-
1
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997;387:296-9.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
2
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997;420:25-7.
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
4
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992;69:1237-45.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
5
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
-
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 1993;362:857-60.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
Gyuris, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
6
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh SY, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 1997;91:325-34.
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
Ikeda, M.2
Taya, Y.3
Prives, C.4
-
7
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
-
Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995;378:206-8.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
Bradley, A.4
-
8
-
-
0028823020
-
-
Montes de Oca Luna R, WD, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995;378:203-6.
-
Montes de Oca Luna R, WD, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995;378:203-6.
-
-
-
-
9
-
-
0346690270
-
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets
-
Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 2003;63:8664-9.
-
(2003)
Cancer Res
, vol.63
, pp. 8664-8669
-
-
Chavez-Reyes, A.1
Parant, J.M.2
Amelse, L.L.3
de Oca Luna, R.M.4
Korsmeyer, S.J.5
Lozano, G.6
-
11
-
-
33751011894
-
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death
-
Boesten LS, Zadelaar SM, De Clercq S, et al. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 2006;13:2089-98.
-
(2006)
Cell Death Differ
, vol.13
, pp. 2089-2098
-
-
Boesten, L.S.1
Zadelaar, S.M.2
De Clercq, S.3
-
12
-
-
33644778697
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S, et al. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A 2006;103:3232-7.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, P.2
Bogaerts, S.3
-
13
-
-
33644772395
-
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
-
Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006;26:192-8.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 192-198
-
-
Grier, J.D.1
Xiong, S.2
Elizondo-Fraire, A.C.3
Parant, J.M.4
Lozano, G.5
-
14
-
-
33644757727
-
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A 2006;103:3226-31.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3226-3231
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
Liu, G.4
Lozano, G.5
-
15
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties of MDM2
-
Shvarts A, Steegenga WT, Riteco N, et al. MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J 1996;15:5349-57.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
-
16
-
-
0034623074
-
Hdmx stabilizes Mdm2 and p53
-
Stad R, Ramos YF, Little N, et al. Hdmx stabilizes Mdm2 and p53. J Biol Chem 2000;275:28039-44.
-
(2000)
J Biol Chem
, vol.275
, pp. 28039-28044
-
-
Stad, R.1
Ramos, Y.F.2
Little, N.3
-
17
-
-
0033963335
-
MdmX protects p53 from Mdm2-mediated degradation
-
Jackson MW, Berberich SJ. MdmX protects p53 from Mdm2-mediated degradation. Mol Cell Biol 2000;20:1001-7.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1001-1007
-
-
Jackson, M.W.1
Berberich, S.J.2
-
18
-
-
0035203715
-
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
-
Stad R, Little NA, Xirodimas DP, et al. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep 2001;2:1029-34.
-
(2001)
EMBO Rep
, vol.2
, pp. 1029-1034
-
-
Stad, R.1
Little, N.A.2
Xirodimas, D.P.3
-
19
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
Sharp DA, Kratowicz SA, Sank MJ, George DL. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 1999;274:38189-96.
-
(1999)
J Biol Chem
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
George, D.L.4
-
20
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ 2006;13:927-34.
-
(2006)
Cell Death Differ
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
Francoz, S.2
Maetens, M.3
Wahl, G.4
Toledo, F.5
Lozano, G.6
-
21
-
-
0036606416
-
Zhang N, mdmx is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D, et al. Zhang N, mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002;62:3221-5.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
Potter, D.3
-
22
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D, Lazzerini Denchi E, Danovi D, et al. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002;22:5527-38.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.1
Lazzerini Denchi, E.2
Danovi, D.3
-
23
-
-
33846239416
-
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
-
Poyurovsky MV, Priest C, Kentsis A, et al. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J 2007;26:90-101.
-
(2007)
EMBO J
, vol.26
, pp. 90-101
-
-
Poyurovsky, M.V.1
Priest, C.2
Kentsis, A.3
-
24
-
-
33846193699
-
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
-
Uldrijan S, Pannekoek WJ, Vousden KH. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J 2007;26:102-12.
-
(2007)
EMBO J
, vol.26
, pp. 102-112
-
-
Uldrijan, S.1
Pannekoek, W.J.2
Vousden, K.H.3
-
25
-
-
0037205454
-
Mutual dependence of MDM2 and MDMX in their functional inactivation of p53
-
Gu J, Kawai H, Nie L, et al. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem 2002;277:19251-4.
