Rapid microglial response around amyloid pathology after systemic anti-Aβ antibody administration in PDAPP mice

Journal of Neuroscience

Volumn 28, Issue 52, 2008, Pages 14156-14164

  Koenigsknecht Talboo, Jessica ^a   Meyer Luehmann, Melanie ^b   Parsadanian, Maia ^a   Garcia Alloza, Monica ^b   Finn, Mary Beth ^a   Hyman, Bradley T ^b   Bacskai, Brian J ^b   Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

amyloid; Alzheimer's disease; Cerebral amyloid angiopathy; Microglia; Neuritic plaques; Passive immunization

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN ANTIBODY M3D6; IMMUNOGLOBULIN FC FRAGMENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; EXPERIMENTAL MODEL; MACROPHAGE ACTIVATION; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION;

AGE FACTORS; ALKENES; ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES; ANTIGENS, CD45; BENZENE DERIVATIVES; CALCIUM-BINDING PROTEINS; CELL COUNT; CELL MOVEMENT; CEREBRAL AMYLOID ANGIOPATHY; DISEASE MODELS, ANIMAL; GREEN FLUORESCENT PROTEINS; MICE; MICE, TRANSGENIC; MICROGLIA; RECEPTORS, CHEMOKINE; SENILE PLAQUES;

EID: 58149401811     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4147-08.2008     Document Type: Article

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