-
1
-
-
0035984815
-
40 in the squirrel monkey: A SPECT study in a primate model of cerebral amyloid angiopathy
-
40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J. Drug Targeting 10, 359-368.
-
(2002)
J. Drug Targeting
, vol.10
, pp. 359-368
-
-
Bading, J.1
Yamada, S.2
Mackic, J.3
Kirkman, L.4
Miller, C.5
Calero, M.6
Ghiso, J.7
Frangione, B.8
Zlokovic, B.9
-
2
-
-
0141620181
-
Structural and functional aspects of the blood-brain barrier
-
(L. Prokai and K. Prokai-Tatrai, eds). Birkhause Velag, Basel
-
Begley D. and Brightman M. (2003) Structural and functional aspects of the blood-brain barrier, In: Progress in Drug Research, Vol. 61 (L. Prokai and K. Prokai-Tatrai, eds). Birkhause Velag, Basel.
-
(2003)
Progress in Drug Research
, vol.61
-
-
Begley, D.1
Brightman, M.2
-
3
-
-
0036917631
-
Serum insulin-like growth factor I regulates brain amyloid-β levels
-
Carro E., Trejo J., Gomez-Isla T., LeRoith D. and Torres-Aleman I. (2002) Serum insulin-like growth factor I regulates brain amyloid-β levels. Nature Med. 8, 1390-1397.
-
(2002)
Nature Med.
, vol.8
, pp. 1390-1397
-
-
Carro, E.1
Trejo, J.2
Gomez-Isla, T.3
LeRoith, D.4
Torres-Aleman, I.5
-
4
-
-
0037703255
-
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
-
Deane R., Yan S., Submamaryan R., LaRue B., Jovanovic S., Hogg E., Welch D., Manness L., Lin C., Yu J. et al. (2003) RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9, 907-913.
-
(2003)
Nat. Med.
, vol.9
, pp. 907-913
-
-
Deane, R.1
Yan, S.2
Submamaryan, R.3
LaRue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
-
5
-
-
0037155581
-
Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DeMattos R., Bales K., Cummins D., Paul S. and Holtzman D. (2002a) Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267.
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
DeMattos, R.1
Bales, K.2
Cummins, D.3
Paul, S.4
Holtzman, D.5
-
6
-
-
0036319503
-
Plaque-associated disruption of CSF and plasma amyloid-β equilibrium in a mouse model of Alzheimer's disease
-
DeMattos R., Bales K., Parsadanian M., O'Dell M., Foss E., Paul S. and Holtzman D. (2002b) Plaque-associated disruption of CSF and plasma amyloid-β equilibrium in a mouse model of Alzheimer's disease. J. Neurochem. 81, 229-236.
-
(2002)
J. Neurochem.
, vol.81
, pp. 229-236
-
-
DeMattos, R.1
Bales, K.2
Parsadanian, M.3
O'Dell, M.4
Foss, E.5
Paul, S.6
Holtzman, D.7
-
7
-
-
0038675764
-
Potential role of endogenous and exogenous Aβ binding molecules in Aβ clearance and metabolism
-
(Saido T. ed). Landes Bioscience, Georgetown, TX, USA
-
DeMattos R., Bales K., Paul S. and Holtzman D. (2003) Potential role of endogenous and exogenous Aβ binding molecules in Aβ clearance and metabolism, In: Aβ Metabolism in Alzheimer's Disease (Saido T. ed). Landes Bioscience, Georgetown, TX, USA.
-
(2003)
Aβ Metabolism in Alzheimer's Disease
-
-
DeMattos, R.1
Bales, K.2
Paul, S.3
Holtzman, D.4
-
8
-
-
0037038813
-
Amyloidosis in Alzheimer's Disease
-
Ghiso J. and Frangione B. (2002) Amyloidosis in Alzheimer's Disease. Adv. Drug Del Rev. 54, 1539-1553.
-
(2002)
Adv. Drug Del Rev.
, vol.54
, pp. 1539-1553
-
-
Ghiso, J.1
Frangione, B.2
-
9
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J. and Selkoe D. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.2
-
10
-
-
0037423387
-
Coaxing the LDL receptor family into the fold
-
Herz J. (2003) Coaxing the LDL receptor family into the fold. Cell 112, 289-292.
-
(2003)
Cell
, vol.112
, pp. 289-292
-
-
Herz, J.1
-
11
-
-
0035947207
-
Metabolic regulation of brain Aβ by neprilysin
-
Iwata N., Tsubuki S., Takaki Y., Shirotani K., Lu B., Gerard N., Gerard C., Hama E., Lee H.-J. and Saido T. C. (2001) Metabolic regulation of brain Aβ by neprilysin. Science 292, 1550-1552.