-
(2002)
J Biol Chem
, vol.277
, pp. 19251-19254
-
-
Gu, J.1
Kawai, H.2
Nie, L.3
-
26
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001;29:92-5.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.1
Chavez-Reyes, A.2
Little, N.A.3
Yan, W.4
Reinke, V.5
Jochemsen, A.G.6
Lozano, G.7
-
27
-
-
34250344087
-
Loss of Mdm4 results in p53-dependent dilated cardiomyopathy
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation 2007;115:2925-30.
-
(2007)
Circulation
, vol.115
, pp. 2925-2930
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
Fernandez-Garcia, B.4
Lozano, G.5
-
28
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992;356:215-21.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
-
30
-
-
19944365214
-
p53 must be competent for transcriptional regulation to suppress tumor formation
-
Nister M, Tang M, Zhang XQ, et al. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene 2005;24:3563-73.
-
(2005)
Oncogene
, vol.24
, pp. 3563-3573
-
-
Nister, M.1
Tang, M.2
Zhang, X.Q.3
-
31
-
-
0026093164
-
Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein
-
Martinez J, Georgoff I, Levine AJ. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev 1991;5:151-9.
-
(1991)
Genes Dev
, vol.5
, pp. 151-159
-
-
Martinez, J.1
Georgoff, I.2
Levine, A.J.3
-
32
-
-
0025111068
-
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
-
Michalovitz D, Halevy O, Oren M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 1990;62:671-80.
-
(1990)
Cell
, vol.62
, pp. 671-680
-
-
Michalovitz, D.1
Halevy, O.2
Oren, M.3
-
33
-
-
0037147143
-
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
-
Badciong JC, Haas AL. MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J Biol Chem 2002;277:49668-75.
-
(2002)
J Biol Chem
, vol.277
, pp. 49668-49675
-
-
Badciong, J.C.1
Haas, A.L.2
-
34
-
-
0033531252
-
Comparative study of the p53 - 2 and p53-MDMX interfaces
-
Bottger V, Bottger A, Garcia-Echeverria C, et al. Comparative study of the p53 - 2 and p53-MDMX interfaces. Oncogene 1999;18:189-99.
-
(1999)
Oncogene
, vol.18
, pp. 189-199
-
-
Bottger, V.1
Bottger, A.2
Garcia-Echeverria, C.3
-
35
-
-
0038075338
-
Decision making by p53: Life, death and cancer
-
Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003;10:431-42.
-
(2003)
Cell Death Differ
, vol.10
, pp. 431-442
-
-
Oren, M.1
-
36
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev LT, Vu BT, Graves B, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
-
37
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006;127:1323-34.
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
Brown-Swigart, L.2
Evan, G.I.3
-
38
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A, Kirsch DG, McLaughlin ME, et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007;445:661-5.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
-
39
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007;445:656-60.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
-
40
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
-
Linares LK, Hengstermann A, Ciechanover A, Muller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proc Natl Acad Sci U S A 2003;100:12009-14.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Hengstermann, A.2
Ciechanover, A.3
Muller, S.4
Scheffner, M.5
-
41
-
-
33748920505
-
Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53
-
Kostic M, Matt T, Martinez-Yamout MA, Dyson HJ, Wright PE. Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53. J Mol Biol 2006;363:433-50.
-
(2006)
J Mol Biol
, vol.363
, pp. 433-450
-
-
Kostic, M.1
Matt, T.2
Martinez-Yamout, M.A.3
Dyson, H.J.4
Wright, P.E.5
-
42
-
-
34547615407
-
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation
-
Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A 2007;104:12365-70.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12365-12370
-
-
Wang, Y.V.1
Wade, M.2
Wong, E.3
Li, Y.C.4
Rodewald, L.W.5
Wahl, G.M.6
-
44
-
-
33750590095
-
Inactivation of the p53 pathway in retinoblastoma
-
Laurie NA, Donovan SL, Shih CS, et al. Inactivation of the p53 pathway in retinoblastoma. Nature 2006;444:61-6.
-
(2006)
Nature
, vol.444
, pp. 61-66
-
-
Laurie, N.A.1
Donovan, S.L.2
Shih, C.S.3
-
45
-
-
4744373426
-
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389
-
Bruins W, Zwart E, Attardi LD, et al. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol 2004;24:8884-94.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 8884-8894
-
-
Bruins, W.1
Zwart, E.2
Attardi, L.D.3
-
46
-
-
27744547091
-
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
-
Wu WS, Heinrichs S, Xu D, et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005;123:641-53.
-
(2005)
Cell
, vol.123
, pp. 641-653
-
-
Wu, W.S.1
Heinrichs, S.2
Xu, D.3
|