-
1
-
-
0022387970
-
Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate. Implications for increased therapeutic ratio of low dose rate irradiation
-
FitzGerald TJ, Daugherty C, Kase K, et al: Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate. Implications for increased therapeutic ratio of low dose rate irradiation. Am J Clin Oncol 8:517-522, 1985
-
(1985)
Am J Clin Oncol
, vol.8
, pp. 517-522
-
-
FitzGerald, T.J.1
Daugherty, C.2
Kase, K.3
-
2
-
-
0023835721
-
The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
-
Sklar MD: The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 239:645-647, 1988
-
(1988)
Science
, vol.239
, pp. 645-647
-
-
Sklar, M.D.1
-
3
-
-
0024363796
-
Radioresistance induced by oncogenic transformation
-
Ling CC, Endlich B: Radioresistance induced by oncogenic transformation. Radiat Res 120:267-279, 1989
-
(1989)
Radiat Res
, vol.120
, pp. 267-279
-
-
Ling, C.C.1
Endlich, B.2
-
5
-
-
0025349484
-
Expression of transfected recombinant oncogenes increases radiation resistance of clonal hematopoietic and fibroblast cell lines selectively at clinical low dose rate
-
FitzGerald TJ, Henault S, Sakakeeny M, et al: Expression of transfected recombinant oncogenes increases radiation resistance of clonal hematopoietic and fibroblast cell lines selectively at clinical low dose rate. Radiat Res 122:44-52, 1990
-
(1990)
Radiat Res
, vol.122
, pp. 44-52
-
-
FitzGerald, T.J.1
Henault, S.2
Sakakeeny, M.3
-
6
-
-
0026562890
-
Differences in effects of oncogenes on resistance of gamma rays, ultraviolet light, and heat shock
-
Suzuki K, Watanabe M, Miyoshi J: Differences in effects of oncogenes on resistance of gamma rays, ultraviolet light, and heat shock. Radiat Res 129:157-162, 1992
-
(1992)
Radiat Res
, vol.129
, pp. 157-162
-
-
Suzuki, K.1
Watanabe, M.2
Miyoshi, J.3
-
7
-
-
0027473872
-
Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p 21ras isoprenylation
-
Miller AC, Kariko K, Myers CE, et al: Increased radioresistance of EJras-transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21ras isoprenylation. Int J Cancer 53:302-307, 1993
-
(1993)
Int J Cancer
, vol.53
, pp. 302-307
-
-
Miller, A.C.1
Kariko, K.2
Myers, C.E.3
-
8
-
-
0027253085
-
Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene
-
Ong A, Li WX, Ling CC: Low-dose-rate irradiation of rat embryo cells containing the Ha-ras oncogene. Radiat Res 134: 251-255, 1993
-
(1993)
Radiat Res
, vol.134
, pp. 251-255
-
-
Ong, A.1
Li, W.X.2
Ling, C.C.3
-
9
-
-
0027362521
-
Oncogene-transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype
-
Pirollo KF, Tong YA, Villegas Z, et al: Oncogene-transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype. Radiat Res 135:234-243, 1993
-
(1993)
Radiat Res
, vol.135
, pp. 234-243
-
-
Pirollo, K.F.1
Tong, Y.A.2
Villegas, Z.3
-
10
-
-
0025191121
-
Synergistic effect of the v-myc oncogene with H-ras on radioresistance
-
McKenna WG, Weiss MC, Endlich B, et al: Synergistic effect of the v-myc oncogene with H-ras on radioresistance. Cancer Res 50:97-102, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 97-102
-
-
McKenna, W.G.1
Weiss, M.C.2
Endlich, B.3
-
11
-
-
0027499524
-
Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen
-
Su LN, Little JB: Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen. Radiat Res 133:73-79, 1993
-
(1993)
Radiat Res
, vol.133
, pp. 73-79
-
-
Su, L.N.1
Little, J.B.2
-
12
-
-
0025761272
-
Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression
-
Samid D, Miller AC, Rimoldi D, et al: Increased radiation resistance in transformed and nontransformed cells with elevated ras proto-oncogene expression. Radiat Res 126:244-250, 1991
-
(1991)
Radiat Res
, vol.126
, pp. 244-250
-
-
Samid, D.1
Miller, A.C.2
Rimoldi, D.3
-
13
-
-
0026129706
-
Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc
-
McKenna WG, Iliakis G, Weiss MC, et al: Increased G2 delay in radiation-resistant cells obtained by transformation of primary rat embryo cells with the oncogenes H-ras and v-myc. Radiat Res 125:283-287, 1991
-
(1991)
Radiat Res
, vol.125
, pp. 283-287
-
-
McKenna, W.G.1
Iliakis, G.2
Weiss, M.C.3
-
14
-
-
0030052074
-
Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: Influence of H-ras on the G 2 delay
-
McKenna WG, Bernhard EJ, Markiewicz DA, et al: Regulation of radiation-induced apoptosis in oncogene-transfected fibroblasts: influence of H-ras on the G2 delay. Oncogene 12:237-245, 1996
-
(1996)
Oncogene
, vol.12
, pp. 237-245
-
-
McKenna, W.G.1
Bernhard, E.J.2
Markiewicz, D.A.3
-
15
-
-
0034548724
-
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines
-
Bernhard EJ, Stanbridge EJ, Gupta S, et al: Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines. Cancer Res 60:6597-6600, 2000
-
(2000)
Cancer Res
, vol.60
, pp. 6597-6600
-
-
Bernhard, E.J.1
Stanbridge, E.J.2
Gupta, S.3
-
16
-
-
0026597173
-
The v-src oncogene may not be responsible for the increased radioresistance of hematopoietic progenitor cells expressing v-src
-
