MAPK pathway activation in colorectal cancer: A therapeutic opportunity for GRP receptor antagonists

Lancet Oncology

Volumn 6, Issue 7, 2005, Pages 444-445

  Schwartsmann, Gilberto ^a   Di Leone, Luciane Pons ^a   Dal Pizzol, Felipe ^a   Roesler, Rafael ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN RELEASING PEPTIDE RECEPTOR; GROWTH FACTOR RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RC 3095;

ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL TRIAL; COLORECTAL CANCER; CONCENTRATION RESPONSE; DISEASE COURSE; DRUG RECEPTOR BINDING; DRUG TARGETING; ENZYME ACTIVATION; GASTROINTESTINAL CARCINOMA; HIPPOCAMPUS; HUMAN; LUNG SMALL CELL CANCER; MITOGENESIS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROSTATE CARCINOMA; SIGNAL TRANSDUCTION;

EID: 21344454231     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(05)70226-6     Document Type: Letter

References (5)

1. Fang JY Richardson BC The MAPK signalling pathways and colorectal cancer Lancet Oncol 6 2005 322-327
2. Yano T Pinski J Groot K Schally AV Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines Cancer Res 52 1992 4545-4547
3. Hellmich MR Ives KL Udupi V et al. Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion J Biol Chem 274 1999 23901-23909
4. Xiao D Qu X Weber HC Activation of extracellular signal-regulated kinase mediates bombesin-induced mitogenic responses in prostate cancer cells Cell Signal 15 2003 945-953
5. Patel O Dumesny C Giraud AS et al. Stimulation of proliferation and migration of a colorectal cancer cell line by amidated and glycine-extended gastrin-releasing peptide via the same receptor Biochem Pharmacol 68 2004 2129-2142