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.6
Gerard, C.7
Hama, E.8
Lee, H.-J.9
Saido, T.C.10
-
12
-
-
0030752288
-
Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset alzheimer's disease
-
Kang D., Saitoh T., Chen X., Xia Y., Masliah E., Hansen L., Thomas R., Thal L. J. and Katzman R. (1997) Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset alzheimer's disease. Neurology 49, 56-61.
-
(1997)
Neurology
, vol.49
, pp. 56-61
-
-
Kang, D.1
Saitoh, T.2
Chen, X.3
Xia, Y.4
Masliah, E.5
Hansen, L.6
Thomas, R.7
Thal, L.J.8
Katzman, R.9
-
13
-
-
0035863055
-
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
-
Kawarabayashi T., Younkin L., Saido T., Shoji M., Ashe K. and Younkin S. (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci. 21, 372-381.
-
(2001)
J. Neurosci.
, vol.21
, pp. 372-381
-
-
Kawarabayashi, T.1
Younkin, L.2
Saido, T.3
Shoji, M.4
Ashe, K.5
Younkin, S.6
-
14
-
-
0033590975
-
High levels of circulting Aβ42 are sequestered by plasma proteins in Alzheimer's disease
-
Kuo Y., Emmerling M., Lampert H., Hempelman S., Kokjohn T., Woods A., Cotter R. and Roher A. (1999) High levels of circulting Aβ42 are sequestered by plasma proteins in Alzheimer's disease. Biochem. Biophys. Res. Comm. 257, 787-791.
-
(1999)
Biochem. Biophys. Res. Comm.
, vol.257
, pp. 787-791
-
-
Kuo, Y.1
Emmerling, M.2
Lampert, H.3
Hempelman, S.4
Kokjohn, T.5
Woods, A.6
Cotter, R.7
Roher, A.8
-
15
-
-
0035112889
-
β-amyloid efflux mediated by p-glycoprotein
-
Lam F. C., Liu R., Lu P. H., Shapiro A. B., Renoir J. M., Sharom F. J. and Reiner P. B. (2001) β-Amyloid efflux mediated by p-glycoprotein. J. Neurochem. 76, 1121-1128.
-
(2001)
J. Neurochem.
, vol.76
, pp. 1121-1128
-
-
Lam, F.C.1
Liu, R.2
Lu, P.H.3
Shapiro, A.B.4
Renoir, J.M.5
Sharom, F.J.6
Reiner, P.B.7
-
16
-
-
2542476698
-
Differential cerebrovascular sequestration and enhanced blood-brain barrier permeability to circulating Alzheimer's amyloid-β peptide in aged Rhesus vs. aged Squirrel monkey
-
Mackic J., Ghiso J., Frangione B., Kirkman L., Bading J. and Zlokovic B. (2002) Differential cerebrovascular sequestration and enhanced blood-brain barrier permeability to circulating Alzheimer's amyloid-β peptide in aged Rhesus vs. aged Squirrel monkey. Vascular Pharmacol. 18, 303-313.
-
(2002)
Vascular Pharmacol.
, vol.18
, pp. 303-313
-
-
Mackic, J.1
Ghiso, J.2
Frangione, B.3
Kirkman, L.4
Bading, J.5
Zlokovic, B.6
-
17
-
-
0032946019
-
Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome
-
Matsubara E., Ghiso J., Frangione B., Amari M., Tomidokoro Y., Ikeda Y., Harigaya Y., Okamoto K. and Shoji M. (1999) Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome. Ann. Neurol. 45, 537-541.
-
(1999)
Ann. Neurol.
, vol.45
, pp. 537-541
-
-
Matsubara, E.1
Ghiso, J.2
Frangione, B.3
Amari, M.4
Tomidokoro, Y.5
Ikeda, Y.6
Harigaya, Y.7
Okamoto, K.8
Shoji, M.9
-
18
-
-
0037223101
-
Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to β-amyloid
-
Matsuoka Y., Saito M., LaFrancois J. et al. (2003) Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to β-amyloid. J. Neurosci. 23, 29-33.
-
(2003)
J. Neurosci.
, vol.23
, pp. 29-33
-
-
Matsuoka, Y.1
Saito, M.2
LaFrancois, J.3
-
19
-
-
0036227489
-
Substitution at codon 22 reduces clearance of Alzheimer's amyloid-β peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood
-
Monro O., Mackic J., Yamada S., Segal M., Ghiso J., Maurer C., Calero M., Frangione B. and Zlokovic B. (2002) Substitution at codon 22 reduces clearance of Alzheimer's amyloid-β peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol. Aging 23, 405-412.
-
(2002)
Neurobiol. Aging
, vol.23
, pp. 405-412
-
-
Monro, O.1
Mackic, J.2
Yamada, S.3
Segal, M.4
Ghiso, J.5
Maurer, C.6
Calero, M.7
Frangione, B.8
Zlokovic, B.9
-
20
-
-
0037118028
-
Targeted pharmacological deletion of serum amyloid P component for treatment of human amyloidosis
-
Pepys M., Herbert J., Hutchinson G. et al. (2002) Targeted pharmacological deletion of serum amyloid P component for treatment of human amyloidosis. Nature 417, 254-259.
