Alzheimer's disease Aβ vaccine reduces central nervous system Aβ levels in a non-human primate, the Caribbean vervet

American Journal of Pathology

Volumn 165, Issue 1, 2004, Pages 283-297

  Lemere, Cynthia A ^a,d   Beierschmitt, Amy ^b   Iglesias, Melitza ^a   Spooner, Edward T ^a   Bloom, Jeanne K ^a   Leverone, Jodi F ^a   Zheng, Jessica B ^a   Seabrook, Timothy J ^a   Louard, Dora ^b   Li, Diana ^a   Selkoe, Dennis J ^a   Palmour, Roberta M ^b,c   Ervin, Frank R ^b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Behav Sci Found Caribbean P L   (Saint Kitts and Nevis)

^c MCGILL UNIVERSITY   (Canada)

^d Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CEREBROSPINAL FLUID; COGNITION; CONTROLLED STUDY; EPITOPE MAPPING; FEMALE; FRONTAL CORTEX; GLIOSIS; IMMUNOTHERAPY; INFLAMMATION; MALE; MONKEY; NEURITIS; NONHUMAN; PLASMA; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE; VACCINATION;

EID: 3042692322     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63296-8     Document Type: Article

References (57)

1. Dickson DW: The pathogenesis of senile plaques. J Neuropathol Exp Neurol 1997, 56:321-339
2. Selkoe DJ: Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999, 399:A23-A31
3. Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y: Amyloid β protein (Aβ) deposition: aβ42(43) precedes Aβ40 in Down syndrome. Ann Neurol 1995, 37:294-299
4. Lemere CA, Blustzjan JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ: Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Disease 1996, 3:16-32
5. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vendevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P: Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400:173-177
6. Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ: Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol 2000, 48:567-579
7. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T: Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000, 6:916-919
8. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW: A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000, 408:982-985
9. Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D: A β peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 2000, 408:979-982
10. Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH: Reversible memory loss in a transgenic model of Alzheimer's disease. J Neuroscience 2002, 22:6331-6335
11. Dodart J-C, Bales K, Gannon K, Greene S, DeMattos R, Mathis C, DeLong C, Wu S, Wu X, Holtzman D, Paul S: Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nature Neurosci 2002, 5:452-457
12. Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ: Nasal Aβ treatment induces anti-Aβ antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann NY Acad Sci 2000, 920:328-331
13. Frenkel D, Katz O, Solomon B: Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration. Proc Natl Acad Sci USA 2000, 97:11455-11459
14. Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B, Wisniewski T: Immunization with a non-toxic/non-fibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am J Pathol 2001, 159:439-447
15. Brayden D, Templeton L, McClean S, Barbour R, Huang J, Nguyen M, Ahern D, Motter R, Johnson-Wood K, Vasquez N, Schenk D, Seubert P: Encapsulation in biodegradable microparticles enhances serum antibody response to parenterally delivered β-amyloid in mice. Vaccine 2001, 19:4185-4193
16. Zhang J, Wu X, Qin C, Qi J, Ma S, Zhang H, Kong Q, Chen D, Ba D, He W: A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease. Neurobiol Dis 2003, 14:365-379
17. Spooner E, Desai R, Mori C, Leverone J, Lemere C: The generation and characterization of potentially therapeutic Aβ antibodies in mice: differences according to strain and immunization protocol. Vaccine 2002, 21:290-297
18. Lemere C, Spooner E, Leverone J, Mori C, Clements J: Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants. Neurobiol Aging 2002, 23:991-1000
19. McLaurin J, Cecal R, Kierstead M, Tian X, Phinney A, Manea M, French J, Lambermon M, Darabie A, Brown M, Janus C, Chishti M, Horne P, Westaway D, Fraser P, Mount H, Przybylski M, St George-Hyslop P: Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 2002, 8:1263-1269
20. DeMattos R, Bales K, Cummins D, Dodart J-C, Paul S, Holtzman D: Peripheral anti-Aβ antibody alters CNS and plasma clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2001, 98:8850-8855
21. Das P, Murphy M, Younkin L, Younkin S, Golde T: Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol Aging 2001, 22:721-727
22. Orgogozo J-M, Gilman S, Dartigues J-F, Laurent B, Puel M, Kirby L, Jouanny P, Dubois B, Eisner L, Flitman S, Michel B, Boada M, Frank A, Hock C: Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 2003, 61:46-54
23. Hock C, Konietzko U, Papassotiropoulos A, Wollmer A, Streffer J, von Rotz RC, Davey G, Moritz E, Nitsch RM: Generation of antibodies for β-amyloid by vaccination of patients with Alzheimer disease. Nat Med 2002, 8:1270-1275
24. Hock C, Konietzko U, Streffer JR, Tracy J, Signorell A, Muller-Tillmanns B, Lemke U, Henke K, Moritz E, Garcia E, Wollmer MA, Umbricht D, deq Uervain DJ, Hofmann M, Maddalena A, Papassotiropoulos A, Nitsch RM: Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003, 38:547-554
25. Nicoll J, Wilkinson D, Holmes C, Steart P, Markham H, Weller R: Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nat Med 2003, 9:448-452
