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Volumn 76, Issue 3, 2009, Pages 151-156

Clinical benefit of new targeted agents in phase I trials in patients with advanced colorectal cancer

Author keywords

Advanced colorectal cancer; Outcome; Phase I trial; Survival

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CETUXIMAB; PANITUMUMAB;

EID: 58349112979     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000195884     Document Type: Article
Times cited : (11)

References (24)
  • 1
    • 0034767957 scopus 로고    scopus 로고
    • Cancer burden in the year 2000. The global picture
    • Parkin DM, Bray FI, Devesa SS: Cancer burden in the year 2000. The global picture. Eur J Cancer 2001;37(suppl 8):S4-S66.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 8
    • Parkin, D.M.1    Bray, F.I.2    Devesa, S.S.3
  • 3
    • 31444450593 scopus 로고    scopus 로고
    • Advances in the treatment of metastatic colorectal cancer
    • Goldberg RM: Advances in the treatment of metastatic colorectal cancer. Oncologist 2005;10(suppl 3):40-48.
    • (2005) Oncologist , vol.10 , Issue.SUPPL. 3 , pp. 40-48
    • Goldberg, R.M.1
  • 4
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 5
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as firstline treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al: Irinotecan combined with fluorouracil compared with fluorouracil alone as firstline treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000;355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 6
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM, et al: Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004;22:1209-1214.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 7
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed FOLFOX 6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, André T, Achille E, et al: FOLFIRI followed FOLFOX 6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004;22:229-237.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    André, T.2    Achille, E.3
  • 8
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-2342.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 9
    • 42949150908 scopus 로고    scopus 로고
    • Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer
    • Cassidy, Clarke S, Diaz-Rubio E, et al: Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol 2008;26:2006-2012.
    • (2008) J Clin Oncol , vol.26 , pp. 2006-2012
    • Cassidy1    Clarke, S.2    Diaz-Rubio, E.3
  • 10
    • 34447264101 scopus 로고    scopus 로고
    • Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (MCRC): The CRYSTAL trial (abstract 4000)
    • 164s
    • Van Cutsem E, Nowacki M, Lang I, et al: Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metastatic colorectal cancer (MCRC): the CRYSTAL trial (abstract 4000). J Clin Oncol 2007;25:164s.
    • (2007) J Clin Oncol , vol.25
    • Van Cutsem, E.1    Nowacki, M.2    Lang, I.3
  • 11
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al: Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 2005;23:3697-3705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 12
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004;351:337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 13
    • 26944454064 scopus 로고    scopus 로고
    • Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan
    • Chong G, Dickson JL, Cunningham D, et al: Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan. Br J Cancer 2005;93:510-514.
    • (2005) Br J Cancer , vol.93 , pp. 510-514
    • Chong, G.1    Dickson, J.L.2    Cunningham, D.3
  • 14
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • Therasse P, Arbruck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000;92:205-216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbruck, S.G.2    Eisenhauer, E.A.3
  • 15
    • 40849111655 scopus 로고    scopus 로고
    • Clinical outcome and prognostic factors for patients treated within the context of a phase I study: The Royal Marsden Hospital experience
    • Arkenau HT, Olmos D, Ang JE, et al: Clinical outcome and prognostic factors for patients treated within the context of a phase I study: the Royal Marsden Hospital experience. Br J Cancer 2008;98:1029-1033.
    • (2008) Br J Cancer , vol.98 , pp. 1029-1033
    • Arkenau, H.T.1    Olmos, D.2    Ang, J.E.3
  • 18
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan EL, Meier P: Non-parametric estimation from incomplete observations. J Am Stat Ass 1958;53:457-481.
    • (1958) J Am Stat Ass , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 19
    • 0000336139 scopus 로고
    • Regression models and life tables
    • Cox DR: Regression models and life tables. J Roy Stat Soc (B) 1972;34:187-202.
    • (1972) J Roy Stat Soc (B) , vol.34 , pp. 187-202
    • Cox, D.R.1
  • 20
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, O'Callaghan CJ, Karapetis CS, et al: Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007;357:2040-2048.
    • (2007) N Engl J Med , vol.357 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 21
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, et al: Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007;25:1658-1664.
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 22
    • 36048992408 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
    • Saltz LB, Rosen LS, Marshall JL, et al: Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007;25:4793-4799.
    • (2007) J Clin Oncol , vol.25 , pp. 4793-4799
    • Saltz, L.B.1    Rosen, L.S.2    Marshall, J.L.3
  • 23
    • 0038352135 scopus 로고    scopus 로고
    • Perceptions of patients and physicians regarding phase I cancer clinical trials: Implications for physician-patients communication
    • Meropol N, Weinfurt KP, Burnett CB, et al: Perceptions of patients and physicians regarding phase I cancer clinical trials: implications for physician-patients communication. J Clin Oncol 2003;21:2589-2596.
    • (2003) J Clin Oncol , vol.21 , pp. 2589-2596
    • Meropol, N.1    Weinfurt, K.P.2    Burnett, C.B.3
  • 24
    • 42549084786 scopus 로고    scopus 로고
    • Targeted therapy of cancer: New roles for pathologists in colorectal cancer
    • Hamilton SR: Targeted therapy of cancer: new roles for pathologists in colorectal cancer. Mod Pathol 2008;21(suppl 2):S23-S30.
    • (2008) Mod Pathol , vol.21 , Issue.SUPPL. 2
    • Hamilton, S.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.