Santucci MA, Anklesaria P, Anderson SM, et al: The v-src oncogene may not be responsible for the increased radioresistance of hematopoietic progenitor cells expressing v-src. Radiat Res 129:297-303, 1992
-
(1992)
Radiat Res
, vol.129
, pp. 297-303
-
-
Santucci, M.A.1
Anklesaria, P.2
Anderson, S.M.3
-
17
-
-
0025072241
-
Target dependence of antisense oligodeoxynucleotide inhibition of c-Ha-ras p21 expression and focus formation in T24-transformed NIH 3T3 cells
-
Daaka Y, Wickstrom E: Target dependence of antisense oligodeoxynucleotide inhibition of c-Ha-ras p21 expression and focus formation in T24-transformed NIH3T3 cells. Oncogene Res 5:267-275, 1990
-
(1990)
Oncogene Res
, vol.5
, pp. 267-275
-
-
Daaka, Y.1
Wickstrom, E.2
-
18
-
-
0027447197
-
Antisense DNA inhibition of tumor growth induced by c-Ha-ras oncogene in nude mice
-
Gray GD, Hernandez OM, Hebel D, et al: Antisense DNA inhibition of tumor growth induced by c-Ha-ras oncogene in nude mice. Cancer Res 53:577-580, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 577-580
-
-
Gray, G.D.1
Hernandez, O.M.2
Hebel, D.3
-
19
-
-
0028347648
-
Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme
-
Kashani-Sabet M, Funato T, Florenes VA, et al: Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme. Cancer Res 54:900-902, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 900-902
-
-
Kashani-Sabet, M.1
Funato, T.2
Florenes, V.A.3
-
20
-
-
0035695283
-
Inhibition of MAPK activity, cell proliferation and anchorage-independent growth by N-Ras antisense in an N-ras-transformed human cell line
-
Sorrentino R, Porcellini A, Spalletti-Cernia D, et al: Inhibition of MAPK activity, cell proliferation and anchorage-independent growth by N-Ras antisense in an N-ras-transformed human cell line. Antisense Nucleic Acid Drug Dev 11:349-358, 2001
-
(2001)
Antisense Nucleic Acid Drug Dev
, vol.11
, pp. 349-358
-
-
Sorrentino, R.1
Porcellini, A.2
Spalletti-Cernia, D.3
-
21
-
-
0035447768
-
A phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma
-
Cunningham CC, Holmlund JT, Geary RS, et al: A phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma. Cancer 92:1265-1271, 2001
-
(2001)
Cancer
, vol.92
, pp. 1265-1271
-
-
Cunningham, C.C.1
Holmlund, J.T.2
Geary, R.S.3
-
22
-
-
0034993675
-
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA
-
Nakano M, Aoki K, Matsumoto N, et al: Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA. Mol Ther 3:491-499, 2001
-
(2001)
Mol Ther
, vol.3
, pp. 491-499
-
-
Nakano, M.1
Aoki, K.2
Matsumoto, N.3
-
23
-
-
0033624988
-
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma
-
Tsuchida T, Kijima H, Hori S, et al: Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma. Cancer Gene Ther 7:373-383, 2000
-
(2000)
Cancer Gene Ther
, vol.7
, pp. 373-383
-
-
Tsuchida, T.1
Kijima, H.2
Hori, S.3
-
24
-
-
0031550257
-
Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells
-
Pirollo KF, Hao Z, Rait A, et al: Evidence supporting a signal transduction pathway leading to the radiation-resistant phenotype in human tumor cells. Biochem Biophys Res Comm 230:196-201, 1997
-
(1997)
Biochem Biophys Res Comm
, vol.230
, pp. 196-201
-
-
Pirollo, K.F.1
Hao, Z.2
Rait, A.3
-
25
-
-
0032695801
-
Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment
-
Russell JS, Lang FF, Huet T, et al: Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment. Cancer Res 59:5239-5244, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 5239-5244
-
-
Russell, J.S.1
Lang, F.F.2
Huet, T.3
-
26
-
-
0037089516
-
Inhibition of radiation-induced nuclear factor-kappaB activation by an anti- Ras single-chain antibody fragment: Lack of involvement in radiosensitization
-
Russell JS, Raju U, Gumin GJ, et al: Inhibition of radiation-induced nuclear factor-kappaB activation by an anti- Ras single-chain antibody fragment: Lack of involvement in radiosensitization. Cancer Res 62:2318-2326, 2002
-
(2002)
Cancer Res
, vol.62
, pp. 2318-2326
-
-
Russell, J.S.1
Raju, U.2
Gumin, G.J.3
-
27
-
-
0028170814
-
Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes
-
Glomset JA, Farnsworth CC: Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes. Annu Rev Cell Biol 10:181-205, 1994
-
(1994)
Annu Rev Cell Biol
, vol.10
, pp. 181-205
-
-
Glomset, J.A.1
Farnsworth, C.C.2
-
28
-
-
0030992130
-
Protein prenylation, et cetera: Signal transduction in two dimensions
-
Gelb MH: Protein prenylation, et cetera: Signal transduction in two dimensions [comment]. Science 275:1750-1751, 1997
-
(1997)
Science
, vol.275
, pp. 1750-1751
-
-
Gelb, M.H.1
-
30
-
-
0030749464
-
Inhibition of Ras prenylation: A novel approach to cancer chemotherapy
-
Sebti S, Hamilton A: Inhibition of Ras prenylation: A novel approach to cancer chemotherapy. Pharmacol Ther 74: 103-114, 1997
-
(1997)
Pharmacol Ther
, vol.74
, pp. 103-114
-
-
Sebti, S.1
Hamilton, A.2
-
31
-
-
0031793978
-
Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target
-
Waddick KG, Uckun FM: Innovative treatment programs against cancer. I. Ras oncoprotein as a molecular target. Biochem Pharmacol 56:1411-1426, 1998
-
(1998)
Biochem Pharmacol
, vol.56
