Suppression of RelA/p65 nuclear translocation independent of IκB-α degradation by cyclooxygenase-2 inhibitor in gastric cancer

Oncogene

Volumn 22, Issue 8, 2003, Pages 1189-1197

  Wong, Benjamin Chun Yu ^a   Jiang, Xiao Hua ^a,b   Fan, Xiao Ming ^a,c   Lin, Marie Chia Mi ^a   Jiang, Shi Hu ^b   Lam, Shiu Kum ^a   Kung, Hsiang Fu ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c JINSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

COX 2 inhibitor; NF B; NSAIDs; p65 (RelA) and gastric cancer

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2 INHIBITOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SC 288; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; GENE ACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOCYTOCHEMISTRY; INFLAMMATION; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; ASPIRIN; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DNA, NEOPLASM; ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; ISOENZYMES; MEMBRANE PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; STOMACH NEOPLASMS; SULFONAMIDES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037468255     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1206234     Document Type: Article

References (40)

1. Baldwin Jr AS (1996). Annu. Rev. Immunol., 14, 649-681.
2. Barnes PJ and Karin M. (1997). N. Engl. J. Med, 336, 1066-1071.
3. Beg AA, Sha WC, Bronson RT, Ghosh S and Baltimore D. (1995). Nature, 376, 167-170.
4. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH and Ballard DW. (1997). Prog. Natl. Acad. Sci. USA, 94, 10057-10062.
5. Connolly EM, Harmey JH, O'Grady T, Foley D, Roche-Nagle G, Kay E, Bouchier-Hayes DJ. (2002). Br. J. Cancer, 87(2), 231-237.
6. Dignam JD, Lebovitz RM and Roeder RG. (1983). Nucleic Acids Res., 11, 1475-1489.
7. DuBois RN and Smalley WE (1996). J. Gastroenterol., 31, 898-906.
8. Elder DJ, Halton DE, Hague A and Paraskeva C. (1997). Clin. Cancer Res., 3, 1679-1683.
9. Grilli MJ, Pizzi M, Memo M and Spano P. (1996). Science, 274, 1383-1385.
10. Grosch S, Tegeder I, Niederberger E, Brautigam L, Geisslinger G. (2001). FASEB J., 15(14), 2742-2744.
11. Gupta RA and DuBois RN. (1998). Gastroenterology, 114, 1095-1098.
12. Hanif R, Pittas A, Feng Y, Koutsos MI, Qiao L, Staiano-Caico L, Shiff SI, Rigas B. (1996). Biochem. Pharmacol., 52, 237-245.
13. He TC, Chan TA, Vogelstein B and Kinzler KW. (1999). Cell, 99, 335-345.
14. Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM, Chen CS. (2000). J. Biol. Chem., 275(15), 11397-11403.
15. Jiang XH, Lam SK, Lin MCM, Jiang SH, Kung HF, Slosberg ED, Soh JW, Weinstein IB and Wong BCY. (2002). Oncogene, 21, 6113-6122.
16. Kargman SL, O'Neill GP, Vichers PJ, Evans JF, Mancini JA and Jothy S. (1995). Cancer Res., 55, 3785-3789.
17. Kopp E and Ghosh S. (1994). Science, 265, 956-959.
18. Li JJ, Westergaard C, Ghosh P and Colburn NH. (1997). Cancer Res., 57, 3569-3576.
19. Manna SK, Mukhopadhyay A and Aggarwal BB. (2000). J. Immunol., 164, 6509-6519.
20. Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BM, Edwards DA, Flickinger AG, Moore RJ and Seibert K (2000). Cancer Res., 60, 1306-1311.
21. Natarajan K, Singh S, Burke Jr TR, Grunberger D and Aggarwal BB. (1996). Proc. Natl. Acad. Sci. USA, 93, 9090-9095.
22. Parett ML, Harris RE, Joarder FS, Ross MS, Clausen KP and Robertson FM. (1997). Int. J. Oncol., 10, 503-507.
23. Penning TD, Talley JJ, Bertenshaw SR, Carter JS, Collins PW and Docter S. (1997). J. Med. Chem., 40, 1347-1365.
24. Reddy BS, Rao CV and Seibert K. (1996). Cancer Res., 56, 4566-4569.
25. Richter M, Weiss M, Weinberger I, Furstenberger G and Marian B. (2001). Carcinogenesis, 22(1), 17-25.
26. Ristimaki A, Honkanen N, Jankala H, Sipponen P and Harkonen M. (1997). Cancer Res., 57, 1276-1281.
27. Sawaoka H, Kawano S, Tsuji S, Tsuji M, Gunawan ES, Takei Y, Nagano K and Hori M. (1998). Am. J. Physiol., 274, G1061-G1065.
28. Sheng H, Shao J, Morrow JD, Beauchamp RD and DuBois RN. (1998). Cancer Res., 58, 362-366.
29. Stark LA, Din FVN, Zwacka RM and Dunlop MG. (2001). FASEB J., 15, 1273-1275.
30. Tegeder I, Niederberger E, Israr E, Guhring H, Brune K, Euchenhofer C, Grosch S and Geisslinger G. (2001). FASEB J., 15, 2-4.
31. Vane JR. (1971). Nat. New Biol., 231, 232-235.
32. Wahl C, Liptay S, Adler G and Schmid RM. (1998). J. Clin. Invest., 101, 1163-1174.
33. Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin Jr AS. (1998). Science, 281, 1680-1683.
34. Weber CK, Liptay S, Wirth T, Adler G and Schmid RM. (2000). Gastroenterology, 119, 1209-1218.
35. Wulczyn FG, Krappmann D and Scheidereit C. (1996). J. Mol. Med., 74, 749-769.
36. Yamamoto Y, Yin MJ, Lin KM and Gaynor RB. (1999). J. Biol. Chem., 274, 27307-27314.
37. Yin MJ, Yamamoto Y and Gaynor RB. (1998). Nature, 396, 77-80.
38. Zhou XM, Wong BCY, Fan XM, Zhang HB, Lin MCM, Kung HF, Fan DM and Lam SK. (2001). Carcinogenesis., 22(9), 1393-1397.
39. Zhu GH, Wong BCY, Eggo MC, Ching CK, Yuen ST, Chan EYT, Lai KC and Lam SK. (1999). Br. J. Cancer., 79, 393-400.
40. Zhu GH, Wong BCY, Slosberg ED, Eggo MC, Ching CK, Yuen ST, Lai KC, Soh JW, Weinstein IB and Lam SK. (2000). Gastroenterology, 118, 507-514.