Insulin-like growth factor binding protein-4 gene therapy increases apoptosis by altering Bcl-2 and Bax proteins and decreases angiogenesis in colorectal cancer

International Journal of Oncology

Volumn 30, Issue 4, 2007, Pages 883-888

  Durai, Rajaraman ^a   Yang, Shi Yu ^a   Sales, Kevin M ^a   Seifalian, Alexander M ^a   Goldspink, Geoffrey ^a   Winslet, Marc C ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Angiogenesis; Apoptosis; Bax; Bcl 2; Colorectal cancer; IGF binding protein 4; IGF I receptor

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; SOMATOMEDIN BINDING PROTEIN 4;

ANIMAL; APOPTOSIS; ARTICLE; COLORECTAL TUMOR; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); VASCULARIZATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; COLORECTAL NEOPLASMS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; MICE; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-BCL-2; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34247880415     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.30.4.883     Document Type: Article

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