Hzf Determines Cell Survival upon Genotoxic Stress by Modulating p53 Transactivation

Cell

Volumn 130, Issue 4, 2007, Pages 624-637

  Das, Sanjeev ^a   Raj, Lakshmi ^a   Zhao, Bo ^b   Kimura, Yuki ^c   Bernstein, Alan ^c   Aaronson, Stuart A ^b   Lee, Sam W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

CELLCYCLE; DNA; SIGNALING

Indexed keywords

PROTEIN HZF; PROTEIN P53; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

APOPTOSIS; ARTICLE; AUTOREGULATION; CELL CYCLE ARREST; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE; GENOTOXICITY; HUMAN; HUMAN CELL; HZF GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; WILD TYPE;

MUS;

EID: 34548049032     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2007.06.013     Document Type: Article

References (46)

1. Attardi L.D., Reczek E.E., Cosmas C., Demicco E.G., McCurrach M.E., Lowe S.W., and Jacks T. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 14 (2000) 704-718
2. Bergamaschi D., Samuels Y., Sullivan A., Zvelebil M., Breyssens H., Bisso A., Del Sal G., Syed N., Smith P., Gasco M., et al. iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat. Genet. 38 (2006) 1133-1141
3. Braithwaite A.W., Del Sal G., and Lu X. Some p53-binding proteins that can function as arbiters of life and death. Cell Death Differ. 13 (2006) 984-993
4. Brooks C.L., and Gu W. p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21 (2006) 307-315
5. Bunz F., Dutriaux A., Lengauer C., Waldman T., Zhou S., Brown J.P., Sedivy J.M., Kinzler K.W., and Vogelstein B. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282 (1998) 1497-1501
6. Canman C.E., Lim D.S., Cimprich K.A., Taya Y., Tamai K., Sakaguchi K., Appella E., Kastan M.B., and Siliciano J.D. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281 (1998) 1677-1679
7. Chehab N.H., Malikzay A., Appel M., and Halazonetis T.D. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14 (2000) 278-288
8. Dornan D., Wertz I., Shimizu H., Arnott D., Frantz G.D., Dowd P., O'Rourke K., Koeppen H., and Dixit V.M. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 429 (2004) 86-92
9. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., and Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 75 (1993) 817-825
10. Groisman R., Polanowska J., Kuraoka I., Sawada J., Saijo M., Drapkin R., Kisselev A.F., Tanaka K., and Nakatani Y. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113 (2003) 357-367
11. Han J.A., Kim J.I., Ongusaha P.P., Hwang D.H., Ballou L.R., Mahale A., Aaronson S.A., and Lee S.W. P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. EMBO J. 21 (2002) 5635-5644
12. Harris S.L., and Levine A.J. The p53 pathway: positive and negative feedback loops. Oncogene 24 (2005) 2899-2908
13. Hermeking H., Lengauer C., Polyak K., He T.C., Zhang L., Thiagalingam S., Kinzler K.W., and Vogelstein B. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell 1 (1997) 3-11
14. Hidaka M., Caruana G., Stanford W.L., Sam M., Correll P.H., and Bernstein A. Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells. Mech. Dev. 90 (2000) 3-15
15. Hupp T.R., Meek D.W., Midgley C.A., and Lane D.P. Regulation of the specific DNA binding function of p53. Cell 71 (1992) 875-886
16. Iwabuchi K., Li B., Bartel P., and Fields S. Use of the two-hybrid system to identify the domain of p53 involved in oligomerization. Oncogene 8 (1993) 1693-1696
17. Kern S.E., Kinzler K.W., Bruskin A., Jarosz D., Friedman P., Prives C., and Vogelstein B. Identification of p53 as a sequence-specific DNA-binding protein. Science 252 (1991) 1708-1711
18. Khosravi R., Maya R., Gottlieb T., Oren M., Shiloh Y., and Shkedy D. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl. Acad. Sci. USA 96 (1999) 14973-14977
