메뉴 건너뛰기




Volumn 6, Issue 6, 2008, Pages 947-954

Mdm2 and Mdm4 loss regulates distinct p53 activities

Author keywords

[No Author keywords available]

Indexed keywords

MDM2 ONCOPROTEIN ANTAGONIST; NUTLIN 3; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; UNCLASSIFIED DRUG; MDM2 PROTEIN, MOUSE; MDM4 PROTEIN, MOUSE; ONCOPROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 50349088876     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-07-2079     Document Type: Article
Times cited : (83)

References (46)
  • 1
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 2
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997;420:25-7.
    • (1997) FEBS Lett , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 3
  • 4
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 6
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997;91:325-34.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 7
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378:206-8.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 8
    • 0028823020 scopus 로고    scopus 로고
    • Montes de Oca Luna R, WD, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995;378:203-6.
    • Montes de Oca Luna R, WD, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995;378:203-6.
  • 10
    • 0034704923 scopus 로고    scopus 로고
    • The loss of mdm2 induces p53-mediated apoptosis
    • de Rozieres S, Maya R, Oren M, Lozano G. The loss of mdm2 induces p53-mediated apoptosis. Oncogene 2000;19:1691-7.
    • (2000) Oncogene , vol.19 , pp. 1691-1697
    • de Rozieres, S.1    Maya, R.2    Oren, M.3    Lozano, G.4
  • 11
    • 33751011894 scopus 로고    scopus 로고
    • Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
    • Boesten LS, Zadelaar SM, De Clercq S, et al. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 2006;13:2089-98.
    • (2006) Cell Death Differ , vol.13 , pp. 2089-2098
    • Boesten, L.S.1    Zadelaar, S.M.2    De Clercq, S.3
  • 12
    • 33644778697 scopus 로고    scopus 로고
    • Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
    • Francoz S, Froment P, Bogaerts S, et al. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A 2006;103:3232-7.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3232-3237
    • Francoz, S.1    Froment, P.2    Bogaerts, S.3
  • 15
    • 10144259344 scopus 로고    scopus 로고
    • MDMX: A novel p53-binding protein with some functional properties of MDM2
    • Shvarts A, Steegenga WT, Riteco N, et al. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 1996;15:5349-57.
    • (1996) EMBO J , vol.15 , pp. 5349-5357
    • Shvarts, A.1    Steegenga, W.T.2    Riteco, N.3
  • 16
    • 0034623074 scopus 로고    scopus 로고
    • Hdmx stabilizes Mdm2 and p53
    • Stad R, Ramos YF, Little N, et al. Hdmx stabilizes Mdm2 and p53. J Biol Chem 2000;275:28039-44.
    • (2000) J Biol Chem , vol.275 , pp. 28039-28044
    • Stad, R.1    Ramos, Y.F.2    Little, N.3
  • 17
    • 0033963335 scopus 로고    scopus 로고
    • MdmX protects p53 from Mdm2-mediated degradation
    • Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000;20:1001-7.
    • (2000) Mol Cell Biol , vol.20 , pp. 1001-1007
    • Jackson, M.W.1    Berberich, S.J.2
  • 18
    • 0035203715 scopus 로고    scopus 로고
    • Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
    • Stad R, Little NA, Xirodimas DP, et al. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep 2001;2:1029-34.
    • (2001) EMBO Rep , vol.2 , pp. 1029-1034
    • Stad, R.1    Little, N.A.2    Xirodimas, D.P.3
  • 19
    • 0033621415 scopus 로고    scopus 로고
    • Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
    • Sharp DA, Kratowicz SA, Sank MJ, George DL. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 1999;274:38189-96.
    • (1999) J Biol Chem , vol.274 , pp. 38189-38196
    • Sharp, D.A.1    Kratowicz, S.A.2    Sank, M.J.3    George, D.L.4
  • 21
    • 0036606416 scopus 로고    scopus 로고
    • Zhang N, mdmx is a negative regulator of p53 activity in vivo
    • Finch RA, Donoviel DB, Potter D, et al. Zhang N, mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002;62:3221-5.
    • (2002) Cancer Res , vol.62 , pp. 3221-3225
    • Finch, R.A.1    Donoviel, D.B.2    Potter, D.3
  • 22
    • 0036311067 scopus 로고    scopus 로고
    • Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
    • Migliorini D, Lazzerini Denchi E, Danovi D, et al. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002;22:5527-38.
    • (2002) Mol Cell Biol , vol.22 , pp. 5527-5538
    • Migliorini, D.1    Lazzerini Denchi, E.2    Danovi, D.3
  • 23
    • 33846239416 scopus 로고    scopus 로고
    • The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
    • Poyurovsky MV, Priest C, Kentsis A, et al. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J 2007;26:90-101.
    • (2007) EMBO J , vol.26 , pp. 90-101
    • Poyurovsky, M.V.1    Priest, C.2    Kentsis, A.3
  • 24
    • 33846193699 scopus 로고    scopus 로고
    • An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    • Uldrijan S, Pannekoek WJ, Vousden KH. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J 2007;26:102-12.
    • (2007) EMBO J , vol.26 , pp. 102-112