, pp. 1411-1426
-
-
Waddick, K.G.1
Uckun, F.M.2
-
32
-
-
0030923192
-
K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte DB, Kirschmeier P, Hockenberry TN, et al: K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem 272:14459-14464, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
-
33
-
-
0032546264
-
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
-
Sun J, Qian Y, Hamilton AD, et al: Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene 16:1467-1473, 1998
-
(1998)
Oncogene
, vol.16
, pp. 1467-1473
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
-
34
-
-
0032522849
-
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes
-
Bernhard EJ, McKenna WG, Hamilton AD, et al: Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes. Cancer Res 58:1754-1761, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 1754-1761
-
-
Bernhard, E.J.1
McKenna, W.G.2
Hamilton, A.D.3
-
35
-
-
0030952552
-
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
-
Lerner EC, Zhang TT, Knowles DB, et al: Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 15:1283-1288, 1997
-
(1997)
Oncogene
, vol.15
, pp. 1283-1288
-
-
Lerner, E.C.1
Zhang, T.T.2
Knowles, D.B.3
-
36
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyl/protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
Sepp-Lorenzino L, Ma Z, Rands E, et al: A peptidomimetic inhibitor of farnesyl/protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Res 55:5302-5309, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 5302-5309
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
-
37
-
-
0031960133
-
Effects of the farnesyltransferase inhibitor UCF-1C/ manumycin on growth and p21-ras post-translational processing in NIH 3T3 cells
-
Servais P, Gulbis B, Fokan D, et al: Effects of the farnesyltransferase inhibitor UCF-1C/ manumycin on growth and p21-ras post-translational processing in NIH3T3 cells. Int J Cancer 76:601-608, 1998
-
(1998)
Int J Cancer
, vol.76
, pp. 601-608
-
-
Servais, P.1
Gulbis, B.2
Fokan, D.3
-
38
-
-
0032521211
-
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice
-
Mangues R, Corral T, Kohl NE, et al: Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice. Cancer Res 58:1253-1259, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 1253-1259
-
-
Mangues, R.1
Corral, T.2
Kohl, N.E.3
-
39
-
-
0033016719
-
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
-
Du W, Lebowitz PF, Prendergast GC: Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol 19:1831-1840, 1999
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1831-1840
-
-
Du, W.1
Lebowitz, P.F.2
Prendergast, G.C.3
-
40
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R 115777 in vivo and in vitro
-
End DW, Smets G, Todd AV, et al: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res 61:131-137, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
-
41
-
-
0028603395
-
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
-
Kohl NE, Wilson FR, Mosser SD, et al: Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A 91:9141-9145, 1994
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9141-9145
-
-
Kohl, N.E.1
Wilson, F.R.2
Mosser, S.D.3
-
42
-
-
0029023145
-
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p 53 deletion
-
Sun J, Qian Y, Hamilton AD, et al: Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res 55:4243-4247, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4243-4247
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
-
43
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
Kohl NE, Omer CA, Conner MW, et al: Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Med 1:792-797, 1995
-
(1995)
Nature Med
, vol.1
, pp. 792-797
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
-
44
-
-
0033214457
-
Antitumor efficacy of a novel class of non-thiol- containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine
-
Sun J, Blaskovich MA, Knowles D, et al: Antitumor efficacy of a novel class of non-thiol- containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res 59:4919-4926, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 4919-4926
-
-
Sun, J.1
Blaskovich, M.A.2
Knowles, D.3
-
45
-
-
0033959438
-
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
-
Lantry LE, Zhang Z, Yao R, et al: Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis 21:113-116, 2000
-
(2000)
Carcinogenesis
, vol.21
, pp. 113-116
-
-
Lantry, L.E.1
Zhang, Z.2
Yao, R.3
-
46
-
-
0033860183
-
RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors
-
Liu A, Du W, Liu JP, et al: RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors. Mol Cell Biol 20:6105-6113, 2000
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6105-6113
-
-
Liu, A.1
Du, W.2
Liu, J.P.3
-
47
-
-
0028892646
-
Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity
-
Lebowitz PF, Davide JP, Prendergast GC: Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity. Mol Cell Biol 15:6613-6622, 1995
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6613-6622
-
-
Lebowitz, P.F.1
Davide, J.P.2
Prendergast, G.C.3
-
48
-
-
