Prolonged survival of microencapsulated neonatal porcine islets in mice treated with a combination of anti-CD154 and anti-LFA-1 monoclonal antibodies

Transplantation

Volumn 80, Issue 6, 2005, Pages 821-827

  Kobayashi, Tsunehiro ^a,b   Harb, George ^a   Rayat, Gina R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

CD154; LFA 1; Microencapsulation; Monoclonal antibodies; Neonatal porcine islets

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTIBODY; PEROXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; GRAFT REJECTION; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOCOMPETENCE; IMMUNOCOMPETENT CELL; MALE; MICROENCAPSULATION; MOUSE; NEWBORN; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; SURVIVAL TIME; SWINE; XENOGRAFT;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; CD40 LIGAND; DRUG COMPOUNDING; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOTHERAPY; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; SURVIVAL RATE; SWINE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 26644446441     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000173773.01811.88     Document Type: Article

References (29)

1. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Eng J Med 2000; 343: 230.
2. Ryan EA, Lakey JR, Rajotte RV, et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710.
3. Korbutt GS, Elliott JF, Ao Z, et al. Large scale isolation, growth, and function of porcine neonatal islet cells. J Clin Invest 1996; 97: 2119.
4. Rayat GR, Rajotte RV, Ao Z, Korbutt GS. Microencapsulation of neonatal porcine islets: protection from human antibody/complement-mediated cytolysis in vitro and long-term reversal of diabetes in nude mice. Transplantation 2000; 69: 1084.
5. Yoon KH, Quickel RR, Tatarkiewicz K, et al. Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant 1999; 8: 673.
6. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, et al. Increase in β-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of β-cells and differentiation of duct cells. Endocrinology 2001; 142: 2115.
7. Kin T, Korbutt GS, Kobayashi T, et al. Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets. Diabetes 2005; 54: 1032.
8. Rayat GR, Johnson ZA, Beilke JN, et al. The degree of phylogenetic disparity of islet grafts dictates the reliance on indirect CD4 T-cell antigen recognition for rejection. Diabetes 2003; 52: 1433.
9. Korbutt GS, Rayat GR, Rajotte RV, Kieffer TJ. In vitro expansion of neonatal porcine islet cells is associated with elevated expression of IDX-1 and NKX2.2. Diabetologia 2000; 42 (Suppl 1): abstract 151.
10. Korbutt GS, Rayat GR, Rajotte RV, Kieffer TJ. Culture of microencapsulated neonatal porcine islets is associated with an increased proportion of β cells/cellular insulin content and elevated expression of IDX-1. Diabetes 1999; 48 (Suppl 1): Abstract 474.
11. Binette TM, Dufour JM, Korbutt GS. In vitro maturation of neonatal porcine islets: a novel model for the study of islet development and xenotransplantation. Ann N Y Acad Sci 2001; 944: 47.
12. Tatarkiewicz K, Garcia M, Lopez-Avalos M, et al. Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel. Transplantation 2001; 71: 1518.
13. Rayat GR, Gill RG. Indefinite survival of neonatal porcine islet xenografts by simultaneous targeting of LFA-1 and CD154 or CD45RB. Diabetes 2005; 54: 443.
14. Berney T, Pileggi A, Molano RD, et al. The effect of simultaneous CD154 and LFA-1 blockade on the survival of allogeneic islet grafts in nonobese diabetic mice. Transplantation 2003; 76: 1669.
15. Nicolls MR, Coulombe M, Beilke J, et al. CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. J Immunol 2002; 169: 4831.
16. Gill RG. Antigen presentation pathways for immunity to islet transplants. Relevance to immunoisolation. Ann N Y Acad Sci 1999; 875: 255.
17. Lanza RP, Kuhtreiber WM, Beyer A, Chick WL. Humoral response to encapsulated islets. Transplant Proc 1994; 26: 3346.
18. Duvivier-Kali VF, Omer A, Lopez-Avalos MD, et al. Survival of microencapsulated adult pig islets in mice in spite of an antibody response. Am J Transplant 2004; 4: 1991.
19. Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591.
20. Caux C, Massacrier C, Vanbervliet B, et al. Activation of human dendritic cells through CD40 cross-linking. J Exp Med 1994; 180: 1263.
21. Karmann K, Hughes CC, Schechner J, et al. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995; 92: 4342.
22. Dustin ML, Carpen O, Springer TA. Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors. J Immunol 1992; 148: 2654.
23. Bachmann MF, McKall-Faienza K, Schmits R, et al. Distinct roles for LFA-1 and CD28 during activation of naïve T cells: adhesion versus costimulation. Immunity 1997; 7: 549.
24. Omer A, Duvivier-Kali VF, Trivedi N, et al. Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes 2003; 52: 69.
25. Lanza RP, Kuhtreiber WM, Ecker D, et al. Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres. Transplantation 1995; 59: 1377.
26. Fritschy WM, Wolters GH, van Schilfgaarde, R. Effect of alginate-polylysine-alginate microencapsulation on in vitro insulin release from rat pancreatic islets. Diabetes 1991; 40: 37.
27. De Vos P, De Haan, B, Wolters GH, Van Schilfgaarde, R. Factors influencing the adequacy of microencapsulation of rat pancreatic islets. Transplantation 1996; 62: 888.
28. De Vos P, De Haan, B, Pater J, Van Schilfgaarde, R. Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. Transplantation 1996; 62: 893.
29. Korbutt GS, Mallett AG, Ao Z, et al. Improved survival of microencapsulated islets during in vitro culture and enhanced metabolic function following transplantation. Diabetologia 2004; 47: 1810.