    • Uldrijan, S.1    Pannekoek, W.J.2    Vousden, K.H.3
  • 25
    • 0037205454 scopus 로고    scopus 로고
    • Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
    • Gu J, Kawai H, Nie L, et al. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem 2002;277:19251-4.
    • (2002) J Biol Chem , vol.277 , pp. 19251-19254
    • Gu, J.1    Kawai, H.2    Nie, L.3
  • 26
    • 0034863683 scopus 로고    scopus 로고
    • Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
    • Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001;29:92-5.
    • (2001) Nat Genet , vol.29 , pp. 92-95
    • Parant, J.1    Chavez-Reyes, A.2    Little, N.A.3    Yan, W.4    Reinke, V.5    Jochemsen, A.G.6    Lozano, G.7
  • 28
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 29
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks T, Remington L, Williams BO, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol 1994;4:1-7.
    • (1994) Curr Biol , vol.4 , pp. 1-7
    • Jacks, T.1    Remington, L.2    Williams, B.O.3
  • 30
    • 19944365214 scopus 로고    scopus 로고
    • p53 must be competent for transcriptional regulation to suppress tumor formation
    • Nister M, Tang M, Zhang XQ, et al. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene 2005;24:3563-73.
    • (2005) Oncogene , vol.24 , pp. 3563-3573
    • Nister, M.1    Tang, M.2    Zhang, X.Q.3
  • 31
    • 0026093164 scopus 로고
    • Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
    • Martinez J, Georgoff I, Levine AJ. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev 1991;5:151-9.
    • (1991) Genes Dev , vol.5 , pp. 151-159
    • Martinez, J.1    Georgoff, I.2    Levine, A.J.3
  • 32
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz D, Halevy O, Oren M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 1990;62:671-80.
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 33
    • 0037147143 scopus 로고    scopus 로고
    • MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
    • Badciong JC, Haas AL. MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J Biol Chem 2002;277:49668-75.
    • (2002) J Biol Chem , vol.277 , pp. 49668-49675
    • Badciong, J.C.1    Haas, A.L.2
  • 34
    • 0033531252 scopus 로고    scopus 로고
    • Comparative study of the p53 - 2 and p53-MDMX interfaces
    • Bottger V, Bottger A, Garcia-Echeverria C, et al. Comparative study of the p53 - 2 and p53-MDMX interfaces. Oncogene 1999;18:189-99.
    • (1999) Oncogene , vol.18 , pp. 189-199
    • Bottger, V.1    Bottger, A.2    Garcia-Echeverria, C.3
  • 35
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003;10:431-42.
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 36
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8.
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 37
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the therapeutic efficacy of p53 restoration in tumors
    • Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006;127:1323-34.
    • (2006) Cell , vol.127 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 38
    • 33846899456 scopus 로고    scopus 로고
    • Restoration of p53 function leads to tumour regression in vivo
    • Ventura A, Kirsch DG, McLaughlin ME, et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007;445:661-5.
    • (2007) Nature , vol.445 , pp. 661-665
    • Ventura, A.1    Kirsch, D.G.2    McLaughlin, M.E.3
  • 39
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007;445:656-60.
    • (2007) Nature , vol.445 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3
  • 41
    • 33748920505 scopus 로고    scopus 로고
    • Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53
    • Kostic M, Matt T, Martinez-Yamout MA, Dyson HJ, Wright PE. Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol 2006;363:433-50.
    • (2006) J Mol Biol , vol.363 , pp. 433-450
    • Kostic, M.1    Matt, T.2    Martinez-Yamout, M.A.3    Dyson, H.J.4    Wright, P.E.5
  • 42
    • 34547615407 scopus 로고    scopus 로고
    • Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation
    • Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A 2007;104:12365-70.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12365-12370
    • Wang, Y.V.1    Wade, M.2    Wong, E.3    Li, Y.C.4    Rodewald, L.W.5    Wahl, G.M.6
  • 44
    • 33750590095 scopus 로고    scopus 로고
    • Inactivation of the p53 pathway in retinoblastoma
    • Laurie NA, Donovan SL, Shih CS, et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006;444:61-6.
    • (2006) Nature , vol.444 , pp. 61-66
    • Laurie, N.A.1    Donovan, S.L.2    Shih, C.S.3
  • 45
    • 4744373426 scopus 로고    scopus 로고
    • Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389
    • Bruins W, Zwart E, Attardi LD, et al. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol 2004;24:8884-94.
    • (2004) Mol Cell Biol , vol.24 , pp. 8884-8894
    • Bruins, W.1    Zwart, E.2    Attardi, L.D.3
  • 46
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • Wu WS, Heinrichs S, Xu D, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005;123:641-53.
    • (2005) Cell , vol.123 , pp. 641-653
    • Wu, W.S.1    Heinrichs, S.2    Xu, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.