-
(2002)
Nature
, vol.417
, pp. 254-259
-
-
Pepys, M.1
Herbert, J.2
Hutchinson, G.3
-
21
-
-
0036846405
-
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
-
Pietrzik C., Busse T., Merriam D., Weggen S. and Koo E. (2002) The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J. 21, 5691-5700.
-
(2002)
EMBO J.
, vol.21
, pp. 5691-5700
-
-
Pietrzik, C.1
Busse, T.2
Merriam, D.3
Weggen, S.4
Koo, E.5
-
22
-
-
0032211830
-
The cell biology of beta-amyloid precursor protein and presenlin in Alzheimer's disease
-
Selkoe D. (1998) The cell biology of beta-amyloid precursor protein and presenlin in Alzheimer's disease. Trends Cell Biol. 8, 447-453.
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.1
-
23
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe D. (2001) Clearing the brain's amyloid cobwebs. Neuron 32, 177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.1
-
24
-
-
0034521392
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106, 1489-1499.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.3
Calero, M.4
Bading, J.5
Frangione, B.6
Holtzman, D.7
Miller, C.8
Strickland, D.9
Ghiso, J.10
-
25
-
-
0034884382
-
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
-
Sigurdsson E., Scholtzova H., Mehta P., Frangione B. and Wisniewski T. (2001) Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol. 159, 439-447.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 439-447
-
-
Sigurdsson, E.1
Scholtzova, H.2
Mehta, P.3
Frangione, B.4
Wisniewski, T.5
-
26
-
-
0038038284
-
Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: A hypothesis
-
Silverberg G., Mayo M., Saul T., Rubenstein E. and McGuire D. (2003) Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol. 2, 506-511.
-
(2003)
Lancet Neurol.
, vol.2
, pp. 506-511
-
-
Silverberg, G.1
Mayo, M.2
Saul, T.3
Rubenstein, E.4
McGuire, D.5
-
27
-
-
0036848549
-
Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein
-
Van Uden E., Mallory M., Veinbergs I., Alford M., Rockenstein E. and Masliah E. (2002) Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. J. Neurosci. 22, 9298-9304.
-
(2002)
J. Neurosci.
, vol.22
, pp. 9298-9304
-
-
Van Uden, E.1
Mallory, M.2
Veinbergs, I.3
Alford, M.4
Rockenstein, E.5
Masliah, E.6
-
28
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B., Babu-Khan S. et al. (1999) Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.2
Babu-Khan, S.3
-
29
-
-
0036797713
-
Deposition of Alzheimer's β-amyloid is inversely correlated with p-glycoprotein expression in the brains of elderly non-demented humans
-
Vogelgesang S., Cascorbi I., Schroeder E., Pahnke J., Kroemer H. K., Siegmund W., Kunert-Keil C., Walker L. and Warzok R. W. (2002) Deposition of Alzheimer's β-amyloid is inversely correlated with p-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12, 535-541.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 535-541
-
-
Vogelgesang, S.1
Cascorbi, I.2
Schroeder, E.3
Pahnke, J.4
Kroemer, H.K.5
Siegmund, W.6
Kunert-Keil, C.7
Walker, L.8
Warzok, R.W.9
-
30
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D., Klyubin I., Fadeeva J., Cullen W., Anwyl R., Wolfe M., Rowaan M. and Selkoe D. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.1
Klyubin, I.2
Fadeeva, J.3
Cullen, W.4
Anwyl, R.5
Wolfe, M.6
Rowaan, M.7
Selkoe, D.8
-
31
-
-
0001358519
-
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
-
Yan S., Zhu H., Zhu A., Du Golabek A. H., Roher A., Yu J., Soto C., Schmidt A., Stern D. and Kindy M. (2000) Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat. Med. 6, 643-651.
-
(2000)
Nat. Med.
, vol.6
, pp. 643-651
-
-
Yan, S.1
Zhu, H.2
Zhu, A.3
Du Golabek, A.H.4
Roher, A.5
Yu, J.6
Soto, C.7
Schmidt, A.8
Stern, D.9
Kindy, M.10
-
32
-
-
0029920929
-
Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's disease amyloid-β at the blood-brain and blood-cerebrospinal fluid barriers
-
Zlokovic B., Martel C., Matsubara E., McComb J., Zheng G., McCluskey R., Frangione B. and Ghiso J. (1996) Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's disease amyloid-β at the blood-brain and blood-cerebrospinal fluid barriers. Proc. Natl Acad. Sci. USA 93, 4229-4234.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 4229-4234
-
-
Zlokovic, B.1
Martel, C.2
Matsubara, E.3
McComb, J.4
Zheng, G.5
McCluskey, R.6
Frangione, B.7
Ghiso, J.8
|