An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

Nature Chemical Biology

Volumn 2, Issue 4, 2006, Pages 202-206

  Brummelkamp, Thijn R ^a,b   Fabius, Armida W M ^a   Mullenders, Jasper ^a   Madiredjo, Mandy ^a   Velds, Arno ^a   Kerkhoven, Ron M ^a   Bernards, René ^a   Beijersbergen, Roderick L ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53; SHORT HAIRPIN RNA; SMALL MOLECULE TRANSPORT AGENT; ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE; NUCLEAR PROTEIN; NUTLIN 3; PHOSPHOPROTEIN; PIPERAZINE DERIVATIVE; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TP53BP1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER SCREENING; CYTOTOXICITY; DNA DAMAGE; GENE MUTATION; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA INTERFERENCE; TARGET CELL; TISSUE SPECIFICITY; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; CHEMICAL MODEL; CHEMISTRY; DNA MICROARRAY; DRUG ANTAGONISM; FIBROBLAST; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETIC PROCEDURES; INFORMATION PROCESSING; METABOLISM; MOUSE; NEOPLASM; NUCLEIC ACID HYBRIDIZATION; PLASMID; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOMATIC DATA PROCESSING; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; DNA DAMAGE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENETIC TECHNIQUES; HUMANS; IMIDAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; NEOPLASMS; NUCLEAR PROTEINS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; PIPERAZINES; PLASMIDS; PROTO-ONCOGENE PROTEINS C-MDM2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33646343474     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio774     Document Type: Article

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