The central region of HDM2 provides a second binding site for p53

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 5, 2006, Pages 1227-1232

  Yu, Grace W ^a   Rudiger, Stefan ^b   Veprintsev, Dmitry ^a   Freund, Stefan ^a   Fernandez Fernandez, M Rosario ^a   Fersht, Alan R ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Isothermal titration calorimetry; Mdm2; NMR

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; LIGASE; PROTEIN MDM2; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; AREA UNDER CURVE; BINDING SITES; BINDING, COMPETITIVE; CALORIMETRY; DNA; DNA, COMPLEMENTARY; ESCHERICHIA COLI; FLUORESCENCE POLARIZATION; GENES, P53; HUMANS; IMMUNOBLOTTING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEIN P53; ZINC FINGERS;

EID: 31944433282     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510343103     Document Type: Article

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