0030916369
-
Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB
-
Lebowitz PF, Casey PJ, Prendergast GC, et al: Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB. J Biol Chem 272:15591-15594, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 15591-15594
-
-
Lebowitz, P.F.1
Casey, P.J.2
Prendergast, G.C.3
-
49
-
-
0033231190
-
Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors
-
Du W, Prendergast GC: Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors. Cancer Res 59:5492-5496, 1999
-
(1999)
Cancer Res
, vol.59
, pp. 5492-5496
-
-
Du, W.1
Prendergast, G.C.2
-
50
-
-
0034703471
-
Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors
-
Liu A, Prendergast GC: Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors. FEBS Lett 481:205-208, 2000
-
(2000)
FEBS Lett
, vol.481
, pp. 205-208
-
-
Liu, A.1
Prendergast, G.C.2
-
51
-
-
0031004491
-
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A 549 cells
-
Miquel K, Pradines A, Sun J, et al: GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells. Cancer Res 57:1846-1850, 1997
-
(1997)
Cancer Res
, vol.57
, pp. 1846-1850
-
-
Miquel, K.1
Pradines, A.2
Sun, J.3
-
52
-
-
0034776102
-
The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M or G(1) pause in sensitive human tumor cell lines
-
Ashar HR, James L, Gray K, et al: The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M or G(1) pause in sensitive human tumor cell lines. Exp Cell Res 262: 17-27, 2001
-
(2001)
Exp Cell Res
, vol.262
, pp. 17-27
-
-
Ashar, H.R.1
James, L.2
Gray, K.3
-
53
-
-
0036097103
-
A phase I trial of the farnesyltransferase inhibitor L- 778,123 and radiotherapy for locally advanced lung and head and neck cancer
-
Hahn SM, Bernhard EJ, Regine W, et al: A phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer. Clin Cancer Res 8:1065-1072, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1065-1072
-
-
Hahn, S.M.1
Bernhard, E.J.2
Regine, W.3
-
54
-
-
0035282901
-
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
-
Peters DG, Hoover RR, Gerlach MJ, et al: Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood 97:1404-1412, 2001
-
(2001)
Blood
, vol.97
, pp. 1404-1412
-
-
Peters, D.G.1
Hoover, R.R.2
Gerlach, M.J.3
-
55
-
-
0011758687
-
K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells
-
Song SY, Meszoely IM, Coffey RJ, et al: K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells. Neoplasia 2:261-272, 2000
-
(2000)
Neoplasia
, vol.2
, pp. 261-272
-
-
Song, S.Y.1
Meszoely, I.M.2
Coffey, R.J.3
-
56
-
-
0035844247
-
The farnesyltransferase inhibitor, FTI- 2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
-
Crespo NC, Ohkanda J, Yen TJ, et al: The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells. J Biol Chem 276:16161-16167, 2001
-
(2001)
J Biol Chem
, vol.276
, pp. 16161-16167
-
-
Crespo, N.C.1
Ohkanda, J.2
Yen, T.J.3
-
57
-
-
0033539952
-
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects
-
Feldkamp MM, Lau N, Guha A: Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Oncogene 18:7514-7526, 1999
-
(1999)
Oncogene
, vol.18
, pp. 7514-7526
-
-
Feldkamp, M.M.1
Lau, N.2
Guha, A.3
-
58
-
-
0031983131
-
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
-
Barrington RE, Subler MA, Rands E, et al: A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol 18:85-92, 1998
-
(1998)
Mol Cell Biol
, vol.18
, pp. 85-92
-
-
Barrington, R.E.1
Subler, M.A.2
Rands, E.3
-
59
-
-
0030774573
-
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner
-
Vogt A, Sun J, Qian Y, et al: The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner. J Biol Chem 272:27224-27229, 1997
-
(1997)
J Biol Chem
, vol.272
, pp. 27224-27229
-
-
Vogt, A.1
Sun, J.2
Qian, Y.3
-
60
-
-
0029857638
-
Protein geranylgeranylation, not farnesylation, is required for the G 1 to S phase transition in mouse fibroblasts
-
Vogt A, Qian Y, McGuire TF, et al: Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene 13:1991-1999, 1996
-
(1996)
Oncogene
, vol.13
, pp. 1991-1999
-
-
Vogt, A.1
Qian, Y.2
McGuire, T.F.3
-
61
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
-
Bernhard EJ, Kao G, Cox AD, et al: The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. Cancer Res 56:1727-1730, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 1727-1730
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
-
62
-
-
0026052208
-
Expression of epidermal growth factor receptor in glotic carcinoma and its relation to recurrence after radiotherapy
-
Miyaguchi M, Olofsson J, Hellquist HB: Expression of epidermal growth factor receptor in glotic carcinoma and its relation to recurrence after radiotherapy. Clin Otolaryngol 16:466-469, 1991
-
(1991)
Clin Otolaryngol
, vol.16
, pp. 466-469
-
-
Miyaguchi, M.1
Olofsson, J.2
Hellquist, H.B.3
-
63
-
-
0029983510
-
Epidermal growth factor receptor: An independent predictor of survival in astrocytic tumors given definitive irradiation
-
Zhu A, Shaeffer J, Leslie S, et al: Epidermal growth factor receptor: an independent predictor of survival in astrocytic tumors given definitive irradiation. Int J Radiat Oncol Biol Phys 34:809-815, 1996