19. Kimura Y., Hart A., Hirashima M., Wang C., Holmyard D., Pittman J., Pang X.L., Jackson C.W., and Bernstein A. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J. Exp. Med. 195 (2002) 941-952
20. Lavin M.F., and Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ. 13 (2006) 941-950
21. Leng R.P., Lin Y., Ma W., Wu H., Lemmers B., Chung S., Parant J.M., Lozano G., Hakem R., and Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112 (2003) 779-791
22. Li B., and Fields S. Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. FASEB J. 7 (1993) 957-963
23. Lin Y., Ma W., and Benchimol S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat. Genet. 26 (2000) 122-127
24. Miyashita T., and Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 (1995) 293-299
25. Nakano K., and Vousden K.H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7 (2001) 683-694
26. Oda E., Ohki R., Murasawa H., Nemoto J., Shibue T., Yamashita T., Tokino T., Taniguchi T., and Tanaka N. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288 (2000) 1053-1058
27. Ongusaha P.P., Kim J.I., Fang L., Wong T.W., Yancopoulos G.D., Aaronson S.A., and Lee S.W. p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22 (2003) 1289-1301
28. Rodriguez M.S., Desterro J.M., Lain S., Midgley C.A., Lane D.P., and Hay R.T. SUMO-1 modification activates the transcriptional response of p53. EMBO J. 18 (1999) 6455-6461
29. Rowan S., Ludwig R.L., Haupt Y., Bates S., Lu X., Oren M., and Vousden K.H. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J. 15 (1996) 827-838
30. Samuels-Lev Y., O'Connor D.J., Bergamaschi D., Trigiante G., Hsieh J.K., Zhong S., Campargue I., Naumovski L., Crook T., and Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8 (2001) 781-794
31. Sharma S., Dimasi D., Higginson K., and Della N.G. RZF, a zinc-finger protein in the photoreceptors of human retina. Gene 342 (2004) 219-229
32. Sugimoto M., Gromley A., and Sherr C.J. Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage. Mol. Cell. Biol. 26 (2006) 502-512
33. Sykes S.M., Mellert H.S., Holbert M.A., Li K., Marmorstein R., Lane W.S., and McMahon S.B. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24 (2006) 841-851
34. Tang Y., Luo J., Zhang W., and Gu W. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol. Cell 24 (2006) 827-839
35. Thornborrow E.C., Patel S., Mastropietro A.E., Schwartzfarb E.M., and Manfredi J.J. A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes. Oncogene 21 (2002) 990-999
36. Trigiante G., and Lu X. ASPP and cancer. Nat. Rev. Cancer 6 (2006) 217-226
37. Villunger A., Michalak E.M., Coultas L., Mullauer F., Bock G., Ausserlechner M.J., Adams J.M., and Strasser A. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 (2003) 1036-1038
38. Vogelstein B., Lane D., and Levine A.J. Surfing the p53 network. Nature 408 (2000) 307-310
39. Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2 (2002) 594-604
40. Waldman T., Lengauer C., Kinzler K.W., and Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381 (1996) 713-716
41. Wang Y., and Prives C. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376 (1995) 88-91
42. Wu X., Bayle J.H., Olson D., and Levine A.J. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7 (1993) 1126-1132
43. Zacchi P., Gostissa M., Uchida T., Salvagno C., Avolio F., Volinia S., Ronai Z., Blandino G., Schneider C., and Del Sal G. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419 (2002) 853-857
44. Zhang L., Yu J., Park B.H., Kinzler K.W., and Vogelstein B. Role of BAX in the apoptotic response to anticancer agents. Science 290 (2000) 989-992
45. Zhang W., Guo X.Y., Hu G.Y., Liu W.B., Shay J.W., and Deisseroth A.B. A temperature-sensitive mutant of human p53. EMBO J. 13 (1994) 2535-2544
46. Zheng H., You H., Zhou X.Z., Murray S.A., Uchida T., Wulf G., Gu L., Tang X., Lu K.P., and Xiao Z.X. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 419 (2002) 849-853