Modulation of p53 Function by SET8-Mediated Methylation at Lysine 382

Molecular Cell

Volumn 27, Issue 4, 2007, Pages 636-646

  Shi, Xiaobing ^a   Kachirskaia, Ioulia ^a   Yamaguchi, Hiroshi ^b   West, Lisandra E ^a   Wen, Hong ^c   Wang, Evelyn W ^c   Dutta, Sucharita ^c   Appella, Ettore ^b   Gozani, Or ^a  

^a STANFORD UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLCYCLE

Indexed keywords

LYSINE; METHYLTRANSFERASE; METHYLTRANSFERASE SET8; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METHYLATION; TRANSCRIPTION INITIATION; TRANSLATION INITIATION;

AMINO ACID SEQUENCE; ANTIBODIES; CELL LINE, TUMOR; DNA DAMAGE; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LYSINE; METHYLATION; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RNA INTERFERENCE; SUBSTRATE SPECIFICITY; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 34547809957     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.07.012     Document Type: Article

References (38)

1. Appella E., and Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268 (2001) 2764-2772
2. Bannister A.J., and Kouzarides T. Histone methylation: recognizing the methyl mark. Methods Enzymol. 376 (2004) 269-288
3. Beisel C., Imhof A., Greene J., Kremmer E., and Sauer F. Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature 419 (2002) 857-862
4. Botuyan M.V., Lee J., Ward I.M., Kim J.E., Thompson J.R., Chen J., and Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127 (2006) 1361-1373
5. Brown M.A., Sims III R.J., Gottlieb P.D., and Tucker P.W. Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol. Cancer 5 (2006) 26
6. Chuikov S., Kurash J.K., Wilson J.R., Xiao B., Justin N., Ivanov G.S., McKinney K., Tempst P., Prives C., Gamblin S.J., et al. Regulation of p53 activity through lysine methylation. Nature 432 (2004) 353-360
7. Couture J.F., Collazo E., Brunzelle J.S., and Trievel R.C. Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev. 19 (2005) 1455-1465
8. Daniel J.A., Pray-Grant M.G., and Grant P.A. Effector proteins for methylated histones: an expanding family. Cell Cycle 4 (2005) 919-926
9. Fang J., Feng Q., Ketel C.S., Wang H., Cao R., Xia L., Erdjument-Bromage H., Tempst P., Simon J.A., and Zhang Y. Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase. Curr. Biol. 12 (2002) 1086-1099
10. Feng L., Lin T., Uranishi H., Gu W., and Xu Y. Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol. Cell. Biol. 25 (2005) 5389-5395
11. Gozani O., Patton J.G., and Reed R. A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J. 13 (1994) 3356-3367
12. Huang J., Perez-Burgos L., Placek B.J., Sengupta R., Richter M., Dorsey J.A., Kubicek S., Opravil S., Jenuwein T., and Berger S.L. Repression of p53 activity by Smyd2-mediated methylation. Nature 444 (2006) 629-632
13. Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
14. Julien E., and Herr W. A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1. Mol. Cell 14 (2004) 713-725
15. Karachentsev D., Sarma K., Reinberg D., and Steward R. PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev. 19 (2005) 431-435
16. Kim J., Daniel J., Espejo A., Lake A., Krishna M., Xia L., Zhang Y., and Bedford M.T. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep. 7 (2006) 397-403
17. Knights C.D., Catania J., Di Giovanni S., Muratoglu S., Perez R., Swartzbeck A., Quong A.A., Zhang X., Beerman T., Pestell R.G., and Avantaggiati M.L. Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J. Cell Biol. 173 (2006) 533-544
18. Krummel K.A., Lee C.J., Toledo F., and Wahl G.M. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc. Natl. Acad. Sci. USA 102 (2005) 10188-10193
19. Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
20. Lokshin M., Tanaka T., and Prives C. Transcriptional regulation by p53 and p73. Cold Spring Harb. Symp. Quant. Biol. 70 (2005) 121-128
21. Luo J., Su F., Chen D., Shiloh A., and Gu W. Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature 408 (2000) 377-381
22. Luo J., Nikolaev A.Y., Imai S., Chen D., Su F., Shiloh A., Guarente L., and Gu W. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107 (2001) 137-148
23. Nishioka K., Chuikov S., Sarma K., Erdjument-Bromage H., Allis C.D., Tempst P., and Reinberg D. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev. 16 (2002) 479-489
24. Nishioka K., Rice J.C., Sarma K., Erdjument-Bromage H., Werner J., Wang Y., Chuikov S., Valenzuela P., Tempst P., Steward R., et al. PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 9 (2002) 1201-1213
25. Rayasam G.V., Wendling O., Angrand P.O., Mark M., Niederreither K., Song L., Lerouge T., Hager G.L., Chambon P., and Losson R. NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J. 22 (2003) 3153-3163
26. Rice J.C., Nishioka K., Sarma K., Steward R., Reinberg D., and Allis C.D. Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev. 16 (2002) 2225-2230
27. Ruthenburg A.J., Allis C.D., and Wysocka J. Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol. Cell 25 (2007) 15-30
28. Schotta G., Lachner M., Sarma K., Ebert A., Sengupta R., Reuter G., Reinberg D., and Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18 (2004) 1251-1262
29. Shi X., Hong T., Walter K.L., Ewalt M., Michishita E., Hung T., Carney D., Pena P., Lan F., Kaadige M.R., et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442 (2006) 96-99
30. Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., and McMahon S.B. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24 (2006) 841-851
31. Tang Y., Luo J., Zhang W., and Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol. Cell 24 (2006) 827-839
32. Toledo F., and Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat. Rev. Cancer 6 (2006) 909-923
33. Vaquero A., Scher M., Lee D., Erdjument-Bromage H., Tempst P., and Reinberg D. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16 (2004) 93-105
34. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., and Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107 (2001) 149-159
35. Wang H., Cao R., Xia L., Erdjument-Bromage H., Borchers C., Tempst P., and Zhang Y. Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Mol. Cell 8 (2001) 1207-1217
36. Xiao B., Jing C., Kelly G., Walker P.A., Muskett F.W., Frenkiel T.A., Martin S.R., Sarma K., Reinberg D., Gamblin S.J., and Wilson J.R. Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev. 19 (2005) 1444-1454
37. Zhang Y. It takes a PHD to interpret histone methylation. Nat. Struct. Mol. Biol. 13 (2006) 572-574
38. Zhang K., and Dent S.Y. Histone modifying enzymes and cancer: going beyond histones. J. Cell. Biochem. 96 (2005) 1137-1148