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.34
, pp. 809-815
-
-
Zhu, A.1
Shaeffer, J.2
Leslie, S.3
-
64
-
-
0033966576
-
In vivo enhancement of tumor radioresponse by C 225 antiepidermal growth factor receptor antibody
-
Milas L, Mason K, Hunter N, et al: In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 6:701-708, 2000
-
(2000)
Clin Cancer Res
, vol.6
, pp. 701-708
-
-
Milas, L.1
Mason, K.2
Hunter, N.3
-
65
-
-
0035254521
-
Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
-
Harari PM, Huang SM: Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation. Int J Radiat Oncol Biol Phys 49:427-433, 2001
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.49
, pp. 427-433
-
-
Harari, P.M.1
Huang, S.M.2
-
66
-
-
0034899452
-
Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor
-
Lammering G, Valerie K, Lin PS, et al: Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor. Clin Cancer Res 7:682-690, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 682-690
-
-
Lammering, G.1
Valerie, K.2
Lin, P.S.3
-
67
-
-
0026061104
-
Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas
-
Santini J, Formento JL, Francoual M, et al: Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas. Head Neck 13:132-139, 1991
-
(1991)
Head Neck
, vol.13
, pp. 132-139
-
-
Santini, J.1
Formento, J.L.2
Francoual, M.3
-
68
-
-
0024315803
-
Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines
-
Weichselbaum RR, Dunphy EJ, Beckett MA, et al: Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines. Head Neck 11:437-442, 1989
-
(1989)
Head Neck
, vol.11
, pp. 437-442
-
-
Weichselbaum, R.R.1
Dunphy, E.J.2
Beckett, M.A.3
-
69
-
-
0036304685
-
Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction
-
Gupta AK, McKenna WG, Weber CN, et al: Local recurrence in head and neck cancer: Relationship to radiation resistance and signal transduction. Clin Cancer Res 8:885-892, 2002
-
(2002)
Clin Cancer Res
, vol.8
, pp. 885-892
-
-
Gupta, A.K.1
McKenna, W.G.2
Weber, C.N.3
-
70
-
-
0032874281
-
The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS
-
Cohen-Jonathan E, Toulas C, Ader I, et al: The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res 152:404-411, 1999
-
(1999)
Radiat Res
, vol.152
, pp. 404-411
-
-
Cohen-Jonathan, E.1
Toulas, C.2
Ader, I.3
-
73
-
-
0034029550
-
Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest
-
Hagan M, Wang L, Hanley JR, et al: Ionizing radiation-induced mitogen-activated protein (MAP) kinase activation in DU145 prostate carcinoma cells: MAP kinase inhibition enhances radiation-induced cell killing and G2/M-phase arrest. Radiat Res 153:371-383, 2000
-
(2000)
Radiat Res
, vol.153
, pp. 371-383
-
-
Hagan, M.1
Wang, L.2
Hanley, J.R.3
-
74
-
-
0034134145
-
Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway
-
Cartee L, Vrana JA, Wang Z, et al: Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway. Int J Oncol 16:413-422, 2000
-
(2000)
Int J Oncol
, vol.16
, pp. 413-422
-
-
Cartee, L.1
Vrana, J.A.2
Wang, Z.3
-
76
-
-
17444454260
-
Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS
-
Cohen-Jonathan E, Muschel RJ, McKenna WG, et al: Farnesyltransferase inhibitors potentiate the antitumor effect of radiation on a human tumor xenograft expressing activated HRAS. Radiat Res 154:125-132, 2000
-
(2000)
Radiat Res
, vol.154
, pp. 125-132
-
-
Cohen-Jonathan, E.1
Muschel, R.J.2
McKenna, W.G.3
-
77
-
-
0000179878
-
R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI): Biochemical and cellular effects in H-ras and K-ras dominant systems
-
abstr
-
End D, Skrzat S, Devine A: R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI): Biochemical and cellular effects in H-ras and K-ras dominant systems. Proc Am Assoc Cancer Res 39:270, 1998 (abstr)
-
(1998)
Proc Am Assoc Cancer Res
, vol.39
, pp. 270
-
-
End, D.1
Skrzat, S.2
Devine, A.3
-
78
-
-
18544412314
-
Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R 115777 in advanced cancer
-
Zujewski J, Horak ID, Bol CJ, et al: Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol 18:927-941, 2000
-
(2000)
J Clin Oncol
, vol.18
, pp. 927-941
-
-
Zujewski, J.1
Horak, I.D.2
Bol, C.J.3
-
79
-
-
0035064808
-
Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R 115777 in patients with advanced solid tumors
-
Punt CJ, van Maanen L, Bol CJ, et al: Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors. Anticancer Drugs 12:193-197, 2001
-
(2001)
Anticancer Drugs
, vol.12
, pp. 193-197
-
-
Punt, C.J.1
Van Maanen, L.2
Bol, C.J.3
-
80
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al: Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial. Blood 97:3361-3369, 2001
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
81
-
-
0000097049
-
The farnesyl protein transferase (FPTase) inhibitor L-778,123 in patients with solid cancers
-
abstr 597
-
Britten CD, Rowinsky E, Yao S-L, et al: The farnesyl protein transferase (FPTase) inhibitor L-778,123 in patients with solid cancers. Proc Am Soc Clin Oncol 18:155a, 1999 (abstr 597)
