xenografts. World J Gastroenterol 2005, 11(42), 6582-6586.
17. Ambrosini, G.; Adida, C.; Altieri, D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997, 3(8), 917-921.
18. Li, F.; Ambrosini, G.; Chu, E.Y.; Plescia, J.; Tognin, S.; Marchisio, P.C.; Altieri, D.C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998, 396(6711), 580-584.
19. 2-M phase arrest and apoptosis, Mol Cancer Ther 2002, 1(10), 841-849.