26. Furlan R, Brambilla E, Sanvito F, Roccatagliata L, Olivieri S, Bergami A, Pluchino S, Uccelli A, Comi G, Martino G: Vaccination with amyloid-β peptide induces autoimmune encephalomyelitis in C57/BL6 mice. Brain 2003, 126:285-291
27. Podlisny MB, Tolan D, Selkoe DJ: Homology of the amyloid β-protein precursor in monkey and human supports a primate model for β-amyloidosis in Alzheimer's disease. Am J Pathol 1991, 138:1423-1435
28. Selkoe DJ, Bell D, Podlisny MB, Cork LC, Price DL: Conservation of brain amyloid proteins in aged mammals and in humans with Alzheimer's disease. Science 1987, 235:873-877
29. Palmour R, Mulligan J, Howbert J, Ervin F: Insights from model systems. Of monkeys and men: vervets and the genetics of human-like behaviors. Am J Hum Genet 1997, 61:481-488
30. McGuire MT: The St. Kitts vervet (Cercopithecus aethiops). J Med Primatol 1974, 3:285-297
31. Lemere C, Spooner E, LaFrancois J, Malester B, Mori C, Leverone J, Matsuoka Y, DeMattos R, Holtzman D, Clements J, Selkoe D, Duff K: Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice. Neurobiol Dis 2003, 14:10-18
32. Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L: High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 2000, 20:4050-4058
33. Lemere CA, Khan K, Saido TC, Haass C, Masliah E, Selkoe DJ, Games D: Temporal sequence of deposition of Aβ peptides bearing heterogeneous N-termini and APO J in PD-APP transgenic mice. Soc Neurosci 1997, 23:534 [209.535]
34. Cribbs D, Ghochikyan A, Vasilevko V, Tran M, Petrushina I, Sadzikava N, Babikyan D, Kesslak P, Kieber-Emmons T, Cotman C, Agadjanyan M: Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with β-amyloid. Int Immunol 2003, 15:505-514
35. Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L: Amyloid precursor protein processing and A β42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci USA 1997, 94:1550-1555
36. Wisniewski HM, Ghetti B, Terry RD: Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 1973, 32:566-584
37. Struble RG, Price Jr. DL, Cork LC, Price DL: Senile plaques in cortex of aged normal monkeys. Brain Res 1985, 361:267-275
38. Walker LC, Kitt CA, Schwam E, Buckward F, Garcia F, Sepinwall J, Price DL: Senile plaques in aged squirrel monkeys. Neurobiol Aging 1987, 8:291-296
39. Cork L, Masters C, Beyreuther K, Price D: Development of senile plaques: relationships of neuronal abnormalities and amyloid deposits. Am J Pathol 1990, 137:1383-1392
40. Martin L, Sisodia S, Koo E, Cork L, Dellovade T, Weidemann A, Beyreuther K, Masters C, Price D: Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci USA 1991, 88
41. Bons N, Mestre N, Petter A: Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus. Neurobiol Aging 1991, 13:99-105
42. Nakamura S, Tamaoka A, Sawamura N, Shoji S, Nakayama H, Ono F, Sakakibara I, Yoshikawa Y, Mori H, Goto N, Doi K: Carboxyl end-specific monoclonal antibodies to amyloid β protein (Aβ) subtypes (Aβ40 and Aβ42(43)) differentiate Aβ in senile plaques and amyloid angiopathy in brains of cynomolgus monkeys. Neuroscience Letters 1995, 201:151-154
43. Uno H, Alsum P, Dong S, Richardson R, Zimbric M, Thieme C, Houser W: Cerebral amyloid angiopathy and plaques, and visceral amyloidosis in aged macaques. Neurobiol of Aging 1996, 17:275-281
44. Gearing M, Tigges J, Mori H, Mirra S: Aβ40 is a major form of β-amyloid in nonhuman primates. Neurobiol of Aging 1996, 17:903-908
45. Gearing M, Tigges J, Mori H, Mirra S: β-amyloid (Aβ) Deposition in the brains of aged orangutans. Neurobiol of Aging 1997, 18:139-146
46. Nakamura S, Nakayama H, Goto N, Ono F, Sakakibara I, Yoshikawa Y: Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys. J Med Primatol 1998, 27:244-252
47. Maclean C, Baker H, Ridley R, Mori H: Naturally occurring and experimentally induced β-amyloid deposits in the brains of marmosets (Callithrix jacchus). J Neural Transmission 2000, 107:799-814
48. Geula C, Nagykery N, W C-K: Amyloid-β deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition. Acta Neuropathol 2002, 103:48-58
49. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina H, Ihara Y: Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 1994, 13:45-53
50. Kanemaru K, Iwatsubo T, Ihara Y: Comparable amyloid-β (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain. Neuroscience Letters 1996, 214:196-198
51. DeMattos R, Bales K, Cummins D, Paul S, Holtzman D: Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 2002, 295:2264-2267
52. Solomon B, Koppel R, Hanan E, Katzav T: Monoclonal antibodies inhibir inhibit in vitro fibrillar aggregation of the Alzheimer β-amyloid peptide. Proc Natl Acad Sci USA 1996, 93:452-455
53. Solomon B, Koppel R, Frenkel D, Hanan-Aharon E: Disaggregation of Alzheimer β-amyloid by site-directed mAb. Proc Natl Acad Sci USA 1997, 94:4109-4112
54. Wilcock DM, Gordon MN, Ugen KE, Gottschall PE, DiCarlo G, Dickey C, Boyett KW, Jantzen PT, Connor KE, Melachrino J, Hardy J, Morgan D: Number of Aβ inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA and Cell Biol 2001, 20:731-737
55. Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D: Intracranially administered anti-Aβ antibodies reduce β-amyloid deposition by mechanisms both independent and associated with microglial activation. J Neurosci 2003, 23:3745-3751
56. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL: Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer's disease. J Clin Invest 2003, 112:415-422
57. Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews P, Jucker M: Cerebral hemorrhage after passive anti-Aβ immunotherapy. Science 2002, 298:1379