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Britten, C.D.1
Rowinsky, E.2
Yao, S.-L.3
-
82
-
-
0035678051
-
A phase I and pharmacological study of the farnesyl protein transferase inhibitor L- 778,123 in patients with solid malignancies
-
Britten CD, Rowinsky EK, Soignet S, et al: A phase I and pharmacological study of the farnesyl protein transferase inhibitor L-778,123 in patients with solid malignancies. Clin Cancer Res 7:3894-3903, 2001
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3894-3903
-
-
Britten, C.D.1
Rowinsky, E.K.2
Soignet, S.3
-
83
-
-
0001800874
-
Long-term survival results for patients with locally advanced, initially unresectable non-small cell lung cancer treated with aggressive concurrent chemoradiation
-
Langer CJ, Curran WJ, Keller SM, et al: Long-term survival results for patients with locally advanced, initially unresectable non-small cell lung cancer treated with aggressive concurrent chemoradiation. Cancer J Sci Am 2:99, 1996
-
(1996)
Cancer J Sci Am
, vol.2
, pp. 99
-
-
Langer, C.J.1
Curran, W.J.2
Keller, S.M.3
-
84
-
-
0002609451
-
Concurrent chemoradiation in unresectable stage III non-small cell lung cancer: Too much pain for no gain
-
Dillman RO: Concurrent chemoradiation in unresectable stage III non-small cell lung cancer: Too much pain for no gain. Cancer J Sci Am 2:76, 1996
-
(1996)
Cancer J Sci Am
, vol.2
, pp. 76
-
-
Dillman, R.O.1
-
85
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak J, Mitsuhashi Y, Bayko L, et al: Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res 55:4575-4580, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
-
86
-
-
0027359953
-
Vascular permeability factor (VPF, VEGF) in tumor biology
-
Senger DR, Van de Water L, Brown LF, et al: Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metast Rev 12:303-324, 1993
-
(1993)
Cancer Metast Rev
, vol.12
, pp. 303-324
-
-
Senger, D.R.1
Van de Water, L.2
Brown, L.F.3
-
87
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak HF, Brown LF, Detmar M, et al: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146: 1029-1039, 1995
-
(1995)
Am J Pathol
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
-
88
-
-
0029166443
-
Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis
-
Kolch W, Martiny-Baron G, Kieser A, et al: Regulation of the expression of the VEGF/VPS and its receptors: Role in tumor angiogenesis. Breast Cancer Res Treat 36:139-155, 1995
-
(1995)
Breast Cancer Res Treat
, vol.36
, pp. 139-155
-
-
Kolch, W.1
Martiny-Baron, G.2
Kieser, A.3
-
89
-
-
0017668169
-
Physicochemical characterization of a vascular permeability factor produced by con A-stimulated human lymphocytes
-
Sobel AT, Branellec AI, Blanc CJ, et al: Physicochemical characterization of a vascular permeability factor produced by con A-stimulated human lymphocytes. J Immunol. 119: 1230-1234, 1977
-
(1977)
J Immunol
, vol.119
, pp. 1230-1234
-
-
Sobel, A.T.1
Branellec, A.I.2
Blanc, C.J.3
-
90
-
-
0031858958
-
Establishing a link between oncogenes and tumor angiogenesis
-
Kerbel RS, Viloria-Petit A, Okada F, et al: Establishing a link between oncogenes and tumor angiogenesis. Mol Med 4:286-295, 1998
-
(1998)
Mol Med
, vol.4
, pp. 286-295
-
-
Kerbel, R.S.1
Viloria-Petit, A.2
Okada, F.3
-
91
-
-
0030447757
-
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels
-
Larcher F, Robles AI, Duran H, et al: Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels. Cancer Res 56:5391-5396, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 5391-5396
-
-
Larcher, F.1
Robles, A.I.2
Duran, H.3
-
92
-
-
0344948143
-
Lovastatin and tumor necrosis factor-alpha exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis
-
Feleszko W, Balkowiec EZ, Sieberth E, et al: Lovastatin and tumor necrosis factor-alpha exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis. Int J Cancer 81:560-567, 1999
-
(1999)
Int J Cancer
, vol.81
, pp. 560-567
-
-
Feleszko, W.1
Balkowiec, E.Z.2
Sieberth, E.3
-
93
-
-
0037036451
-
Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases. Their implication in vascular endothelial growth factor gene transcription
-
Milanini-Mongiat J, Pouyssegur J, Pages G: Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases. Their implication in vascular endothelial growth factor gene transcription. J Biol Chem 277: 20631-20639, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 20631-20639
-
-
Milanini-Mongiat, J.1
Pouyssegur, J.2
Pages, G.3
-
94
-
-
0030869787
-
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras- transformed cells through a hypoxia inducible factor- 1 transcriptional element
-
Mazure NM, Chen EY, Laderoute KR, et al: Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras- transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood 90:3322-3331, 1997
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
-
95
-
-
0035477438
-
Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway
-
Blancher C, Moore JW, Robertson N, et al: Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Res 61:7349-7355, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 7349-7355
-
-
Blancher, C.1
Moore, J.W.2
Robertson, N.3
-
96
-
-
0034146420
-
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers
-
Konishi T, Huang CL, Adachi M, et al: The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers. Int J Oncol 16:501-511, 2000
-
(2000)
Int J Oncol
, vol.16
, pp. 501-511
-
-
Konishi, T.1
Huang, C.L.2
Adachi, M.3
-
97
-
-
0032928810
-
The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor
-
Charvat S, Duchesne M, Parvaz P, et al: The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor. Anticancer Res 19:557-561, 1999
-
(1999)
Anticancer Res
, vol.19
, pp. 557-561
-
-
Charvat, S.1
Duchesne, M.2
Parvaz, P.3
-
98
-
-
0035863297
-
Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa- 4 murine mammary carcinomas
-
Ding I, Sun JZ, Fenton B, et al: Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas. Cancer Res 61:526-531, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 526-531
-
-
Ding, I.1
Sun, J.Z.2
Fenton, B.3
-
99
-
-
0027376264
-
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts
-
Lord EM, Harwell L, Koch CJ: Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 53:5721-5726, 1993
-
(1993)
Cancer Res
, vol.53
, pp. 5721-5726
-
-
Lord, E.M.1
Harwell, L.2
Koch, C.J.3
-
100
-
-
0028839715
-
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro, 1H-imidazol-1-yl)-N- (2,2,3,3,3-pentaluoropropyl)acetamide]: Analysis of drug adducts by fluorescent antibodies vs bound radioactivity
-
Koch CJ, Evans SM, Lord EM: Oxygen dependence of cellular uptake of EF5 [2-(2-nitro, 1H-imidazol-1-yl)-N- (2,2,3,3,3-pentaluoropropyl)acetamide]: Analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br J Cancer 72:869-874, 1995
-
(1995)
Br J Cancer
, vol.72
, pp. 869-874
-
-
Koch, C.J.1
Evans, S.M.2
Lord, E.M.3
-
101
-
-
0028864565
-
Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker
-
Waleh NS, Brody MD, Knapp MA, et al: Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res 55:6222-6226, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 6222-6226
-
-
Waleh, N.S.1
Brody, M.D.2
Knapp, M.A.3
-
102
-
-
0028784382
-
Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl) acetamide]
-
Evans SM, Joiner B, Jenkins WT, et al: Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3- pentafluoropropyl) acetamide]. Br J Cancer 72:875-882, 1995
-
(1995)
Br J Cancer
, vol.72
, pp. 875-882
-
-
Evans, S.M.1
Joiner, B.2
Jenkins, W.T.3
-
103
-
-
0029094054
-
Modification of radiation-induced strand breaks by glutathione: Comparison of single- and double-strand breaks in SV40 DNA
-
Ayene IS, Koch CJ, Krisch RE: Modification of radiation-induced strand breaks by glutathione: Comparison of single- and double-strand breaks in SV40 DNA. Radiat Res 144: 1-8, 1995
-
(1995)
Radiat Res
, vol.144
, pp. 1-8
-
-
Ayene, I.S.1
Koch, C.J.2
Krisch, R.E.3
-
104
-
-
0033959520
-
Cancer statistics, 2000
-
Greenlee RT, Murray T, Bolden S, et al: Cancer statistics, 2000. CA Cancer J Clin 50:7-33, 2000
-
(2000)
CA Cancer J Clin
, vol.50
, pp. 7-33
-
-
Greenlee, R.T.1
Murray, T.2
Bolden, S.3
-
105
-
-
0030032940
-
Effect of cisplatin on the clinically relevant radiosensitivity of human cervical carcinoma cell lines
-
Britten RA, Evans AJ, Allalunis-Turner MJ, et al: Effect of cisplatin on the clinically relevant radiosensitivity of human cervical carcinoma cell lines. Int J Radiat Oncol Biol Phys 34:367-374, 1996
-
(1996)
Int J Radiat Oncol Biol Phys
, vol.34
, pp. 367-374
-
-
Britten, R.A.1
Evans, A.J.2
Allalunis-Turner, M.J.3
-
106
-
-
0032961720
-
Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO 2 saturation measurements
-
Fenton BM, Paoni SF, Lee J, et al: Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements. Br J Cancer 79: 464-471, 1999
-
(1999)
Br J Cancer
, vol.79
, pp. 464-471
-
-
Fenton, B.M.1
Paoni, S.F.2
Lee, J.3
-
107
-
-
0343530603
-
Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF 5 cellular adducts
-
Lee J, Siemann DW, Koch CJ, et al: Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int J Cancer 67: 372-378, 1996
-
(1996)
Int J Cancer
, vol.67
, pp. 372-378
-
-
Lee, J.1
Siemann, D.W.2
Koch, C.J.3
-
108
-
-
0032783745
-
A comparison in individual murine tumors of techniques for measuring oxygen levels
-
Kavanagh MC, Tsang V, Chow S, et al: A comparison in individual murine tumors of techniques for measuring oxygen levels. Int J Radiat Oncol Biol Phys 44:1137-1146, 1999
-
(1999)
Int J Radiat Oncol Biol Phys
, vol.44
, pp. 1137-1146
-
-
Kavanagh, M.C.1
Tsang, V.2
Chow, S.3
-
109
-
-
0035266246
-
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras
-
Cohen-Jonathan E, Evans SM, Koch CJ, et al: The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras. Cancer Res 61:2289-2293, 2001
-
(2001)
Cancer Res
, vol.61
, pp. 2289-2293
-
-
Cohen-Jonathan, E.1
Evans, S.M.2
Koch, C.J.3
-
110
-
-
0021723471
-
Reduced oxygen enhancement ratio at low doses of ionizing radiation
-
Palcic B, Skarsgard LD: Reduced oxygen enhancement ratio at low doses of ionizing radiation. Radiat Res 100:328-339, 1984
-
(1984)
Radiat Res
, vol.100
, pp. 328-339
-
-
Palcic, B.1
Skarsgard, L.D.2
-
111
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber TG, Osmanian C, Jacks T, et al: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [see comments]. Nature 379:88-91, 1996
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
-
112
-
-
0023932431
-
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
-
Gatenby RA, Kessler HB, Rosenblum JS, et al: Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14:831-838, 1988
-
(1988)
Int J Radiat Oncol Biol Phys
, vol.14
, pp. 831-838
-
-
Gatenby, R.A.1
Kessler, H.B.2
Rosenblum, J.S.3
-
113
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
Nordsmark M, Overgaard M, Overgaard J: Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41:31-39, 1996
-
(1996)
Radiother Oncol
, vol.41
, pp. 31-39
-
-
Nordsmark, M.1
Overgaard, M.2
Overgaard, J.3
-
114
-
-
0030742027
-
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
-
Brizel DM, Sibley GS, Prosnitz LR, et al: Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38:285-289, 1997
-
(1997)
Int J Radiat Oncol Biol Phys
, vol.38
, pp. 285-289
-
-
Brizel, D.M.1
Sibley, G.S.2
Prosnitz, L.R.3
-
115
-
-
0027339592
-
Intratumoral pO 2 predicts survival in advanced cancer of the uterine cervix
-
Hockel M, Knoop C, Schlenger K, et al: Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26:45-50, 1993
-
(1993)
Radiother Oncol
, vol.26
, pp. 45-50
-
-
Hockel, M.1
Knoop, C.2
Schlenger, K.3
-
116
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M, Schlenger K, Aral B, et al: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56:4509-4515, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
Schlenger, K.2
Aral, B.3
-
117
-
-
0033922706
-
Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
-
Rofstad EK, Sundfor K, Lyng H, et al: Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis. Br J Cancer 83:354-359, 2000
-
(2000)
Br J Cancer
, vol.83
, pp. 354-359
-
-
Rofstad, E.K.1
Sundfor, K.2
Lyng, H.3
-
118
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
Fyles AW, Milosevic M, Wong R, et al: Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48:149-156, 1998
-
(1998)
Radiother Oncol
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
Milosevic, M.2
Wong, R.3
-
119
-
-
0036467638
-
Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer
-
Fyles A, Milosevic M, Hedley D, et al: Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer. J Clin Oncol 20:680-687, 2002
-
(2002)
J Clin Oncol
, vol.20
, pp. 680-687
-
-
Fyles, A.1
Milosevic, M.2
Hedley, D.3
-
120
-
-
0023673220
-
Reoxygenation and repopulation in irradiated tumors
-
Kallman RF: Reoxygenation and repopulation in irradiated tumors. Front Radiat Ther Oncol 22:30-49, 1988
-
(1988)
Front Radiat Ther Oncol
, vol.22
, pp. 30-49
-
-
Kallman, R.F.1
-
121
-
-
0030022119
-
Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft
-
Znati CA, Rosenstein M, Boucher Y, et al: Effect of radiation on interstitial fluid pressure and oxygenation in a human tumor xenograft. Cancer Res 56:964-968, 1996
-
(1996)
Cancer Res
, vol.56
, pp. 964-968
-
-
Znati, C.A.1
Rosenstein, M.2
Boucher, Y.3
-
122
-
-
0032413391
-
Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia
-
Fenton BM, Paoni SF, Koch CJ, et al: Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia. Adv Exp Med Biol 454:619-628, 1998
-
(1998)
Adv Exp Med Biol
, vol.454
, pp. 619-628
-
-
Fenton, B.M.1
Paoni, S.F.2
Koch, C.J.3
-
123
-
-
0028675107
-
Metalloproteinases in tumor progression: The contribution of MMP- 9
-
Himelstein BP, Canete-Soler R, Bernhard EJ, et al: Metalloproteinases in tumor progression: The contribution of MMP-9. Invasion Metas 14:46-258, 1994
-
(1994)
Invasion Metas
, vol.14
, pp. 46-258
-
-
Himelstein, B.P.1
Canete-Soler, R.2
Bernhard, E.J.3
-
124
-
-
0034956272
-
The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis
-
John A, Tuszynski G: The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res 7:14-23, 2001
-
(2001)
Pathol Oncol Res
, vol.7
, pp. 14-23
-
-
John, A.1
Tuszynski, G.2
-
125
-
-
0025195509
-
Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells
-
Bernhard EJ, Muschel RJ, Hughes EN: Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells. Cancer Res 50:3872-3877, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 3872-3877
-
-
Bernhard, E.J.1
Muschel, R.J.2
Hughes, E.N.3
-
126
-
-
0028346025
-
Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
-
Bernhard EJ, Gruber SB, Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci U S A 91:4293-4297, 1994
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 4293-4297
-
-
Bernhard, E.J.1
Gruber, S.B.2
Muschel, R.J.3
-
127
-
-
0028950493
-
The effect of E1A transfection on MMP- 9 expression and metastatic potential
-
Bernhard EJ, Hagner B, Wong C, et al: The effect of E1A transfection on MMP-9 expression and metastatic potential. Int J Cancer 60:718-724, 1995
-
(1995)
Int J Cancer
, vol.60
, pp. 718-724
-
-
Bernhard, E.J.1
Hagner, B.2
Wong, C.3
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